Clinical trials: sponsored by Peking University First Hospital
Older Patients, Surgery
Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery
Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse long-term outcomes.
- Conditions
- Older Patients, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07576543
- Testing
- Dex-Esk, Active tDCS
- Where
- 6 sites in China
- Volunteers
- 1,996 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Older Patients, Surgery
Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After Surgery
Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse outcomes.
- Conditions
- Older Patients, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07576517
- Testing
- Dex-Esk, Active tDCS
- Where
- 6 sites in China
- Volunteers
- 1,996 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Hepatocellular Carcinoma
Surgery vs. Watch-and-Wait Strategy in Complete Responders for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Some people with HCC have no visible active tumor on imaging after receiving anticancer treatment.
- Trial name
- SWITCH-R (NCT07866612)
- Testing
- Curative-Intent Liver Resection, Immunotherapy-Based Systemic Maintenance Therapy
- Where
- 9 sites in China
- Volunteers
- 60 people
- Sponsor
- West China Hospital
Membranous Nephropathy
Combination of Rituximab and Cyclosporine in the Treatment of Primary Membranous Nephropathy
High-grade proteinuria is one of the key determinants of adverse renal prognosis in patients with primary membranous nephropathy (PMN).The main purpose of this study is to determine whether Rituximab combined with Cyclosporine is…
- Trial name
- NCT07861204
- Testing
- Rituximab combined with cyclosporine, rituximab
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking University First Hospital
Cutaneous T-Cell Lymphoma/Mycosis Fungoides/Sézary Syndrome
A Prospective Clinical Study of Zeprumetosta in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma
Patients with relapsed or refractory cutaneous T-cell lymphoma (R/R CTCL) face a poor prognosis and limited therapeutic options. Advanced or relapsed disease yields a 5-year overall survival rate of <50%.
- Trial name
- NCT07854639
- Testing
- Zeprumetostat Tablets
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Peking University First Hospital
Obesity; Chronic Kidney Disease; Albuminuria
Study on the Efficacy and Safety of Initial Combination of Finerenone and Semaglutide in Non-Diabetic Adult Patients With Obesity Complicated by Chronic Kidney Disease With Albuminuria
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate whether starting finerenone together with semaglutide provides an additional reduction in urinary albumin-to-creatinine ratio…
- Trial name
- NCT07849348
- Testing
- Finerenone, Semaglutide
- Volunteers
- 266 people
- Sponsor
- Peking University People's Hospital
Chronic Rhinitis
The Epidemiological and Intrinsic Characteristics of Chronic Rhinitis
Chronic rhinitis affects 10-40% of China's population, or over 300 million people, and can lead to respiratory and psychological issues.
- Trial name
- NCT06370468
- Testing
- Epidemiological investigation
- Where
- China
- Volunteers
- 150,000 people, healthy volunteers welcome
- Sponsor
- Zheng Liu ENT
Cancer Patients Receiving Radiotherapy for Kidney Malignancies
Efficacy Evaluation of Modified Zhixiao Tongmai Ning in Preventing Radiation-Induced Kidney Injury
This prospective randomized controlled study evaluates the clinical efficacy of modified Zhixiao Tongmai Ning in preventing radiation-induced kidney injury in cancer patients.
- Trial name
- NCT07849088
- Testing
- Modified Zhixiao Tongmai Ning, Standard Radiotherapy Alone
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Peking University First Hospital
Alzheimer's Disease (AD)
Multimodal Ophthalmic Imaging and Plasma Biomarkers for the Early Detection of Alzheimer's Disease
With the accelerating global aging population, dementia has become a pressing worldwide issue. This project aims to identify specific plasma biomarkers and ocular indicators for the early detection of Alzheimer's disease (AD).
- Trial name
- MOIPAD (NCT06924359)
- Testing
- Multimodal Ophthalmic Imaging and plasma biomarker
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Solid Tumor Malignancies, Hematologic Cancer
The Application of 18F-G1 PET/CT Targeting Granzyme B in the Pan-cancer Immunotherapy
The purpose of this study is to explore the effectiveness of 18F-G1 PET/CT in patients with solid tumors and hematological malignancies receiving immunotherapy
- Conditions
- Solid Tumor Malignancies, Hematologic Cancer, Lung Cancer, Esophagus Cancer
- Trial name
- NCT07039474
- Testing
- 18F-G1
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Upper Tract Urothelial Carcinoma
Disitamab Vedotin Plus Radiotherapy for Adjuvant Treatment of HER2-Expressing Cisplatin-Ineligible Upper Tract Urothelial Carcinoma
This randomized, open-label, multicenter phase III study is designed to compare disitamab vedotin plus radiotherapy with gemcitabine plus carboplatin as adjuvant treatment in patients with HER2-expressing upper tract urothelial…
- Trial name
- LUXUS41 (NCT07498907)
- Testing
- Disitamab Vedotin (RC48), radiotherapy, Gemcitabine (1000 mg/m2)
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Peking University First Hospital
Alzheimer's Disease, Blood Biomarkers
Blood Biomarkers for Screening of Alzheimer's Disease
The goal of this observational study is to estimate the screen performance of blood biomarkers of interest (Aβ40 and Aβ42, P-Tau181, P-Tau217, GFAP and NfL) in patients with Alzheimer's disease (AD), mild cognitive impairment due…
- Trial name
- NCT06477484
- Testing
- Blood biomarker
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Risk Grading System, Pheochromocytoma and Paraganglioma (PPGL)
The IUPU-PPGL Score: A Imaging-Based Tool for Stratifying Surgical Complexity in Patients With Pheochromocytoma and Paragangliom（PPGL）
This study aimed to develop the imaging-based IUPU-PPGL score and evaluate its ability to stratify surgical complexity and its association with perioperative outcomes.
- Conditions
- Risk Grading System, Pheochromocytoma and Paraganglioma (PPGL), Quantitative Assessment
- Trial name
- NCT07412158
- Testing
- observational diagnostic model development
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking University First Hospital
Pancreatic Carcinoma
Effects of Aromatherapy With Essential Oils on Anxiety and Depression in Perioperative Patients With Pancreatic Cancer
The objective of this study is to investigate whether aromatherapy essential oils are effective in alleviating anxiety and depression in participants undergoing perioperative pancreatic cancer treatment.
- Trial name
- NCT06833658
- Testing
- Experimental: Aromatherapy with essential oil intervention, Control Group 0.9% Isotonic Saline
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Peking University First Hospital
Plasma Cell Disorders, Multiple Myeloma (MM)
GPRC5D Targeted PET/CT Imaging in Plasma Cell Disorders
This is a prospective, single-center, single-arm Phase I study evaluating GPRC5D-targeted PET/CT imaging in patients with plasma cell disorders, including multiple myeloma.
- Trial name
- NCT07660939
- Testing
- GPRC5D-Targeted PET/CT Imaging
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Neuroendocrine Tumors
Comparing DLL3 PET/CT to Standard Scans in Neuroendocrine Cancer
This study is testing a new PET/CT scan that uses a special tracer called [⁶⁸Ga]Ga-DLL3 nanobody to see if it can better detect cancer spread (metastases) in people with neuroendocrine tumors than the standard scans currently…
- Trial name
- DSC-NEC (NCT07733024)
- Testing
- 68Ga-PFD3
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Tingting Yuan
ST-elevation Myocardial Infarction (STEMI)
Drug-Coated Balloon Versus Drug-Eluting Stent in Patient With ST-Segment Elevation Myocardial Infarction
Acute ST-segment elevation myocardial infarction (STEMI) is a life-threatening emergency requiring immediate intervention. The incidence of premature coronary artery disease (PCAD) is rising rapidly in China; its long-term…
- Trial name
- DCB-STEMI (NCT06742125)
- Testing
- Drug-coated balloon (DCB), Drug-eluting stent (DES)
- Where
- China
- Volunteers
- 1,244 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
CKD, Renal Fibrosis
FAP-targeting PET/CT for Noninvasive Monitoring of Renal Fibrosis
Chronic kidney disease (CKD) is an irreversible change of kidney function and structure caused by many reasons. The main threat of CKD to human health is progressive renal function decline.
- Trial name
- NCT06563765
- Testing
- FAP-targeting PET/CT imaging will be performed on the enrolled patients.
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University First Hospital
Inflammatory Bowel Diseases
A Multi-Center Randomized Controlled Trial on the Impact of Disease Subtype-Based Active Video Education on Bowel Preparation Quality in Patients With Inflammatory Bowel Disease
This multi-center, prospective, randomized controlled trial evaluates whether disease subtype-based active video education improves bowel preparation quality in patients with inflammatory bowel disease (IBD) undergoing…
- Trial name
- NCT07582731
- Testing
- Disease Subtype-Based Active Video Education, standard bowel preparation education
- Where
- 12 sites in China
- Volunteers
- 600 people
- Sponsor
- Jie Liang
Spasticity Post Stroke
Spinal Cord Stimulation for Poststroke Spasticity
The goal of this clinical trial is to learn whether spinal cord stimulation (SCS) is effective in treating post-stroke spasticity in adults. It will also evaluate the safety of the implanted SCS system.
- Trial name
- SCS-PSS (NCT07744659)
- Testing
- Active spinal cord stimulation
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Pins Medical Co., Ltd
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