Clinical trials: sponsored by Unity Health Toronto
Ductus Arteriosus
The Role of Fetal Ductus Arteriosus in Predicting Spontaneous Preterm Birth
Preterm birth still remains a major cause of perinatal morbidity and mortality worldwide. The exact mechanism stimulating term and preterm births in humans is still unknown.
- Trial name
- NCT03073512
- Testing
- Ultrasound examination
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Group B Streptococcus
The Prevalence of Group B Streptococcus Positive Pregnant Patients in an Inner City Tertiary Care Center
A retrospective review of the prevalence of Group B Streptococcus Positive Pregnant Patients in an Inner City Tertiary Care Center
- Trial name
- NCT01251289
- Volunteers
- 628 people
- Sponsor
- Unity Health Toronto
Endometriosis, Chronic Pain
Virtual Mindfulness for the Management of Endometriosis Pelvic Pain.
Endometriosis is a gynecologic condition that can cause severe pelvic pain and significantly impair quality of life. Endometriosis symptoms cannot always be controlled by medical therapy or surgery alone, indicating a need for…
- Trial name
- NCT05554497
- Testing
- Mindfulness-based stress reduction curriculum
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Preterm Labor, Fetal Glucocorticoid Exposure
The Effect of Antenatal Corticosteroids on the Fetal Thymus - a Possible Role in Fetal Immune Programming
Administration of corticosteroids is standard practice for pregnant patients at risk of preterm labour to reduce the risk of neonatal respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis and…
- Trial name
- NCT03057717
- Testing
- 2D ultrasound assessment
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Infertility
Access to Infertility Services: Clinic Perspective
Since the identification of the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS) in the 1980s, there have been significant advances made in the management and long-term prognosis for infected…
- Trial name
- NCT00782132
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cancer
Incidental Genomics
Health care providers (HCP) are increasingly using genomic sequencing (GS) to diagnose diseases and target treatment for patients. However, GS may incidentally reveal inherited risks for thousands of current and future diseases.
- Trial name
- NCT03597165
- Testing
- Incidental Genomic Sequencing Results, GS Results for Primary Indications only
- Where
- 3 sites in Canada
- Volunteers
- 289 people
- Sponsor
- Unity Health Toronto
Emotional Distress, Quality of Life
At-risk and vulNerable Individuals To Infection With COVID-19 and ProActive inTervention With intEgrated Health and Social Care
This randomized control trial aims to explore a data-driven, proactive approach to identifying patients at greatest risk during the pandemic, and assess the impact of an embedded System Navigator in a primary health care setting.
- Conditions
- Emotional Distress, Quality of Life, Mental Health
- Trial name
- ANTICIPATE (NCT05197608)
- Testing
- System Navigator, Tailored list of resources
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Treatment-resistant Depression (TRD)
Auditory MMN EEG in TRD in Response to Ketamine
To develop and test a neurocomputational model of ketamine treatment response predictions in TRD.
- Trial name
- NCT05464264
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Social Anxiety, Sexual Risk
Sexual Confidence: CBT for Social Anxiety Disorder With HIV Risk Reduction Counselling for HIV-negative gbMSM
Given the continued high human immunodeficiency virus (HIV) prevalence rates among gay, bisexual, and other men who have sex with men (MSM) in North American cities, there is a critical need for HIV prevention interventions for…
- Conditions
- Social Anxiety, Sexual Risk, HIV
- Trial name
- SC-RCT (NCT04381559)
- Testing
- Cognitive Behavioural Therapy, Applied Relaxation
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Obesity, Childhood, Nutrition
Nutrition Recommendation Intervention trialS in Children's Healthcare
NuRISH is a suite of clinical trials for children from low-income families which will determine whether primary healthcare prescription for: 1) Optimal breastfeeding with support from a mobile lactation consultant vs.
- Conditions
- Obesity, Childhood, Nutrition, Health Risk Behaviors, Breastfeeding
- Trial name
- NuRISH (NCT05477628)
- Testing
- Childcare Navigator, Lactation Consultant, Lactation Consultant Support and Childcare Navigator Support
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Diabetes Mellitus, Type 2
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion
FIERCE is an observational cross-sectional study. Approximately 90 individuals living with type 2 diabetes (T2D) and/or individuals living without diabetes will be randomized (2:1).
- Trial name
- FIERCE (NCT06108388)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Suicidal Ideation, Suicide
Mitigating Suicide Risk With Single Session 'Brief Skills for Safer Living'
Mental health concerns have been on the rise since the onset of the COVID-19 pandemic. The pandemic has worsened risk factors for suicide, including job loss, anxiety, depression, and loneliness.
- Conditions
- Suicidal Ideation, Suicide, Mental Health Issue, Depression
- Trial name
- NCT04495543
- Testing
- Brief Skills for Safer Living
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- Unity Health Toronto
Multiple Sclerosis, Primary Progressive, Cognitive Impairment
Improving Cognition in People With Progressive Multiple Sclerosis Using Aerobic Exercise and Cognitive Rehabilitation
Given that up to 70% of people with secondary progressive MS are cognitively impaired, the search for effective treatments is considered a priority by people living with the disease.
- Trial name
- NCT03679468
- Testing
- Cognitive Rehabilitation, Aerobic Exercise
- Where
- Canada
- Volunteers
- 309 people
- Sponsor
- Sunnybrook Health Sciences Centre
Alcohol Withdrawal Delirium, Alcohol Withdrawal
Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome
Severe acute alcohol withdrawal syndrome is a potentially life-threatening condition characterized by agitation, confusion, abnormal heart rhythms and seizures.
- Conditions
- Alcohol Withdrawal Delirium, Alcohol Withdrawal, Alcohol Withdrawal Seizures
- Trial name
- PHENOMANAL (NCT03586089)
- Testing
- Phenobarbital Sodium
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia
Topical Anti-angiogenic Therapy for Telangiectasia in HHT: Proof of Concept
Hereditary hemorrhagic telangiectasia (HHT) is a hereditary vascular condition characterized by the development of abnormal connections between arteries and veins throughout the body, called vascular malformations.
- Trial name
- NCT01752049
- Testing
- Topical timolol maleate
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Unity Health Toronto
Depression, Anxiety
Mobile Interventions for the Prevention and Detection of Distress
Stress, anxiety, distress and depression are exceptionally high among healthcare providers at the frontline of the COVID-19 pandemic.
- Conditions
- Depression, Anxiety, Stress, Loneliness
- Trial name
- NCT05072210
- Testing
- Mobile Intervention
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetic Foot Ulcer
A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers
Foot ulcers represent a significant common complication in patients with diabetes. Wound healing is a challenge. Some wounds do not respond to the best practices in wound care.
- Trial name
- NCT00338702
- Testing
- Autologous Platelet Gel
- Where
- Canada
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome
Predicting ICU Mortality in ARDS Patients
The investigators are planning to perform a secondary analysis of an academic dataset of 1,303 patients with moderate-to-severe acute respiratory distress syndrome (ARDS) included in several published cohorts (NCT00736892…
- Trial name
- POSTCARDS (NCT05611177)
- Testing
- machine learning analysis
- Where
- 3 sites in Spain
- Volunteers
- 1,303 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Cardiovascular Disease, Metabolic Syndrome
Canola Oil Multi-center Intervention Trial II
Building on the findings from the investigators previous study, COMIT I, the purpose of the COMIT II study is to supplement the DEXA measurement of body composition with a supplementary DEXA measurement of visceral adipose tissue…
- Trial name
- COMITII (NCT03054779)
- Testing
- Canola Oil, High oleic acid canola oil, Western diet oil combination
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Penn State University
Atherosclerosis, Cardiovascular Diseases
Semaglutide and Vascular Regeneration
SEMA-VR is a prospective, randomized, 6-month long, open-label study of semaglutide. Approximately 100 participants with type 2 diabetes and/or obesity will be randomized (1:1) to receive semaglutide at escalating doses (up to…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Obesity
- Trial name
- SEMA-VR (NCT05870462)
- Testing
- Semaglutide Pen Injector
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group