Clinical trials: sponsored by Emory University
Foot Injuries and Disorders, Ankle Injuries and Disorders
Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients
This clinical trial aims to determine the effects of a 6-day low-dose methylprednisolone course on pain, nausea, and total opioid consumption in patients undergoing foot and ankle surgeries.
- Conditions
- Foot Injuries and Disorders, Ankle Injuries and Disorders, Achilles Tendon Injury
- Trial name
- NCT06780202
- Testing
- medrol dosepak, HYDROcodone Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Emory University
Opioid Abuse
Community Trial in the Cherokee Nation
The target population is students attending high schools in small rural towns in the 14 counties that partially or fully fall within the Cherokee Nation reservation.
- Trial name
- NCT04839978
- Testing
- Connect Program, Communities Mobilizing for Change and Action (CMCA)
- Where
- United States
- Volunteers
- 919 people
- Sponsor
- Emory University
Malignant Brain Glioma
Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors
This trial studies how well spectroscopic magnetic resonance imaging (MRI) guided proton therapy works in assessing metabolic change in pediatric patients with brain tumors.
- Trial name
- NCT04908709
- Testing
- Magnetic Resonance Spectroscopic Imaging, Proton Therapy
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma
TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer
This phase Ib trial tests the safety, side effects and best dose of tumor membrane vesicle (TMV) vaccine therapy alone and in combination with pembrolizumab and evaluates how well it works in treating patients with head and neck…
- Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma, Metastatic Laryngeal Squamous Cell Carcinoma
- Trial name
- NCT06868433
- Testing
- Autologous Tumor Membrane Vesicles Vaccine, Biospecimen Collection, Computed Tomography
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Influenza
A/Texas Flu Challenge
This study is designed to help us better understand how the immune system responds to the flu and how flu is transmitted in the environment.
- Trial name
- NCT06753474
- Testing
- Influenza Virus influenza A H3N2 strain
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetic Retinopathy
Levodopa for Diabetic Retinopathy
The purpose of this study is to determine optimum dosing strategies of levodopa and determine the physiologic mechanisms that provide the therapeutic response to restore abnormalities in the electrical conductivity of the retina…
- Trial name
- NCT07444892
- Testing
- Levodopa
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Emory University
Cancer
Sirolimus in Combination With Metronomic Chemotherapy in Children With Recurrent and/or Refractory Solid and CNS Tumors
This study aims to determine the efficacy of daily sirolimus and celecoxib, with low dose etoposide alternating with cyclophosphamide for pediatric participants with relapsed or refractory tumors.
- Trial name
- AflacST1502 (NCT02574728)
- Testing
- Sirolimus, Celecoxib, Etoposide
- Where
- 6 sites in United States
- Volunteers
- 46 people
- Sponsor
- Emory University
Alzheimers Disease, Mild Cognitive Impairment
Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor…
- Trial name
- NCT06484244
- Testing
- 5 Sessions of Split-belt Treadmill-based Locomotor Adaptation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Digestive System Neuroendocrine Tumor, Unresectable Digestive System Neuroendocrine Neoplasm
Combination External Radiation and PRRT for Large GI Neuroendocrine Tumors.
This phase I trial tests the safety and effectiveness of stereotactic body radiation therapy (SBRT) followed by 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) in treating patients with large well-differentiated grade…
- Conditions
- Digestive System Neuroendocrine Tumor, Unresectable Digestive System Neuroendocrine Neoplasm, Unresectable Digestive System Neuroendocrine Tumor G1, Unresectable Digestive System Neuroendocrine Tumor G2
- Trial name
- NCT07150546
- Testing
- Stereotactic Body Radiation Therapy, Lutetium Lu 177 Dotatate, Computed Tomography
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Emory University
Solid Tumor
Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors
The primary objective of this study is to improve the 2-year progression-free survival in children with high-risk solid tumors who are administered a maintenance regimen with continuous sirolimus administered on a backbone of…
- Trial name
- AflacST1903 (NCT04469530)
- Testing
- Sirolimus, Cyclophosphamide, Etoposide
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Emory University
Mild Cognitive Impairment, Alzheimer Disease
Improving Sleep and AD Biomarkers
The purpose of this research is to learn whether a dietary citicoline supplement will impact sleep and cognition. Cognitive disorders include such things as memory disorders and mild cognitive impairment.
- Trial name
- NCT06029894
- Testing
- Citicoline Supplement
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Sun Safety
Go Sun Smart Georgia Evaluation
The goal of this clinical trial is to evaluate the dissemination of the Go Sun Smart Georgia (GSSG) program with Georgia worksites and learn whether the intervention changes the employees' sun protection behavior in outdoor…
- Trial name
- GSSG (NCT06418672)
- Testing
- Go Sun Smart Georgia (GSSG)
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Emory University
Nicotine Addiction
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.
- Trial name
- NCT07165808
- Testing
- Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Graft Versus Host Disease
Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant
This trial will see if extended abatacept administration (combined with a standard regimen of tacrolimus and mycophenolate mofetil) will prevent acute and chronic graft-versus-host disease (GVHD) in children and adolescents…
- Trial name
- ASCENT (NCT03924401)
- Testing
- Abatacept
- Where
- 9 sites in United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Recruitment
Optimizing Strategies to Maximize Patient Recruitment Yield
This platform trial aims to evaluate the effectiveness of different messaging strategies within a MyChart messaging program for research recruitment.
- Trial name
- OSPREY (NCT07290335)
- Testing
- Baseline (control) message, Positively-valenced message, Payment-inclusive message
- Where
- United States
- Volunteers
- 100,000 people
- Sponsor
- Emory University
Recurrent Prostate Carcinoma, Stage III Prostate Cancer AJCC v8
REVELUTION-2: Relugolix+Abiraterone Acetate (AA) Versus Leuprolide+AA Cardiac Trial
This phase III/IV trial compares the impact of leuprolide and abiraterone acetate (AA) versus relugolix and AA on the heart in hormone-naive patients with advanced prostate cancer receiving pelvic radiation therapy.
- Conditions
- Recurrent Prostate Carcinoma, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
- Trial name
- NCT06650579
- Testing
- Abiraterone Acetate, Bicalutamide, Biospecimen Collection
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- Emory University
Sepsis
Novel Sepsis Sub-phenotypes Based on Trajectories of Vital Signs
Sepsis is a dysregulated host response to infection resulting in organ dysfunction. Over the past three decades, more than 30 pharmacological therapies have been tested in >100 clinical trials and have failed to show consistent…
- Trial name
- NCT05826223
- Testing
- Implementation and evaluation of a sepsis sub-phenotyping algorithm
- Where
- 4 sites in United States
- Volunteers
- 1,916 people
- Sponsor
- Emory University
COVID-19
Promoting Engagement and COVID-19 Testing for Health
PEACH2 is a community-based study, targeting individuals affected by diabetes. Study participants will be randomized into the PEACH2 Intervention Arm or the Control Arm.
- Trial name
- PEACH2 (NCT06141850)
- Testing
- COVID-19 Test Reporting, Personalized Nudges via Text Messaging, Non-personalized Nudges via Text Messaging
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Emory University
Low Birthweight, Preterm Birth
Low Birthweight and Preterm Infant Feeding Trial and Supportive Care Package: Implementation Research
Low Birthweight and Preterm Infant Feeding Trial and Supportive Care Package (LIFT-UP) aims to improve feeding and growth outcomes among low birthweight (LBW; <2.5kg) or preterm (<37 weeks gestational age) infants admitted to…
- Trial name
- LIFT-UP (NCT06390943)
- Testing
- Facility-based feeding support package plus (FB-FSP+), Transition-to-home feeding support package plus (TTH-FSP+)
- Where
- 5 sites in India, Malawi and 1 more
- Volunteers
- 632 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Total Ankle Arthroplasty, Postsurgical Analgesia
Efficacy of EXPAREL vs. Bupivacaine
The goal of this clinical study is to learn about pain management strategies in subjects undergoing total ankle replacement. arthroplasty surgery The primary objective is to compare the magnitude of the analgesic effect following…
- Trial name
- NCT07212114
- Testing
- EXPAREL, 0.25% bupivacaine (HCl): 50 ml, 0.25% bupivacaine (HCl): 30 ml
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Emory University