Clinical trials: sponsored by Unity Health Toronto
Ductus Arteriosus
The Role of Fetal Ductus Arteriosus in Predicting Spontaneous Labour at Term
The exact mechanism stimulating the parturition in humans is still relatively unknown. Prostaglandins, by mediating cervical ripening and early stimulation of myometrial contractions, are likely to play a major role in the…
- Trial name
- NCT03073460
- Testing
- Ultrasound examination
- Sponsor
- Unity Health Toronto
Gestational Diabetes
The Use of the CPR to Predict Adverse Outcomes in GDM Pregnancies
The cerebro-placental ratio (CPR) is a tool for assessment of fetal wellbeing in the management of the growth restricted fetus. CPR is the ratio of the fetal middle cerebral artery pulsatility index (PI) to the umbilical artery…
- Trial name
- CPR GDM (NCT03072563)
- Where
- Canada
- Volunteers
- 207 people
- Sponsor
- Unity Health Toronto
Gestational Diabetes Mellitus
The Impact of Activity Promoting Video Games on Glycemic Control in Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) affects up to 3-5% of all pregnancies. When diagnosed with GDM, women undergo nutritional counseling, blood sugars monitoring and are encouraged to exercise regularly.
- Trial name
- NCT03073551
- Testing
- Wii Group
- Volunteers
- 150 people
- Sponsor
- Unity Health Toronto
Renal Transplant
Pregnancy Outcomes in Renal Transplant Recipients
This is a retrospective study involving all patients with a history of renal transplant that attended antenatal clinics at various Toronto hospitals and subsequently delivered between January 2000 and December 2014.
- Trial name
- NCT03073434
- Volunteers
- 17 people
- Sponsor
- Unity Health Toronto
Medication Adherence, Inappropriate Prescribing
Carefully seLected and Easily Accessible at No Charge Medications
This trial evaluates the effect of providing primary care patients with free and convenient access to a set of essential medicines.
- Conditions
- Medication Adherence, Inappropriate Prescribing, Diabetes, Hypertension
- Trial name
- CLEAN-Meds (NCT02744963)
- Testing
- Free and convenient medicine access
- Where
- 3 sites in Canada
- Volunteers
- 784 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Shoulder Dislocation
Non-operative Versus Operative Treatment of Acute Acromioclavicular Joint Dislocation
The purpose of this study is to compare non-operative treatment versus operative treatment in patients who suffer a complete, acute acromioclavicular (AC) joint dislocation.
- Trial name
- ACJoint (NCT00594841)
- Testing
- Open Reduction Internal Fixation of AC joint dislocation, Non operative treatment of AC joint dislocation (sling)
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Unity Health Toronto
Humeral Fractures, Ulnar Nerve Compression
Simple Decompression Versus Anterior Transposition of the Ulnar Nerve
Both simple decompression and anterior transposition of the elbow nerve (ulnar nerve) for acute displaced fractures of the elbow (distal humerus) treated with plate fixation are currently used by surgeons.
- Trial name
- NCT01051869
- Testing
- Simple decompression, anterior subcutaneous transposition
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Unity Health Toronto
Vascular Inflammation, Atherosclerotic Cardiovascular Disease
Cardiovascular Inflammation Reduction Trial - Inflammation Imaging Study
Vascular inflammation, a central feature of atherosclerosis, participates in the initiation, perpetuation and instability of plaques.
- Trial name
- CIRT (NCT02576067)
- Testing
- Low dose methotrexate
- Where
- 3 sites in United States, Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pleural Empyema
Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)
Bacterial pneumonia can be complicated by the development of excess fluid and pus (pleural empyema) around the lungs in children. The incidence of pleural empyema in children has increased significantly in the last 10 years.
- Trial name
- NCT01717742
- Testing
- TPA (Tissue Plasminogen Activator), DNase
- Where
- 6 sites in Canada
- Volunteers
- 97 people
- Sponsor
- The Hospital for Sick Children
Diabetes Mellitus, Non-Insulin-Dependent, Heart Failure
Saxagliptin and Cardiac Structure and Function
Diabetes is associated with a substantially increased risk of heart failure, which is associated with substantial morbidity and mortality.
- Trial name
- SCARF (NCT02481479)
- Testing
- Saxagliptin
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Tuberculosis
Training Lay Healthcare Workers to Optimize TB Care and Improve Outcomes in Malawi
Task shifting of less complex healthcare tasks to lay health workers (LHWs) is increasingly employed strategy to address the global shortage of skilled health workers.
- Trial name
- NCT02533089
- Testing
- KT intervention
- Where
- Malawi
- Volunteers
- 1,153 people
- Sponsor
- Dignitas International
Cannabis Use, Driving Impaired
Neural Correlates of Driving and Cannabis
Driving is a set of complex tasks and requires use of multiple cognitive domains, including attention, planning, and memory. In laboratory studies, the main psychoactive component in cannabis, delta-9-tetrahydrocannabinol (THC)…
- Trial name
- NCT03581058
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Unity Health Toronto
Gastrointestinal Cancer, Colorectal Cancer
Exercise to Reduce Chemotherapy-Induced Peripheral Neuropathy
This randomized, controlled, pilot experiment will evaluate the effects of an aerobic walking intervention on OIPN (oxaliplatin-induced peripheral neuropathy) in patients with gastrointestinal (GI) cancer who are already…
- Conditions
- Gastrointestinal Cancer, Colorectal Cancer, Pancreatic Cancer, Gastric Cancer
- Trial name
- NCT03515356
- Testing
- MI-Walk Intervention, Physical Activity Education Pamphlet
- Where
- 7 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of Michigan Rogel Cancer Center
Nephrolithiasis
Mirabegron And Ureteral Stent-related Pain (MAP) Trial
Ureteric stents are used often following ureteroscopy for prevention of obstruction from edema and/or stone fragments. Up to 75% of patients experience pain following stenting, as well as lower urinary tract symptoms (LUTS) such…
- Trial name
- MAP (NCT04286152)
- Testing
- Mirabegron 50 MG
- Where
- Canada
- Volunteers
- 142 people
- Sponsor
- Unity Health Toronto
Pain, Postoperative, Fractures, Closed
Cognitive Behavioural Therapy to Reduce Persistent Post-Surgical Pain After Fracture
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Fractures, Closed, Fractures, Open
- Trial name
- SPOC_CBT (NCT03196258)
- Testing
- Cognitive behavioural therapy
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McMaster University
Sedative Adverse Reaction, Sleep
Reducing Sedatives in Hospital Study
Inappropriate prescription of unnecessary and potentially harmful medications continues to be a widespread problem for hospitalized patients.
- Trial name
- NCT03420898
- Testing
- Quality Improvement Intervention, prescription reduction
- Where
- Canada
- Volunteers
- 19,090 people
- Sponsor
- Mount Sinai Hospital, Canada
Mild Cognitive Impairment
Improving Performance in Drivers With Mild Cognitive Impairment
The objective of this study is to assess the effectiveness of an intervention to address both executive function and processing speed changes that contribute to poor driving performance in adults with Mild Cognitive Impairment…
- Trial name
- NCT01935219
- Testing
- Goal Management Training, Processing Speed Training, Brain Health Workshop
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Baycrest
Sleep, Pregnancy
Perinatal Effects of Mindfulness Phone App Use in Pregnancy (PaMPPr Study)
There is evidence to show that mindful meditation has a positive impact on health. To date, all the studies done to investigate the effect of mindfulness on pregnancy outcomes have been done through a traditional 8-10 weeks…
- Trial name
- PaMPPr (NCT03802734)
- Testing
- Mindful meditation phone app
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Pelvic Organ Prolapse, Pessary
Extended Pessary Interval for Care (EPIC Study)
Objectives: Pelvic organ prolapse (POP) is a common condition for which pessaries are commonly used in conservative treatment. Despite their prevalence, there is no literature to guide the management of pessaries.
- Trial name
- EPIC (NCT01644214)
- Testing
- 6 month follow up for pessary check in the clinic setting
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Unity Health Toronto
Overactive Bladder
Educating Patients on Management of Overactive Bladder: Written Versus Verbal Instructions
Background: Overactive bladder (OAB) is a common condition among postmenopausal women, requiring a multifaceted treatment approach that requires patient retention of information given to them in clinic.
- Trial name
- NCT02197533
- Testing
- Written List
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto