Clinical trials: sponsored by Ohio State University Comprehensive Cancer Center
Cancer Survivor, Stage 0 Breast Cancer
Cardiac Rehabilitation Program in Improving Cardiorespiratory Fitness in Stage 0-III Breast Cancer Survivors
This clinical trial studies a cardiac rehabilitation program in improving cardiorespiratory fitness in stage 0-III breast cancer survivors.
- Conditions
- Cancer Survivor, Stage 0 Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer
- Trial name
- NCT03039140
- Testing
- Educational Intervention, Exercise Intervention, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Advanced Malignant Neoplasm, ALK Fusion Protein Expression
Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers
This phase II trial studies how well brigatinib works in treating patients with ALK and ROS1 gene alterations and solid cancers that have spread to nearby tissue and lymph nodes or other places in the body.
- Conditions
- Advanced Malignant Neoplasm, ALK Fusion Protein Expression, ALK Gene Amplification, ALK Gene Mutation
- Trial name
- NCT03868423
- Testing
- Brigatinib, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- United States
- Sponsor
- Sameek Roychowdhury
Platelet Disorder
Avatrombopag for the Treatment of Thrombocytopenia After Donor Hematopoietic Stem Cell Transplant
This phase II trial studies the side effects and how well avatrombopag works for the treatment of thrombocytopenia after donor hematopoietic stem cell transplant.
- Trial name
- NCT04312789
- Testing
- Avatrombopag
- Sponsor
- Ayman Saad
Head and Neck Cancer
Ph 2 Intensification Regimen for Previously Untreated, Resectable, Advanced Squamous Cell Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00566540
- Testing
- Cisplatin, Paclitaxel, Intensity-Modulated Radiation Therapy (IMRT) External Beam Radiation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Adult Lymphocyte Depletion Hodgkin Lymphoma, Adult Lymphocyte Predominant Hodgkin Lymphoma
Gemcitabine and Bendamustine in Patients With Relapsed or Refractory Hodgkin's Lymphoma
This phase I/II trial studies the side effects and best dose of bendamustine hydrochloride when given together with gemcitabine hydrochloride and to see how well it works in treating patients with relapsed or refractory Hodgkin…
- Conditions
- Adult Lymphocyte Depletion Hodgkin Lymphoma, Adult Lymphocyte Predominant Hodgkin Lymphoma, Adult Mixed Cellularity Hodgkin Lymphoma, Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma
- Trial name
- NCT01535924
- Testing
- gemcitabine hydrochloride, bendamustine hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Beth Christian
Chronic Lymphocytic Leukemia, Loss of Chromosome 17p
Ibrutinib and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia After Ibrutinib Resistance
This phase II trial studies how well the combination of ibrutinib and venetoclax works in treating patients with chronic lymphocytic leukemia whose cancer has stopped responding to ibrutinib alone.
- Trial name
- NCT03943342
- Testing
- Ibrutinib, Venetoclax
- Sponsor
- Kerry Rogers
Recurrent Breast Cancer, Recurrent Colon Cancer
Comprehensive Gene Sequencing in Guiding Treatment Recommendations Patients With Metastatic or Recurrent Solid Tumors
This pilot clinical trial studies comprehensive gene sequencing in guiding treatment recommendations in patients with metastatic or recurrent solid tumors.
- Conditions
- Recurrent Breast Cancer, Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Breast Cancer
- Trial name
- NCT01987726
- Testing
- cytology specimen collection procedure, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Child-Pugh Class A, Child-Pugh Class B
Stereotactic Body Radiation Therapy and Transarterial Chemoembolization in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery
This pilot clinical trial studies stereotactic body radiation therapy (SBRT) and transarterial chemoembolization (TACE) in treating patients with liver cancer that cannot be removed by surgery.
- Conditions
- Child-Pugh Class A, Child-Pugh Class B, Stage IIIA Hepatocellular Carcinoma, Stage IIIB Hepatocellular Carcinoma
- Trial name
- NCT02507765
- Testing
- Laboratory Biomarker Analysis, Stereotactic Body Radiation Therapy, Transarterial Chemoembolization
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Mood, Stress, Psychological
Stress Management for Cancer Patients: How Well Does it Work? (C2H-D)
Psychological interventions for cancer patients have been tested and found to reduce stress and improve quality of life. These interventions have been tested at academic medical centers but have not been available for use by…
- Trial name
- C2H-D (NCT02070250)
- Testing
- From Cancer to Health (C2H-D)
- Where
- 15 sites in United States
- Volunteers
- 158 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Recurrent Plasma Cell Myeloma
HDAC Inhibitor AR-42 and Pomalidomide in Treating Patients With Relapsed Multiple Myeloma
This pilot phase I trial studies the side effects and best dose of histone deacetylase (HDAC) inhibitor AR-42 (AR-42) when given together with pomalidomide in treating patients with multiple myeloma that has returned after a…
- Trial name
- NCT02569320
- Testing
- Dexamethasone, HDAC Inhibitor AR-42, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colon Cancer, Rectal Cancer
Adherence to Colon Cancer Screening (ACCS)
This randomized clinical trial studies website access or genetic counseling with or without patient navigators on adherence to colorectal cancer screening recommendations in patients with newly diagnosed colorectal cancer and…
- Trial name
- NCT02112747
- Testing
- Patient Navigator
- Where
- United States
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer, Cervical Cancer
Ohio Patient Navigator Research Program
The Ohio Patient Navigator Research Program (OPNRP) proposes to alleviate disparities in relation to the timely diagnosis and treatment of breast, cervical and colorectal cancer in Columbus, OH.
- Conditions
- Breast Cancer, Cervical Cancer, Colon Cancer, Rectal Cancer
- Trial name
- OPNRP (NCT01569672)
- Testing
- Patient Navigator matched with subject, Subjects are mailed informational/educational materials
- Where
- United States
- Volunteers
- 941 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Lorcaserin in Treating Chemotherapy-Induced Peripheral Neuropathy in Patients With Stage I-IV Gastrointestinal or Breast Cancer
This phase I trial studies how well lorcaserin works in treating chemotherapy-induced peripheral neuropathy in patients with stage I-IV gastrointestinal or breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT04205071
- Testing
- Lorcaserin, Lorcaserin Hydrochloride, Questionnaire Administration
- Sponsor
- Ohio State University Comprehensive Cancer Center
Vestibular Schwannoma, NF2
Concentration and Activity of Lapatinib in Vestibular Schwannomas
Tumors can grow on the auditory nerves and can cause hearing loss. A common type of tumor that does this is a vestibular schwannoma (VS), or acoustic neuroma. These tumors are not cancerous. Most often, people have only one VS.
- Conditions
- Vestibular Schwannoma, NF2, Neurofibromatosis 2, Acoustic Neuroma
- Trial name
- NCT00863122
- Testing
- lapatinib
- Where
- 7 sites in United States
- Volunteers
- 26 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Gastrointestinal Cancer, Neuroendocrine Carcinoma
Inhaled Essential Oil Effect on Common QOL Concerns During Cancer Treatment
This single-blind, randomized controlled trial studies how well inhaled essential oils work for common quality of life concerns in patients who are undergoing cancer treatment such as chemotherapy, targeted therapy, and/or…
- Conditions
- Gastrointestinal Cancer, Neuroendocrine Carcinoma, Skin Cancer
- Trial name
- NCT03858855
- Testing
- Aromatherapy and Essential Oils, Subject Diary
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Hospitalization, Malignant Neoplasm
Checklist Tool in Engaging Patients in the Discharge Planning Process
This clinical trial studies how well a checklist tool works in engaging patients in the discharge planning process. Engaging patients in the discharge process may increase participation in the discharge process and improve…
- Conditions
- Hospitalization, Malignant Neoplasm, Transitional Care Planning
- Trial name
- TEPID (NCT02942524)
- Testing
- Communication Intervention, Questionnaire Administration, Survey Administration
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Healthy, Obesity
Communication & Peer Support Effects on Physical Activity in Overweight Postmenopausal Women
This randomized clinical trial studies the feasibility of tailored physical activity intervention that is administered using Interactive Voice Response technology and cell phones.
- Conditions
- Healthy, Obesity, Postmenopausal
- Trial name
- BePHIT (NCT01940016)
- Testing
- communication intervention, exercise intervention
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Anxiety, Depression
iPad Use in Reducing Anxiety and Depression in Patients Undergoing Bone Marrow Transplant
This randomized clinical trial studies iPad use in reducing anxiety and depression in patients undergoing bone marrow transplant.
- Conditions
- Anxiety, Depression, Malignant Neoplasm
- Trial name
- BUCKiPAD (NCT02378012)
- Testing
- Computer-Assisted Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Major Depressive Disorder
Computerized Cognitive Behavior Therapy in Treating Depression in Patients With Cancer
This randomized clinical trial studies how well a computerized cognitive behavior therapy program works in treating depression in patients with cancer.
- Trial name
- NCT02837887
- Testing
- Computerized Cognitive Behavior Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Multiple Myeloma, Plasma Cell Neoplasm
Vorinostat and Lenalidomide After Autologous Stem Cell Transplant in Treating Patients With Multiple Myeloma
RATIONALE: Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide may stop the growth of multiple myeloma by blocking blood flow to the cancer.
- Trial name
- NCT00729118
- Testing
- lenalidomide, vorinostat
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ohio State University Comprehensive Cancer Center