Clinical trials: sponsored by Ruijin Hospital
Rectal Neoplasms, Rectal Cancer, Adenocarcinoma
SCRT + Fruquintinib + Tislelizumab + CAPOX Versus SCRT + Tislelizumab + CAPOX as Neoadjuvant Therapy for Locally Advanced Low Rectal Cancer
The goal of this randomized controlled clinical trial is to learn if adding fruquintinib to short-course radiotherapy, tislelizumab, and CAPOX can improve neoadjuvant treatment response and is safe for adults with locally…
- Trial name
- TRIP-FAST (NCT07888309)
- Testing
- Short-Course Radiotherapy, Fruquintinib, Tislelizumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Esophageal Cancer
Modular Robot-Assisted Versus Conventional Minimally Invasive Esophagectomy for Esophageal Cancer
This study evaluates the safety, efficacy, and health economic outcomes of modular robotic-assisted minimally invasive esophagectomy (RAMIE) compared with conventional thoracoscopic minimally invasive esophagectomy (MIE) in…
- Trial name
- mRAMIE2026 (NCT07888140)
- Testing
- Modular Robot-Assisted Esophagectomy, Conventional Minimally Invasive Esophagectomy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Ruijin Hospital
Primary IgA Nephropathy
Efficacy and Safety of Obinutuzumab Beta in Primary IgA Nephropathy With Active Pathological Lesions
The goal of this clinical trial is to evaluate if obinutuzumab beta works to treat primary IgA nephropathy with active proliferative lesions in adults. It will also learn about the safety of obinutuzumab beta.
- Trial name
- NCT07888335
- Testing
- Obinutuzumab Beta
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Prostate Cancer
Integrated ¹⁸F-PSMA-1007 PET/MR Combined With Diffusion-Relaxation Correlation Spectrum Imaging for Preoperative Prediction of Postoperative Adverse Pathology and High ISUP Grade in Prostate Cancer
This retrospective observational study evaluates whether integrated ¹⁸F-PSMA-1007 PET/MR combined with diffusion-relaxation correlation spectrum imaging (DR-CSI) can help predict aggressive pathological features in patients with…
- Trial name
- PSMA-DRCSI (NCT07887555)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijin Hospital
Acute-On-Chronic Liver Failure
Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients
The goal of this clinical trial is to learn if CG-BM1 Allogeneic Human Bone Marrow Mesenchymal Stem Cell Injection (hereinafter referred to as CG-BM1) can treat acute-on-chronic liver failure (ACLF) patients.
- Trial name
- NCT06740149
- Testing
- Bone marrow mesenchymal stem cells (low dose), Solvent of CG-BM1, Bone marrow mesenchymal stem cells (medium dose)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- GuangZhou Cellgenes Biotechnology Co., Ltd.
Extensive-Stage Small Cell Lung Cancer
Real-World Use of Tarlatamab in Chinese Patients With Small-Cell Lung Cancer
This is an investigator-initiated, single-center, observational, noninterventional retrospective real-world cohort study evaluating the effectiveness and safety of tarlatamab as second-line or later-line therapy in Chinese adults…
- Trial name
- NCT07885332
- Testing
- Tarlatamab
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Ruijin Hospital
Malignant Pleural Mesothelioma, Advanced
Safety and Preliminary Antitumor Activity of Ivonescimab Plus Pemetrexed and Platinum-Based Chemotherapy in Advanced Malignant Pleural Mesothelioma
This Phase 1a, open-label, dose-escalation study evaluates the safety, tolerability, and preliminary antitumor activity of ivonescimab in combination with pemetrexed and platinum-based chemotherapy as first-line treatment for…
- Trial name
- NCT07885306
- Testing
- Ivonescimab Combined With Chemotherapy
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- Ruijin Hospital
HER2-mutant Advanced Non-Small Cell Lung Cancer
Real-World Outcomes of Sevabertinib in HER2-Mutant Advanced NSCLC: A Bidirectional Cohort Study
This is a single-center, observational, bidirectional cohort study evaluating the real-world effectiveness, safety, and quality of life associated with sevabertinib in Chinese adults with HER2-mutant advanced non-small cell lung…
- Trial name
- NCT07880353
- Testing
- Sevabertinib
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Ruijin Hospital
Still's Disease, Adult-Onset
A Study of Firsekibart Versus Anakinra in Adult-Onset Still's Disease
The purpose of this study is to compare the efficacy and safety of firsekibart versus anakinra in patients with AOSD.
- Trial name
- NCT07191444
- Testing
- Firsekibart, Anakinra
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Sleep Apnea, Obstructive
Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea
The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between…
- Trial name
- NCT04712656
- Testing
- CPAP therapy
- Where
- United States
- Volunteers
- 1,739 people
- Sponsor
- Ohio State University
Rectal Neoplasms Malignant, Surgery
Transanal Versus Laparoscopic Total Mesorectal Excision For Rectal Cancer
Laparoscopic surgery for rectal cancer has been successfully proven to be a non-inferior alternative regarding resection quality, and oncological outcomes of patients as compared to open surgery in mangy clinical trails.
- Trial name
- NCT02966483
- Testing
- TaTME, LpTME
- Where
- 16 sites in China
- Volunteers
- 1,115 people
- Sponsor
- Sun Yat-sen University
Hypertension, Resistant Hypertension
The Effect of Ablation Duration of Renal Denervation on Antihypertensive Efficacy
This is a prospective, multicenter, randomized controlled study designed to evaluate the effect of renal denervation (RDN) ablation duration on blood pressure reduction in patients with hypertension.
- Trial name
- RDN-DA (NCT07876479)
- Testing
- Renal Denervation Using a Multielectrode Radiofrequency Ablation Catheter (RDN016)
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Ruijin Hospital
Gastric Adenocarcinoma
Neoadjuvant Iparomlimab and Tuvonralimab With Nab-P-SOX in Locally Advanced Gastric or Gastroesophageal Junction Cancer
This is a single-center, single-arm, phase 2 clinical study testing a new neoadjuvant (pre-surgery) treatment for patients with locally advanced gastric cancer or gastroesophageal junction (GEJ) cancer.
- Trial name
- NCT07867392
- Testing
- Iparomlimab and Tuvonralimab (QL1706), nab-P-SOX（nab-paclitaxel, oxaliplatin, S-1）
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Ruijin Hospital
Locally Advanced Pancreatic Carcinoma (LAPC)
Surgery Versus Stereotactic Ablative Radiotherapy for Patients With Locally Advanced Pancreatic Cancer With Favourable Biological Response Following Induction Chemotherapy
The primary objective of this study is to assess the added value of surgical exploration with intention for resection compared to MRI guided stereotactic ablative radiotherapy (SABR) in improving overall survival in patients with…
- Trial name
- PREOPANC-4 RCT (NCT07867873)
- Testing
- Pancreatic surgery, MRI guided stereotactic ablative radiotherapy
- Volunteers
- 230 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Respiratory Failure, Electrical Impedance Tomography (EIT)
Predicting High-Flow Nasal Oxygen Failure Within 72 Hours Using a Physiology-Informed Dual-Domain Model at 30 Minutes
This is a single-center, ambispective observational cohort study of adults with acute hypoxemic respiratory failure (AHRF) receiving high-flow nasal oxygen (HFNO) as initial respiratory support. The study includes three stages.
- Conditions
- Acute Respiratory Failure, Electrical Impedance Tomography (EIT), High-Flow Nasal Oxygen Therapy
- Trial name
- EFI-HFNO (NCT07366541)
- Testing
- High-Flow Nasal Oxygen Therapy, Electrical Impedance Tomography Monitoring
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Ruijin Hospital
Type 1 AIP
Inebilizumab for the Treatment of Patients With Type 1 Autoimmune Pancreatitis
Autoimmune pancreatitis (AIP) is an immune-related inflammatory disease of the pancreas. Relapse can occur after treatment, and long-term treatment with glucocorticoids and conventional immunosuppressants can cause significant…
- Trial name
- NCT07862075
- Testing
- Inebilizumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Type 1 AIP
A Trial on the Remission Rates of Type I Autoimmune Pancreatits With High-risk of Recurrence
Autoimmune pancreatitis (AIP) is an autoimmune disease with low incidence rate and involving the pancreas. In China, type I AIP is predominant. Glucocorticoids (GC) have a significant therapeutic effect.
- Trial name
- AIP；MMF (NCT06468709)
- Testing
- Glucocorticoids, Glucocorticoids+MMF
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Ruijin Hospital
B-cell Acute Lymphoblastic Leukemia
Dual-Targeted Umbilical Cord Blood CAR-T Cells Against CD19 and CD22 for the Treatment of Relapsed or Refractory Acute B-Cell Lymphoblastic Leukemia
This investigator-initiated, prospective, single-arm, phase I dose-escalation trial aims to evaluate the safety and tolerability of anti-CD19/CD22 dual-target cord blood-derived CAR-T cells in adult patients with…
- Trial name
- NCT07838714
- Testing
- Anti-CD19/CD22 Dual-Target Cord Blood CAR-T Cells, Fludarabine, Cyclophosphamide
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Ruijin Hospital
Breast Cancer
12 weekS Adjuvant dOcetaxel Plus trastuzumaB in Patients With Small, Node-negative, HER2-positive Breast cancER (SOBER)
This phase II trial aims to study the efficacy and safety of 12 weeks adjuvant docetaxel plus trastuzumab in patients with tumors ≤1cm, node-negative, HER2-positive breast cancer.
- Trial name
- SOBER (NCT03367676)
- Testing
- Trastuzumab, Docetaxel
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Ruijin Hospital
Chronic Pancreatitis, Complication
The Natural History of Chronic Pancreatitis
Chronic pancreatitis (CP) is a disease characterized by inflammation and their replacement by fibrotic tissue. The destruction of pancreatic function and structure are the main complications.
- Conditions
- Chronic Pancreatitis, Complication, Risk Factors
- Trial name
- NCT03324698
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Changhai Hospital