Clinical trials: sponsored by Case Comprehensive Cancer Center
Bone Marrow Fibrosis, Myeloproliferative Neoplasm
Captopril Use on the Degree of Marrow Fibrosis in Bone Marrow Fibrosis/Myeloproliferative Neoplasms
The purpose of this study is to evaluate the safety and tolerability of captopril and evaluate the effectiveness captopril as measured by changes in the grade of bone marrow scar tissue.
- Trial name
- NCT04629651
- Testing
- Captopril
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Metastatic Triple Negative Breast Cancer
Carboplatin, Nab-Paclitaxel and Pembrolizumab for Metastatic Triple-Negative Breast Cancer
The purpose of this study is to see how effective the combination of the two chemotherapy drugs (carboplatin and nab-paclitaxel) are when added to a third drug, pembrolizumab.
- Trial name
- NCT03121352
- Testing
- Carboplatin, Nab-paclitaxel, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia
Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention
This randomized clinical trial studies standard GVHD prophylaxis with tacrolimus and methotrexate compared to tacrolimus, mycophenolate mofetil and a reduced-dose methotrexate in patients with hematologic malignancies undergoing…
- Conditions
- Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Biphenotypic Leukemia
- Trial name
- NCT01951885
- Testing
- tacrolimus, methotrexate, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Case Comprehensive Cancer Center
Monoclonal Gammopathy, Smoldering Myeloma
Dendritic Cell DKK1 Vaccine for Monoclonal Gammopathy and Stable or Smoldering Myeloma
The purpose of this study is to study the safety and preliminary efficacy of a dendritic cell DKK1 vaccine against myeloma. Dendritic cells are immune cells that are collected from the blood of the patient at Case Western Reserve…
- Conditions
- Monoclonal Gammopathy, Smoldering Myeloma, Myeloma
- Trial name
- NCT03591614
- Testing
- DKK1
- Where
- 2 sites in United States
- Sponsor
- Case Comprehensive Cancer Center
Metastatic Renal Cell Cancer
Axitinib Given on an Individualized Schedule for Metastatic Renal Cell Cancer
Axitinib is a drug which is approved by the FDA for patients with advanced kidney cancer who have already received some treatment. It works by reducing blood flow to a tumor.
- Trial name
- NCT02579811
- Testing
- Axitinib
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Reconstruction Following Mastectomy
Prepectoral vs Partial Subpectoral Two-Stage Implant-Based Breast Reconstruction
The purpose of this study is to investigate the to analyze the patient satisfaction and complication rates under controlled conditions of the increasingly popular prepectoral technique for implant-based breast reconstruction.
- Trial name
- NCT04874402
- Testing
- Prepectoral approach, Partial Subpectoral approach
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate Cancer
MRI is being increasingly relied upon for detection, staging and management of prostate cancer. In this study patients with risk of prostate cancer will be recommended to have a pelvic MRI prior to the standard biopsy of the…
- Trial name
- NCT03122470
- Testing
- MRI guided biopsy, TRUS biopsy
- Sponsor
- Case Comprehensive Cancer Center
Glioblastoma Multiforme
BG & TMZ Therapy of Glioblastoma Multiforme
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01269424
- Testing
- MGMTP140K-encoding retroviral vector, O6-benzylguanine, temozolomide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanton Gerson MD
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803
The purpose of this study is to find the number of natural killer (NK) cells from non-HLA matched donors that can be safely infused into patients with cancer. NK cells are a form of lymphocytes that defend against cancer cells.
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia
- Trial name
- NCT02890758
- Testing
- Natural Killer (NK) Cells, ALT803
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brenda Cooper, MD
Pancreatic Resection, Preoperative Frailty
Prehabilitation in Pancreatic Surgery
The purpose of this study is to use functional studies to study the effectiveness of prehabilitation prior to surgery. The investigators know that stronger patients have better outcomes after surgery compared to weaker patients.
- Trial name
- NCT03688867
- Testing
- Prehabilitation regimen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Malignant Small Bowel Obstruction, Malignant Gastric Outlet Obstruction
AspireAssist for Palliative Venting Gastrostomy in Malignant Bowel Obstruction Patients
Individuals with cancer causing an intestinal or stomach obstruction often require gastric drainage to prevent symptoms of nausea, vomiting, and to prevent aspiration.
- Trial name
- NCT04375462
- Testing
- AspireAssist device, Standard decompressive PEG tube, gastric outlet obstruction scoring system (GOOSS) questionnaire
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Stage IIIA Non-Small Cell Lung Cancer
Neoadjuvant Chemoradiation Plus Pembrolizumab Followed By Consolidation Pembrolizumab in NSCLC
The purpose of this study is to determine the feasibility and evaluate the safety of delivering chemoradiotherapy, the usual approach to non-small cell lung cancer, in combination with pembrolizumab (MK-3745), followed by…
- Trial name
- NCT02987998
- Testing
- Cisplatin, Etoposide, Pembrolizumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Nathan Pennell, MD, PhD
Breast Cancer, Metastatic Breast Cancer
Type I-Polarized Autologous Dendritic Cell Vaccine With Tumor Blood Vessel Antigen-Derived Peptides in Metastatic Breast Cancer Patients
This pilot clinical trial studies the safety of a dendritic cell vaccine when given with gemcitabine hydrochloride in treating patients with breast cancer that has spread beyond the breast and local lymph nodes to other organs in…
- Trial name
- NCT02479230
- Testing
- tumor blood vessel antigen peptide-pulsed alpha-type-1 polarized dendritic cell vaccine, gemcitabine hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Joseph Baar, MD, PhD
Diffuse Large B-cell-lymphoma
Venetoclax Plus R-ICE Chemotherapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma
The purpose of this study is to determine the correct dose and safety of adding a new cancer drug, venetoclax, to a standard combination of chemotherapy drugs as a second treatment for relapsed/refractory DLBCL.
- Trial name
- NCT03064867
- Testing
- Venetoclax, Rituximab, Ifosfamide
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- Molly Gallogly
B Cell Lymphoma, Lymphoma
Lenalidomide, Ixazomib, and Rituximab as Front-Line Therapy for High Risk Indolent B-Cell Lymphoma
A Phase IB/II Trial of Lenalidomide (Revlimid®), Ixazomib and Rituximab (RIXAR) as Front-line Therapy for High Risk Indolent B cell Lymphoma
- Trial name
- NCT02898259
- Testing
- Ixazomib, Lenalidomide, Rituximab
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Brian Hill
Lung Cancer
Bevacizumab, Docetaxel, and Gemcitabine Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00970684
- Testing
- bevacizumab, docetaxel, gemcitabine hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 13 people
- Sponsor
- Nathan Pennell, MD, PhD
Breast Cancer
Assessment of Candidate Protein Expression in Breast Cancer Specimens
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00918892
- Testing
- gene expression analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Carcinoma
Informed Decision Making Intervention in Screening for Prostate Cancer of Predominantly African American Participants in a Community Outreach Program
This clinical trial studies an informed decision making intervention of screening for prostate cancer in predominantly African American participants.
- Trial name
- NCT02419846
- Testing
- Educational Intervention, digital rectal examination, Pre-test administration
- Where
- United States
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Gastro-Intestinal Acute Graft Versus Host Disease (GI-aGVHD)
Fecal Microbiota Transplantation For The Treatment Of Gastro-Intestinal Acute GVHD
Gastro-Intestinal Acute Graft Versus Host Disease (GI-aGVHD) is a complication of allogeneic stem cell transplant which is usually treated with steroids.
- Trial name
- NCT04059757
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- United States
- Sponsor
- Leland Metheny
Gynecologic Malignancies
Weight-based Dosing for Dense Weekly Paclitaxel and Carboplatin in Overweight Patients w/ Body Surface Area (BSA) > 2.0
The purpose of this study is to evaluate the side effects and effectiveness of giving standard paclitaxel chemotherapy in doses based on actual body surface area in combination with standard dosed carboplatin chemotherapy for…
- Trial name
- NCT02756013
- Testing
- Paclitaxel, Carboplatin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Case Comprehensive Cancer Center