Clinical trials: sponsored by Indiana University
Open Angle Glaucoma (OAG), Glaucoma
Adaptive Optics OCT Evaluation of Rhopressa's Effects on the Retinal Ganglion Cells in Glaucoma Patients
The purpose of this study is to compare how two FDA-approved eye drops: netarsudil (Rhopressa) and timolol, protect nerve cells in the eye of adults with open-angle glaucoma.
- Trial name
- NCT07847073
- Testing
- Netarsudil 0.02% Ophthalmic Solution [RHOPRESSA], Timolol Maleate 0.25% Ophthalmic Solution
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Brett King
Acute Lymphoblastic Leukemia, Pediatric, Pediatric Cancer
Biology and Benefits of Music Play and Stories for Kids/Parents During ALL Treatment
Music therapy has become a standard palliative care service in many pediatric and adult hospitals; however, a majority of music therapy research has focused on the use of music to improve psychosocial dimensions of health…
- Trial name
- NCT04400071
- Testing
- Active Music Engagement, Audio Storybooks
- Where
- 4 sites in United States
- Volunteers
- 192 people
- Sponsor
- Indiana University
Alcohol Use, Adolescent
Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems
Intervention for mild severity alcohol use among U.S. teens is crucial, as alcohol is the most commonly used substance in this age group, yet few receive the necessary interventions.
- Conditions
- Alcohol Use, Adolescent, Mild Alcohol Use Disorder, Mild Substance Use Disorder
- Trial name
- NCT06593652
- Testing
- Teen Intervene - Adolescent Only, Teen Intervene with Caregiver Session, Family Check Up
- Where
- United States
- Volunteers
- 615 people
- Sponsor
- Indiana University
Acute Kidney Injury, Fluid Overload
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0
There is a growing focus on short- and long-term kidney health in neonates, including those with acute kidney injury (AKI). AKI occurs commonly in the Neonatal Intensive Care Unit (NICU) and is associated with adverse outcomes.
- Conditions
- Acute Kidney Injury, Fluid Overload, Prematurity Complications, Risk Factors
- Trial name
- AWAKEN 2 (NCT06823115)
- Where
- 125 sites in United States, Argentina and 31 more
- Volunteers
- 8,000 people
- Sponsor
- Indiana University
Heart Failure With Preserved Ejection Fraction
Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
The objective of this pilot study is to establish evidence to support the validity of HT in improving skeletal muscle function and physical capacity of patients with HFpEF.
- Trial name
- NCT06388226
- Testing
- Leg heat therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
Autism, Autism Spectrum Disorder
COMPASS Across Settings (CAST) for Improving Transition Outcomes for Students With ASD
Purpose: The purpose of this project is to develop and test the COMPASS [Collaborative Model for Competence and Success] Across Settings (CAST) intervention to enhance the goal setting and attainment skills of autistic youth.
- Conditions
- Autism, Autism Spectrum Disorder, Autistic Disorder
- Trial name
- CAST (NCT06309160)
- Testing
- COMPASS Across Settings (CAST)
- Where
- United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Ball State University
Lung Neoplasms
Circulating Tumor Cells (CTC) in Lung Cancer
The primary objective of this study is to establish circulating tumor cell (CTC) derived xenografts and assess the activity of novel DNA repair inhibitors as a function of DNA repair mutations detected in CTC samples (personalize…
- Trial name
- NCT02630615
- Testing
- Blood draw
- Where
- 2 sites in United States
- Volunteers
- 71 people
- Sponsor
- Shadia Jalal
Pregnancy
Impact of Standardization on Outcomes Following Cervical Ripening
The primary purpose of this study is to determine if vaginal delivery rate is impacted by the use of standardized methods of cervical ripening. Additional outcomes will be evaluated including maternal and fetal outcomes of labor.
- Trial name
- NCT07576881
- Testing
- Cervical Ripening with a double balloon catheter only, Cervical ripening with a double balloon catheter plus misoprostol, Usual-care control group
- Where
- United States
- Volunteers
- 1,158 people, healthy volunteers welcome
- Sponsor
- Indiana University
Breast Cancer, HER2-positive Breast Cancer
NearWave Optical Molecular Monitoring
The purpose of this study is to assess the feasibility of the NearWave optical molecular monitoring system for monitoring therapy progression and predicting pathologic complete response (pCR) of breast cancer patients undergoing…
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, TNBC - Triple-Negative Breast Cancer, HER2-negative Breast Cancer
- Trial name
- NCT06744465
- Testing
- NearWave monitoring
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
Obesity & Overweight, Breast Cancer
Testing Health-Related Interventions: Voices of Equity Needed to Overcome Weight-bias in Obesity-Cancer Care
This study is testing an 8-week behavioral weight loss and wellness program adapted to the needs of Black/African American breast cancer survivors.
- Trial name
- THRIVE NOW (NCT07897890)
- Testing
- THRIVE NOW
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Spina Bifida, Myelomeningocele
Incontinence and Quality of Life in Children With Spina Bifida
This study aims to develop an innovative, interactive tool for joint use by spina bifida patients and their urologists to identify patients interested in addressing their urinary and fecal incontinence and establish continence…
- Trial name
- NCT03410667
- Testing
- Phase One: Exploration, Phase Two: Creation, Phase Three: Reflection
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Indiana University
Coronary Artery Disease
Needle Free Assessment of Myocardial Oxygenation in Healthy Subjects
This is a prospective pilot study to evaluate the safety, tolerability and efficacy of utilizing precise computer controlled gas challenge in healthy subjects for identification of coronary artery disease.
- Trial name
- NIMO-Healthy (NCT06000540)
- Testing
- RespirAct
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alzheimer Dementia (AD), Caregiver Burden of People With Dementia
VICA: A Virtual Care Assistant for Dementia Caregivers
This pilot randomized controlled trial evaluates the feasibility and preliminary efficacy of VICA, an AI-powered virtual care assistant that delivers evidence-based education, symptom monitoring, and coaching to informal…
- Trial name
- VICA (NCT07779785)
- Testing
- VICA - Virtual Informal Care Assistant, Education only BPSD mobile app
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
Treatment Resistant Depression, Substance Use Disorders
Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder
The goal of this clinical trial is to learn if a single dose of psilocybin (5mg Vs 10mg Vs 25mg) alongside psychotherapy is safe and can help treat treatment resistant depression (TRD) with co-occurring substance use disorder…
- Trial name
- NCT07499583
- Testing
- Psilocybin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Indiana University
Cytomegalovirus Infections, Primary Immune Deficiency Disorder
Virus Specific Cytotoxic T-Lymphocytes (CTLs) for Refractory Cytomegalovirus (CMV)
CMV cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults (CAYA) with refractory cytomegalovirus (CMV) infection post…
- Trial name
- NCT03266640
- Testing
- viral specific cytotoxic t-lymphocytes
- Where
- 9 sites in United States
- Volunteers
- 20 people
- Sponsor
- New York Medical College
Astigmatism, Ametropia
Optimization for Toric Contact Lenses
The aim of this study is to evaluate the agreement between subjective and objective toric lens prescriptions.
- Trial name
- NCT07557030
- Testing
- Lens 1 ( stenfilcon A ), Lens 2 ( comfilcon A )
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- CooperVision International Limited (CVIL)
Epstein-Barr Virus Infections, Primary Immune Deficiency Disorder
EBV-specific Cytotoxic T-lymphocytes (CTLs) for Refractory EBV Infection
Related donor Epstein-Barr Virus (EBV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults with refractory EBV…
- Trial name
- NCT03266653
- Testing
- cytotoxic t-lymphocytes
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- New York Medical College
Adenovirus, Primary Immune Deficiency Disorder
Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection
Related donor Adenovirus (ADV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered intravenously in in children, adolescents and young adults with…
- Trial name
- NCT03266627
- Testing
- cytotoxic t-lymphocytes
- Where
- 10 sites in United States
- Volunteers
- 20 people
- Sponsor
- New York Medical College
Stroke, Acute, Gait, Hemiplegic
Focused Intensive Repeated Stepping During Inpatient Rehabilitation Poststroke - A Quality Improvement Project
The purpose of this quality improvement project was first to monitor usual physical therapy care (types \& cardiovascular intensity of interventions and amount of stepping practice provided) and outcomes.
- Trial name
- FIRST-IN (NCT05393661)
- Testing
- inpatient physical therapy poststroke
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Indiana University
Prostate Cancer Surgery, Prostate Cancer Metastatic Disease
Safety and Efficacy of OTL78
This is a trial to assess the accuracy of an imaging agent, PSMA targeted fluorescent dye OTL78 (zopocianine), in combination with Near InfraRed (NIR) fluorescent imaging, to improve the detection of malignant (growing in an…
- Trial name
- NCT07725523
- Testing
- 0.06 mg/kg ZOPOCIANINE given 1-7 days prior to surgery
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Clinton Bahler
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