Clinical trials: sponsored by CHU de Reims
Colorectal Adenocarcinoma
Measurement of MMP-14 Protein, a Potential New Marker for Colorectal Cancer Detection, in Plasma Vesicles Named Exosomes
Colorectal cancer is the third most common cancer in men, and the second most common in women. Screening for colorectal cancer is based on the search for blood in the stool using fecal immunochemical test (FIT).
- Trial name
- EXOSCOL02 (NCT06955767)
- Testing
- Blood will be drawn from 2 additional tubes of 5 ml each
- Where
- France
- Volunteers
- 650 people
- Sponsor
- CHU de Reims
Bipolar Disorder, Major Depressive Disorder
Functional Magnetic Resonance Imaging Study of Inhibitory Control in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder and unipolar depressive disorder are two chronic mood disorders associated with a significant social impact, even during euthymic phases.
- Trial name
- COLIBRI (NCT07503275)
- Testing
- Analysis of inhibitory control
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Stroke
Mirror Therapy Rehabilitation of the Upper Limb After Stroke (NEURO-MIROIR 2)
Hemiparesis is a common motor disorder after a stroke. The majority of patients do not recover functional use of their paretic upper limb.
- Trial name
- NEUROMIROIR2 (NCT04119544)
- Testing
- Conventional rehabilitation, Intensive Visual Simulation
- Where
- 5 sites in France
- Volunteers
- 66 people
- Sponsor
- Clinique Les Trois Soleils
Bipolar Disorder and Major Depressive Disorder
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their…
- Trial name
- COMET (NCT06740331)
- Testing
- Analysis of social cognition, memory functioning, and executive functioning processes
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Stress Disorder, Post-traumatic
Sensory Stimulation Program Delivered by Family Members of Brain-injured Patients in Critical Care: Effect on Relatives' Post-traumatic Stress
Severe traumatic brain injuries are common and can lead to major long-term disability. Patients with severe brain injury often require admission to critical care.
- Trial name
- StimulSensRea (NCT07456384)
- Testing
- Standardized family-delivered neurosensory stimulation protocol
- Where
- France
- Volunteers
- 200 people
- Sponsor
- CHU de Reims
Postnatal Depression
New Cognitive Treatment for Peripartum Depression
The peripartum period is the period between the last month of pregnancy and up to a year after childbirth. It can be considered a difficult time for women, as it is a period of transition during which vulnerability to psychiatric…
- Trial name
- MCT-DPP (NCT06253390)
- Testing
- Metacognitive training, control
- Where
- France
- Volunteers
- 96 people
- Sponsor
- CHU de Reims
Chronic Obstructive Pulmonary Disease, Asthma
A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Bronchiectasis, Cystic Fibrosis
- Trial name
- PALMIRE (NCT07274631)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Catheter Related Complication
Difficult Intravenous Access in Pediatric Patients: Paramedical Care Using Ultrasound Guidance
Obtaining intravenous access is difficult in the pediatric population. Ultrasound-guidance allows real-time visualization of target veins which are invisible and impalpable.
- Trial name
- VVParamECHO (NCT06465121)
- Testing
- peripheral intravenous catheterization performed with ultrasound guidance by a trained nurse
- Where
- France
- Volunteers
- 120 people
- Sponsor
- CHU de Reims
Ankle Sprains
Osteopathic Consultation in the Emergency Department for Fresh Lateral Ligament Sprain
The study consists in recruiting patients with ankle sprains who visit the emergency department (ED). Each patient will be tested by an osteopath who we will measure pain, swelling and/or edema, and mobility of the ankle.
- Trial name
- OASED (NCT04999254)
- Testing
- Medical treatment, osteopathic treatment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Very Preterm Birth
Evaluation of a Sensory-tonic Stimulation on Development of Parent-infant Interactions and Social Cognition in Very Premature Children
Attachment is built primarily on the first interactions of the first 9 months of a baby's life. These first interactions and their effects of stress, pleasure and displeasure are retained to establish some of the baby's…
- Trial name
- CALIN (NCT04380051)
- Testing
- sensory-tonic stimulation, skin-to-skin contact
- Where
- France
- Volunteers
- 120 people
- Sponsor
- CHU de Reims
Corneal Graft Rejection, CD160
CD160 Expression in Corneal Vessels
Despite improvements in corneal transplantation, anti-angiogenic and anti-lymphangiogenic factors remain to be be identified. CD160 is an anti-angiogenic target: its expression seems to be restricted to some immune cells and to…
- Conditions
- Corneal Graft Rejection, CD160, Angiogenesis, Lymphangiogenesis
- Trial name
- NCT05009407
- Testing
- Immunohistochemistry and clinical analyses on patients and corneas
- Where
- France
- Volunteers
- 43 people
- Sponsor
- CHU de Reims
Hypovolemia
Arterial Pressure Derived Dynamic Parameters to Detect Preload Responsiveness in Spontaneously Breathing Patients
The management of septic shock patients includes the infusion of fluids, however fluids may be deleterious if the patient does not respond by increasing cardiac output.
- Trial name
- NCT06480942
- Testing
- Detection of preload responders by a PLR test
- Where
- France
- Volunteers
- 39 people
- Sponsor
- CHU de Reims
Chronic Kidney Diseases, Pregnancy
Kynurenine Concentrations During Pregnancy in Women With or Without Chronic Kidney Disease - A Prospective Multicenter Study
Chronic kidney disease (CKD) affects more than 10% of the population worldwide and represents the second most important risk factor for preeclampsia, a life-threatening complication of pregnancy responsible for approximately…
- Conditions
- Chronic Kidney Diseases, Pregnancy, Preeclampsia
- Trial name
- KIDNEY-MOM (NCT07411937)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 204 people
- Sponsor
- CHU de Reims
General Glucocorticoid Resistance
Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia
As the investigators observed a case of glucocorticoid mutation revealed by incidentally discovered bilateral adrenal nodular hyperplasia, it was postulated that this molecular anormality could be more frequent than previously…
- Trial name
- MUTA-GR (NCT02810496)
- Testing
- blood collection for mutation characterization
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Lumbar Radicular Pain
Interest of Virtual Reality Headset During Injection in Patients With Back Pain and Sciatica
For a few years, publications have been published concerning the use of virtual reality headsets in the field of medicine and particularly in various specialities.
- Trial name
- Epi-RéV (NCT05505968)
- Testing
- Virtual Reality Headset
- Where
- France
- Volunteers
- 116 people
- Sponsor
- CHU de Reims
Alcohol Use Disorder
Social Cognition and Executive Functions in Alcohol Use Disorders - Transverse Study
Over the past few years, researchers and clinicians have stressed the major role of executive and social cognition impairments in the development and the maintenance of Alcohol Use Disorders (AUD).
- Trial name
- COSEFEX-T (NCT04647422)
- Testing
- Analysis of executive functioning and of social cognition processes
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Hidradenitis Suppurativa
Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients
The objective is to investigate ex vivo the inflammatory response in hidradenitis suppurativa (HS) (activation of an inflammasome, role of pro-inflammatory cytokines) in the skin of patients treated surgically for this disease.
- Trial name
- NCT02833909
- Testing
- surgery
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Obesity
Smallest Significant Value in Osteodensitomery in an Obese Population
The aim of this study is to determined the smallest significant value in osteodensitometry in obese population. The study population will be divided in 3 groups according to their BMI.
- Trial name
- PPVS-ob (NCT04301427)
- Testing
- Bone mineral density
- Where
- France
- Volunteers
- 120 people
- Sponsor
- CHU de Reims
Parkinson's Disease
Attributional Style and Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disorder affecting 1-2% of the population over 65 years-old. In addition to the motor impairment characterized by resting tremor, bradykinesia, rigidity and postural…
- Trial name
- ParkAIHQ (NCT03371277)
- Testing
- Medical visit for specific questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CHU de Reims
Rheumatoid Arthritis
Kinetics of Elimination of Methotrexate and Its Major Metabolite 7-OH-methotrexate for Observant Patients
Methotrexate is a key treatment for inflammatory rheumatism. Therapeutic compliance with methotrexate is difficult to measure because of a lack of objective testing; however, therapeutic compliance is essential for the proper…
- Trial name
- MetU (NCT03852888)
- Testing
- Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level
- Where
- France
- Volunteers
- 62 people
- Sponsor
- CHU de Reims