Clinical trials: sponsored by Duke University
Long COVID, Long COVID-19
RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple…
- Conditions
- Long COVID, Long COVID-19, Hypersomnia
- Trial name
- NCT06404099
- Testing
- Modafinil, Solriamfetol
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- Duke University
Trauma, Critical Illness
Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery
This is a prospective, randomized, controlled trial designed to evaluate the impact of enhanced protein supplementation compared to a standard of care nutrition delivery in critically ill older adult trauma patients.
- Trial name
- NCT06521086
- Testing
- Nutrition Supplements - Fresubin KCAL Drinks
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Leukemia
Selection of Allogeneic Hematopoietic Cell Donors Based on KIR and HLA Genotypes
This study tests whether adding certain genetic factors to the process of picking a stem cell donor can decrease the chances that the patient's leukemia will come back after bone marrow transplantation.
- Trial name
- NCT02450708
- Testing
- KIR genotyping, HLA genotyping
- Where
- 10 sites in United States
- Volunteers
- 511 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Pain, Opioid Use
Neuroimaging of Opioid Phase (OPAL)
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and…
- Trial name
- OPAL (NCT05905419)
- Testing
- Opioid Phase
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Duke University
Point-of-care Ultrasound, Simulation Training
Ultrasound Simulation Case-based Workshop Implementation and Impact Assessment
This study is a prospective cohort study implementing a point-of-care ultrasound (POCUS) simulation case-based workshop in emergency (EM) physicians at different training levels as an educational and competency-based assessment…
- Conditions
- Point-of-care Ultrasound, Simulation Training, Medical Education in Emergency Ultrasound
- Trial name
- US Sim cases (NCT06960837)
- Testing
- ultrasound simulation training case-based workshop during resident sim days
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
Bacterial Colonization
Bacterial Decolonization Within Dyads
The goal of this study is to measure bacterial burden, specifically Staph aureus, and how it spreads between mothers and their infants.
- Trial name
- BADMC (NCT06541145)
- Testing
- Mupirocin, Chlorhexidine baths
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Knee Stiffness After Total Knee Arthroplasty
Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia
The purpose of this study is to determine if changing the type of anesthesia improves the outcomes of manipulation and pain control after the procedure.
- Trial name
- NCT07348614
- Testing
- Spinal Anesthesia, General Anesthesia, Propofol
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Duke University
Lung Transplant Failure and Rejection
Long Term Follow up of the LTOG Cohort
The purpose of the study is to follow participants who enrolled in the Lung Transplant Outcomes Group. Clinical data, functional assessments, and surveys will be collected to determine long term graft function and functional…
- Trial name
- LTOG (NCT04787822)
- Where
- 10 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- University of Pennsylvania
Cardiovascular Disease Acute, Emergency Department Patient
Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers
The aim of this study is to assess emergency medicine physician and advanced practice provider (APP) knowledge and technical skill in performance of a point-of-care ultrasound simulation and just-in-time training pathway to…
- Conditions
- Cardiovascular Disease Acute, Emergency Department Patient, Heart Failure Acute, Pulmonary Embolism (Diagnosis)
- Trial name
- NCT07159269
- Testing
- Cardiac point-of-care ultrasound (POCUS) training and clinical pathway
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Duke University
Trauma, Critical Illness
Personalized Nutrition Delivery to Improve Resilience in Older Adult Trauma Patients
This is a Pilot study designed to set up for an randomized clinical trial (RCT) comparing the SeND Home pathway to a standard of care nutrition delivery in critically ill older adult trauma patients.
- Trial name
- SeND Home (NCT05544162)
- Testing
- Nutrition supplement - Ensure shakes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Congenital Heart Disease, Congenital Heart Defect
Peer Coaching Intervention in Young Adults With Congenital Heart Disease
The purpose of the study is to evaluate a peer coaching intervention in young adults with congenital heart disease.
- Trial name
- CHASM in ACHD (NCT04271358)
- Testing
- Peer Health Coaching
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
HIV -1 Infection, Mental Health Issue
Integrating iSYV Within HIV Clinical Care for Youth Living With HIV in Tanzania
Youth living with HIV (YLWH) experience mental health (MH) challenges that compromise their HIV care. Though the MH gap is well described, MH service delivery to YLWH is rare, especially in low resource settings.
- Trial name
- NCT07621510
- Testing
- iSYV (integrated Sauti ya Vijana; The Voice of Youth), mHealth, eSOC
- Where
- Tanzania
- Volunteers
- 5,000 people
- Sponsor
- Duke University
Decompression Sickness
NASA Prebreathe Study
This study will validate the experimental method and chamber facility at the Duke Center for Hyperbaric Medicine \& Environmental Physiology and test team capabilities to support NASA decompression sickness (DCS) studies.
- Trial name
- NASA Prebreath (NCT06740305)
- Testing
- Altitude, 100% Oxygen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Duke University
Hematopoietic Cell Transplantation
A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).
This is a prospective international multi-center registry and biorepository trial of children and adolescents/young adults (AYA) undergoing hematopoietic cell transplantation (HCT) to assess the impact of endotheliopathies in the…
- Trial name
- NCT05090345
- Testing
- Biorepository Trial
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Stress Urinary Incontinence, Vaginal Prolapse
BELIEVE Trial: Bulking vErsus sLing for Treating Stress Urinary IncontinEnce at the Time of Vaginal prolapsE Repair (BELIEVE)
The goal of this clinical trial is to learn if retropubic midurethral sling (RP-MUS) or bulkamide injection (PAHG) at the time of pelvic organ prolapse repair is better from the patient's perspective.
- Trial name
- BELIEVE (NCT06754046)
- Testing
- RP-MUS, PAHG
- Where
- United States
- Volunteers
- 476 people
- Sponsor
- University Hospitals Cleveland Medical Center
Antiphospholipid Syndrome
Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome
Antiphospholipid antibody syndrome (APS) is characterized by the presence of antiphospholipid antibodies, which are proteins in the blood that interfere with the body's ability to perform normal blood clotting.
- Trial name
- APS (NCT00482794)
- Where
- United States
- Volunteers
- 2,800 people
- Sponsor
- Duke University
Liver Failure, Liver Diseases, Alcoholic
BRIDGE Device for Post-operative Pain Control
Auricular neurostimulation is a potential novel and non-invasive method of pain control following liver transplantation in a growing patient population with the probability of significant impact on economics and morbidity.
- Conditions
- Liver Failure, Liver Diseases, Alcoholic, Liver Diseases, Pain, Postoperative
- Trial name
- BRIDGE (NCT03265249)
- Testing
- BRIDGE device
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Duke University
Lung Cancer
Virtual Agent Feasibility in Oncology Patients (NTT Data)
The purpose of this study is to compare the use of a virtual agent vs. a human agent when onboarding oncology patients over the telephone to Remote Patient Monitoring (RPM) devices.
- Trial name
- NCT06682013
- Testing
- Virtual agent, Human agent
- Where
- United States
- Sponsor
- Duke University
Heart Failure; With Decompensation
Evaluation Of A Virtual Cardiology Program To Improve Outcomes After Acute Decompensated Heart Failure
The purpose of this study is to evaluate how safe and effective a remote, virtual, cardiology program is that provides heart failure education to patients, monitors for worsening heart failure, and quickly adjusts heart failure…
- Trial name
- ELEVATE-HF (NCT06592508)
- Testing
- Remote Virtual Cardiology Program
- Where
- 5 sites in United States
- Volunteers
- 73 people
- Sponsor
- Duke University
Depression, Anxiety
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
The goal is to improve mental health. The study will evaluate the impact of community-based mental health services. Successful completion of this study will contribute to the National Institute of Mental Health Strategic Plan…
- Conditions
- Depression, Anxiety, Psychological Distress, PTSD
- Trial name
- RECOUP-NY (NCT04913766)
- Testing
- Problem Management Plus, Services as Usual
- Where
- United States
- Volunteers
- 1,206 people
- Sponsor
- George Washington University
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