Clinical trials: not yet recruiting
Opioid Use Disorder
Behavioral Optimization for Overcoming Suboptimal Treatment Retention (BUP-BOOSTeR)
Buprenorphine, a medication for opioid use disorder (MOUD), is associated with decreased opioid overdose and all-cause mortality.
- Trial name
- BUP-BOOSTeR (NCT07607743)
- Testing
- Behavioral Activation (BA), Attendance Reinforcement (AR), Peer-Delivered Motivational Interviewing (PDMI)
- Volunteers
- 240 people
- Sponsor
- Boston University
Brain Injuries
Implementation Study on Hospital-to-home Advanced Rehabilitation Technologies (ART)
To study the feasibility of the various model of ART rental service for home use, prescribed and supervised by experienced rehabilitation professionals and supported by tech partners, and its efficacy in improving function in…
- Trial name
- R@H (NCT07904624)
- Testing
- ART
- Where
- 3 sites in Singapore
- Volunteers
- 1,000 people
- Sponsor
- National University Hospital, Singapore
Solid Tumor, Neoplasms
Intratumoral Chlorine Dioxide Injection in Advanced Solid Tumors
The purpose of this study is to evaluate the safety of injecting a 2% chlorine dioxide solution directly into tumors in adults with advanced solid tumors, and to determine whether the injected solution stays within the tumor…
- Trial name
- NCT07911293
- Testing
- Chlorine Dioxide Injection 2%
- Volunteers
- 50 people
- Sponsor
- SunGlow Innovations LLC
Benign Prostatic Hyperplasia, Postoperative Hemorrhage
Perioperative Dutasteride for Hemorrhage Control in Bipolar TURP Under Anticoagulation.
A prospective, randomized, double-blinded controlled trial to evaluate the efficacy of a 2-week preoperative and 2-week postoperative course of oral dutasteride (0.5 mg daily) in reducing perioperative blood loss, irrigation…
- Conditions
- Benign Prostatic Hyperplasia, Postoperative Hemorrhage, Perioperative Hemorrhage Control During Bipolar Transurethral Resection of the Prostate (TURP) in Patients on Anticoagulant or Antiplatelet Therapy
- Trial name
- DUT-TURP (NCT07911501)
- Testing
- Dutasteride (0.5mg)
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Mohamed Mahmoud Dogha
Lower Limb Surgery, Pain
Role of Perineural Catheter in Pain Control and Opioid Consumption After Major Amputation of Lower Limb
The goal of this randomized controlled clinical trial is to evaluate the effectiveness of postoperative bupivacaine infusion through a perineural catheter in managing postoperative pain and to determine the opioid consumption…
- Conditions
- Lower Limb Surgery, Pain, Phantom Limb Pain After Amputation, Stump Pain
- Trial name
- NCT07896798
- Testing
- Bubpivacaine, Tramadol, Saline
- Volunteers
- 96 people
- Sponsor
- Aga Khan University
Small Cell Lung Cancer (SCLC), SCLC, Extensive Stage
Low-Dose Radiotherapy Plus Adebrelimab and Chemotherapy for Extensive-Stage Small Cell Lung Cancer
This is a phase II study evaluating a novel combination therapy for untreated extensive-stage small cell lung cancer. The treatment involves an initial induction phase with the drug Adebrelimab plus standard chemotherapy and…
- Trial name
- NCT07909863
- Testing
- Adebrelimab + Chemotherapy + Radiotherapy
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Renal Tumors
The Edison™ System for Treatment of Renal Tumors Using Histotripsy (Histo-Renal Trial)
This is a prospective single-center, single-arm, feasibility trial designed to evaluate the safety of the HistoSonics Histotripsy System for treatment of renal tumors.
- Trial name
- NCT07911527
- Testing
- HistoSonics® Edison System (US)
- Volunteers
- 15 people
- Sponsor
- Chinese University of Hong Kong
Heart Failure
Notification Of High-Risk Veterans for Access to Heart Failure Prevention
The purpose of this study is to learn whether connecting people at high risk for developing heart failure to a heart doctor (cardiologist) leads to greater use of treatments that can lower that risk.
- Trial name
- NOVA-HF (NCT07910084)
- Testing
- Notification and Cardiology Referral, Notification and Cardiology Referral Plus Care Navigation
- Volunteers
- 250 people
- Sponsor
- Palo Alto Veterans Institute for Research
Acute Myeloid Leukemia
Phase I Study Of PLM-102 In Patients With Relapsed And Refractory Acute Myeloid Leukemia
The goal of this clinical research study is to find the highest tolerable dose of PLM-102 that can be given to patients who have AML/MDS that is refractory and/or relapsed. The safety of PLM-102 will also be studied.
- Trial name
- NCT07549464
- Testing
- PLM-102
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Plaque-Induced Gingivitis
Efficacy of Thymus Vulgaris Mouthwash in the Management of Biofilm-Induced Gingivitis
The goal of this clinical trial is to determine whether a mouthwash made from thyme (Thymus vulgaris) helps improve gum health in people with plaque-induced gingivitis.
- Trial name
- NCT07905456
- Testing
- 0.2% Thymus vulgaris mouthwash, Chlorhexidine 0,12%
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- University of Sulaimani
High-altitude Pulmonary Edema
High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in Children High-altitude Pulmonary Edema
This study aims to evaluate whether High-flow Nasal Cannula Oxygen Therapy (HFNC) provides superior respiratory support compared to Conventional Oxygen Therapy (COT) in children with High-Altitude Pulmonary Edema (HAPE).
- Trial name
- NCT07910357
- Testing
- High-flow Nasal Cannula Oxygen Therapy (HFNC)
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Ye Fan
Dyslipidemia
Study of the Safety and Efficacy of Prenofitol Tablets
Stage 1 of the Study Stage 1 of the study will consist of: a screening period (Visit 0) conducted within 0-14 days prior to the start of treatment; an inpatient treatment period, including Visit 1 (Days 1-4) and Visit 2 (Days…
- Trial name
- NCT07908433
- Testing
- 1 tablet of Prenofitol, 2 tablets of Prenofitol
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Breast Cancer (Early Breast Cancer), Obesity
Semaglutide for Weight Management During Hormone Therapy for Early Breast Cancer
This study will assess whether women with obesity and early estrogen receptor-positive breast cancer can complete 26 weeks of semaglutide treatment while continuing their prescribed hormone therapy for breast cancer.
- Trial name
- WISPER (NCT07909889)
- Testing
- Semaglutide (Wegovy®)
- Where
- 2 sites in Denmark
- Volunteers
- 32 people
- Sponsor
- Aarhus University Hospital
Large B-cell Lymphoma
A Study to Evaluate Surovatamig Combined With R-CHOP in Participants of 18 to < 80 Years of Age With Previously Untreated Large B-cell Lymphoma With IPI Score 2 to 5
This is a study to evaluate the efficacy of surovatamig combined with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) in participants aged 18 to < 80 years of age with previously untreated large B-cell…
- Trial name
- Soundtrack D3 (NCT07911553)
- Testing
- Surovatamig, Rituximab, Cyclophosphamide
- Volunteers
- 1,200 people
- Sponsor
- AstraZeneca
T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma
Multi-CAR T Cell Therapy Targeting CD7-positive Malignancies
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of CAR T cell therapy against CD7-positive hematological malignancies using CD7 specific CAR T cells.
- Conditions
- T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma, Acute Myeloid Leukemia, NK Cell Lymphoma
- Trial name
- NCT04033302
- Testing
- CD7-specific CAR gene-engineered T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Kidney Stones, Urolithiasis, Hypocitraturia, Pain, Postoperative
Intertransverse Process Block Versus Erector Spinae Plane Block for Postoperative Analgesia After Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is the preferred minimally invasive procedure for renal stones larger than 2 cm, staghorn calculi and complex stone burdens, but it is frequently associated with moderate-to-severe…
- Trial name
- NCT07908992
- Testing
- Ultrasound-guided intertransverse process block, Ultrasound-guided erector spinae plane block
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Depression - Major Depressive Disorder, Generalised Anxiety Disorder
Effectiveness of Internet-based Unified Protocol (iUP) for Emotional Problems: A Randomized Controlled Trial
The goal of this clinical trial is to learn if an internet-based Unified Protocol (iUP) intervention is effective for treating depression and anxiety disorders in Hong Kong young adults aged 18-29 years.
- Conditions
- Depression - Major Depressive Disorder, Generalised Anxiety Disorder, Anxiety Disorder (Panic Disorder or GAD), Depressive and Anxiety Disorders
- Trial name
- NCT07908628
- Testing
- Internet-based Unified Protocol (iUP), Waitlist Control Group
- Where
- Hong Kong
- Volunteers
- 78 people
- Sponsor
- New Life Psychiatric Rehabilitation Association
Pregnancy, Substance Use Disorder (SUD)
Justice Core Trial
The goal of this clinical trial is to learn if Justice Core, an intervention that moves pregnant women with substance use disorder (SUD) from jail into community-based SUD treatment while awaiting trial, can improve the health of…
- Conditions
- Pregnancy, Substance Use Disorder (SUD), Prisoners
- Trial name
- NCT07911332
- Testing
- Jail Diversion into Treatment, Referral at Release
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of North Carolina, Chapel Hill
Forearm Surgeries, Brachial Plexus Blockade
Perfusion Index in Monitoring Recovery From Brachial Plexus Block After Forearm Surgery
Postoperative differentiation between residual regional anesthetic effect and other causes of persistent sensory or motor deficit is a common clinical problem after peripheral nerve blocks.
- Trial name
- NCT07909941
- Testing
- Perfusion index measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University Research Hospital
Acute Respiratory Failure, Critical Illness
Lactate/Albumin Ratio and Mortality in Respiratory Failure
This retrospective observational study aims to evaluate the association between the lactate-to-albumin ratio (LAR) measured at ICU admission and 28-day mortality in adult patients admitted to the intensive care unit with acute…
- Conditions
- Acute Respiratory Failure, Critical Illness, Mortality, Mortality Prediction
- Trial name
- NCT07909226
- Testing
- Assessment of Admission Serum Lactate-to-Albumin Ratio (LAR)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,250 people
- Sponsor
- Kocaeli City Hospital
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