Clinical trials: sponsored by UNC Lineberger Comprehensive Cancer Center
Breast Neoplasms
Defining the HER2 Positive (+) Breast Cancer Kinome Response to Trastuzumab, Pertuzumab, Combination Trastuzumab +Pertuzumab, or Combination Trastuzumab + Lapatinib
Kinases are a group of proteins that are important in how cancer cells grow. HER2 is a kind of kinase. This study looks at a new approach to identifying kinases, which may help target therapy more precisely.
- Trial name
- NCT01875666
- Testing
- Trastuzumab, pertuzumab, lapatinib
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212
Research into treatments for breast cancer relies more and more on an understanding of how the cells of tumor tissue act when they are exposed to a new or different drug.
- Trial name
- NCT01467310
- Testing
- GSK1120212
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Head and Neck Cancer, Squamous Cell Carcinoma of the Head and Neck
Weekly Carboplatin, Paclitaxel and Cetuximab Treatment for Patients With Recurrent or Metastatic SCCHN
This is a non-randomized, open-label phase II trial of 38 patients with recurrent or metastatic SCCHN. Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 with good organ function and will be…
- Trial name
- NCT02124707
- Testing
- Cetuximab, Paclitaxel, Carboplatin
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Endometrium Cancer, Sentinel Lymph Node
Multimedia Aid Gynecologic Counseling and Consent
This is an interventional trial to introduce two short animated videos into preoperative counseling/consent and to compare patient comprehension and satisfaction with a multimedia approach compared to standard of care currently.
- Conditions
- Endometrium Cancer, Sentinel Lymph Node, Perioperative/Postoperative Complications
- Trial name
- NCT03899441
- Testing
- Video
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Endometrial Cancer
A Pre-Op Window Study Evaluating Anti-Proliferative Effects of Atorvastatin on the Endometrium
This is a preoperative window, phase 0 study of short-term atorvastatin treatment in obese women who are to undergo surgical staging for endometrial cancer.
- Trial name
- NCT02767362
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
PET/MR in Surgical Planning for Breast CA Treated With Neoadj Chemo
Purpose: To assess the utility of combined, simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI), collectively called PET-MR, in assessing response to neoadjuvant chemotherapy and surgical…
- Trial name
- NCT04149353
- Testing
- PET/MR
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Invasive Bladder Cancer
Testing the Utilization of a Mobile Health App for Patients Undergoing Cystectomy Surgery for Bladder Cancer
This is a pilot study that involves human subjects undergoing cystectomy surgery for bladder cancer, testing the utilization of a mobile health app that promotes postoperative patient engagement, along with provider monitoring…
- Trial name
- NCT03862105
- Testing
- Mobile Health app tool - Twistle
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer, Fatigue
Physical Activity Intervention for Older Patients During Chemotherapy for Colorectal Cancer
This study will see if patient who undergo a physical activity intervention called Walk With Ease report experiencing less fatigue and a higher quality of life during chemotherapy for colorectal cancer than those who do not…
- Trial name
- NCT02191969
- Testing
- Walk With Ease
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Aging
Impact of Physical Activity on Biomarker of Aging and Body Composition Among Breast Cancer Survivors Age 65 and Older
To determine if exercise will affect the increase in p16 expression that is associated with both chemotherapy administration and advancing age.
- Conditions
- Breast Cancer, Aging, Physical Activity
- Trial name
- NCT02328313
- Testing
- Walk with Ease Program
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer of Prostate, Cancer of the Prostate
North Carolina Prostate Cancer Comparative Effectiveness & Survivorship Study (NC ProCESS)
NC ProCESS is a cohort of patients from diverse backgrounds diagnosed with early prostate cancer, who were enrolled from January 2011-June 2013.
- Conditions
- Cancer of Prostate, Cancer of the Prostate, Prostate Cancer, Prostatic Cancer
- Trial name
- NCT02564120
- Where
- United States
- Volunteers
- 1,556 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Metastatic Castrate-Resistant Prostate Cancer
Observational Longitudinal Study of Pain in Men With Metastatic Castrate-Resistant Prostate Cancer
This is a single-arm observational longitudinal study in of patients with metastatic castrate-resistant prostate cancer designed to assess the longitudinal trajectory of pain and other symptoms.
- Trial name
- NCT02008058
- Testing
- Survey
- Where
- 4 sites in United States
- Volunteers
- 213 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Thoracic, Pulmonary Injury
Radiation Induced Cardiopulmonary Injury in Humans
The purpose of the study is to assess the time, dose dependence, and fraction-size dependence of radiation (RT)-induced changes in regional lung and heart perfusion/function/structure following thoracic RT delivered using newer…
- Conditions
- Thoracic, Pulmonary Injury, Heart Injuries
- Trial name
- NCT02259452
- Testing
- SPECT Lung Perfusion Scan, SPECT Heart Perfusion Scan, Pulmonary Function Tests
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Neoplasm
Development of a Tumor Molecular Analyses Program and Its Use to Support Treatment Decisions
The primary objective of this specimen correlative study is two-fold: to provide a mechanism for the association of known molecular alterations with clinical outcomes, and to provide rapid genetic profiling of alterations with…
- Trial name
- NCT01457196
- Testing
- Tumor Genetic Sequencing
- Where
- United States
- Volunteers
- 2,798 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Prostate Cancer, Bladder Cancer
Using PROMIS as Part of Routine Clinical Care for Racially Diverse Prostate and Bladder Cancer Patients
In this pilot study, a total of 80 patients with prostate or bladder cancer (40 black, 40 white) will complete 3 patient-reported outcome (PRO) surveys: baseline (pre-treatment), during treatment, and after treatment.
- Trial name
- NCT03156244
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Bladder Cancer
Positron Emission Tomography (PET) Study for Staging of Muscle Invasive Bladder Cancer
This prospective pilot study will enroll 30 patients with cT2/T3-N0-M0 urothelial carcinoma of the bladder for whom radical cystectomy with pelvic lymph node dissection is planned.
- Trial name
- NCT01655745
- Testing
- FDG PET/MR
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Xerostomia
Prospective Evaluation of Patient Reported Xerostomia After Whole Brain Radiation
The goal of this prospective observational study is to investigate whether whole brain radiation leads to measurable xerostomia from parotid gland toxicity.
- Trial name
- NRR (NCT02682199)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
A History of Radiation Therapy for a Tumor in the Vicinity of the Retina(s)
Retinal Oxygen Function After Radiation Therapy
The investigators propose using retinal oximetry to assess for abnormalities in regional retinal oxygen consumption in previously- irradiated patients, and relate these abnormalities to changes in regional retinal function (i.e.
- Trial name
- NCT02043470
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Signs and Symptoms
Comparison of the Sensitivity and Specificity of Acoustic Angiography to the Sensitivity and Specificity of Conventional Ultrasound
Purpose: This study will evaluate a new ultrasound imaging technology called acoustic angiography. Acoustic angiography uses an ultrasound contrast agent, already FDA approved for use in cardiology, to enhance imaging of blood…
- Trial name
- NCT02175628
- Testing
- Acoustic Angiography
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Anxiety, Depression
Assessing the Feasibility of Screening and Treating Anxiety and Depression in the Bone Marrow Transplant Population
The primary purpose of this study is twofold: (1) to assess the feasibility of screening adult hematopoietic stem cell transplantation (HSCT) candidates for psychiatric comorbidity (depression and anxiety), and (2) to assess the…
- Trial name
- NCT04025190
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Oncology
Geriatric Assessment Reporting in Real Time (GARRT) in Non-electively Hospitalized Older Cancer Patients
This study prospectively evaluates the impact of geriatric assessment reporting in real-time (GARRT) on key hospital based outcomes in a cohort of non-electively hospitalized older (> 70 years) adults with cancer.
- Trial name
- NCT03951090
- Testing
- Results of the brief geriatric assessment, No results of brief geriatric assessments
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center