Clinical trials: sponsored by Unity Health Toronto
Cystic Fibrosis, Burkholderia Cepacia Infection
Tobramycin Inhalation Powder (TIP) in Cystic Fibrosis Patients Infected With Burkholderia Cepacia Complex
The objective of this study is to determine if tobramycin inhalation powder (TIP) can reduce the amount of Burkholderia Cepacia Complex (BCC) species - type of bacteria, in the sputum of cystic fibrosis patient.
- Trial name
- NCT02212587
- Testing
- TOBI
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Hysteroscopy Surgery, Informed Consent
Assessing the Impact of a Patient Education Platform to Augment the Informed Consent Process for Obstetrics and Gynecology Procedures
Over the past few decades, there has been a shift in the informed consent process, whereby the focus is centered on patient comprehension, preparedness and satisfaction.
- Trial name
- NCT04614688
- Testing
- Patient Education Platform
- Volunteers
- 78 people
- Sponsor
- Unity Health Toronto
Paroxysmal Atrial Fibrillation
Atrial Electromechanical Function in Endurance Athletes With and Without Atrial Fibrillation
This study evaluates cardiac structure and function differences between healthy endurance trained athletes with atrial fibrillation and healthy age matched endurance trained athletes without atrial fibrillation.
- Trial name
- NCT03305744
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Subarachnoid Hemorrhage, Aneurysmal
Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a special type of stroke that typically results from a ruptured intracranial aneurysm, a weakening in the wall of a blood vessel.
- Trial name
- NCT01865630
- Testing
- Etanercept
- Where
- Canada
- Sponsor
- Unity Health Toronto
Depression, Anhedonia
Dimensional Approach to Evaluate Reward Processing in Major Depressive Disorder Pre- and Post-Desvenlafaxine Treatment
Anhedonia (the lack of pleasure in normally pleasurable things) is a common symptom of major depressive disorder (MDD), and it may impact how patients with depression experience reward.
- Trial name
- NCT02859103
- Testing
- Desvenlafaxine
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Peripheral Arterial Disease
Personalizing Aspirin Therapy in Peripheral Arterial Disease Patients
Antiplatelet therapies are important to decrease the morbidity and mortality associated with Peripheral Arterial Disease (PAD) through the prevention of thrombus formation.
- Trial name
- NCT04269863
- Testing
- Aspirin
- Volunteers
- 150 people
- Sponsor
- Unity Health Toronto
Immune Thrombocytopenia
Proof-of-Concept: A Pilot, Randomized, Double-Blind Study of Oseltamivir Versus Placebo for Immune Thrombocytopenia
Immune Thrombocytopenia (ITP) is a disorder resulting in impaired platelet production and enhanced destruction on the basis of autoantibody-mediated mechanisms. Patients with ITP are at increased risk of bleeding and infection.
- Trial name
- NCT03520049
- Testing
- Oseltamivir
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Pulmonary Arteriovenous Malformations
Reperfusion of Pulmonary Arteriovenous Malformations After Embolotherapy
AVMs are abnormal collections of blood vessels which can occur in any part of the body including the lungs. These blood vessels are weakened and can rupture anytime causing bleeding which can be massive, leading to…
- Trial name
- NCT01856842
- Testing
- Angiography and embolotherapy
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Uterine Artery Flow
Uterine Artery Doppler Changes
In uncomplicated pregnancies, the uterine spiral arteries undergo a series of structural changes that result in a low resistance in the uterine arteries as pregnancy progresses.
- Trial name
- NCT03064698
- Testing
- Post-partum Doppler ultrasound
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Full Thickness Rotator Cuff Tear
Latissimus Dorsi Tendon Transfer or Partial Arthroscopic Repair of Massive Rotator Cuff Tears
A massive tear of the rotator cuff is a debilitating condition that causes pain, significant impairments in strength, and resultant loss of activity of the affected arm.
- Trial name
- NCT01481480
- Testing
- Latissimus dorsi tendon transfer, Arthroscopic repair
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Multiple Sclerosis
Medical Education for Better Multiple Sclerosis Outcomes
The main objectives of this study are: i) To design an educational tool to train physicians in overcome cognitive factors associated with therapeutic inertia.
- Trial name
- EDUCAR MS (NCT03134794)
- Testing
- Educational intervention applying the traffic light system (TLS)
- Where
- 4 sites in Argentina, Canada and 2 more
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Frail Elderly, Exercise
The PERFORM-TAVR Trial
The PERFORM-TAVR trial (Protein and Exercise to Reverse Frailty in OldeR Men and women undergoing Transcatheter Aortic Valve Replacement) is a multicenter randomized clinical trial with a parallel-group design.
- Conditions
- Frail Elderly, Exercise, Dietary Supplements, Postoperative Care
- Trial name
- PERFORM-TAVR (NCT03522454)
- Testing
- Protein-rich oral nutritional supplement, Home-based supervised exercise program
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Jewish General Hospital
Anastomotic Leak
Use of NERv's Inline Device as an Early Diagnostic Method for Anastomotic Leak.
NERv's early feasibility clinical trial is a first-in-human, multi-center, pre-market, non-randomized clinical trial intended to evaluate the safety and collect preliminary data necessary for the detection of clinical…
- Trial name
- NCT04253028
- Testing
- NERv's Inline Device
- Where
- 2 sites in Egypt
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- FluidAI Medical
COVID-19
Direct Income SupporT and Advice Negating Spread of Epidemic COVID-19: a Randomized Controlled Trial
This is a clinical trial of a cash transfer on symptoms consistent with COVID-19 and adherence to physical distancing guidance.
- Trial name
- DISTANSE COVID (NCT04359264)
- Testing
- Cash transfer
- Where
- 2 sites in Canada
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Response Rates
Contacting Authors to Retrieve Individual Patient Data
The objective of this study is to examine the impact of incentivizing authors of RCTs that are eligible for a systematic review and meta-analysis, versus usual contact strategies to obtain original IPD
- Trial name
- NCT02569411
- Testing
- Financial Incentive
- Volunteers
- 129 people
- Sponsor
- Unity Health Toronto
Stroke, Transient Ischemic Attack
SLEep APnea Screening Using Mobile Ambulatory Recorders After TIA/Stroke
Obstructive sleep apnea (OSA) is common after stroke/TIA and, left untreated, is associated with recurrent vascular events, poor functional outcomes, and long-term mortality.
- Conditions
- Stroke, Transient Ischemic Attack, Obstructive Sleep Apnea
- Trial name
- SLEAP SMART (NCT02454023)
- Testing
- Portable sleep monitor (ApneaLink Air), In-laboratory polysomnography
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis
Prospective Pilot Study of Floseal for the Treatment of Anterior Epistaxis in Patients With (HHT)
Current management strategies for severe and recurrent epistaxis secondary to Hereditary hemorrhagic telangiectasia (HHT) include surgical procedures, and uncomfortable nasal packing, both of which are often only short-term…
- Trial name
- NCT02638012
- Testing
- Floseal, Packing
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Unity Health Toronto
Type 2 Diabetes
Fibre Grain Herb Trial in Type 2 Diabetes
Despite the availability of multiple medications for the treatment of Type 2 diabetes, patients often continue to have difficulty attaining blood glucose targets and managing cardiovascular disease risk factors.
- Trial name
- FIGHT (NCT02553382)
- Testing
- Dietary, Herbal, Positive Control
- Where
- 2 sites in Canada, Croatia
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Embolism, Femoral Fractures
Effect of a Novel Reamer-Irrigator-Aspirator on the Incidence of Fat Embolism
The purpose of this study is to determine the effect on the incidence of fat emboli when using a Reamer-Irrigator Aspirator during reamed IM nail fixation of femoral shaft fractures
- Trial name
- RIA (NCT00509171)
- Testing
- Reamer Irrigator Aspirator
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Uptake of Systematic Review Evidence
Testing New Formats for the Presentation of Research Evidence to Health Care Managers and Policy Makers
The purpose of this project is to identify and use our knowledge on the barriers and facilitators to using systematic reviews (SR) by health care managers (HCM) and policy markers (PM) to develop and test a novel format for…
- Trial name
- NCT03041454
- Testing
- Novel systematic review format
- Where
- Canada
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto