Clinical trials: sponsored by Unity Health Toronto
Diabetes
Avoiding Diabetes After Pregnancy Trial in Moms
Mothers with previous gestational diabetes mellitus (GDM) represent a population at higher risk of future Type 2 diabetes mellitus (T2DM), which is preventable through lifestyle modification.
- Trial name
- ADAPT-M (NCT01918345)
- Testing
- Home-based Physical Activity Program with Health Coach, Home-based Low-GI Diet Program with Health Coach
- Where
- 5 sites in Canada
- Volunteers
- 345 people
- Sponsor
- Women's College Hospital
Major Depressive Disorder
Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study
This is a validation study that will replicate a completed study designed to assess biomarkers of treatment response to standard antidepressant treatment.
- Trial name
- NCT04162522
- Testing
- Escitalopram, Brexpiprazole
- Where
- 6 sites in Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Cardiovascular Diseases, Left Ventricular Hypertrophy
Empagliflozin and Cardiac Remodelling in People Without Diabetes
The purpose of this study is to evaluate the effects of empagliflozin on cardiac structure, function and circulating biomarkers in patients with cardiovascular risk factors, but without diabetes.
- Trial name
- EMPA-HEART 2 (NCT04461041)
- Testing
- Empagliflozin
- Where
- 4 sites in Canada, Taiwan
- Volunteers
- 169 people
- Sponsor
- Unity Health Toronto
Diabetes, Type 1 Diabetes
The Role of South Asian vs European Origins on Circulating Regenerative Cell Exhaustion
ORIGINS-RCE is an observational, cross-sectional, two-arm study aimed at determining if an individual's ethnic origin influences the number of blood vessel-forming stem cells in the bloodstream.
- Conditions
- Diabetes, Type 1 Diabetes, Type 2 Diabetes, Ischemic Heart Disease
- Trial name
- ORIGINS-RCE (NCT05253521)
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Retinal Detachment, Metamorphopsia
Retinal Displacement After Pneumatic Versus Vitrectomy for Retinal Detachment (ALIGN)
This is a prospective cohort study, comparing the functional outcomes and the retinal displacement rates between two techniques for primary rhegmatogenous retinal detachment repair: Pars Plana Vitrectomy (PPV) and Pneumatic…
- Conditions
- Retinal Detachment, Metamorphopsia, Aniseikonia
- Trial name
- ALIGN (NCT04089033)
- Testing
- Pneumatic Retinopexy, Pars Plana Vitrectomy
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Unity Health Toronto
Acute Kidney Injury, Fluid Overload
Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury
Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a mediator of complications.
- Conditions
- Acute Kidney Injury, Fluid Overload, Ultrasonography
- Trial name
- ECHO-AKI (NCT04095143)
- Testing
- Portal vein flow, Intra-renal flow, Hepatic vein flow
- Where
- 6 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Communication
Electrolarynx for Enabling Communication in the CHrOnically Critically Ill (EECCHO)
All critically ill patients receiving mechanical ventilation experience a period of inability to speak due to the need for cuffed endotracheal or tracheostomy tubes.
- Trial name
- EECCHO (NCT05604079)
- Testing
- Electrolarynx
- Where
- 3 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Michael Garron Hospital
Colonic Polyp
Impact of Augmented Reality in Polypectomy Skills Acquisition in Simulation-based Endoscopy Training
Simulation-based training (SBT) is a safe and effective strategy for improving skills development in gastrointestinal endoscopy.
- Trial name
- NCT03826069
- Testing
- Augmented reality-based curriculum, Conventional Simulation Curriculum
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Gestational Diabetes Mellitus in Pregnancy
A Novel Care Pathway in Women With "Low-risk" Gestational Diabetes Mellitus
This study is a randomized controlled trial to study the effect of the use of a risk stratification screening tool for high- and low-risk gestational diabetes mellitus (GDM), and the implementation of a new low-impact care…
- Trial name
- NCT05596812
- Testing
- New Care Pathway
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Peripheral Arterial Disease
Novel Blood Biomarker for Peripheral Arterial Disease
This study focuses on validating the clinical efficacy of a novel point of care diagnostic blood test for peripheral arterial disease (PAD) within a large, heterogeneous patient population.
- Trial name
- NCT05596136
- Testing
- Artery Alert
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Opioid Use, Opioid-Related Disorders
Surviving Opioid Overdose With Naloxone Education and Resuscitation Trial (SOONER)
Among people at risk of opioid overdose and receiving care in an academic emergency department, family practice, opioid substitution clinic or general inpatient units, does brief opioid overdose resuscitation training and…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Withdrawal, Opioid Overdose
- Trial name
- SOONER (NCT04740099)
- Testing
- SOONER Video & Kit, Standard of Care
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Amyloidosis
A PILOT Study on LSGB vs EMB in the Diagnosis of Cardiac Transthyretin Amyloidosis
Transthyretin (TTR) is a plasma protein mainly synthesized in the liver, recognized as a transporter of thyroxine and retinol-binding protein.
- Trial name
- NCT05375279
- Testing
- Lip Salivary Gland Biopsy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Breast Cancer
Diet, Exercise and Vitamin D in Breast Cancer Recurrence
The purpose of this study is to reduce breast cancer recurrence and hence increase disease-free survival through a lifestyle program that includes a low glycemic diet, physical activity and vitamin D supplementation in women with…
- Trial name
- DEDiCa (NCT02786875)
- Testing
- low Glycemic Index Mediterranean diet, Mediterranean diet, Moderate physical activity
- Where
- 7 sites in Italy
- Volunteers
- 506 people
- Sponsor
- National Cancer Institute, Naples
Overdose
SOONER Feasibility Study Protocol
Opioid Overdose Education and Naloxone Distribution programs (OEND) involve training and equipping people who are likely to be bystanders to opioid overdose to recognize and respond to opioid-related emergencies by activating…
- Trial name
- SOONER (NCT03821649)
- Testing
- SOONER Training and Naloxone Kit Kit, Community or Hospital-Based Training
- Where
- 4 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Mental Health Disorder
Coordinating Access to Care for People Experiencing Homelessness (CATCH-FI)
Coordinating Access to Care for the Homeless (CATCH) initiative is a multidisciplinary brief intervention for homeless adults with mental health needs discharged from hospital in Toronto, Canada.
- Trial name
- NCT03770221
- Testing
- CATCH, Financial Incentive
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- Unity Health Toronto
Mortality, Oral Health
De-adoption of Oral Chlorhexidine Prophylaxis and Implementation of an Oral Care Bundle (CHORAL)
The objective of the CHORAL study is to evaluate the de-adoption of oral chlorhexidine and the introduction of a bundle of oral care practices on selected outcomes in critically ill mechanically ventilated adults.
- Conditions
- Mortality, Oral Health, Dryness, Mouth, Pain, Orofacial
- Trial name
- CHORAL (NCT03382730)
- Testing
- Chlorhexidine Mouth Rinse, Chlorhexidine Mouth Rinse De-Adoption
- Where
- 5 sites in Canada
- Volunteers
- 3,260 people
- Sponsor
- University of Toronto
Educational Achievement
School Based Health Care: A Model for Improving Educational Achievement for Children in Inner City Schools
Developmental problems have tremendous impact on children, affecting academic achievement and mental health later in life.The process of receiving a developmental assessment is long and arduous, and may require multiple physician…
- Trial name
- NCT04540003
- Testing
- Access to School Based Health Centre
- Where
- Canada
- Volunteers
- 147 people
- Sponsor
- Unity Health Toronto
Chronic Disease
Pilot Evaluation of "KeepWell" Using a Hybrid Effectiveness-Implementation Pragmatic Randomized Controlled Trial
The burden of chronic disease is a global phenomenon, particularly amongst seniors. Aging is an expensive process. In Canada, 10% of seniors who have the most complex health needs account for 60% of the total annual health care…
- Trial name
- NCT04437238
- Testing
- KeepWell tool, Control - Usual care
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- North York General Hospital
Abdominal Trauma, Abdominal Injury
A Non-Traumatic Binder for Temporary Abdominal Wall Closure
At the end of most abdominal operations, the fascial layer is closed by stitching edges of the wound together. However, because of logistic and/or technical reasons or the patient's critical condition, the surgeon is forced to…
- Conditions
- Abdominal Trauma, Abdominal Injury, Abdominal Infection, Abdominal Sepsis
- Trial name
- ABRO (NCT03815370)
- Testing
- Experimental: ABRO™ Binder Arm
- Where
- 4 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
Myocarditis and Cardiomyopathy
Myocarditis After SARS-CoV2-Vaccination
Background The novel coronavirus disease 2019 (COVID-19) caused by an infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global pandemic with more than 190.000.000 infections and…
- Trial name
- MYOVACC (NCT05268458)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Theresien Hospital Mannheim