Clinical trials: sponsored by Emory University
Advanced Lung Adenocarcinoma, Refractory Lung Adenocarcinoma
Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer
This phase II trial tests how well defactinib and avutometinib in combination with nivolumab works in treating patients with LKB1-mutant non-small cell lung cancer that has not responded (refractory) to an anti-PD1 treatment and…
- Conditions
- Advanced Lung Adenocarcinoma, Refractory Lung Adenocarcinoma, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT06495125
- Testing
- Avutometinib, Biopsy, Biospecimen Collection
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Communication Issues in Patient and Provider Discussions of Immunotherapy
This trials studies communication issues in patient and provider discussions about immunotherapy. The goal of this study is to describe where patients have heard about immunotherapy, what the participants understand about it, how…
- Trial name
- NCT05873608
- Testing
- Educational video, Interview, Observation
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Emory University
Kidney Transplant Recipient
Subcutaneous Abatacept in Renal Transplant Recipients
After a kidney transplant, patients take drugs called anti-rejection drugs (immunosuppressives) to prevent their bodies from rejecting the new kidney.
- Trial name
- RTB-016 (NCT05975450)
- Testing
- Abatacept 125Mg/Ml Syringe
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Idelberto Badell
Exposure to Environmental Pollution, Exposure to Household Air Pollution
Applied Implementation Research for Clean Cooking in Cambodia
The goal of this study is to learn how to help families in Cambodia switch to using electric induction stoves instead of traditional stoves that burn wood or charcoal.
- Trial name
- AIR-C3 (NCT06942715)
- Testing
- Electric Induction Cookstoves
- Where
- Cambodia
- Volunteers
- 6,150 people, healthy volunteers welcome
- Sponsor
- Emory University
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Oropharyngeal HPV-Positive Squamous Cell Carcinoma
Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer
This phase II trial tests whether reduced dose radiation therapy after transoral robotic surgery works in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer.
- Trial name
- NCT05387915
- Testing
- Radiation Therapy
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Emory University
Obstructive Sleep Apnea of Adult
Melatonin's Effect on Nighttime Blood Pressure and Sleep in OSA Patients (MEBP-OSA)
The goal of this clinical trial is to learn if melatonin works to treat comorbid insomnia in adults with OSA and nocturnal non-dipping blood pressure pattern.
- Trial name
- MEBP-OSA (NCT06380491)
- Testing
- Melatonin 3 MG Oral Tablet
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Status Epilepticus
Improving Status Epilepticus Treatment Times
This is a stepped-wedge cluster randomized effectiveness-implementation hybrid study aimed at determining the effect of dissemination of a QI bundle on the time to treatment of SE among hospitalized, non-critically ill children.
- Trial name
- QuITT-SE (NCT06194747)
- Testing
- Quality improvement bundle, Quality improvement bundle and local PDSA cycles with central support, Quality improvement bundle and local PDSA cycles without central support
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Nationwide Children's Hospital
HIV, STI
Parrying the Pitfalls of PrEP: Project PEACH
The study is a prospective cohort of young MSM who are followed for 2 years either in-person at the PRISM Health Research Clinic and/or virtually with telehealth study visits.
- Trial name
- NCT05072093
- Testing
- PrEP discontinuation intervention, Offering of on-demand oral PrEP, Offering of STI PEP
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Emory University
Inflammatory Bowel Diseases
Heart Rate Variability and Inflammatory Bowel Disease
The goals of this study are to test the effectiveness of a virtually delivered, group-based coping skills treatment program incorporating heart rate variability biofeedback to target autonomic dysfunction in youth diagnosed with…
- Trial name
- NCT06537258
- Testing
- Biofeedback Enhanced Treatment
- Where
- 3 sites in United States
- Volunteers
- 128 people
- Sponsor
- Emory University
Meningitis
Meningococcal Serogroup ACYWX Conjugate Vaccine in Comparison With MenACWY-TT Conjugate Vaccine
Infants aged 9 months will be randomized to receive a meningococcal vaccine at 9 months or 15 months. Infants randomized to the 9-month age group will be further randomized in a 2:1 ratio to receive a single dose of the…
- Trial name
- NCT05093829
- Testing
- NmCV-5, MenACWY-TT
- Where
- Mali
- Volunteers
- 1,325 people, healthy volunteers welcome
- Sponsor
- Emory University
Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma
MRX-2843 and Osimertinib for the Treatment of Advanced EGFR Mutant Non-small Cell Lung Cancer
This phase Ib trial evaluates the best dose and side effects of MRX-2843 when given in combination with osimertinib in treating patients with EGFR gene mutant non-small cell lung cancer that has spread to other places in the body…
- Conditions
- Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8
- Trial name
- NCT04762199
- Testing
- Flt3/MerTK Inhibitor MRX-2843, Osimertinib
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Emory University
Posttraumatic Stress Disorder
Multisite Feasibility of Compassion Meditation for Veterans With Posttraumatic Stress Disorder (PTSD)
Compassion meditation (CM) is a contemplative practice that builds compassion for and connectedness with others. CM has shown promise as a way of enhancing recovery for Veterans with Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT04793698
- Testing
- Compassion meditation, Applied relaxation
- Where
- 3 sites in United States
- Volunteers
- 113 people
- Sponsor
- Veterans Medical Research Foundation
Influenza
Revealing Protective Immunity to Influenza Using Systems Immunology
The goals of this study are to better understand the human immune response to influenza vaccines, specifically the live attenuated (weakened) influenza vaccine given as a nasal spray.
- Trial name
- PRISM (NCT06501963)
- Testing
- Live Attenuated Influenza Vaccine
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetic Foot, Diabetes Type 2 With Diabetic Ulcer of Toe, Skin Breakdown
CGM and DFU Healing Post-discharge
The purpose of this study is to look at the benefits of using a Continuous Glucose Monitoring (CGM) system compared with standard-of-care testing for patients with type 2 diabetes and diabetic foot ulcers (DFU) and how this will…
- Trial name
- NCT06054659
- Testing
- Real Time Continuous Glucose Monitoring (rt-CGM), Fingerstick blood glucose (FBG) monitoring, Diabetes Education
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- Emory University
Influenza
Influenza Human Challenge Model
This study examines how the immune system responds to the flu virus (H3N2) during and after infection and how the flu virus is transmitted in the environment.
- Trial name
- NCT05332899
- Testing
- Influenza Virus Type A H3N2 Challenge
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetes Mellitus, Type 2
Closed Loop Glucose Control in Patients With Type 2 Diabetes
This is a proof of concept safety study of an artificial intelligence based closed loop glucose control system designed for use in the intensive care unit setting.
- Trial name
- NCT05386849
- Testing
- FUSION closed loop glucose control system
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Ideal Medical Technologies
Withdrawal Symptoms, Opioid Use Disorder
Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3
This study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will…
- Conditions
- Withdrawal Symptoms, Opioid Use Disorder, Opioid Use
- Trial name
- VNS in OUD UH3 (NCT05834478)
- Testing
- Transcutaneous Cervical Vagal Nerve Stimulation, [F-18]Fallypride
- Where
- 6 sites in United States
- Volunteers
- 103 people
- Sponsor
- Emory University
Human Immunodeficiency Virus
Baricitinib for Reduction of HIV - CNS
There is still no cure for the human immunodeficiency virus (HIV). While combination antiretroviral therapy (cART) is effective in decreasing deaths from HIV, infected individuals face a lifetime of treatment and many potential…
- Trial name
- NCT05452564
- Testing
- Baricitinib 2 MG Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 95 people
- Sponsor
- William Tyor
Sepsis
Precision Resuscitation With Crystalloids in Sepsis
Fluids are one of the most common treatments given to patients in the hospital. Fluids are especially important in treating patients with sepsis.
- Trial name
- PRECISE (NCT06253585)
- Testing
- Algorithm Alarm- Crystalloids, Standard of Care
- Where
- 7 sites in United States
- Volunteers
- 2,012 people
- Sponsor
- Emory University
Stroke, Upper Extremity Paresis
Therapies for Recovery of Hand Function After Stroke
After a stroke, it is very common to lose the ability to open the affected hand. The purpose of this study is to compare the effects of three different therapies on recovery of hand function after stroke and determine if any one…
- Conditions
- Stroke, Upper Extremity Paresis, Hemiplegia
- Trial name
- NCT03574623
- Testing
- Electrical Stimulator, Occupational Therapy
- Where
- 4 sites in United States
- Volunteers
- 132 people
- Sponsor
- MetroHealth Medical Center
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