Clinical trials: sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Interstitial Cystitis, Vulvar Diseases
Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis
OBJECTIVES: I. Estimate the optimal safe dose of intravesical capsaicin in patients with interstitial cystitis. II. Evaluate the efficacy of 0.025% topical capsaicin in relieving chronic burning pain in patients with vulvar…
- Trial name
- NCT00004316
- Testing
- capsaicin
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Urinary Incontinence, Diabetes
ORWH:SCOR on Sex and Gender Factors Affecting Women's Incontinence
This study consists of two studies with overlapping cohorts. One is a follow up epidemiological study of urinary incontinence, the other is a case control study of lower urinary tract dysfunction in women with diabetes.
- Trial name
- NCT00069368
- Where
- United States
- Volunteers
- 2,161 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Chronic Kidney Diseases, Hypertension
Inspiratory Muscle Strength Training in Chronic Kidney Disease
More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control <130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney…
- Conditions
- Chronic Kidney Diseases, Hypertension, Aging, Blood Pressure
- Trial name
- NCT04911491
- Testing
- IMST
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Colorado, Denver
Diabetes, Type2 Diabetes
A Study to Establish a New Onset Hyperglycemia and Diabetes Cohort
Create a large biobank of blood samples and data from subjects with new onset hyperglycemia and diabetes (NOD).
- Conditions
- Diabetes, Type2 Diabetes, Diabetes Mellitus
- Trial name
- NOD (NCT03731637)
- Where
- 18 sites in United States
- Volunteers
- 2,269 people
- Sponsor
- Fred Hutchinson Cancer Center
IBS - Irritable Bowel Syndrome
Irritable Bowel Syndrome and Control Volunteers: Diet Challenge
The purpose of this study is to study the relationship between the bile acids, short chain fatty acids and bacteria within the intestines.
- Trial name
- NCT03983434
- Testing
- Inulin
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
Irritable Bowel Syndrome
A Longitudinal Study to Identify IBS Phenotypes Using Fecal Microbiota and Hydrogen Breath Testing
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a highly prevalent but poorly understood condition with limited treatment options.
- Trial name
- NCT03219528
- Testing
- Rifaximin 550 MG, Low FODMAP Diet
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Michigan
All-cause Mortality, Hospitalization
HiLo: Pragmatic Trial of Higher vs Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis
HiLo will be a pragmatic, open-label, multicenter, clinical trial with individual level randomization of ~4400 patients with ESRD undergoing in-center maintenance hemodialysis at 120-150 units maintained by two dialysis…
- Trial name
- NCT04095039
- Testing
- Hemodialysis
- Where
- 84 sites in United States
- Volunteers
- 793 people
- Sponsor
- Duke University
Energy Expenditure
Quantifying the Persistence of Metabolic Adaptation and Weight Regain Following Extreme Weight Loss
Background: Many people regain the weight they lose through diet and exercise. This might happen because the weight loss slows their metabolism. This slowing is called metabolic adaptation.
- Trial name
- NCT02544009
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Appetite
Study of the Effect of a Very-Low-Carbohydrate Diet on Energy Expenditure
Background: Popular weight loss plans often restrict carbohydrates or fat. Research shows that very-low-carbohydrate (ketogenic) diets lead to greater weight loss than low-fat diets.
- Conditions
- Obesity, Appetite, Healthy Volunteers
- Trial name
- NCT01967563
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Inflammatory Bowel Diseases, Psychological
Stress in Inflammatory Bowel Disease
This is a prospective, assessment-based study to examine the relationship between psychophysiological functioning and psychological symptoms in youth newly diagnosed with inflammatory bowel disease (IBD) compared to healthy…
- Trial name
- NCT05202418
- Testing
- Biofeedback Enhanced Treatment
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Emory University
Type 1 Diabetes
Closed Loop Context Aware AID
An artificial pancreas (AP) is a control system for automatic insulin delivery. The investigators have implemented a high blood sugar detection and dosing algorithm for use within an AP control system.
- Trial name
- NCT06676657
- Testing
- iPancreas automated insulin delivery system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Cystic Fibrosis Liver Disease
Longitudinal Assessment of Transient Elastography in Cystic Fibrosis
To determine if transient elastography (TE), when combined with ultrasound (US) pattern characterization can improve the prediction of progression to a nodular pattern on US.
- Trial name
- NCT03001388
- Testing
- Transient Elastography (TE)
- Where
- 8 sites in United States, Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Disordered Eating Behaviors
The BEET Diabetes Feasibility Trial
Disordered eating behaviors (DEBs, e.g., binge eating or restrictive eating) can significantly impact type 2 diabetes (T2D) self-management and engagement in treatment for diabetes.
- Trial name
- NCT06247514
- Testing
- The BEET Diabetes Program, Cognitive Behavioral Therapy Guided Self-Help
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis Liver Disease, Pancreatic Insufficiency
MRI to Characterize and Predict CF Liver Disease in PUSH Cohort
Specific Aim 1. Determine if valid results of non-sedated MRI based assessments of liver stiffness and lipid content can be obtained in more than 90% of children and young adults with cystic fibrosis. Specific Aim 2.
- Trial name
- NCT02979340
- Testing
- MRI
- Where
- 8 sites in United States
- Volunteers
- 115 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cystic Fibrosis, Pancreatic Insufficiency
Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis
The specific aims for this study are: 1. To determine if sonographic findings predict the risk of progression of liver disease to cirrhosis by comparing cystic fibrosis subjects with heterogeneous echogenicity pattern on…
- Trial name
- PUSH (NCT01144507)
- Testing
- Abdominal Ultrasound, Sample collection procedures
- Where
- 11 sites in United States, Canada
- Volunteers
- 774 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus
Effects of a Patient Portal Intervention to Address Diabetes Care Gaps
The purpose of this study is to evaluate the effect of a novel patient portal intervention on the number of patients with diabetes care gaps (e.g., no diabetes eye exam i the last 12 months).
- Trial name
- NCT04894903
- Testing
- Diabetes Care Gaps Patient Portal Intervention
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
Laryngopharyngeal Reflux
Reflux Band in Laryngopharyngeal Reflux
This 12 week biomarker targeted double blind randomized controlled trial (RCT) will enroll subjects with salivary pepsin positive laryngopharyngeal reflux (LPR) to assess efficacy of the external upper esophageal sphincter (UES)…
- Trial name
- NCT04827355
- Testing
- External Upper Esophageal Sphincter (UES) Compression Device
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Diego
T2DM (Type 2 Diabetes Mellitus)
Group Emotion-Focused Behavioral Intervention for Diabetes Distress/A1c in T2D.
T2D is a major public health problem and is currently the 7th leading cause of death in the US. Despite a range of efficacious treatments, less than 50% of patients achieve a glycemic target of A1c < 7.0%, suggesting that this is…
- Trial name
- NCT06912737
- Testing
- Group Emotion Focused Behavioral Intervention (G-EFBI), Group - With Every Heartbeat is Life (G-WEHL)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University
Diet
Increasing Affordable Fruits and Vegetables for Families With Food Insecurity
Investigator will test an intervention to increase use of a fruit and vegetable incentive program in South Carolina for families in the Supplemental Nutrition Assistance Program (SNAP) experiencing food insecurity.
- Trial name
- NCT06828445
- Testing
- Veggie Vouchers
- Where
- United States
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Type 2 Diabetes, PreDiabetes
Evaluating a Type 2 Diabetes Prevention Program
This study aims to test the effectiveness of a Type 2 Diabetes (T2D) prevention program for individuals who have been diagnosed with prediabetes compared to a T2D educational control group.
- Trial name
- NCT05822648
- Testing
- Project Health, Educational Video Control
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Stanford University
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