Clinical trials: sponsored by University Hospital Heidelberg
Rare Cancer
Treatment Guided by Comprehensive Genome and Transcriptome Analysis Versus Standard of Care in Advanced Rare Cancers
Rare cancers, defined by an incidence of fewer than 6 cases per 100,000 persons per year, constitute nearly 25% of adult malignancies.
- Trial name
- RATIONALE (NCT06855134)
- Where
- 16 sites in Germany
- Volunteers
- 946 people
- Sponsor
- German Cancer Research Center
Systemic Lupus Erythematosus
LUPUS-BEST - Treat-to-target in Systemic Lupus Erythematosus
Multicenter, national, two-armed cluster-randomized controlled trial to evaluate the effect of a treat-to-target (T2T) strategy in in systemic lupus erythematosus (SLE).
- Trial name
- Lupus-Best (NCT05714930)
- Testing
- Treat-to-target as a new treatment concept
- Where
- 14 sites in Germany
- Volunteers
- 606 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Osteoarthritis, Arthroplasty
Heidelberg Registry for Hip and Knee Joint Implants and Revisions
The Endoprosthesis Registry Heidelberg (EPR-HD) is a clinical registry designed to systematically collect and analyze data from patients undergoing primary implantation or revision surgery of artificial hip and knee joints.
- Trial name
- EPR-HD (NCT06850818)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital Heidelberg
Borderline Personality Disorder (BPD)
The Role of Gender in Borderline Personality Disorder
This study is a mixed-methods, single-arm cross-sectional study comprising 1) a qualitative, exploratory, critical-constructivist content analysis examining the significance of gender in relationship experiences and…
- Trial name
- BPD-G (NCT07639957)
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital Heidelberg
High Altitude
HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men
Randomized clinical trial evaluating the effect of acetazolamide on pulmonary artery pressure in women compared to men travelling to 3600 m.
- Trial name
- NCT06498505
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sleep-Disordered Breathing
HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men
Randomized clinical trial evaluating the effect of acetazolamide on sleep disordered breathing in women compared to men travelling to 3600 m.
- Trial name
- NCT06498531
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sleep-Disordered Breathing
HighCycle Study: Effect of High Altitude on Sleep Disordered Breathing in Women Related to Their Menstrual Cycle Phase
Prospective cohort study investigating the menstrual cycle phase (MCP) dependent sleep disordered breathing (SDB) in women travelling to 3600 m.
- Trial name
- NCT06498544
- Testing
- Exposure to 3600 m
- Where
- Kyrgyzstan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Mountain Sickness
HighCycle Study: Effect of High Altitude on Acute Mountain Sickness in Women Related to Their Menstrual Cycle Phase
Prospective cohort study investigating the menstrual cycle phase (MCP)-dependent incidence of acute mountain sickness (AMS) in women travelling to 3600 m.
- Trial name
- NCT06499714
- Testing
- Exposure to 3600 m
- Where
- Kyrgyzstan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cancer, Cancer in Pregnancy
ProspectiveFemaleAYA - Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, the evidence-based knowledge on the prevalence and risk factors for gonads impairment, including infertility, following cancer and numerous cancer treatment regimen has significantly increased.
- Conditions
- Cancer, Cancer in Pregnancy, Infertility, In Vitro Fertilisation (IVF) Treatment
- Trial name
- FemFertilAYA (NCT07622420)
- Volunteers
- 3,000 people
- Sponsor
- Karolinska Institutet
Cancer, Reproduction
ProspectiveMaleAYA - Frequency and Prediction of Therapy-induced Testicular Dysfunction in AYA Cancer Survivors
This study describes the ProspectiveMaleAYA cohort, a multicentre, prospective, longitudinal European study designed to investigate the long-term impact of cancer and cancer treatments on reproductive and endocrine health in…
- Conditions
- Cancer, Reproduction, Infertility, Late Effects
- Trial name
- FertiTestAYA (NCT07612943)
- Volunteers
- 1,000 people
- Sponsor
- Karolinska Institutet
Glioblastoma
Glioblastoma Radiotherapy Using IMRT or Proton Beams
Radiation therapy is an integral part of the multimodal primary therapy of glioblastomas. As the overall prognosis in this tumor entity remains unfavorable, current research is focused on additional drug therapies, which are…
- Trial name
- GRIPS (NCT04752280)
- Testing
- Proton irradiation, Photon irradiation
- Where
- 3 sites in Germany
- Volunteers
- 326 people
- Sponsor
- University Hospital Heidelberg
Brain Metastases, Radiotherapy
Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases
Patients suffering from malignancies in advanced stages often develop brain metastases, which limit both the life span and the quality of life.
- Trial name
- Radcav (NCT05871307)
- Testing
- Preoperative Radiotherapy, Intraoperative Radiation, Postoperative Radiotherapy
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Heidelberg
Glycogen Storage Disease Type I
Dietary Treatment Strategies and Metabolic Control in Glycogen Storage Disease Type I
The present project will specifically assess metabolic effects of dietary interventions with controlled intake of fructose and fructose/galactose in GSDI, with the aim to provide evidence whether relaxed dietary restrictions of…
- Trial name
- GSD-DIET (NCT06852612)
- Testing
- Fructose, Fructose and galactose
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Metastatic Breast Cancer
Effects of Exercise in Patients With Metastatic Breast Cancer
Currently, the effect of exercise on metastatic breast cancer has not been extensively studied, even though the benefits are evident in the curative setting.
- Trial name
- EFFECT (NCT04120298)
- Testing
- Supervised exercise
- Where
- Netherlands
- Volunteers
- 357 people
- Sponsor
- UMC Utrecht
Tuberculosis
Rapid Research in Diagnostics Development for TB Network
To reduce the burden of TB worldwide through more accurate, faster, simpler, and less expensive diagnosis of TB Every year, more than 3 million people with TB remain undiagnosed and 1 million die.
- Trial name
- R2D2TB Network (NCT04923958)
- Testing
- Novel mycobacterial culture techniques, Novel sputum smear microscopy techniques, Sputum-based molecular assays
- Where
- 16 sites in Georgia, India and 6 more
- Volunteers
- 26,436 people
- Sponsor
- University of California, San Francisco
Odontoid Fracture, Elderly
SCORE Study: Comparing Surgery and Rigid Collar Treatment for Odontoid Fractures in Adults Over 70
The goal of this clinical trial is to compare two treatment options-surgery or rigid collar bracing-for unstable neck fractures (odontoid fractures) in adults aged 70 years and older.
- Trial name
- NCT06961578
- Testing
- C1-2 instrumentation, External immobilization with rigid cervical collar
- Where
- 16 sites in Germany
- Volunteers
- 322 people
- Sponsor
- Technical University of Munich
Breast Cancer
Intraoperative Electron Radiotherapy for Low-risk Early Breast Cancer
Breast cancer is the most frequent malignancy in women. Standard therapy for early-stage breast cancer is breast conserving surgery (BCS) followed by adjuvant whole breast irradiation (WBI), which usually requires a treatment…
- Trial name
- COSMOPOLITAN (NCT03838419)
- Testing
- intraoperative radiotherapy, whole breast irradiation
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- University Hospital Heidelberg
Brain Metastases
Supportive Care With or Without Repeated Whole Brain Radiotherapy in Patients With Recurrent Brain Metastases
Patients with solid cancers may develop cerebral metastases, requiring whole brain radiotherapy (WBRT). Furthermore, in several cases, a secondary course of WBRT might be required due to intracerebral recurrence and limited…
- Trial name
- RECARE (NCT04084431)
- Testing
- Radiation, OSC
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Acute Hypoxemic Respiratory Failure
Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia
Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia.
- Trial name
- PROSA (NCT06931938)
- Testing
- Awake Prone Positioning
- Where
- Germany
- Volunteers
- 342 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Takotsubo Cardiomyopathy
Cyclosporine In Takotsubo Syndrome
The goal of this clinical trial is to investigate the impact of repetitive acute Cyclosporine A (CsA) bolus therapy in patients suffering from TTS with an elevated risk of impaired outcome.
- Trial name
- CIT (NCT05946772)
- Testing
- Cyclosporine A
- Where
- 24 sites in Germany
- Volunteers
- 204 people
- Sponsor
- University Hospital Heidelberg