Clinical trials: sponsored by Unity Health Toronto
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma -2
Chronic subdural hematoma (CSDH), a common disease after minor head trauma, is characterized by blood collection in the subdural space, which can result in severe neurological impairment.
- Trial name
- TRACE-2 (NCT04898712)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Unity Health Toronto
Subscapularis Injury
Comparison of Two Methods of Subscapularis Management in Shoulder Arthroplasty: Tenotomy Versus Peel
What is the difference in subscapularis strength between two different methods of subscapularis mobilization: incision of the tendon (tenotomy) versus peel.
- Trial name
- NCT01404143
- Testing
- Subscapularis Tenotomy, subscapularis peel
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Covid-19, ARDS
Prone Positioning for Patients on General Medical Wards With COVID19
COVID-PRONE is a multicenter, pragmatic, unblinded, 2-arm, parallel, randomized controlled trial seeking to compare the pre-emptive prone positioning (i.e.
- Trial name
- COVID-PRONE (NCT04383613)
- Testing
- Prone positioning
- Where
- 8 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Cardiac Arrhythmias, Atrial Fibrillation and Flutter
Increasing Detection of Sub-Clinical Atrial Fibrillation in Defibrillator Patients With the Use of a VDD-ICD Lead
This study aims to compare the Dx-ICD system (experimental) to standard VVI-ICD (control) on the ability to diagnose silent AF in patients without prior AF receiving an ICD for standard indications.
- Conditions
- Cardiac Arrhythmias, Atrial Fibrillation and Flutter, Cardiovascular Diseases, Implantable Cardioverter-Defibrillators
- Trial name
- Dx-AF (NCT03110627)
- Testing
- VDD ICD (experimental group), Single chamber VVI ICD (control group)
- Where
- 9 sites in Canada
- Volunteers
- 188 people
- Sponsor
- Unity Health Toronto
Diabetic Nephropathies, Kidney Disease, Chronic
Molecular Analysis of Diabetic Kidney Disease Biopsies
Despite decades of research, the pathogenesis of human diabetic kidney disease remains largely unclear. Our goal is to use archived human kidney biopsy tissue from patients with and with diabetic nephropathy to identify new…
- Trial name
- NCT04029402
- Testing
- RNA sequencing
- Where
- 4 sites in Canada
- Volunteers
- 500 people
- Sponsor
- Unity Health Toronto
Age Related Macular Degeneration, Diabetic Macular Edema
Cytokine and Visual Outcome Variations in Eyes Receiving Aflibercept
Objective: To determine the association between baseline aqueous cytokine levels and treatment intervals for patients under a variable dosing regimen with intravitreal aflibercept in patients with neovascular age-related macular…
- Conditions
- Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Macular Edema
- Trial name
- COVARIANT (NCT03056079)
- Testing
- Intravitreal aflibercept
- Where
- 2 sites in Canada
- Volunteers
- 168 people
- Sponsor
- Unity Health Toronto
Retinal Detachment, Metamorphopsia
Effect of Type of Head Positioning on Retinal Displacement in Vitrectomy for Retinal Detachment
Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments especially those with a detached macula.
- Trial name
- DIAMOND (NCT04035343)
- Testing
- Face down positioning, Supine positioning
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Unity Health Toronto
Age Related Macular Degeneration, Diabetic Macular Edema
Cytokine and Visual Outcome Variations in Eyes Receiving Ranibizumab
Objective: To determine the association between baseline aqueous cytokine levels and treatment intervals for patients under a variable dosing regimen with intravitreal ranibizumab in patients with neovascular age-related macular…
- Conditions
- Age Related Macular Degeneration, Diabetic Macular Edema, Macular Edema, Retinal Vein Occlusion
- Trial name
- COVERT (NCT03056092)
- Testing
- Intravitreal ranibizumab
- Where
- 2 sites in Canada
- Volunteers
- 168 people
- Sponsor
- Unity Health Toronto
Obstructive Sleep Apnea
Obstructive Sleep Apnea in Bariatric Surgical Patients
Purpose: The purpose of this study is to develop a novel pathway to decrease the cost and waiting time to manage bariatric surgical patients with obstructive sleep apnea.
- Trial name
- NCT01852305
- Testing
- Lab Sleep Study Group, Oximetry
- Where
- Canada
- Volunteers
- 316 people
- Sponsor
- University Health Network, Toronto
Retinal Detachment, Metamorphopsia
Retinal Displacement Rates in Pneumatic Retinopexy Versus Pars Plana Vitrectomy For Primary Retinal Detachment
Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments (RRDs) especially those with a detached macula.
- Trial name
- REVEAL (NCT04158622)
- Testing
- PnR + laser/cryotherapy, PPV + laser/cryotherapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Invasive Mechanical Ventilation, Critical Illness
Mechanical Ventilation Discontinuation Practices
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Conditions
- Invasive Mechanical Ventilation, Critical Illness, Spontaneous Breathing Trial, Weaning Invasive Mechanical Ventilation
- Trial name
- IOS (NCT03955874)
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,868 people
- Sponsor
- Unity Health Toronto
Humeral Fractures, Proximal
Determinants of Function and Clinically Important Outcomes in Proximal Humerus Fractures
The proposed project will be a multi-centre, prospective observational study to determine the prognosis and determinants of functional outcomes of patients with proximal humerus fractures.
- Trial name
- NCT02212600
- Testing
- Observational
- Where
- 2 sites in Canada
- Volunteers
- 500 people
- Sponsor
- London Health Sciences Centre
Covid19, Respiratory Disease
COVID-19 Longitudinal Biomarkers in Lung Injury
Profile known and novel biomarkers in blood in COVID19 patients to characterize the host response to SARS-CoV-2 over time and in response to treatment. The investigators aim to: Better understand the disease.
- Conditions
- Covid19, Respiratory Disease, Critical Illness
- Trial name
- COLOBILI (NCT04747782)
- Testing
- no interventions performed. Just collecting data, blood samples and post-mortem biopsies.
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dr. Andrew Baker
Traumatic Knee Dislocation
Late Compared to Early Physiotherapy Following Knee Dislocation
A knee dislocation is an unusual and extremely serious injury and is defined as complete displacement of the tibia with respect to the femur, usually with disruption of 3 or more of the stabilizing ligaments.
- Trial name
- Co_Leap (NCT01296750)
- Testing
- Early Physiotherapy start
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Unity Health Toronto
Endoscopy, Gamification
Applying Gamification to Postgraduate Endoscopic Training
Simulation-based training curricula for gastrointestinal endoscopy have been developed and have been shown to be effective. It is possible that these curricula may be further improved.
- Conditions
- Endoscopy, Gamification, Simulation
- Trial name
- NCT03176251
- Testing
- Gamified-Integrated Curriculum
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Frailty, Transcatheter Aortic Valve Replacement
Physiological Reconditioning Program Administered Remotely in Patients Undergoing Transcatheter Aortic Valve Replacement: A Pilot Study
The PREPARE TAVR pilot study will examine the effects of remotely administered physiological reconditioning program (RAPR) on quality of life (QOL) and clinical outcomes at one year post TAVR in frail older adults.
- Conditions
- Frailty, Transcatheter Aortic Valve Replacement, Rehabilitation
- Trial name
- PREPARE-TAVR (NCT03801460)
- Testing
- Remotely administered physiological reconditioning program
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus
Impact of an Interprofessional Shared Decision-making and Goal-setting Decision Aid for Patients With Diabetes
Diabetes care is complicated for people with diabetes as well as for health care providers: they have to watch their diet, exercise, take medications, checking blood sugars and blood pressure, get tests and see multiple doctors.
- Trial name
- NCT02379078
- Testing
- Shared decision-making aid, Generic hard copy diabetes resources, Generic online diabetes resources
- Volunteers
- 225 people
- Sponsor
- Unity Health Toronto
COVID, Corona Virus Infection
RIC as an Adjunct Therapy for Severe COVID-19 Disease: a Prospective Randomized Pilot Study
This research aims to assess the use of an experimental and non-invasive procedure, Remote Ischemic Conditioning (RIC), as an adjunct therapy in attenuating severe COVID-19 disease.
- Conditions
- COVID, Corona Virus Infection, Acute Lung Injury, Ischemia Limb
- Trial name
- NCT04659460
- Testing
- Remote Ischemic Conditioning
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Polyp Colorectal
An Integrated Management Pathway for Complex Colorectal Polyps
The purpose of this study is to evaluate the impact of implementing an integrated clinical care pathway for the diagnosis, referral, evaluation and treatment of large complex colorectal polyps on clinical outcomes
- Trial name
- NCT04576780
- Testing
- Integrated Large Complex Polyp Referral Pathway
- Volunteers
- 400 people
- Sponsor
- Unity Health Toronto
Cardiac Arrest, Long QT Syndrome
Registry of Unexplained Cardiac Arrest
The CASPER will collect systematic clinical assessments of patients and families within the multicenter Canadian Inherited Heart Rhythm Research Network.
- Conditions
- Cardiac Arrest, Long QT Syndrome, Brugada Syndrome, Catecholaminergi Polymorphic Ventricular Tachycardia
- Trial name
- NCT00292032
- Where
- Canada
- Volunteers
- 1,529 people
- Sponsor
- University of British Columbia