Clinical trials: sponsored by The Netherlands Cancer Institute
Breast Cancer
Prospective Pilot Study ANDPrecise
This study aims at providing first evidence that axillary clearance by using an operation technique including the precise LigaSure instrument and closure of dead space of the axilla will result in an operation were a drain is not…
- Trial name
- ANDPrecise (NCT02292407)
- Testing
- LigaSure Precise instrument
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- The Netherlands Cancer Institute
Non Small Cell Lung Cancer Stage III
An International Study on the Use of PET/CT in Radiotherapy Planning in Low and Middle Income Countries
A part retrospective, part prospective cohort study to assess the difference in 2-year overall survival in patients with stage III NSCLC receiving chemoradiotherapy with curative intent in low and middle income countries before…
- Trial name
- PERTAIN (NCT02247713)
- Volunteers
- 520 people
- Sponsor
- The Netherlands Cancer Institute
Thyroid Neoplasms, Differentiated Thyroid Cancer
PET Evaluation of Recurrent Differentiated Thyroid Cancer
After initial treatment of differentiated thyroid cancer patients (DTC) are followed by a blood test, a biomarker called thyroglobulin, in order to detect a possible recurrence.
- Trial name
- THYROPET (NCT01641679)
- Where
- 15 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- The Netherlands Cancer Institute
Neoplasms
Pharmacogenomic and Pharmacokinetic Safety and Cost-saving Analysis in Patients Treated With Fluoropyrimidines
The primary purpose of this study is to prospectively determine whether capecitabine and 5-FU-induced toxicity is preventable by dose reduction prior to start of the first administration in patients heterozygous or homozygous…
- Trial name
- NCT00838370
- Testing
- Capecitabine, 5-fluorouracil
- Where
- 3 sites in Netherlands
- Volunteers
- 22 people
- Sponsor
- The Netherlands Cancer Institute
Psychosocial Issues, Cancer Genetics
The Signal-Trial: Evaluation of a Screening Tool for Psychosocial Problems in Cancer Genetics
Background An important part of individuals undergoing genetic counseling and/or testing for cancer experience psychosocial problems and worries during or after this process.
- Trial name
- NCT01562431
- Testing
- Feed-back
- Where
- Netherlands
- Volunteers
- 246 people
- Sponsor
- The Netherlands Cancer Institute
Uterine Cervical Neoplasms
Repetitive Functional Imaging in Locally Advanced Cervical Cancer
Background: The Apparent Diffusion Coefficient (ADC) acquired by Diffusion Weighted Imaging (DWI-MR) has been shown to correlate with cellular density.
- Trial name
- IMAP (NCT01989364)
- Where
- 3 sites in Belgium, Denmark and 1 more
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Meningeal Carcinomatosis
Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases
Leptomeningeal metastases (LM) develop when tumor cells reach the cerebrospinal fluid (CSF) and infiltrate the leptomeninges. The median survival of patient with breast cancer and LM is 4-6 months with up to 25% long-term…
- Trial name
- NCT01818713
- Testing
- 2B3-101
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- The Netherlands Cancer Institute
Squamous Cell Carcinoma of the Head and Neck
Interstitial Photodynamic Therapy (PDT) With Temoporfin for Advanced Head and Neck Cancers
Presently, there is no effective treatment for patients with advanced head and neck cancer (AHNC) that failed to respond to the standard therapy (radiation, chemotherapy and surgery) in the US.
- Trial name
- NCT01415986
- Testing
- Temoporfin, Medical diode laser emitting light at a wavelength of 652 nm. (Ceralas PDT 652, CeramOptec GmbH)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Breast Neoplasms
Effects of Rapid Genetic Counseling and Testing in Newly Diagnosed Breast Cancer Patients
5-10% of breast cancer patients carry a mutation in the BRCA1 or BRCA2 gene. Genetic counseling and DNA testing are usually offered to selected patients after primary treatment has been completed (e.g.
- Trial name
- TIME (NCT00783822)
- Testing
- RGCT
- Where
- Netherlands
- Volunteers
- 265 people
- Sponsor
- The Netherlands Cancer Institute
Total Laryngectomy
Long Term Use of the Provox Vega 22.5
The purpose of this study was to investigate the long-term feasibility of the new Provox Vega 22.5 voice prosthesis (outer diameter of 22.5 French) and its insertion system (SmartInserter) in laryngectomized patients who…
- Trial name
- NCT00884910
- Testing
- Provox Vega voice prosthesis 22.5 Fr
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- Atos Medical AB
Breast Cancer, HER2 Positive
Trastuzumab in a Neo-adjuvant Regimen for HER2+ Breast Cancer - the TRAIN Study
To determine the activity of the combination of paclitaxel, trastuzumab and carboplatin as neo-adjuvant treatment in patients with stage II or III HER2 positive breast cancer
- Trial name
- TRAIN (NCT00768859)
- Testing
- paclitaxel, trastuzumab and carboplatin
- Where
- 9 sites in Netherlands
- Volunteers
- 111 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer, Lung Cancer
The Effectiveness of the Screening Inventory of Psychosocial Problems (SIPP) in Cancer Patients
The purpose of this study is to evaluate the effectiveness and feasibility of the Screening Inventory of Psychosocial Problems (SIPP) in consultation settings with respect to early recognition and treatment of psychosocial…
- Conditions
- Breast Cancer, Lung Cancer, Prostate Cancer, Bladder Cancer
- Trial name
- NCT00859768
- Testing
- Questionnaire administration
- Where
- Netherlands
- Volunteers
- 568 people
- Sponsor
- Netherlands Open University
Total Laryngectomy
Short-term Clinical Feasibility of the Provox XtraHMEs for Pulmonary Rehabilitation After Total Laryngectomy
This study is a short term feasibility study that aims to investigate patient satisfaction with and performance of new Provox Xtra HME in 20 laryngectomized patients.
- Trial name
- N08HME (NCT00942903)
- Testing
- Provox Xtra HME
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Atos Medical AB
Prostatic Neoplasms
Radiotherapy for Prostate Cancer: Conventional Dose Versus High Dose
3-D conformal radiotherapy offers the opportunity to reach higher tumor doses with acceptable complication rates compared to conventional radiotherapy.
- Trial name
- NCT00692107
- Testing
- Gray
- Where
- 4 sites in Netherlands
- Volunteers
- 669 people
- Sponsor
- The Netherlands Cancer Institute
Menopausal Symptoms in Breast Cancer Patients With Treatment-Induced Complaints
Cognitive Behavioral Therapy (CBT) and Physical Exercise for Climacteric Symptoms in Breast Cancer Patients Experiencing Treatment-Induced Menopause: a Multicenter Randomized Trial
Background: Breast cancer is the most common form of cancer among women in the Netherlands. Approximately 11,000 women are diagnosed with breast cancer annually, of whom about 30% are below 50 years of age.
- Trial name
- EVA project (NCT00582244)
- Testing
- CBT and relaxation, Physical activity, CBT and physical activity
- Volunteers
- 325 people
- Sponsor
- The Netherlands Cancer Institute
Bronchogenic Carcinoma
Randomized Trial of Fluticasone in Bronchial Premalignancy
The purpose of this study is to assess the efficacy of fluticasone on the development of lung cancer in smokers
- Trial name
- NCT00407264
- Testing
- Fluticasone propionate
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc