Clinical trials: sponsored by University of Rochester
Depression, Insomnia
Digital CBT for Insomnia and Depression
This study has two primary objectives, each of which addresses critical clinical and research gaps for individuals who have co-occurring insomnia and depression.
- Trial name
- NCT05456607
- Testing
- Cognitive Behavioral Therapy for Insomnia, Cognitive Behavioral Therapy for Depression, Mood Monitoring
- Where
- United States
- Volunteers
- 1,175 people
- Sponsor
- University of Rochester
DLBCL
A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma
The overarching goals of this study are to measure levels of circulating tumor DNA (ctDNA) in patients with early stage diffuse large B cell lymphoma (DLBCL), to assess the change in ctDNA during treatment in order to…
- Trial name
- NCT03758989
- Testing
- Rituximab Prednisone, Cyclophosphamide, Doxorubicin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Vestibular Disease
Human Visual and Vestibular Motion Perception Study
The purpose this study is to measure sensitivity to visual and vestibular or balance motion. It is hoped that the results may help researchers better understand how aging and disease affect motion perception.
- Trial name
- NCT04142697
- Testing
- Heading direction adaptation
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Asthma in Children
SBAT for Health Equity
The goal of this research trial is to: 1) Solidify a population health SBAT implementation strategy with our longstanding community collaborators, 2) Perform a district-wide hybrid type 3, stepped-wedge, cluster randomized trial…
- Trial name
- NCT05744869
- Testing
- SBAT Implementation, Usual Care
- Volunteers
- 300 people
- Sponsor
- University of Rochester
Huntington Disease
Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease
The objective of the study is to validate the use of wearable sensors and digital health technologies for monitoring disease activity in Huntington's Disease (HD).
- Trial name
- BioDigit HD-02 (NCT07315984)
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- BioSensics
Atrial Fibrillation
Renal Denervation + PVI vs PVI Alone for Persistent AF
Pulmonary vein isolation (PVI) is the cornerstone of ablation for atrial fibrillation (AF). Increased cardiac sympathetic stimulation can facilitate AF and reduction can be accomplished by renal artery denervation (RDN).
- Trial name
- ERADICATE-AF (NCT05116384)
- Testing
- catheter ablation, renal artery denervation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Allergy and Immunology, Peanut and Nut Allergy
Expecting Mother's Study of Consumption or Avoidance of Peanut and Egg
Peanut allergy is the most common cause of fatal and near-fatal food-allergic reactions and egg allergy is among the two most common causes of food-induced anaphylaxis.
- Conditions
- Allergy and Immunology, Peanut and Nut Allergy, Egg Allergy, Food Allergy in Infants
- Trial name
- ESCAPE (NCT06260956)
- Testing
- Consumption, Avoidance
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Anemia, Iron Deficiency Anemia
Sucrosomial Vs Intravenous Iron for Preoperative Anemia
50 patients with anemia scheduled for heart surgery or procedures will be randomized to receive either oral sucrosomial iron or standard-of-care intravenous iron before surgery to see if the oral iron is as effective as…
- Trial name
- RSIVI (NCT07287371)
- Testing
- Treatment with oral sucrosomial iron, Treatment with intravenous iron
- Where
- United States
- Sponsor
- University of Rochester
Cardiotoxicity, Heart Failure
Novel On-body Evaluation of Cardiac Health for Oncology
The goal of this study is to develop a wearable sensor system that can estimate left ventricular ejection fraction (LVEF), which is a measurement of the heart's function.
- Trial name
- NOECHO (NCT07158450)
- Where
- 11 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Skribe Medical
Atrial Flutter Typical
Prophylactic Pulmonary Vein Isolation During Atrial Flutter Ablation
Pulmonary vein isolation (PVI) via catheter ablation has been successfully employed for years to treat symptomatic atrial fibrillation (AF).
- Trial name
- PREVENT-AF II (NCT07649603)
- Testing
- Catheter ablation
- Volunteers
- 620 people
- Sponsor
- University of Rochester
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors
This phase III trial studies how well bupropion works in reducing cancer related fatigue in cancer survivors. Cancer and its treatment can cause fatigue.
- Trial name
- NCT03996265
- Testing
- Biospecimen Collection, Bupropion Hydrochloride Controlled-release, Quality-of-Life Assessment
- Where
- 542 sites in United States
- Volunteers
- 422 people
- Sponsor
- University of Rochester NCORP Research Base
Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm
Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy
This phase II trial studies whether using exercise is better than the usual approach for treating chemotherapy-induced peripheral neuropathy (CIPN).
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- CIPN (NCT04888988)
- Testing
- Best Practice, Exercise Counseling, Exercise Intervention
- Where
- 93 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of Rochester NCORP Research Base
Intellectual and Developmental Differences, Dental Anxiety
Music Therapy to Improve Dental Procedure Tolerance and Reduce Distress in Adults With Intellectual and Developmental Differences
Adults with intellectual and developmental differences may experience behavioral distress, sensory sensitivity, and difficulty tolerating dental procedures.
- Trial name
- NCT07806201
- Testing
- Live Music Therapy, Recorded Music
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Cardiovascular Diseases
Re-thinking the Role of Peers And Training Patients [RePeAT]
This study, Re-thinking the role of Peers And Training Patients [RePeAT], is designed to test the feasibility of training peer-coaches to prepare limited health literacy (LHL) patients to engage in shared-decision making (SDM)…
- Trial name
- RePeAT (NCT05933655)
- Testing
- Peer Coach
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Rochester
Early Childhood Caries
Povidone Iodine Efficacy Study
This is a single center, randomized, double-blind, placebo-controlled Phase II clinical trial (RCT) to evaluate the efficacy of topical 10% Polyvinylpyrrolidone-Iodine (PVPI) to prevent new caries lesions when applied to the…
- Trial name
- PIES (NCT05272254)
- Testing
- 10% povidone iodine + FV
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Treatment Resistant Depression (TRD), Chronic Pain
Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression
The goal of this clinical trial is to understand the effect of ketamine on the brain in people with treatment-resistant depression (TRD).
- Trial name
- NCT07247006
- Testing
- Ketamine hydrochloride injection
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Rochester
End Stage Renal Disease, Chronic Kidney Diseases
Shared Decision Making in Dialysis
Older patients ≥65 years with chronic kidney disease (CKD) face challenges in decision making about dialysis. These patients report little effort by physicians to elicit treatment preferences, discuss prognoses, or explain the…
- Trial name
- DIAL-SDM (NCT04392440)
- Testing
- DIAL-SDM, usual care
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Rochester
Well-Being, Psychological
Health Protection and Promotion of Sign Language Interpreters Through Implementation of Total Worker Health®
Using mixed-methods and a clinical efficacy trial design, the overall objective of this study will employ implementation strategies to adapt and evaluate a previous integrated Total Worker Health® (TWH®) program and pilot test…
- Trial name
- NCT06058949
- Testing
- Health Protection and Promotion, General Health Program
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Rochester
DLBCL, Lymphoma, B-Cell
A Study of Polatuzumab Vedotin, Rituximab and Dose Attenuated CHP in Older Patients With DLBCL
The purpose of this study is to test the effectiveness and safety of polatuzumab vedotin in combination with R-miniCHP in patients 75 years and older with DLBCL.
- Trial name
- NCT04594798
- Testing
- Polatuzumab vedotin, Rituximab, Cyclophosphamide
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Rochester
Pulmonary Embolism
Home Rehabilitation After Acute Pulmonary Embolism
The purpose of this study is to evaluate whether a home rehabilitation program after hospitalization for acute pulmonary embolism (PE) improves clinical outcomes at 3 months compared to usual care.
- Trial name
- NCT05571189
- Testing
- Daily Activity Text, Control Text
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Rochester
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