Clinical trials: sponsored by Unity Health Toronto
Surgical Videos, Pre-operative Training
Effect of Pre-operative Training Using Surgical Videos on Resident Performance of Unilateral Salpigo-oophrectomy
There is a need for the development and validation of new teaching strategies and resources for surgical training that can occur outside of the operating room.
- Trial name
- NCT03230552
- Testing
- Instructional surgical video
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Chronic Rhinosinusitis
A Randomized Controlled Trial Evaluating Postoperative Debridement Following Endoscopic Sinus Surgery
Chronic rhinosinusitis (CRS) is a common sinus and nasal condition affecting more than 33 million Americans. The treatment of CRS typically begins with maximal medical therapy however, when this fails to improve patient symptoms…
- Trial name
- NCT02154555
- Testing
- debridement
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Premature Ventricular Complexes
Optimal EGM Configuration for Morphology Discrimination
The study will be a prospective cohort study of 20 patients recruited from site's Defibrillator Clinic patient population who are followed at the site.
- Trial name
- SVT Morphology (NCT00888667)
- Testing
- Pacing interventions
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Abbott Medical Devices
Post-Traumatic Stress Disorder
Lending a Hand to Our Future: PTSD in Refugee Children and Youth
Immigrant and refugee children and youth are the fastest growing segment of Canadian society, but their mental health is too often overlooked even though their high rates of symptoms are increasingly of concern.
- Trial name
- LHOF (NCT02334566)
- Testing
- NET TX
- Volunteers
- 588 people
- Sponsor
- Unity Health Toronto
Retinopathy of Prematurity, Pain
The Effect of Eyemasks on Neonatal Stress Following Dilated Retinal Examination
Although screening exams for retinopathy of prematurity (ROP) prevent blindness they are physiologically stressful for infants. The investigators postulate that photosensitivity during mydriasis contributes to post-examination…
- Conditions
- Retinopathy of Prematurity, Pain, Premature Infant, Retinal Disease
- Trial name
- MASK-ROP (NCT03824782)
- Testing
- Phototherapy Mask
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Deep Venous Thrombosis
Pneumatic Compression for Preventing Venous Thromboembolism
Patients admitted to the intensive care unit are at high risk of developing clots in the veins of the lower extremities. The objective of this study is to examine whether the use of a device that provides intermittent compression…
- Trial name
- PREVENT (NCT02040103)
- Testing
- pneumatic compression
- Where
- Saudi Arabia
- Volunteers
- 2,000 people
- Sponsor
- King Abdullah International Medical Research Center
Mitral Valve Prolapse
The Canadian Mitral Research Alliance (CAMRA) Trial CardioLink-2
Multicentre, double-armed, randomized controlled trial designed to compare mitral valve leaflet resection versus leaflet preservation with regards to the development of functional mitral stenosis following surgical repair of…
- Trial name
- CAMRA (NCT02552771)
- Testing
- Mitral repair with leaflet preservation, Mitral repair with leaflet resection
- Where
- 6 sites in Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Critically Ill
The Frequency of Screening and SBT Technique Trial: The FAST Trial
Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing.
- Trial name
- NCT02969226
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 17 sites in United States, Canada
- Volunteers
- 760 people
- Sponsor
- Unity Health Toronto
DALK Corneal Transplant, Keratoconus
Comparison Between Standard Deep Anterior Lamellar Keratoplasty (S-DALK) and Intralase Enabled Deep Anterior Lamellar Keratoplaty (IE-DALK)
A prospective comparison between standard deep anterior lamellar keratoplasty (S-DALK) performed manually using a blade (trephine) and femtosecond laser-enabled deep anterior lamellar keratoplasty (IE DALK), where incisions are…
- Conditions
- DALK Corneal Transplant, Keratoconus, Scar
- Trial name
- NCT03732599
- Testing
- Standard Deep Anterior Keratoplasty (S-DALK), IE-DALK (femtosecond)
- Volunteers
- 100 people
- Sponsor
- University of Toronto
Heart Failure With Normal Ejection Fraction
Flow Regulation by Opening the Septum in Patients With Heart Failure Trial
To investigate the safety and efficacy of a novel atrial flow regulator (AFR) device in patients with heart failure and preserved ejection fraction.
- Trial name
- FROST-HF (NCT03751748)
- Testing
- AFR implantation
- Where
- 3 sites in Canada
- Volunteers
- 230 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus Type 2, Hypertension
Combined Rg3-enriched Korean Red Ginseng and American Ginseng in the Management of Hypertension in Type 2 Diabetes
The study is a combined Phase-I like (safety) and Phase-II like (efficacy) double blind randomized placebo controlled trial. The objective is to investigate whether the combination of AG and Rg3-enriched Korean Red ginseng added…
- Trial name
- R-KAT (NCT01578837)
- Testing
- Ginseng, Wheat Bran
- Where
- 2 sites in Canada, Croatia
- Volunteers
- 90 people
- Sponsor
- Unity Health Toronto
Type2 Diabetes, Coronary Heart Disease
Konjac-Mannan Improves Glycemia and Other Risk Factors for CHD in T2DM
To examine whether Konjac-mannan fiber improves metabolic control measured by glycemia, lipidemia, and blood pressure in individuals with type-2 diabetes.
- Trial name
- NCT03741660
- Testing
- konjac glucomannan, wheat bran
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto
Insulin Resistance Syndrome
Effect of Konjac-mannan in Individuals With Insulin-Resistance Syndrome
To study whether a diet high in fiber from Konjac-mannan (KJM) has an effect on metabolic control in individuals with insulin resistance syndrome.
- Trial name
- NCT03741686
- Testing
- konjac glucomannan, wheat bran
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto
Lipidemia, Healthy
Viscosity of Fibre Predicts Cholesterol-lowering in Healthy Individuals
To investigate the role of fibre viscosity (low, medium, high) in lowering cholesterol in healthy individuals
- Trial name
- NCT03741621
- Testing
- Viscous Fibre Blend, Psyllium, Wheat Bran
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Total Hip Replacement, Arthroplasty Complications
REVISITS: Revision Single or Two Stage Surgery
Hip replacement surgery is common, with over 60,000 cases in Canada annually. After hip replacement, about 1-2% patients develop a deep infection in their artificial hip implant, called a periprosthetic joint infection (PJI).
- Trial name
- REVISITS (NCT03741296)
- Testing
- Single stage revision, Two-stage revision
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Colorectal Cancer
A Randomized Control Trial of a Simulation-based Curriculum to Enhance Skills in Colonoscopy
Colonoscopy is a commonly used medical procedure. Medical and surgical residents learning colonoscopy typically learn the procedure experientially but simulation based teaching is increasingly being integrated into training…
- Trial name
- NCT01991522
- Testing
- Curriculum Group, Self-directed learning group
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Unity Health Toronto
Weaning
Effect of NAVA on Weaning Duration in Difficult to Wean Patients
It has been showed that over assist and patient ventilator asynchrony often occur in mechanical ventilated patients, especially in patients who failed weaning, which are associated with a prolonged duration of mechanical…
- Trial name
- NCT01280773
- Testing
- NAVA
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Ling Liu
End Stage Renal Disease
The Routine Use of SSRI's at the Initiation of End-stage Renal Disease Treatment (RoSIE)
In this study the investigators hypothesize that antidepressant therapy may improve the overall welling of patients with acute or chronic kidney disease when given around the time of starting chronic dialysis therapy.
- Trial name
- RoSIE (NCT02407821)
- Testing
- Escitalopram
- Where
- 3 sites in Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes, Obesity
Canola-Mediterranean Diet Study in T2DM
The purpose of the study is to assess whether a Mediterranean-type weight-loss diet, enriched with canola oil, high in plant protein, and low in carbohydrates will produce blood sugar control, reduce coronary heart disease (CHD)…
- Conditions
- Type 2 Diabetes, Obesity, Overweight, Cardiovascular Diseases
- Trial name
- NCT02245399
- Testing
- A canola oil enriched mediterranean diet, A high wheat fiber diet
- Where
- 3 sites in Canada
- Volunteers
- 164 people
- Sponsor
- Unity Health Toronto
Aortic Aneurysm, Thoracic
The Aortic Surgery Cerebral Protection Evaluation (ACE) Randomized CardioLink-3 Trial
The ACE trial is a multicentre, randomized controlled trial comparing axillary vs. innominate artery cannulation for established antegrade cerebral perfusion in patients having aortic surgery (thoracic and aortic arch) requiring…
- Trial name
- NCT02554032
- Testing
- Axillary artery cannulation, Innominate artery cannulation
- Where
- 2 sites in Canada
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto