Clinical trials: sponsored by Umeå University
End-stage Heart Failure
Swedish Evaluation of Left Ventricular Assist Device as Permanent Treatment in End-stage Heart Failure
The study is a prospective, randomized, non-blinded, national, multi-center study. The study will consist of the assignment of eligible patients to treatment with either a HeartMate III (HM III) left ventricular assist device…
- Trial name
- SweVAD (NCT02592499)
- Testing
- HM III, OMM, optimal medical management
- Where
- 7 sites in Sweden
- Volunteers
- 74 people
- Sponsor
- Vastra Gotaland Region
Ventilator Acquired Pneumonia, Mechanical Ventilation Complication
ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units.
- Trial name
- ClusterVAP (NCT07245888)
- Where
- 4 sites in France, Portugal and 1 more
- Volunteers
- 400 people
- Sponsor
- Region Skane
Cardiovascular Diseases
Visualization of Asymptomatic Atherosclerotic Disease for Optimum Cardiovascular Prevention
The purpose of VIPVIZA is to assess the impact of pictorial information about asymptomatic atherosclerotic disease to both physician and patient, for improving physicians' adherence to prevention guidelines and patient perception…
- Trial name
- VIPVIZA (NCT01849575)
- Testing
- Intervention
- Where
- Sweden
- Volunteers
- 3,532 people, healthy volunteers welcome
- Sponsor
- Umeå University
Malnutrition
Nutritional Status in Patients With Chronic Kidney Disease
The goal of this observational study is to investigate how the GLIM criteria* for the diagnosis of malnutrition should be operationalized in patients with chronic kidney disease (CKD) treated with hemodialysis.
- Trial name
- NCT06580093
- Where
- Sweden
- Volunteers
- 69 people
- Sponsor
- Umeå University
ADHD - Attention Deficit Disorder With Hyperactivity
Evaluation of the Relationship Between Medication, Eye Movements, and Autonomic Nervous System (ANS) Functions in Children and Adolescents With ADHD
An increasing number of children are being diagnosed with ADHD, and the demand for ADHD medication has been rising. Although ADHD medication is often effective, this is unfortunately not the case for all children and adolescents…
- Trial name
- POP-Eye/ANSA (NCT07634809)
- Testing
- metylphenidate
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Umeå University
Spinal Cord Injuries, Chronic Pain
Development of a Pain Rehabilitation Program for Chronic Pain After SCI
Pain rehabilitation programs are essential for optimal treatment of chronic pain and are usually based on the biopsychosocial model.
- Conditions
- Spinal Cord Injuries, Chronic Pain, Neuropathic Pain, Interprofessional Team Collaboration
- Trial name
- NCT07634796
- Testing
- multi-modality pain management
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Umeå University
Bladder Cancer (BC)
Local Radiotherapy for Urinary Bladder Cancer in Patients Not Eligible for Curative Treatment
The goal of this clinical trial is to improve the quality of life and prolong survival in bladder cancer patients unfit for curative treatment.
- Trial name
- LORUP (NCT07524426)
- Testing
- Local hypo fractionated adaptive radiotherapy and Standard of Care, Standard of Care (Investigator Choice)
- Where
- Sweden
- Volunteers
- 248 people
- Sponsor
- Umeå University
Heart Failure, Diastolic Heart Failure
Heart Failure and Postoperative Outcome in Surgery - a National Registry Study
The study is an exploratory study that aims to explore the incidence of heart failure in a national surgical cohort, and to compare postoperative mortality and morbidity in patients with and without heart failure.
- Conditions
- Heart Failure, Diastolic Heart Failure, Systolic Heart Failure
- Trial name
- NCT07634822
- Where
- 2 sites in Sweden
- Volunteers
- 2,200,000 people
- Sponsor
- Umeå University
Paraphilic Disorders, Sexual Addiction
Paraphilic Disorders and Other Conditions With Risk for Sexual Violence: a Case-control Study
The goal of this case-control study is to compare clinical characteristics in help-seeking individuals with paraphilic disorders or sexsomnia (sexual behaviors during sleep- a diagnosis in the American Psychiatric Association's…
- Conditions
- Paraphilic Disorders, Sexual Addiction, Parasomnia
- Trial name
- NCT05861752
- Testing
- Treatment as usual
- Where
- Sweden
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Healthy Lifestyle
STAR-C Digital Coaching Intervention
Objectives: The overall objective is to evaluate the effectiveness of the STAR-C digital coaching intervention for health-related lifestyle behavioural change.
- Trial name
- STAR-C (NCT05864001)
- Testing
- STAR-C mobile app
- Where
- Sweden
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Umeå University
Functional Gastrointestinal Disorder
Long Term Follow up on Functional Gastrointestinal Disorder (FGID)
Long term prognosis and risk factors in functional gastrointestinal disorder (FGID) is largely unknown. The investigators plan to retrospectively analyse a cohort of children who were referred to the Pediatric Clinic due to…
- Trial name
- LUFT (NCT02689648)
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Umeå University
Vegan Diet
Vegan Diet in Small Children
Following increased knowledge about climate change and how food production affects greenhouse gas emissions, the interest in vegetarian diets is increasing.
- Trial name
- VHS (NCT05442281)
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Umeå University
Health of Formula-fed Children, Infant Infections in Formula-fed Children
Effect of Infant Formula With Bovine Lactoferrin and Low Iron Concentration on Infant Health and Immune Function
Breast milk is the gold standard of early infant nutrition and breastfed infants have advantages in several short and long term outcomes compared to those formula-fed.
- Conditions
- Health of Formula-fed Children, Infant Infections in Formula-fed Children, Iron Status of Formula-fed Children
- Trial name
- LIME (NCT02103205)
- Testing
- Formula with low iron concentration (2 mg/L) supplemented with bovine lactoferrin, Formula with low iron concentration (2mg/L) without lactoferrin, Formula with normal iron concentration (8 mg/L) without lactoferrin
- Where
- Sweden
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Umeå University
Diabetes Mellitus, Type 2
Reduced Occupational Sitting in Type 2 Diabetes Using mHealth (Mobile Health)
Type 2 diabetes mellitus (T2DM) patients are suboptimal treated due to low uptake of physical activity. Recent research shows promising beneficial health effects from reducing sitting time by regular short bouts of…
- Trial name
- ROSEBUD (NCT04219800)
- Testing
- Patient-centered counselling and written material, mHealth
- Where
- 6 sites in Sweden
- Volunteers
- 46 people
- Sponsor
- Umeå University
Infraposition, Estethics
Risk Factors Associated With Infraposition of Implant Supported Single Crowns in the Anterior Maxilla
Losing a tooth in the front part of the upper jaw can affect both appearance and the ability to bite and chew. Treatment to replace missing teeth is therefore often required.
- Trial name
- NCT07593131
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Region Västerbotten
PARKINSON DISEASE (Disorder), Physical Activity
Physical Activity in Persons With Parkinson's Disease
This project aims to identify why some people with Parkinson's disease (PwPD) become less physically active, and which factors support or hinder activity.
- Conditions
- PARKINSON DISEASE (Disorder), Physical Activity, Sedentary Behaviors
- Trial name
- ActivPARK (NCT07585409)
- Where
- Sweden
- Volunteers
- 450 people
- Sponsor
- Karolinska Institutet
Nicotine, Mental Health
The SCAPIS-Snus Study
Historically, snus use in Sweden was very stable, primarily used by about 20% of men and only 4-5% of women. However, the recent introduction of "white snus" (nicotine pouches) has dramatically changed this landscape.
- Conditions
- Nicotine, Mental Health, Cardiovascular (CV) Risk, Metabolic Abnormalities
- Trial name
- SUCCESS (NCT07573319)
- Where
- 5 sites in Sweden
- Volunteers
- 30,154 people
- Sponsor
- Karolinska Institutet
Metabolic Syndrome
Impacts of Fermented Pea- and Legume-based Product on Gut Microbiota and Health
This study aims to investigate the effects of consuming fermented pea- and legume-based product on gut and overall human health. It is a randomized, single-blinded, controlled, cross-over trial with a dietary intervention.
- Trial name
- HealthFerm (NCT06743828)
- Testing
- Fermented meat alternative, Unfermented meat alternative
- Where
- Finland
- Volunteers
- 56 people
- Sponsor
- University of Eastern Finland
Rectal Cancer
Defunctioning Left-sided Colostomy in Low Anterior Resection for Rectal Cancer
This is prospective, multi centre study evaluating a novel type of defunctioning loop stoma after low anterior resection for rectal cancer.
- Trial name
- STOMALEFT (NCT06149741)
- Testing
- Defunctioning left-sided loop colostomy
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Umeå University
Dysphagia, Stroke
Dysphagia Evaluation After Stroke- Effect Oral Neuromuscular Training on Swallowing Dysfunction
The aim of this study is to investigate the effect of a specific rehabilitation program with an oral device used in stroke patients with persistent oral-and pharyngeal dysphagia.
- Trial name
- DESIRE (NCT02960737)
- Testing
- Oral neuromuscular training using an oral device
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University