Clinical trials: sponsored by Fox Chase Cancer Center
Urothelial Carcinoma
Gemcitabine and Carboplatin After Progression on Enfortumab Vedotin and Pembrolizumab in Advanced/Metastatic Urothelial Carcinoma
The goal of this clinical trial is to learn if a chemotherapy combination called gemcitabine and carboplatin (GC) works to treat advanced urothelial cancer in people who have already been treated with enfortumab vedotin and…
- Trial name
- NCT07043972
- Testing
- Gemcitabine, Carboplatin
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Fox Chase Cancer Center
Uterine Cervical Neoplasm
HPV Self-sampling for Underscreened Latinas
The goal of this study is to learn if women of Hispanic/Latina ethnicity are willing to self-collect a cervico-vaginal sample for HPV testing.
- Trial name
- NCT06439706
- Testing
- HPV Self-Sampling, Group Education
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Cancer
Testing Gene PilotLX With Latinx Cancer Patients
This is a randomized controlled trial designed to evaluate the efficacy of an electronic health decision support tool called Gene PilotLX to increase informed decision making regarding hereditary risk information from tumor…
- Trial name
- NCT06476938
- Testing
- Gene PilotLX
- Where
- 4 sites in United States
- Volunteers
- 239 people
- Sponsor
- Fox Chase Cancer Center
Urothelial Cancer, Renal Pelvis Cancer
A Genotype-Phenotype Urothelial Cancer Registry
This study is being done to create a registry to help us learn more about urinary and other cancers. This will let us look at large groups of people who do and do not have this kind of cancer.
- Conditions
- Urothelial Cancer, Renal Pelvis Cancer, Ureter Cancer, Bladder Cancer
- Trial name
- NCT00902590
- Testing
- saliva sample and questionaire, saliva sample, questionaire
- Where
- 4 sites in United States
- Volunteers
- 3,519 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Malnutitrion, Cancer
Indirect Calorimetry-Guided Parenteral Nutrition Prescribing in Oncology Patients
This study compares two methods of prescribing parenteral nutrition (PN) in adults with cancer who are unable to meet nutritional needs by oral or enteral intake.
- Trial name
- NCT07776704
- Testing
- Indirect Calorimeter, Weight-Based Parenteral Nutrition Dosing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fox Chase Cancer Center
Lung Cancer
Pilot Study of Biopsy Scanner for Evaluation of Bronchoscopic Small Biopsy Specimens to Determine Adequacy
The aim of the study is to assess the performance of Aquyre Biopsy Scanner technology (the FDA class I medical device) at determining if tissue from the lymph nodes and lung nodules, taken during a bronchoscopy procedure, is…
- Trial name
- NCT05393154
- Testing
- Biopsy Adequacy Evaluation by Aquyre Biopsy Scanner
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Aquyre Bioscience, Inc
Cancer
Engaging and Activating Cancer Survivors in Genetic Services Study
To address the gap in access to genetic services, this study will evaluate the effectiveness of an adapted model of remote delivery of genetic services to increase the uptake of recommended genetic assessment and testing in…
- Trial name
- ENGAGE (NCT04455698)
- Testing
- Remote Telegenetic Counseling by Phone, Remote Telegenetic Counseling by Videoconferencing, Usual Care Arm
- Where
- 3 sites in United States
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Breast Cancer, Prostate Cancer
African Cancer Genome: GMD
The goal of this study is to develop a comprehensive characterization of genetic and molecular drivers of breast and prostate cancer in individuals of African ancestry.
- Trial name
- NCT05754658
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 854 people
- Sponsor
- Fox Chase Cancer Center
Cancer
Genetic Information for Families After Tumor Testing Study
The purpose of this study is to develop and implement a methodology of digital tools paired with telemedicine to improve cascade testing for clinically significant germline mutations among family members of children with cancer…
- Trial name
- GIFTT (NCT07517666)
- Testing
- Interactive Chatbot
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Metastatic Renal Cell Carcinoma, Clear-cell Metastatic Renal Cell Carcinoma
Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma and Neuroendocrine Tumors
This is a multi-site, three-cohort phase II trial of cabozantinib for IMDC all-risk frontline metastatic renal cell carcinoma (mRCC) patients OR any line mRCC patients who have not previously been treated with cabozantinib, and…
- Conditions
- Metastatic Renal Cell Carcinoma, Clear-cell Metastatic Renal Cell Carcinoma, Neuroendocrine Tumors, Carcinoid Tumor
- Trial name
- NCT05263050
- Testing
- Cabozantinib, Nivolumab
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Fox Chase Cancer Center
Head and Neck Cancer
Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Populations
The PI and the research team developed the New York University (NYU) Electronic Patient Visit Assessment (ePVA) for head and neck cancer (HNC) as a patient-reported outcome measure (PRO) for the early detection of uncontrolled…
- Trial name
- NCT06030011
- Testing
- NYU Electronic Patient Visit Assessment (ePVA), Usual Care
- Where
- 5 sites in United States
- Volunteers
- 270 people
- Sponsor
- The University of Texas Health Science Center, Houston
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
PET-CT in Determining the Radioembolization Dose Delivered to Patients With Liver Metastasis, Primary Liver Cancer, or Biliary Cancer
This clinical trial studies positron emission tomography (PET)-computed tomography (CT) in determining the radiation dose delivered with radioactive spheres to patients with liver metastasis or primary liver or biliary cancer.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Metastatic Extrahepatic Bile Duct Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT02088775
- Testing
- PET scan, CT Scan, hepatic artery embolization
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Fox Chase Cancer Center
Cancer
Engaging M-health for Symptom Monitoring and Health Promotion for Women on Endocrine Therapy for Breast Cancer (EmSHAPE)
The purpose of the study is to learn more about ways to help patients understand and manage side-effects from hormone therapy. The investigators will use the information from this study to design future studies to better…
- Trial name
- NCT07454499
- Testing
- Digital Endocrine therapy Symptom Monitoring and Education Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Gynecologic Cancers
Communication About Sexual Health in Gynecologic Cancer
The goal of this clinical trial is to learn if an educational video and workbook can help gynecologic cancer patients talk to their cancer providers about sexual health concerns. The main questions it aims to answer are: 1.
- Trial name
- NCT06904339
- Testing
- Starting the Conversation, Sexual Health Resources
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fox Chase Cancer Center
Solid Tumor
Phase I Study in Advanced Malignancies With 5-ALA
RDT aims to take advantage of the relatively safer toxicity profiles of both lower dose radiation therapy and systemic ALA to treat non-superficial lesions in a manner similar to photodynamic therapy.
- Trial name
- NCT04381806
- Testing
- 5-ALA
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Fox Chase Cancer Center
Soft Tissue Sarcoma
Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)
This is a two center, 2 arm, Phase II study evaluating the combination of Ribociclib and Everolimus in patients with advanced DDL and LMS who have had at least 1 prior systemic therapy.
- Trial name
- NCT03114527
- Testing
- Ribociclib, Everolimus
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Fox Chase Cancer Center
Renal Cell Carcinoma
Study of Nivolumab and Axitinib in Patients With Advanced Renal Cell Carcinoma
This is a Phase I/II, open-label, multi-center study of axitinib in combination with nivolumab in patients with previously treated and untreated advanced RCC.
- Trial name
- NCT03172754
- Testing
- Nivolumab, Axitinib
- Where
- 4 sites in United States
- Volunteers
- 98 people
- Sponsor
- Fox Chase Cancer Center
HER2-positive Breast Cancer
Clinical Trial of Atezolizumab With Paclitaxel, Trastuzumab, and Pertuzumab in Patients With Metastatic HER-2 Positive Breast Cancer
This is a single arm, Phase IIA clinical trial assessing the safety and efficacy of atezolizumab in combination with paclitaxel, trastuzumab, and pertuzumab in 50 patients with locally advanced, unresectable, or metastatic…
- Trial name
- NCT03125928
- Testing
- Atezolizumab, Paclitaxel, Trastuzumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Fox Chase Cancer Center
Locally Advanced or Metastatic Melanoma
Study of CBL0137 in Combination With Ipilimumab and Nivolumab Therapy in Melanoma
Phase I, open label, dose-escalation, and safety study designed to assess the safety and biologic activity of the investigational agent CBL0137 in combination with standard of care drugs, ipilimumab and nivolumab in sequential…
- Trial name
- NCT05498792
- Testing
- CBL0137, Ipilimumab, Nivolumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Fox Chase Cancer Center
Soft Tissue Sarcoma
Study to Assess TOPO2A as a Biomarker for Sensitivity to Doxorubicin/Doxil in Soft Tissue Sarcoma
The primary aim of this study is to determine the utility of TOPO2A as a biomarker for sensitivity to doxorubicin or its derivatives.
- Trial name
- NCT04055753
- Testing
- Doxil, Doxorubicin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Fox Chase Cancer Center