Clinical trials: not yet recruiting
Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumor Cancer
A Phase 1 Study of MC001 in Patients With Advanced or Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) and Other Folate Receptor Alpha (FRα)-Expressing Solid Tumors
The purpose of this First-in-Human, Phase 1 study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and preliminary antitumor activity of MC001 in adults with advanced or…
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumor Cancer, Metastatic Pancreatic Cancer, Metastatic Solid Tumors
- Trial name
- NCT07909356
- Testing
- MC001
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Medicovestor, Inc
Schizophrenia
A Study to Assess the Safety, Tolerability and Pharmacokinetics of XEP527 in Patients With Stable Schizophrenia
This study is designed to assess the safety and tolerability of the effects of XEP527, with particular emphasis on disease status and its compatibility with the standard of care in patients with stable schizophrenia.
- Trial name
- NCT07908680
- Testing
- XEP527
- Volunteers
- 36 people
- Sponsor
- Novartis Pharmaceuticals
Nephrotic Syndrome, Lipodystrophy
Effects of Meal Macronutrients on Postprandial Lipids
Background: Abnormal fats in the blood can lead to many problems, including heart disease. Researchers want to learn more about how eating meals with different levels of nutrients affects fats in the blood.
- Conditions
- Nephrotic Syndrome, Lipodystrophy, Metabolic Syndrome, Healthy Volunteer
- Trial name
- NCT07313787
- Testing
- High carb then high fat breakfast, High fat then high carb breakfast
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Multiple Myeloma in Remission
Universal CAR-T Cells Targeting Multiple Myeloma
The aim of this study is to assess the feasibility, safety and efficacy of universal CAR T cells targeting multiple myeloma. Another goal of the study is to learn more about the persistence and function of the universal CAR T…
- Trial name
- NCT06006741
- Testing
- MM-specific universal CAR T cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Healthy Volunteers
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year.
- Trial name
- NCT07504601
- Testing
- (2R,6R)-Hydroxynorketamine
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Workplace Wellbeing
Primed to Thrive: Investigating the Combined Impact of Mindfulness Education and Meditation Practice on Psychological and Workplace Outcomes
Employees commonly experience stress and reduced well-being that can affect workplace functioning. This interventional study will evaluate whether combining mindfulness-related educational materials with a brief daily guided…
- Trial name
- BEGIN III (NCT07534683)
- Testing
- Meditation, Mindful Educational Material
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Kidney Stones
Comparison of Smart Pressure-Controlled Flexible Ureteroscopy and Flexible Suction Ureteral Access Sheath-Assisted Flexible Ureteroscopy for 2-3 cm Renal Stones
This prospective, multicenter, randomized, non-inferiority controlled trial aims to compare the efficacy and safety of smart pressure-controlled flexible ureteroscopy and flexible ureteroscopy assisted by a distal flexible…
- Trial name
- NCT07909577
- Testing
- Smart Pressure-Controlled Flexible Ureteroscopy, Distal Flexible Suction Ureteral Access Sheath-Assisted Flexible Ureteroscopy
- Volunteers
- 750 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm After Subarachnoid Hemorrhage
Endovascular Therapy for Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Cerebral vasospasm is a common and serious complication after aneurysmal subarachnoid hemorrhage and is an important cause of delayed cerebral ischemia and poor neurological outcomes.
- Trial name
- RESCUE-CV (NCT07643922)
- Testing
- Intra-arterial and Intravenous Milrinone Therapy, Standardized Medical Management
- Where
- 2 sites in China
- Volunteers
- 306 people
- Sponsor
- Beijing Tiantan Hospital
Aortic Aneurysm and Dissection
Clinical Health Outcomes Evaluation of Terumo Aortic Hybrid Devices
This prospective, non-interventional, study of Thoraflex Hybrid devices is part of Terumo Aortic's clinical development and Post Market Clinical Follow-Up (PMCF) plan and will provide insights into both the short- and long-term…
- Trial name
- CHEETAH (NCT07911163)
- Testing
- Thoraflex Hybrid
- Volunteers
- 150 people
- Sponsor
- Vascutek Ltd.
Knee Osteoarthritis
Tempo-controlled Low-load Resistance Training in Patients With Knee Osteoarthritis.
This randomized controlled trial aims to evaluate the effects of tempo-controlled low-load resistance training compared to conventional low-load resistance training on pain, muscle performance, and functional disability in…
- Trial name
- NCT07908589
- Testing
- Tempo-controlled low-load resistance training, Conventional Physiotherapy Training
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- University of Management and Technology Lahore
Weight Bias
Digital SSI to Reduce IWS
The purpose of this research is to evaluate a brief digital single-session intervention designed to reduce internalized weight stigma among Dartmouth Health Weight Center patients.
- Trial name
- NCT07911462
- Testing
- Psychoeducation, Self-compassion, Body functionality
- Volunteers
- 610 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Adenocarcinoma, Prostate Cancer
Multitargeted Recombinant Ad5 PSA/MUC-1/Brachyury-Based Immunotherapy (TriAdeno) Vaccine With IL-15 Superagonist N-803 in Participants With Clinically Localized Prostate Cancer Undergoing Active Surveillance
Background: Prostate cancer is the second most common cause of cancer-related death among men in the United States. Early-stage, low-grade prostate cancer is managed with active monitoring.
- Conditions
- Adenocarcinoma, Prostate Cancer, Neoplasms, Carcinoma
- Trial name
- NCT07574541
- Testing
- TriAdeno vaccine, N-803
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Obstructive Sleep Apnea, Sleep Apnea, Obstructive
Orthognathic Surgery and Obstructive Sleep Apnea Assessed by Mandibular Jaw Movement Monitoring (SUNRISE-ORTHO)
Orthognathic surgery changes the skeletal framework of the upper airway, but its functional effect on sleep-disordered breathing remains poorly documented, particularly with respect to respiratory effort.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Obstructive, Dentofacial Deformities
- Trial name
- SUNRISE-ORTHO (NCT07910461)
- Testing
- Orthognathic surgery (BSSO with or without Le Fort I osteotomy), Sunrise mandibular jaw movement monitoring, Facial multidetector CT in natural head position
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- CHR Sambre et Meuse Site Meuse
Multiple Myeloma
BCMA Polymorphisms in Patients With Multiple Myeloma
The aim of this study is to investigate the effect of B cell maturation antigen (BCMA, TNFRSF17) gene polymorphisms on treatment response and survival in patients with multiple myeloma.
- Trial name
- BCMA in MM (NCT07906418)
- Testing
- BCMA polymorphism analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Acute Myeloid Leukemia
Universal CAR-T Cells Targeting AML
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of universal CAR T-cell products targeting CLL-1, CD33, CD38 and CD123 in patients with relapsed and refractory AML.
- Trial name
- NCT05995041
- Testing
- CLL-1, CD33, CD38 and/or CD123-specific universal CAR- T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Type II Diabetes Mellitus
cfMSC Therapy for Diabetes
The purpose of this study is to assess the feasibility, safety and clinical efficacy of the novel clonal fetal mesenchymal stem cell (cfMSC) therapy in patients with type II diabetes mellitus.
- Trial name
- NCT07495956
- Testing
- cfMSC therapy for diabetes
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
B Cell Malignancies
CD19/22 Bi-specific CAR-T Cell Therapy
The purpose of this study is to assess the feasibility, safety and efficacy of anti-CD19/22 bi-specific CAR-T cell therapy in patients with CD19 and/or CD22 positive B cell malignancies.
- Trial name
- NCT05432882
- Testing
- bi-4SCAR CD19/22 T cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Bladder Carcinoma, Prostate Carcinoma
Remote Screening and Navigation to Increase Trial Enrollment, INVITE Trial
This clinical trial studies the feasibility, acceptability, appropriateness, and effectiveness of a remote screening and navigation program in increasing clinical trial enrollment among patients with prostate and bladder cancer…
- Trial name
- INVITE (NCT07908407)
- Testing
- Electronic Health Record Review, Patient Navigation, Prescreen
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fred Hutchinson Cancer Center
Dyslipidemia
Study of the Safety and Efficacy of Prenofitol Tablets
Stage 1 of the Study Stage 1 of the study will consist of: a screening period (Visit 0) conducted within 0-14 days prior to the start of treatment; an inpatient treatment period, including Visit 1 (Days 1-4) and Visit 2 (Days…
- Trial name
- NCT07908433
- Testing
- 1 tablet of Prenofitol, 2 tablets of Prenofitol
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Ablation Techniques, Atrial Fibrillation (Paroxysmal)
Paroxysmal Atrial Fibrillation Repeat Ablation Strategies With Durably Isolated Pulmonary Veins
This study looks at participants who have undergone an ablation procedure for atrial fibrillation previously, and atrial fibrillation has occurred and a second ablation procedure is needed.
- Conditions
- Ablation Techniques, Atrial Fibrillation (Paroxysmal), Quality of Life
- Trial name
- PARADISO (NCT07910825)
- Testing
- Tailored Strategy, Control Strategy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Heart Institute Research Corporation
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