Clinical trials: sponsored by Changhai Hospital
Delirium, Anxiety
Intraoperative Midazolam on Delirium Outcome of Elderly Patients
This study was a multicenter, randomized, double-blind, placebo-controlled trial to treat elderly surgical patients with low-dose midazolam or placebo for anesthesia induction.
- Trial name
- IMODE (NCT06963112)
- Testing
- Midazolam, Saline
- Where
- 5 sites in China
- Volunteers
- 612 people
- Sponsor
- Chinese PLA General Hospital
Deep Brain Stimulation
Efficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental Disorders
This is a multi-center, single arm, prospective, open-label, extendable study for the efficacy and safety of combo-stim deep brain stimulation for treatment-refractory mental disorders (obsessive-compulsive disorder…
- Trial name
- NCT06112067
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Mental Health Center
Primary Central Nervous System Lymphoma
Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSL
This is a three-arm, multicenter, randomized controlled trial. Eligible participants will be randomized to one of three induction regimens via stratified block randomization at a 2:2:1 ratio.
- Trial name
- NCT07185373
- Testing
- Teniposide, Orelabrutinib, MTX
- Where
- 15 sites in China
- Volunteers
- 215 people
- Sponsor
- Huashan Hospital
Chronic Pancreatitis, Pancreatic Cancer
Blood Biomarkers and Gut Microbiota for Pancreatic Cancer Risk in Chronic Pancreatitis
The goal of this observational study is to learn more about pancreatic cancer risk in people with chronic pancreatitis. Researchers will study blood markers and gut microorganisms, which are bacteria and other microbes living in…
- Trial name
- NCT07762950
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Nutrition Assessment, Nutritional Support
The Effect of Perioperative Nutritional Assessment and Nutritional Support on Clinical Outcomes
It is a study to evaluate the relationship between preoperative nutritional assessment and clinical outcomes and to explore the effect of preoperative nutritional support on clinical outcomes in patients after abdominal operation.
- Conditions
- Nutrition Assessment, Nutritional Support, Clinical Outcomes, General Surgery
- Trial name
- PNAS (NCT03115931)
- Testing
- no intervention
- Where
- China
- Volunteers
- 4,880 people
- Sponsor
- Jinling Hospital, China
Carotid Artery Stenosis
A Cohort Study Comparing PCSK9 Inhibitor Plus Statin With Statin Monotherapy for Carotid Artery Stenosis
A multicenter cohort study
- Trial name
- TRIP-CAS (NCT07036991)
- Testing
- PCSK9 inhibitor (biweekly injections) + Rosuvastatin/Atorvastatin ± Ezetimibe, Rosuvastatin/Atorvastatin ± Ezetimibe
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Changhai Hospital
Healthy People, Benign Prostatic Hyperplasia
The Application of Multimodal Artificial Intelligence Systems in Prostate Cancer Diagnosis and Prognosis Analysis
Prostate-specific antigen (PSA) testing has limited specificity for prostate cancer diagnosis, leading to a high rate of unnecessary biopsies.
- Conditions
- Healthy People, Benign Prostatic Hyperplasia, Prostate Cancer
- Trial name
- NCT06589154
- Testing
- Multi-modal artificial intelligence model (BEAM)
- Where
- 10 sites in China
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Bladder Cancer
Toripalimab Combined With BCG Perfusion for the Treatment of HR-NMIBC After TURBT Surgery Exploration
This is a single-center, prospective, open-label, non-randomized clinical study initiated and conducted by the Department of Urology, Shanghai Changhai Hospital.
- Trial name
- MARINE-01 (NCT07307456)
- Testing
- Treatment with toripalimab combined with BCG perfusion following transurethral resection of bladder tumor (TURBT)
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Changhai Hospital
Pregnancy Complication, Aortic Dissection
PregnAncy-Related Aortic DISsEction in China
A multicenter observational study on pregnancy-related aortic dissection
- Conditions
- Pregnancy Complication, Aortic Dissection, Marfan Syndrome, Loeys-Dietz Syndrome
- Trial name
- PARADISE (NCT07672210)
- Testing
- Intervention strategies including medication or surgery
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- DeltaHealth Hospital · Shanghai
Atrial Fibrillation (AF), Cardiac Events
Prevention of Atrial Fibrillation After Cardiac Surgery by Pericardiotomy
PRINCE-CH is a multicentre, randomized controlled trial which evaluates the effectiveness and safety of posterior pericardiotomy in preventing POAF after cardiac surgery in Chinese population.
- Conditions
- Atrial Fibrillation (AF), Cardiac Events, Pericardial Effusion
- Trial name
- PRINCE-CH (NCT06728826)
- Testing
- Posterior pericardiotomy
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
Neoadjuvant HRS-4642 Plus Chemotherapy With or Without Immunotherapy for Pancreatic Cancer
To evaluate the safety and efficacy of neoadjuvant HRS-4642 plus chemotherapy with or without adebrelimab in patients with pancreatic ductal adenocarcinoma.
- Trial name
- NCT07691593
- Testing
- HRS-4642+NALIRIFOX, HRS-4642+NALIRIFOX+Adebrelimab
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Ischemic Stroke, Acute
Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial
Several clinical trials have produced variable conclusions regarding the effects of intensive blood pressure (BP) lowering in post-EVT acute ischaemic stroke (AIS) patients.
- Trial name
- ENCHANTED3/MT (NCT06352619)
- Testing
- Conservative SBP Control, Moderate SBP Control, Intensive SBP Control
- Where
- 2 sites in Australia, Canada
- Volunteers
- 2,000 people
- Sponsor
- The George Institute
Obsessive-Compulsive Disorder
The Efficacy and Safety of ALIC/NAcc-DBS for Treatment-refractory OCD
The present study aims to explore the efficacy and safety of DBS targeted the combination of the anterior limb of internal capsule and nucleus accumbens (ALIC/NAcc-DBS) to refractory OCD, based on multicenter, randomized…
- Trial name
- NCT04967560
- Testing
- deep brain stimulation
- Where
- 7 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Sessile Serrated Lesion, Serrated Polyp
Study on the Association Between Serrated Polyps and Metachronous Advanced Colorectal Neoplastic Lesions
This study aims to explore the risk factors associated with the development of ACN and same-site ACN in patients with SP, thereby informing the optimization of clinical surveillance strategies
- Trial name
- NCT07678788
- Volunteers
- 750 people
- Sponsor
- Changhai Hospital
Nephropathy
An Exploratory Clinical Study of Anti-CD19 CAR NK Cell (KN5501) in the Treatment of Relapsed/Refractory Immune Nephropathy
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19 CAR NK cell injection (KN5501) in patients with immune nephropathy.
- Trial name
- NCT06469190
- Testing
- anti-CD19 CAR NK cells
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Changhai Hospital
Gastrointestinal Tumors, Surgical Wound Infection
Non-Dressing vs. Routine Dressing Change After Gastrointestinal Cancer Surgery
The goal of this randomized non-inferiority trial is to evaluate whether omitting postoperative wound dressings is noninferior to routine dressing changes in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Tumors, Surgical Wound Infection, Pain, Postoperative
- Trial name
- Dressing (NCT06263205)
- Testing
- Non-Dressing of Surgical Wound, Regular Dressing Change of Surgical Wound
- Where
- 4 sites in China
- Volunteers
- 1,138 people
- Sponsor
- Fudan University
Rectal Cancer
SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter RCT on Anastomotic Leak
The goal of this clinical trial is to learn whether using a reinforcing material called SIS (small intestinal submucosa) during bowel connection after rectal cancer surgery can help prevent anastomotic leakage-a serious…
- Trial name
- NCT07209787
- Testing
- SIS-reinforced anastomosis
- Where
- China
- Volunteers
- 966 people
- Sponsor
- Beijing Chao Yang Hospital
Fasting Mimicking Diet, Colorectal Cancer
Effect of FMD on Colorectal Cancer Patients
Extensive preclinical evidence suggests that short-term fasting and fasting mimicking diets (FMDs) can protect healthy cells and render cancer cells more vulnerable to chemotherapy and other therapies.
- Trial name
- FCRC22 (NCT05384444)
- Testing
- Fasting mimicking diet
- Where
- 6 sites in China
- Volunteers
- 602 people
- Sponsor
- Fudan University
Pancreatitis, Chronic, Pancreatic Duct Stone
Comparison of Efficacy of Basket and Balloon in the Removal of Pancreatic Duct Stones in Chronic Pancreatitis Under ERCP
This study will compare the efficacy of basket and balloon in the removal of pancreatic duct stones under ERCP.
- Trial name
- NCT05289362
- Testing
- Basket group, Balloon group
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Changhai Hospital
Pancreatic Neuroendocrine Tumor
A Study of Surufatinib as Adjuvant Therapy for Pancreatic Neuroendocrine Tumors
pNENs still have a risk of recurrence after radical resection, and the overall recurrence and metastasis rate is as high as 13.7%-36.2% in China.
- Trial name
- NCT06158516
- Testing
- Surufatinib
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Changhai Hospital