Clinical trials: sponsored by University of Bern
Stent Thrombosis
Flow Patterns and Stent Thrombosis
The goal of this observational study is to study the effect of haemodynamic forces on thrombus formation and identify haemodynamic markers that predict stent thrombosis events in patients who have undergone OCT-guided…
- Trial name
- TISIS registry (NCT06700018)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Queen Mary University of London
Atrial Fibrillation (AF), Cardiomyopathy, Secondary
Patient Selection and Long-Term Outcomes of Pace & Ablate Strategy in Atrial Fibrillation
Atrioventricular node ablation with permanent pacing (the "pace-and-ablate" strategy) controls ventricular rate in atrial fibrillation that has not responded to drug therapy or catheter ablation.
- Conditions
- Atrial Fibrillation (AF), Cardiomyopathy, Secondary, Pacing-Induced Cardiomyopathy, Heart Failure
- Trial name
- REPACE (NCT07852221)
- Where
- 5 sites in Poland, Switzerland and 1 more
- Volunteers
- 2,600 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hyperthermia, Chronic Primary Pain
Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain
This study, in a quasi-experimental matched two-group pre-post design, investigates the effect of serial water-filtered whole-body hyperthermia on circadian core body temperature, the somatosensory system (nociception) and the…
- Conditions
- Hyperthermia, Chronic Primary Pain, Widespread Pain, Muscular Disease
- Trial name
- HYPPRI-1 (NCT07101978)
- Testing
- serial whole body hyperthermia
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Obesity (BMI>30), Immune Abnormalities
NutrImmune: Precision Nutrition to Improve Immunity in Individuals With Obesity
Obesity is a complex health condition defined by the World Health Organization (WHO) as an excess of body weight that may be harmful to health.
- Conditions
- Obesity (BMI>30), Immune Abnormalities, Low-grade Inflammation
- Trial name
- NutrImmune (NCT07850206)
- Testing
- Mixed test meal, Biological sampling, Questionnaires
- Where
- 4 sites in France, Germany and 1 more
- Volunteers
- 168 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Acute Kidney Injury
Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery
This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery.
- Trial name
- POAKIDS (NCT07351149)
- Where
- 16 sites in Australia, Brazil and 8 more
- Volunteers
- 2,000 people
- Sponsor
- Uppsala University
Contrast Enhanced Ultrasound, Ultrasonic Diagnosis
International Delphi Study to Develop Standardized Quality Criteria and a Rating Tool for Liver CEUS Image Quality Assessment
This study aims to establish international consensus-based quality criteria for contrast-enhanced ultrasound (CEUS) examinations of the liver and to develop a standardized tool for assessing CEUS image and examination quality.
- Conditions
- Contrast Enhanced Ultrasound, Ultrasonic Diagnosis, Liver
- Trial name
- ICON LiverCEUS (NCT07656181)
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Bern
Myopathy, Muscle Weakness
Reliability of Cardiac Troponins for the Diagnosis of Myocardial Infarction in the Presence of Skeletal Muscle Disease
Visits to the emergency department (ED) for chest pain are extremely common and require a safe, rapid and efficacious treatment algorithm to exclude a possible AMI.
- Conditions
- Myopathy, Muscle Weakness, Muscle Damage, Muscle Spasticity
- Trial name
- H&M (NCT03660969)
- Where
- 5 sites in Austria, Switzerland
- Volunteers
- 797 people
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes Mellitus, Type 1, Energy Metabolism
Menstrual Cycle Mapping While Using Closed-Loop Insulin Delivery
The hypothesis is that menstrual cyclicity affects glucose and energy metabolism in women with type 1 diabetes. The rationale of the hypothesis on cycle effects builds on the assumption that fluctuations of female sex hormones…
- Trial name
- MCM-Loop (NCT07478211)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Lia Bally
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Stibium Metallicum Praeparatum D6 Versus Placebo in the Reduction of Paclitaxel-induced Peripheral Neurotoxicity
Chemotherapy induced peripheral neuropathy (CIPN) is one of the most limiting side effects of chemotherapy and often leads to adaptations in the protocol of the chemotherapy including dose reduction or even discontinuation of…
- Trial name
- STING-CIPN (NCT04715542)
- Testing
- Stibium metallicum praeparatum 6x
- Volunteers
- 86 people
- Sponsor
- University of Bern
Neuroendocrine Tumors, Carcinoid Tumor
SwissNET - a Registry for Neuroendocrine Tumours in Switzerland
Gastroentero-pancreatic neuroendocrine tumours (GEP-NETs) are regarded as a fairly rare disease. They are derived from the neuroendocrine system of the gastrointestinal tract and the pancreas and share common clinical features.
- Trial name
- SwissNET (NCT01039922)
- Where
- 55 sites in Switzerland
- Volunteers
- 1,245 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Interstitial Lung Disease, Fibrotic Lung Disease
Self-efficacy and Well-being of Patients With Fibrotic Interstitial Lung Disease
Patients with fibrotic insterstitial lung disease (ILD) participating in inpatient rehabilitation or in outpatient pulmonary care will be invited to participate in this observational study.
- Conditions
- Interstitial Lung Disease, Fibrotic Lung Disease, Self Efficacy, Self-management
- Trial name
- NCT06027333
- Testing
- Inpatient rehabilitation (BRZ) or regular outpatient consultations (Insel), Blended patient education and self-management programme (PESM)
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- Berner Reha Zentrum AG
Communication Research, Communication, Multidisciplinary
STOP? II: Testing of a Toolbox for Structured Communication in the Operating Room
The purpose of the study is to test the impact of the StOP?-protocol - an intra-operative communication briefing, on post-operative mortality and important patient outcomes.
- Trial name
- StOP? (NCT05356962)
- Testing
- StOP?-protocol
- Where
- 13 sites in Austria, Switzerland
- Volunteers
- 400 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Depressive Disorder, Major Depressive Disorder, Healthy Volunteer
Exploring the Role of the Prefrontal Cortex in Decision-Making
The goal of this study is to examine whether high-definition transcranial direct current stimulation (HD-tDCS) can influence decision-making for emotionally valenced content in younger and older adults, with or without major…
- Conditions
- Depressive Disorder, Major Depressive Disorder, Healthy Volunteer, Aging
- Trial name
- NCT07080489
- Testing
- Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/F4, Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/ kathodal F4
- Where
- Switzerland
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- University of Bern
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Compartmentalized Postoperative Radiotherapy in Head and Neck Cancer
COMPORT is a multicenter phase II clinical trial evaluating a personalized approach to postoperative radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC).
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
- Trial name
- COMPORT (NCT07058805)
- Testing
- Compartmentalized Postoperative Radiotherapy
- Where
- 3 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- Olgun Elicin
Fear of Falling
Feasibility of Aktiv Gegen Sturzangst (AGES) in Assisted Living Facilities
Aktiv Gegen Sturzangst (AGES) is a multicomponent group intervention combining cognitive behavioral therapy and structured exercise to address fear of falling in older adults receiving services from assisted living facilities.
- Trial name
- AGES (NCT07787819)
- Testing
- Multicomponent fear of falling intervention
- Where
- 3 sites in Switzerland
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Eric Lenouvel
Difficult Airway, Difficult Airway Intubation
SEALion: Study on Supplemental Oxygenation Via Nasal Cannula for Young Children During Intubation
Tracheal intubation in neonates can be technically challenging, even for experienced pediatric anesthesiologists, with a high first-attempt success rate crucial to ensure safety.
- Conditions
- Difficult Airway, Difficult Airway Intubation, Neonate
- Trial name
- SEALION (NCT06683599)
- Testing
- Apneic oxygenation
- Where
- 4 sites in Australia, Brazil and 2 more
- Volunteers
- 240 people
- Sponsor
- Vinícius C Quintão, MD, MSc, PhD
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Overweight or Obesity, Chronic Low-back Pain
Lifestyle Intervention in Overweight/Obese Chronic Low Back Pain (CLBP) Patients: an International Multi-center RCT
Chronic low back pain (CLBP) is the most expensive cause of workrelated disability: it causes the highest number of years lived with disability.
- Trial name
- BO2WL (NCT05811624)
- Testing
- Physiotherapy intervention, including behavioral weight reduction program combined with pain neuroscience education and cognition-targeted exercise therapy., Physiotherapy intervention, including pain neuroscience education and cognition-targeted exercise therapy alone.
- Where
- 2 sites in Belgium, Switzerland
- Volunteers
- 252 people
- Sponsor
- Vrije Universiteit Brussel
Statin Treatment for Primary Prevention
STREAM Trial - Statins in Multimorbid Older Adults Without Cardiovascular Disease
Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older…
- Trial name
- STREAM (NCT05178420)
- Testing
- Statin discontinuation
- Where
- 24 sites in France, Netherlands and 1 more
- Volunteers
- 1,880 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Childhood Cancer
Underweight, Overweight, and Linear Growth of Childhood Cancer Patients - the Growth Study
The Growth study investigates nutritional status, BMI, and linear growth trajectories from birth to adulthood in childhood cancer patients and survivors.
- Trial name
- Growth (NCT07750444)
- Where
- 11 sites in Switzerland
- Volunteers
- 12,150 people
- Sponsor
- Fabiën Belle