Clinical trials: terminated
Non-Small Cell Lung Cancer
Efficacy and Safety of Almonertinib Combined With Recombinant Human Endostatin in the Treatment of Stage IIIB-IV Non-small Cell Lung Cancer
Rationale: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in the world, and patients with stage IIIB-IV have a poor prognosis.
- Trial name
- NCT07897019
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Three Gorges Hospital of Chongqing University
Dry Eye Syndromes
Xiidra vs. Xiidra + Dextenza Treatment for Dry Eye Disease
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in patients with dry eye who are beginning treatment with Xiidra (lifitegrast ophthalmic solution) to reduce the signs and…
- Trial name
- NCT04413253
- Testing
- Lifitegrast 5% Ophthalmic Solution, Dexamethasone Intracanalicular Insert, 0.4mg with Lifitegrast 5% Ophthalmic Solution
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Eye Surgeons of Indiana
Telomere Disease
Low-Dose Danazol for the Treatment of Telomere Related Diseases
Background: DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA.
- Trial name
- NCT03312400
- Testing
- Danazol
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Appendicitis
Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure - UCSF
The purpose of this study is to demonstrate the safety, efficacy, and feasibility of short-course post-operative antibiotic treatment for simple and complicated appendicitis
- Trial name
- CASA RELAX (NCT05966454)
- Testing
- Multiple standard of care antibiotics for appendicitis, at physicians' discretion
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Francisco
Primary Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
Selinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors
This is a phase II, open label, prospective, single-arm study evaluating the efficacy and safety of selinexor in patients with PMF or secondary MF (PPV-MF or PET-MF) who are refractory or intolerant to ruxolitinib and/or any…
- Conditions
- Primary Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Post-polycythemia Vera Myelofibrosis
- Trial name
- ESSENTIAL (NCT03627403)
- Testing
- Selinexor
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Utah
Fall
Impact of Telephone Coaching on Physical Performance in a Physical Exercise Maintenance Program for Fallers Elderly Patients Living at Home
At home, maintenance, physical performance declines more or less rapidly from 6 weeks depending advancing age and duration of the training period .
- Trial name
- STEP-PA (NCT02828826)
- Testing
- telephone coaching
- Where
- 10 sites in France
- Volunteers
- 101 people
- Sponsor
- Nantes University Hospital
Provoked Localized Vulvodynia
Remote Mindfulness Education PLV
This is a study designed to learn more about the use of an online remote education and mindfulness practice program for the pain and anxiety associated with provoked localized vulvodynia.
- Trial name
- NCT03541512
- Testing
- Mindfulness + Education, Education
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Oregon Health and Science University
Sensorineural Hearing Loss, Bilateral
Cross-sectional and Prospective Study to Characterize Early-onset Presbycusis
The purpose of this study is to characterize and assess the evolution of hearing impairment of patients with adulthood-onset bilateral sensorineural hearing loss carrying mutations on GJB2 gene.
- Trial name
- SONG (NCT06354010)
- Testing
- Genotyping, Audiological assessments
- Where
- 2 sites in United States, France
- Volunteers
- 134 people
- Sponsor
- Sensorion
Hemodynamic Instability
Advanced vs Standard Hemodynamic Monitoring During Propofol Sedation for ERCP: A Prospective Study
The aim of this study is to evaluate whether there is a difference in hemodynamic events requiring intervention between patients monitored with advanced hemodynamic monitoring using the MostCare system and those monitored with…
- Trial name
- NCT07538115
- Testing
- Hemodynamic Monitoring, Standard Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hitit University
Breast Cancer, Germ Cell Tumor
Multidisciplinary Approach to Fatigue
Prospective longitudinal, single-center, non-randomized study for the implementation of an integrated multidisciplinary fatigue follow-up for young patients with breast cancer or germ cell tumour
- Trial name
- NCT05502224
- Testing
- Ergospirometry
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Jules Bordet Institute
Low Back Pain, Mechanical
Short Terms Effects of Medial Branch Block vs Para-spinal Muscle Injection in Patients With Non-specific CLBP
This study compares the efficacy of medial branch block (MBB) vs. paravertebral deep intramuscular (PDI) injection for pain relief in chronic low back pain.
- Trial name
- NCT02521519
- Testing
- Medial branch block in one side, paravertebral deep intramuscular (PDI) injection
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Domestic Violence
Project INSPIRE: INtervention Support Groups: Peers Inspiring Resilience and Empowerment
The investigators will develop a new, integrated, group intervention to enhance safety, support, and empowerment for survivors of intimate partner violence in the community.
- Trial name
- NCT05826041
- Testing
- (INSPIRE) INtervention Support groups: Peers Inspiring Resilience and Empowerment., Traditional Domestic Violence Support Group
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Type2 Diabetes
Evaluation of Efficacy and Safety of Curalin As Add-On Therapy in Adults With Type 2 Diabetes Mellitus
Evaluation of Efficacy and Safety of Curalin As Add-On Therapy in Adults with Type 2 Diabetes Mellitus
- Trial name
- NCT05631431
- Testing
- Curalin
- Where
- 4 sites in Israel
- Volunteers
- 135 people
- Sponsor
- CuraLife
Non-Small Cell Lung Cancer Metastatic, Gastric Cancer
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
A phase 1/2 open-label multicenter study will be performed with an initial dose escalation part to determine the MTD and/or the RP2D of MCLA-129 in monotherapy or in combination in patients with NSCLC, HNSCC, GC/GEJ, ESCC, or…
- Conditions
- Non-Small Cell Lung Cancer Metastatic, Gastric Cancer, Esophageal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT04868877
- Testing
- MCLA-129, Osimertinib, Chemotherapy
- Where
- 51 sites in United States, Belgium and 7 more
- Volunteers
- 194 people
- Sponsor
- Merus B.V.
Metastatic Colorectal Cancer
A Study of ES104 in Patients With Metastatic Colorectal Cancer
The purpose of this open-label, Multicenter Phase I/II study is to evaluate the safety, tolerability, preliminary anti-tumor efficay, pharmacokinetics, anti-drug antibodies and biomarkers of ES104 in patients with unresectable…
- Trial name
- NCT05167448
- Testing
- ES104
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Elpiscience (Suzhou) Biopharma, Ltd.
Optic Nerve
Measurement of the Optic Nerve Sheath Diameter
This study is a prospective assessment of the accuracy of ocular ultrasound as a tool to measure the diameter of the optic nerve sheath and the eyeball transverse diameter in healthy adult patients presenting to the Emergency…
- Trial name
- NCT05548335
- Testing
- Ocular Ultrasound
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cleveland Clinic Akron General
Eyelid; Wound
Evaluation of Patient Satisfaction With Blephaderm as a Complementary Care in Post-eyelid Surgery
The goal of this non-interventional, open and monocentric study is to evaluate the satisfaction of 30 patients, after 3 months with Blephaderm eyelid cream, as a complementary care in post-eyelid surgery (Blepharopasty or…
- Trial name
- NCT07234292
- Testing
- Cosmetic: Blephaderm
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Laboratoires Thea
Pancreatic Carcinoma
Pilot Study of Pancreatic Cancer Screening
This study investigates how often abnormal findings from routine magnetic resonance imaging occur in people with genetic mutations in BReast CAncer gene.
- Trial name
- NCT05058846
- Testing
- Biospecimen Collection, Magnetic Resonance Cholangiopancreatography, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Bone Reconstruction by Free Fibula Flap
Functional Impact of Reconstructive Surgery by Harvesting a Vascularized Free Fibula Flap Postoperatively.
The fibula is a leg bone that can be used in complex bone reconstruction by reconstructive surgery. This innovative surgical procedure is increasingly used in complex facial (mandibular) reconstructions following cancer and…
- Trial name
- FIBULAM (NCT05641597)
- Testing
- Actimetric measurement, Evaluation of plantar flexion, dorsal flexion and ankle eversion forces, Assessment of static and dynamic balance and quality of life
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Heparin-induced Thrombocytopenia (HIT)
Optimizing the Diagnosis of Heparin Induced Thrombocytopenia
Multicentre (Ottawa and Halifax) prospective cohort study using a diagnostic approach in patients clinically suspected to have HIT that combines pretest probability assessment with quantitative interpretation of anti-PF4 assay.
- Trial name
- HIT (NCT03148912)
- Testing
- Diagnostic algorithm
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- Ottawa Hospital Research Institute