Clinical trials: sponsored by National Taiwan University Hospital
CVD
EEG/MECG/EMG Evaluating the Severity of Aortic Stenosis, Heart Failure and Ischemic Stroke Through an Artificial Intelligenceassisted System.
The specific objectives and methods of this project are: (1) To test the feasibility and accuracy of integrating EEG, MECG and EMG for detecting the severity of diseases such as aortic stenosis, heart failure and ischemic stroke.
- Trial name
- NCT05716659
- Where
- Taiwan
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Surgical Procedure, Unspecified
Dome-type (Modified C-incision) Manual Morcellation During Laparoscopic Uterine Surgery
In-bag manual morcellation is a safe alternative procedure after FDA's discouragement of electronic power morcellator. The traditional wedging (V-type incision) or semicircular coring (C-type incision or ExCITE) method are the…
- Trial name
- NCT05804617
- Testing
- Dome-type (Modified C-incision) manual morcellation
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- National Taiwan University Hospital
Motivation, Efficacy, Self
Learning Efficacy and Motivation of Medical Students in Clinical Training With Virtual Reality
We created a curriculum based on clinical events with 360° camera on an interactive learning platform. We hypothesize that medical students will learn better and be motivated with the immersive 360 video and virtual reality…
- Trial name
- NCT05803213
- Testing
- Virtual Reality 360 interactive video, Traditional mini-lecture
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Ataxia, Cerebellar, Multiple System Atrophy
Tllsh2910 for Ataxia and Gut Microbiota Alteration in Patients of Multiple System Atrophy
Multiple system atrophy (MSA) is a fetal, rare neurodegenerative disease presenting with parksinonism, autonomic dysfunction, and cerebellar ataxia. Numerous anti-parkinsonism agents have been developed.
- Trial name
- NCT03901638
- Testing
- Tllsh2910
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- National Taiwan University Hospital
Wisdom Tooth, Dental Impaction
Efficacy and Safety of Articaine and Lidocaine in Extraction of Wisdom Teeth of Upper and Lower Jaws
Local anesthesia drugs and anesthesia technique play an imperative role in dental treatment. The purpose of this study was to compare the efficacy and safety of different dental local anesthetics drugs and brands in clinical use…
- Trial name
- NCT05804630
- Testing
- Different dental anesthetic agents during wisdom tooth surgery (Orabloc®, Octocaine®, and Xylestesin-A®)
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Literacy, Bowel Symptoms
Effectiveness of Experiential Learning on Dietary Fiber Literacy
Acute symptom onset is the most common problem in colorectal cancer surgery, and it is also the source of the most painful impact on patients' lives.
- Trial name
- NCT04642417
- Testing
- dietary fiber literacy, routine care
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- National Taiwan University Hospital
The Influence of the UGT1A1 Genotype
UGT1A1 Genotyping in Taiwanese Cancer Patients
Irinotecan is commonly used to treat lung, colorectal, pancreatic, stomach, esophageal, and other types of cancer. The main metabolic pathway of SN-38, the active product of Irinotecan, is grape glycoalkaloid acidification by UDP…
- Trial name
- NCT05792943
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Craving, Depression, Anxiety
Repetitive Transcranial Magnetic Stimulation in Amphetamine Addiction
The study aims to test whether transcranial magnetic stimulation (TMS) improves the craving, depression, anxiety and cognitive function during the abstinent period of methamphetamine users.
- Conditions
- Craving, Depression, Anxiety, Amphetamine Addiction
- Trial name
- NCT04993300
- Testing
- transcranial magnetic stimulation (TMS)
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus, Stroke
Pioglitazone and SGLT2 Inhibitors vs. DPP4 Inhibitors in Patients With Stroke
Introduction: An optimal combination of antidiabetic drugs for diabetic patients with ischemic stroke is not well-established. The objective of this randomized trial is to evaluate whether combination of pioglitazone and a sodium…
- Trial name
- NCT04419337
- Testing
- Metformin plus Pioglitazone plus an SGLT2 inhibitor
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Orthopedic Disorder, Hemodynamic Instability
Hypotension Prediction Index Based Perioperative Protocolized Hemodynamic Management in Geriatric Orthopedic Surgery
Blood pressure optimization has been considered as a crucial factor to avoid perioperative vital organ hypoperfusion, and perioperative hypotension has been addressed as a risk factor for complications and adverse clinical…
- Trial name
- NCT05274412
- Testing
- hypotension prediction index(HPI), ordinary goal-directed hemodynamic therapy
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- National Taiwan University Hospital
Usability, Anesthesia
Usability Comparison of a mHealth Application for Pre-anesthesia Evaluation Before and After Re-design of User Interface
Pre-anesthesia assessment is an important part of anesthesiologists daily routine. A thorough assessment leads to an impeccable anesthesia plan.
- Trial name
- NCT04070261
- Testing
- iOS application usability test
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Overactive Bladder Syndrome
Comparisons of the Effects of Solifenacin Versus Mirabegron on Autonomic System, Arterial Stiffness and Psychosomatic Distress and Clinical Outcomes
Background/Purpose: The overactive bladder syndrome (OAB) affects around 17 % of female population. Antimuscarinics can affect autonomic system, arterial stiffness and psychosomatic distress.
- Trial name
- NCT02540707
- Testing
- solifenacin, mirabegron
- Where
- Taiwan
- Volunteers
- 113 people
- Sponsor
- National Taiwan University Hospital
Parkinson Disease
Single Bout Exercise on Learning in PD
Parkinson's disease (PD) is a neurodegenerative disorder associated with a loss of dopamine in the basal ganglia and is characterized by several cardinal motor signs.
- Trial name
- NCT04189887
- Testing
- aerobic exercise (cycling), Implicit sequence learning
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pancreatic Fistula
Trans-drain Occlusion for Postoperative Pancreatic Fistula- A Double Blind Randomized Clinical Trial
This is a multicenter, investigator initiated, prospective, superiority, parallel-group, randomized, double-blinded trial that aims to compare the efficacy and safety of trans-drain occlusion followed by gradual withdrawal of…
- Trial name
- NCT03800940
- Testing
- Fistulography and trans-drain occlusion, Fistulography
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Colorectal Neoplasms
Efficacy of Web-based Self-management Support Intervention on Health Outcomes in Patients With Colorectal Cancer
The study aims to test the efficacy of a web-based interactive self-management support intervention on the primary outcome, quality of life, secondary outcomes, symptom distress, emotional distress, physical activity, and the…
- Trial name
- NCT05045976
- Testing
- Web-based interactive self-management support program
- Where
- 2 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Skin Diseases
Deep Learning on 3D Cellular-resolution Tomogram
Skin biopsy is the main method to diagnose skin tumors, skin inflammation, and pigmented diseases. However, biopsy is an invasive method that can cause wounds and scars.
- Trial name
- NCT04679961
- Testing
- ApolloVue® S100 Image System (Apollo Medical Optics)
- Where
- Taiwan
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Breast Cancer, Hormone Receptor-positive Breast Cancer
A Randomized Study Comparing the Immune Modulation Effect of Ribociclib, Palbociclib, and Abemaciclib in ER+/HER2- EBC
The 3 FDA-approved CDK4, 6 inhibitors, palbociclib, ribociclib, and abemciclib, all provided progression-free survival benefits when combined with endocrine therapy in advanced ER+/HER2- breast cancer.
- Conditions
- Breast Cancer, Hormone Receptor-positive Breast Cancer, Hormone Therapy
- Trial name
- ORACLE-RIPA (NCT05766410)
- Testing
- Palbociclib, Ribociclib, Abemaciclib
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
H. Pylori Infection
Comparison of Vonoprazan-based Versus Lansoprazole-based Triple Therapy, High Dose Dual Therapy, Bismuth and Non-bismuth Quadruple Therapy in the First-line Treatment of Helicobacter Pylori Infection
Background: Bismuth quadruple therapy is currently the recommended first-line regimen for Helicobacter pylori (H. pylori) infection in regions with high clarithromycin resistance.
- Trial name
- NCT04713670
- Testing
- (A) T-V14, (B) T-V7, (C) D-V14
- Where
- Taiwan
- Volunteers
- 1,200 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury
Multidiscipline Care for Acute Kidney Disease (AKD)
The Taiwan Consortium of Acute Kidney Injury and Renal Diseases (TCTC) is leading a clinical trial group in Asia-Pacific to reduce the morbidity and mortality associated with acute kidney injury (AKI).
- Trial name
- AKD (NCT05064904)
- Testing
- never received RAAS blockers or received RAAS blockers before AKI.
- Where
- 7 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Hepatocellular Carcinoma, Hepatitis b Virus
A Novel Biomarker for Response and Prognosis of HBV-related Hepatocellular Carcinoma
The investigators will first use our previously collected serum samples and surgical/biopsied tissues from HBV-related HCC patients undergoing radiotherapy.
- Conditions
- Hepatocellular Carcinoma, Hepatitis b Virus, Radiotherapy, Biomarker
- Trial name
- NCT05752890
- Volunteers
- 95 people
- Sponsor
- National Taiwan University Hospital
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