Clinical trials: sponsored by Yonsei University
Intracranial Aneurysm
Endovascular Coiling Using Target Tetra® Coils for Small Intracranial Aneurysm
The goal of this study was to verify the safety and effectiveness of Target Tetra® Detachable Coil in the endovascular embolization treatment of small intracranial aneurysm (≤5mm).
- Trial name
- NCT06064435
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Breast Neoplasms
Pembrolizumab and Paclitaxel in Hypermutated Breast Cancer
Abbreviated Title: Pembrolizumab in hypermutated breast cancer Trial Phase: II Clinical Indication: Hormone receptor-positive metastatic breast cancer Trial Type: Interventional Type of control: None Route of administration…
- Trial name
- NCT03492918
- Testing
- Pembrolizumab, paclitaxel
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Yonsei University
Lumbar Spinal Stenosis With Bilateral Lower Extremity Radiculopathy
Effect of Skin Stretching on Pain Reduction During Local Anesthetic Injections: A Randomized Clinical Study
The purpose of this study is to investigate the potential analgesic effect of skin stretching during local anesthetic injection in patients with chronic lumbar pain and bilateral lower extremity radiculopathy undergoing selective…
- Trial name
- NCT06976580
- Testing
- conventional local anesthetic injection, skin stetching technique for local anesthetic injection
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Efficacy and Safety of the Angionix Balloon in Patients With Coronary Artery Disease Undergoing PTCA
A Multi-center, Registry evaluating the efficacy and safety of the use of Angionix Balloon in Patient with Coronary Artery Disease
- Trial name
- Angionix (NCT07869602)
- Testing
- Angionix Balloon
- Where
- 3 sites in South Korea
- Volunteers
- 600 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Gangwon PCI Prospective Registry
This prospective, multicenter registry will consecutively enroll patients of all ages undergoing percutaneous coronary intervention (PCI) at four university hospitals in Gangwon Province, Republic of Korea.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Unstable Angina (UA), Non-ST Elevated Myocardial Infarction
- Trial name
- GWPCI (NCT02038127)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- 4 sites in South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Non-small Cell Lung Cancer
Lazertinib+Pemetrexed/Carboplatin in Patients With EGFR Sensitizing Mutation Positive Recurrent or Metastatic Non-Small Cell Lung Cancer Failed to Prior Lazertinib
This trial is Phase II Trial of Lazertinib+Pemetrexed/Carboplatin in Patients with EGFR Sensitizing Mutation Positive Recurrent or Metastatic Non-Small Cell Lung Cancer Failed to prior lazertinib.
- Trial name
- LUCAS (NCT05786430)
- Testing
- Lazertinib/Pemetrexed/Carboplatin
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Yonsei University
Stent Thrombosis
Flow Patterns and Stent Thrombosis
The goal of this observational study is to study the effect of haemodynamic forces on thrombus formation and identify haemodynamic markers that predict stent thrombosis events in patients who have undergone OCT-guided…
- Trial name
- TISIS registry (NCT06700018)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Queen Mary University of London
Colorectal Neoplasms, Sedentary Behavior
An Intervention to Reduce Sedentary Behavior and Promote Physical Activity in Colorectal Cancer Chemotherapy
This single-group feasibility study develops and evaluates an intervention designed to reduce sedentary behavior and promote physical activity in patients with colorectal cancer undergoing chemotherapy.
- Trial name
- NCT07845877
- Testing
- Sedentary behavior reduction intervention for patients with colorectal cancer undergoing chemotherapy
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Parathyroid Carcinoma
Lenvatinib in Patients With Advanced Parathyroid Carcinoma
This is a multicenter, open-label, single-arm, phase II study evaluating the efficacy and safety of lenvatinib in patients with unresectable, advanced or metastatic parathyroid carcinoma.
- Trial name
- ALPS (NCT07843901)
- Testing
- Lenvatinib
- Volunteers
- 18 people
- Sponsor
- Yonsei University
All Emergency Department Visits Meeting Eligibility Criteria
Prospective Evaluation of AI Generated History of Present Illness Drafts in the Emergency Department
This single-center prospective observational study evaluates whether an on-premise, large language model-based tool (EDnote) that generates a draft history of present illness (HPI) from real-time transcription of the…
- Trial name
- NCT07804407
- Testing
- EDnote HPI (AI-generated HPI draft), Conventional physician HPI
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Dyspnea
Prognostic Value of Pulse Oximetry Differences
This prospective observational study aims to evaluate whether the difference between finger, earlobe and forehead SpO₂ (ΔSpO₂) measured at emergency department (ED) presentation is associated with clinical outcomes in adult…
- Trial name
- NCT07824414
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Yonsei University
Unresectable or Metastatic Melanoma
Phase 1b/2 Clinical Trial to Evaluate the Safety and Efficacy of Combination Therapy With Pembrolizumab and Irinotecan in Patients With Metastatic or Recurrent Malignant Melanoma
This is a single-center, open-label, single-arm Phase 1b/2 clinical trial designed to evaluate the safety, tolerability, and preliminary efficacy of pembrolizumab in combination with irinotecan in patients with metastatic…
- Trial name
- NCT07817901
- Testing
- Pembrolizumab and Irinotecan
- Volunteers
- 46 people
- Sponsor
- Yonsei University
Severe Aortic Stenosis
Coronary Access After Evolut FX Plus TAVI: Impact of Commissural Alignment and the Large-Cell Frame Design: ACCESS-FX+ Registry
The ACCESS-FX+ Registry is a prospective, multicenter, single-arm study designed to evaluate the feasibility of coronary access after transcatheter aortic valve implantation (TAVI) using the Evolut FX Plus transcatheter heart…
- Trial name
- NCT07813273
- Volunteers
- 122 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Venous Closure System After AF Ablation
This prospective, randomized, participant-blinded study will compare a suture-based venous closure system (Perclose ProGlide™) with a conventional figure-of-8 suture for femoral venous access-site closure in patients undergoing…
- Trial name
- NCT07814144
- Testing
- Perclose ProGlide™, Figure-of-8 suture
- Where
- South Korea
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Parkinson Disease
Disease-modifying Efficacy of Sitagliptin Therapy in Early-stage Parkinson's Disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of α-synuclein (α-syn) aggregates.
- Trial name
- ARREST-PD (NCT07804381)
- Testing
- Sitagliptin
- Volunteers
- 160 people
- Sponsor
- Yonsei University
Bradycardia, Atrioventricular Block
Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal Capture
This is a prospective, multicenter, randomized controlled trial designed to determine whether direct capture of the left ventricular conduction system must be achieved as the procedural endpoint of left bundle branch area pacing…
- Conditions
- Bradycardia, Atrioventricular Block, Sick Sinus Syndrome, Cardiac Pacing
- Trial name
- COMPARE-SYNC (NCT07804394)
- Testing
- LBBAP with mandatory left ventricular conduction system capture (LBBP or LFP), LBBAP with left ventricular septal capture as the accepted procedural endpoint (LVSP)
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Appropriate Duration of Anti-Platelet and Thrombotic Strategy After 12 Months in Patients With Atrial Fibrillation Treated With Drug Eluting Stents
Atrial fibrillation patients with risk factors for stroke and systemic embolism require long-term anticoagulant therapy. Recently, non-vitamin K antagonist oral anticoagulant (NOAC) has shown their excellent safety and efficacy…
- Trial name
- NCT04250116
- Testing
- NOAC monotherapy, Dual antithrombotic therapy with NOAC and clopidogrel
- Where
- South Korea
- Volunteers
- 960 people
- Sponsor
- Yonsei University
Carcinoma, Small Cell Lung
Lurbinectedin Plus Paclitaxel Versus Paclitaxel in Patients With Previously Treated Small Cell Lung Cancer
This clinical trial is designed to compare and evaluate the efficacy and safety of the combination therapy of Lurbinectedin plus Paclitaxel (Combination Arm) versus Paclitaxel monotherapy (Monotherapy Arm) in patients with…
- Trial name
- LUPINE (NCT07640932)
- Testing
- Lurbinectedin, Paclitaxel
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Yonsei University
Carcinoma, Non-Small-Cell Lung
JIN-A02 Plus Amivantamab in EGFR-Mutant NSCLC After Third-Generation EGFR-TKI Failure
This Phase 1 study will evaluate the safety, maximum tolerated dose, recommended Phase 2 dose, and preliminary antitumor activity of JIN-A02 in combination with amivantamab in participants with advanced EGFR-mutant non-small cell…
- Trial name
- NCT07798921
- Testing
- JIN-A02 in Combination with Amivantamab
- Volunteers
- 36 people
- Sponsor
- Yonsei University
Triple Negative Breast Neoplasms
Sacituzumab Govitecan and Q901 in Advanced TNBC
This is a multicenter, open-label, single-arm phase II clinical trial designed to evaluate the efficacy and safety of Sacituzumab govitecan (SG) in combination with Q901 in patients with advanced…
- Trial name
- NCT07788222
- Testing
- Sacituzumab govitecan and Q901
- Volunteers
- 48 people
- Sponsor
- Yonsei University
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