Clinical trials: sponsored by Unity Health Toronto
Cancer, Heart Failure
Statins for the Primary Prevention of Heart Failure in Patients Receiving Anthracycline Pilot Study
Anthracycline (AC) chemotherapy has substantially reduced the mortality rate from several common cancers globally. Unfortunately, AC treatment is associated with up to 19% risk of heart failure (HF).
- Conditions
- Cancer, Heart Failure, Cardiotoxicity
- Trial name
- SPARE-HF (NCT03186404)
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- University Health Network, Toronto
Covid19, Myocardial Injury
Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19
With the results of this study the investigators aim to identify an effective treatment that will reduce morbidity and mortality of patients with symptomatic COVID-19 infection, which would in turn reduce the burden on the…
- Trial name
- SEMPATICO (NCT04615871)
- Testing
- semaglutide
- Where
- 10 sites in Brazil, Canada and 2 more
- Volunteers
- 400 people
- Sponsor
- Vladimír Džavík
Surgery
The Evolving Use of Robotic Surgery
A retrospective, population-based analysis examining the rates of robotic surgery between the years of 2009 - 2018.
- Trial name
- NCT05211128
- Testing
- Robotic Surgery, Open Surgery, Laparoscopic Surgery
- Where
- Canada
- Volunteers
- 123,074 people
- Sponsor
- Sunnybrook Health Sciences Centre
Coronavirus Infections, Post-exposure Prophylaxis
COVID-19 Ring-based Prevention Trial With Lopinavir/Ritonavir
COVID-19 has rapidly evolved into a generalized global pandemic. Post-exposure prophylaxis (PEP) against on COVID-19 was identified as an urgent research priority by the WHO, and lopinavir/ritonavir (LPV/r) is a promising…
- Trial name
- CORIPREV-LR (NCT04321174)
- Testing
- Lopinavir/ritonavir
- Where
- 4 sites in Canada
- Volunteers
- 123 people
- Sponsor
- Unity Health Toronto
Sleep Disordered Breathing, Chronic Pain
Sleep Health Program for Patients With Chronic Pain
This is a pilot, prospective, randomized controlled trial of a novel sleep health program versus no sleep intervention in chronic pain patients.
- Conditions
- Sleep Disordered Breathing, Chronic Pain, Sleep
- Trial name
- NCT04299100
- Testing
- Sleep Health Program for Participants with No/Mild Sleep Apnea, Sleep Health Program for Participants with Moderate/Severe Sleep Apnea
- Where
- 5 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Acromegaly
Strict IGF-1 Control in Acromegaly
Acromegaly is a rare, chronic, and debilitating disease, usually caused by a benign tumor on the pituitary gland, which leads to excessive production of growth hormone (GH).
- Trial name
- I-Con (NCT02952885)
- Testing
- Pegvisomant
- Where
- 5 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
HIV Infections
Optimizing the Delivery of HIV nPEP
Despite decades of traditional prevention efforts based on behavior change and condom use, Ontario has seen over 700 new HIV infections annually over the past 10 years.
- Trial name
- NCT03259698
- Testing
- nPEP, Text Messaging Support, Nurse-Led nPEP
- Where
- 3 sites in Canada
- Volunteers
- 434 people
- Sponsor
- Unity Health Toronto
Cancer and Chronic Disease Prevention
BETTER HEALTH: Durham
The BETTER intervention consists of supportive meetings between a specially trained prevention practitioner nurse and individuals aged 40-64 years to review recommended chronic disease prevention and screening activities (CDPS).
- Trial name
- NCT03052959
- Testing
- Immediate Intervention, Wait List Intervention
- Where
- Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
COVID, Coronavirus Infection
A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation Versus Standard Care as a Rapid Response to (SARS-CoV-2) COVID-19 Pandemic
Coagulopathy of COVID-19 afflicts approximately 20% of patients with severe COVID-19 and is associated with need for critical care and death.
- Conditions
- COVID, Coronavirus Infection, Severe Acute Respiratory Syndrome, Thromboembolism, Venous
- Trial name
- RAPID-BRAZIL (NCT04444700)
- Testing
- Therapeutic anticoagulation
- Where
- Brazil
- Volunteers
- 465 people
- Sponsor
- University of Sao Paulo General Hospital
Moral Injury, Distress, Emotional
Digital Interventions for Detection and Reduction of Moral Distress
Stress, anxiety, distress and depression are exceptionally high among healthcare workers at the frontline of the COVID-19 pandemic.
- Trial name
- VR (NCT05001542)
- Testing
- Educational moral injury video
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
ARDS, Acute Hypoxemic Respiratory Failure
Incidence of Dyssynchronies in Early ARDS
Patients sedated under mechanical ventilation with acute hypoxemic respiratory failure with a PaO2/FiO2 equal or less than 200mmHg (Acute Respiratory Distress Syndrome, ARDS and non-ARDS) will be included in the study early in…
- Trial name
- BEARDS (NCT03447288)
- Where
- 14 sites in Canada, China and 8 more
- Volunteers
- 300 people
- Sponsor
- Unity Health Toronto
Poverty, Income
addressInG iNcome securITy in Primary carE
Social processes that impact the health of individuals have been labeled the social determinants of health (SDOH). These are "the conditions in which people are born, grow, live, work and age.
- Conditions
- Poverty, Income, Social Determinants of Health
- Trial name
- IGNITE (NCT02459184)
- Testing
- Income Security Health Promotion
- Where
- Canada
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm
Several types of spontaneous breathing trials (SBTs) have been proposed to evaluate when a patient is ready to be weaned from the ventilator based on breathing pattern measurements.
- Trial name
- OWED (NCT02539732)
- Where
- 3 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Femur Fractures
Types of Fixation of Vancouver B1 Periprosthetic Fractures
The purpose of this study is to compare two different but standard treatments for the fixation of Vancouver B1 periprosthetic. The investigators aim to compare open reduction internal fixation using a locked plating system versus…
- Trial name
- NCT01354535
- Testing
- Isolated Locked Compression Plate, Cable Plating and Strut Allograft with Cerclage Wiring
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- Unity Health Toronto
Rotator Cuff Tear
The Impact of Psychological Factors on the Outcome of Surgical Repair for Rotator Cuff
The proposed study will be a multi-centre, prospective, observational cohort to determine if psychological well-being has an impact on the outcome of surgical repair for rotator cuff tears.
- Trial name
- IMPROVE (NCT03018210)
- Testing
- Surgical repair of the rotator cuff
- Where
- 5 sites in Canada
- Volunteers
- 267 people
- Sponsor
- Unity Health Toronto
Periprosthetic Fractures, Distal Femur Fractures
Periprosthetic Distal Femur Fracture
A periprosthetic distal femur fracture is a fracture close to a knee implant. This type of fracture is often difficult to fix because of the close proximity of the two surgical implants which can sometimes interfere with proper…
- Trial name
- NCT01973712
- Testing
- Locked Compression Plating, Retrograde Intramedullary Nailing (RIMN)
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- Unity Health Toronto
Blunt Injury of Thorax, Flail Chest
Treatment of Acute, Unstable Chest Wall Injuries
Unstable chest injuries are common in poly trauma patients. They can lead to severe pulmonary restriction, loss of lung volume, difficulty with ventilation and can render the patient to require intubation and mechanical…
- Conditions
- Blunt Injury of Thorax, Flail Chest, Chest Wall Injury Trauma, Rib Fracture
- Trial name
- NCT01367951
- Testing
- Surgical fixation
- Where
- Canada
- Volunteers
- 207 people
- Sponsor
- Unity Health Toronto
Patella Fracture, Aging
Patella Fracture : A Randomized Controlled Trial
This is a multi-centre, randomized controlled trial comparing operative and non operative treatment for displaced patella fractures in elderly, low-demand patients.
- Trial name
- NCT03445819
- Testing
- Group A: Surgical Treatment, Group B: Conservative Treatment
- Where
- 3 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Unity Health Toronto
Atrial Fibrillation, Atrial Flutter
Detection of Atrial Fibrillation After Cardiac Surgery
The aim of the SEARCH-AF trial is to evaluate a novel diagnostic tool for detecting post-operative atrial fibrillation or flutter (POAF/AFL) in cardiac surgical subjects during the early, sub-acute post-operative period.
- Conditions
- Atrial Fibrillation, Atrial Flutter, C.Surgical Procedure; Cardiac, Arrhythmias, Cardiac
- Trial name
- SEARCH-AF (NCT02793895)
- Testing
- Medtronic SEEQ™ mobile cardiac telemetry system, Usual Care, CardioSTAT (Icentia Inc.) cardiac rhythm monitoring device
- Where
- 10 sites in Canada
- Volunteers
- 336 people
- Sponsor
- Unity Health Toronto
Anemia, Iron Deficiency, Anemia of Chronic Disease
Hemoglobin Optimization to Prevent Transfusion and Adverse Events in Perioperative Patients With Iron Restricted Anemia
The HOPE-Hb trial is a phase II study to determine the feasibility and impact of a combination treatment (intravenous iron plus erythropoietin) versus intravenous iron treatment alone on preoperative hemoglobin concentration…
- Conditions
- Anemia, Iron Deficiency, Anemia of Chronic Disease, Hip Arthropathy, Knee Arthropathy
- Trial name
- HOPE-Hb (NCT03528564)
- Testing
- Iron sucrose, Epoetin Alfa
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Unity Health Toronto