Clinical trials: sponsored by Ottawa Hospital Research Institute
Occult Cancer
Intensive Cancer Screening After Cryptogenic Stroke
The INCOGNITO Pilot Trial is a single centre pilot prospective randomized open-label blinded endpoint (PROBE) trial to assess the feasibility of a full-scale randomized trial to determine whether an occult cancer screening…
- Trial name
- INCOGNITO (NCT05733416)
- Testing
- FDG PET/CT, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Ottawa Hospital Research Institute
Hypertension
SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy
The goal of this clinical trial is to determine whether a renin-guided antihypertensive treatment strategy is feasible to implement in community primary care clinics and to explore whether spironolactone improves blood pressure…
- Trial name
- SPIRO-First (NCT07687160)
- Testing
- Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams.
- Where
- 4 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Lung Cancer
Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer
This is a two arm RCT evaluating the effect of intravenous vitamin C versus placebo in patients with incurable non-small cell lung cancer.
- Trial name
- AIVAA (NCT05849129)
- Testing
- Ascorbic acid, Normal Saline
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Chronic Obstructive Pulmonary Disease (COPD)
Urolithin A Supplementation During Pulmonary Rehabilitation in Patients With COPD
SUPRA-COPD is a multicenter triple-blind, parallel arm, placebo-controlled randomized controlled trial investigating the efficacy and safety of Urolithin A supplementation during pulmonary rehabilitation in patients with COPD.
- Trial name
- SUPRA-COPD (NCT07871357)
- Testing
- Urolithin A
- Volunteers
- 198 people
- Sponsor
- Bryan A. Ross
GastroIntestinal Bleeding, Anticoagulant-induced Bleeding
Anticoagulation After GI Bleeding Pilot Study and Registry
PANTHER-GI Pilot Study will assess the feasibility of a full-scale multicentre cohort management study evaluating the safety of a standardized strategy for resuming direct oral anticoagulants (DOACs) after major DOAC-related…
- Trial name
- PANTHER-GI (NCT05290857)
- Testing
- Restart DOAC within 7 days of clinical hemostasis after GI bleeding, Restart DOAC between 7 to 14 days of clinical hemostasis after GI bleeding
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Atrial Fibrillation
COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation
Atrial Fibrillation (AF) affects 200,000 Canadians and increases risk of stroke, morbidity and mortality. Having a stroke can affect a patient's ability to speak, eat, walk, work, care for themselves, and interact with others.
- Trial name
- COBRRA-AF (NCT04642430)
- Testing
- Apixaban, Rivaroxaban
- Where
- 8 sites in Canada
- Volunteers
- 3,018 people
- Sponsor
- Ottawa Hospital Research Institute
Revision Arthroplasty
Watson Extraction System for Femoral Stem Extraction
A revision total hip replacement surgery requires the surgeon to remove, or extract, the femoral stem (the rod that was placed into the thigh bone during your first hip replacement).
- Trial name
- WES (NCT07836608)
- Testing
- Watson Extraction System, Standard of Care Stem Extraction
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Mild Cognitive Impairment
Memory Support System Feasibility Study
The purpose of this study is to determining the feasibility of providing the Memory Support System (MSS) to individuals with mild cognitive impairment (MCI) and their partners at a clinic in Ontario, Canada.
- Trial name
- NCT05999929
- Testing
- Memory Support System
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Bruyère Health Research Institute.
COPD, Asthma
Early Diagnosis and Treatment of Undiagnosed Asthma or COPD: THE UCAP 2 TRIAL
Our research group has found that Canadians with undiagnosed asthma or chronic obstructive pulmonary disease (COPD) have increased respiratory symptoms and worse health-related quality of life.
- Trial name
- UCAP2 (NCT06392776)
- Testing
- Early diagnosis and treatment
- Where
- 6 sites in Canada
- Volunteers
- 420 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thromboembolism, Cancer
Secondary Prevention of VTE in Patients With Cancer and Catheter-Related Upper Extremity Deep Vein Thrombosis
This trial seeks to evaluate a management strategy after the acute treatment duration (≥ 3 months of therapeutic anticoagulation) for patients with cancer and catheter-related upper extremity deep vein thrombosis (DVT).
- Conditions
- Venous Thromboembolism, Cancer, Upper Extremity Deep Vein Thrombosis, Catheter-Related Infections
- Trial name
- STREAM-Line (NCT06603870)
- Testing
- Anticoagulation Therapy
- Where
- 2 sites in Canada
- Volunteers
- 330 people
- Sponsor
- Ottawa Hospital Research Institute
First Episode Psychosis (FEP), Psychosis
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Psychotic disorders affect approximately 4% of Canadians and have a significant impact on individuals' well-being, their families and social networks, and healthcare systems.
- Conditions
- First Episode Psychosis (FEP), Psychosis, Schizophreni-form Disorder, Dependence Addictive
- Trial name
- Mobile Health (NCT07811466)
- Testing
- CHAMPS, I Can Change
- Volunteers
- 550 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Trimalleolar Ankle Fracture, Unstable Trimalleolar Ankle Fracture
Early Ambulation Safely in Unstable Ankle Fractures (EASY-Ankle)
This pilot randomized controlled trial will evaluate the safety and feasibility of beginning weight-bearing earlier after surgery for an unstable trimalleolar ankle fracture.
- Trial name
- EASY-Ankle (NCT07811804)
- Testing
- Postoperative Weight-Bearing Rehabilitation Protocol
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Deterioration, Clinical
Feasibility and Initial Clinical Impressions of Predictive Monitoring Integrated With the RACE Team
Rapid response teams (RRTs) have been adopted by hospitals to provide urgent critical care to hospitalized patients who require quick intervention to prevent further deterioration.
- Trial name
- VSI (NCT05108376)
- Testing
- Visensia Safety Index (VSI)
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Ottawa Hospital Research Institute
Thrombosis, Cancer
Safety of Perioperative Anticoagulation Management in People With Active Cancer Undergoing Cancer-Related Surgery or Procedures (ACE-HIGH Study)
The purpose of this study is to help find how safe current practices are when managing blood thinners in people with cancer who are having surgery or medical procedures.
- Conditions
- Thrombosis, Cancer, Thrombosis, Deep Vein, Atrial Fibrillation (AF)
- Trial name
- ACE-HIGH (NCT07372716)
- Testing
- standardized perioperative anticoagulation management Guideline
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Ottawa Hospital Research Institute
Organ Donation
Donation Advisor Clinical Decision Support Tool Study
Every year, thousands of Canadians receive life-saving, cost-effective organ transplants, while thousands more still wait or die because not enough organs are available.
- Trial name
- NCT04661787
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Ottawa Hospital Research Institute
Anemia, Hip Osteoarthritis
Can Pre-operative Anemia be Timely Identified and Optimized in Patients Awaiting Primary Arthroplasty Surgery? A Randomized Clinical Trial
Reducing the occurrence of anemia (low circulating hemoglobin levels) post-surgery has been associated with improved outcome, as it reduces complications and allows for faster return to pre-operative function.
- Trial name
- NCT05648942
- Testing
- Anemia testing
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis, Hip
Measured vs Navigated Techniques in Total Hip Arthroplasty
Accurate reconstruction of the native hip parameters following total hip arthroplasty is associated with improved outcome. In order to improve ability for optimum reconstruction, 3-D templating software can be utilized that…
- Trial name
- NCT05393778
- Testing
- Measured Technique, Navigated Technique
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Bariatric Surgery Candidate
The Use of Laparoscopic Transversus Abdominis Plane Block in Gastric Bypass Surgery (LapTAP)
Randomized, Double-Blinded, Placebo-Controlled Trial of Laparoscopic Transverse Abdominis Plane (Lap TAP) and Rectus Sheath Block in elective Gastric Bypass Surgery aiming to evaluate the benefit of a laparoscopically -guided…
- Trial name
- LapTAP (NCT03367728)
- Testing
- Ropivacaine, Normal saline
- Where
- Canada
- Volunteers
- 148 people
- Sponsor
- Ottawa Hospital Research Institute
Cellulitis
High-dose Cephalexin for Cellulitis (HI-DOCC)
Cellulitis is a common condition diagnosed and managed in the ED that carries significant burden on healthcare systems globally. Cellulitis is the 8th most common reason patients present to an ED in Canada.
- Trial name
- HI-DOCC (NCT05852262)
- Testing
- Cephalexin
- Where
- 10 sites in Canada
- Volunteers
- 454 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Depressive Symptoms, Depression, Anxiety
Transcranial Magnetic Stimulation for Psychological Distress in Patients With Advanced Illness
Psychological and existential distress are a common cause of suffering among patients nearing the end of life, and a major reason for requesting medical aid in dying.
- Conditions
- Depressive Symptoms, Depression, Anxiety, Psychological Distress, Terminal Illness
- Trial name
- NCT04257227
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Ottawa Hospital Research Institute