Clinical trials: sponsored by Unity Health Toronto
Dysphonia, Singing
Effects of External Vibration on Voice Quality in Muscle Tension Dysphonia Patients and Classically Trained Singers
Muscle tension dysphonia (MTD) is a disabling voice disorder which causes severe voice change, neck pain, and voice fatigue. Current therapy modalities to treat these disorders include multiple visits to a qualified speech…
- Trial name
- NCT02083341
- Testing
- Lelo® Siri vibrator, Lelo® Siri vibrator with vibration component removed
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes, Cardiovascular Disease
Effects of Empagliflozin on Cardiac Structure in Patients With Type 2 Diabetes
The purpose of this study is to evaluate the effects of Empagliflozin on cardiac structure, function and circulating biomarkers in patients with Type II diabetes.
- Trial name
- EMPA-HEART (NCT02998970)
- Testing
- Empagliflozin
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Unity Health Toronto
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Transfusion Requirements in Cardiac Surgery III
TRICS-III is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in high risk patients having cardiac surgery using a non-inferiority trial design.
- Trial name
- TRICS-III (NCT02042898)
- Testing
- Restrictive Transfusion Strategy, Liberal transfusion strategy
- Where
- 74 sites in United States, Australia and 17 more
- Volunteers
- 5,028 people
- Sponsor
- Unity Health Toronto
Syphilis
Evaluation of Enhanced Syphilis Screening Among HIV-positive Men
This study aims to enhance syphilis testing among HIV-positive men who have sex with men (MSM), so that more men will undergo testing, they will test more often, and more cases will be treated early.
- Trial name
- NCT02019043
- Testing
- Syphilis testing with routine HIV bloodwork
- Where
- 4 sites in Canada
- Volunteers
- 3,895 people
- Sponsor
- Unity Health Toronto
Traumatic Brain Injury With Prolonged Loss of Consciousness
A Trial to Determine the Feasibility and Effectiveness of Early Multisensory Stimulation Intervention in Patients in the Trauma-Neurosurgical Intensive Care Unit (TNICU) Following Severe Acquired Brain Injury
St. Michael's Hospital (SMH) provides service to individuals with some of the most severe brain injuries and intensive care needs in Canada.
- Trial name
- NCT02589223
- Testing
- Multisensory Stimulation, Control
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus
Assessment of Tissue Oxygenation Using Multispectral Imaging
In Canada, the age-standardized prevalence of diabetes is on the rise (increasing from 3.3% in 1998/99 to 5.6% in 2008/2009 Public Health Agency of Canada (July 2011)) and is almost 1 in 10 globally.
- Trial name
- NCT03516864
- Testing
- MIMOSA Imager, Kent Camera
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes
Investigating Ultrasound Debridement in Wound Care
The initial step of wound management, debridement, is thought to be critical in promoting wound healing. Of the numerous debridement modalities, ultrasound seems to hold promising results in accelerate healing in our own clinical…
- Trial name
- NCT03516422
- Testing
- ULTRASOUND DEBRIDEMENT, STANDARD CARE GROUP
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetic Foot
Using mHealth to Modernize Diabetes Care
In this study the investigators are testing a device that may help us tell how well the participants' wound is healing. This device is called the MIMOSA, and it shines different "colours" of light on the participants' skin.
- Trial name
- MDM (NCT03516474)
- Testing
- MIMOSA Diagnostics
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
PAD, Optical Imaging
Pulse Wave Velocity Imaging in the Assessment of PAD
The purpose of this study is to predict the outcome of peripheral revascularization surgery by use of a new technology developed by our team, Pulse Wave Velocity imaging (PWVI), which has the capability to detect pulse transit…
- Trial name
- PWVi (NCT03516383)
- Testing
- PWVi
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Age Related Macular Degeneration
Intravitreal Aflibercept in Wet Age Related Macular Degeneration Patients With an Incomplete Response to Routine Ranibizumab Injections
SHIFT-2 is a national, multi-center, non-randomized, open label trial of aflibercept in patients with wet age related macular degeneration who have incomplete response with routineranibizumab treatment.
- Trial name
- SHIFT-2 (NCT02002377)
- Testing
- Aflibercept
- Where
- 9 sites in Canada
- Volunteers
- 23 people
- Sponsor
- Unity Health Toronto
HIV
Bone Antiresorptive Therapy With Antiretroviral Initiation (BATARI) Pilot Trial
This is a two-site, three-arm, open-label, pilot randomized controlled trial of bone anti-resorptive therapy during ART initiation in HIV-infected adults.
- Trial name
- BATARI (NCT01968850)
- Testing
- alendronate/vitamin D
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Acute Kidney Injury, Chronic Kidney Disease
Nephrologist Follow-up Versus Usual Care After an Acute Kidney Injury Hospitalization
The primary objective is to evaluate the impact of an AKI Follow-up Clinic on major adverse kidney events (MAKE) in comparison to hospitalized patients surviving an episode of AKI who are not exposed to the AKI Follow-up Clinic…
- Trial name
- FUSION (NCT02483039)
- Testing
- AKI Follow-up Clinic
- Where
- 4 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Glioblastoma, Hypoxia
qBOLD MRI of Glioblastoma Multiforme for Assessment of Tumor Hypoxia.
Glioblastoma multiforme (GBM) is the most common primary malignant brain neoplasm in adults. Despite recent diagnostic and therapeutic advances, including aggressive surgical resection and chemoradiation, the prognosis of GBM has…
- Trial name
- NCT02466828
- Testing
- Feraheme®
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cancer
Evaluation of a Decision Aid for Incidental Genomic Findings
Health care providers (HCP) are increasingly using genomic sequencing (GS) to target treatment for patients. However, GS may incidentally reveal inherited risks for thousands of current and future diseases.
- Trial name
- NCT03244202
- Testing
- Decision Aid Plus Counselling, Genetic Counselling Only
- Where
- 2 sites in Canada
- Volunteers
- 133 people
- Sponsor
- Unity Health Toronto
Stress, Psychological, Compassion Fatigue
Achieving Resilience in Acute Care Nurses (ARISE).
Nurses are exposed to myriad stressors, both in the workplace and in their everyday lives, which can lead to adverse personal and professional outcomes.
- Trial name
- NCT03017469
- Testing
- ARISE
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Unity Health Toronto
Other Functional Disturbances Following Cardiac Surgery
Study of Methemoglobin as a Biomarker of Tissue Hypoxia During Acute Hemodilution in Heart Surgery Patients
Acute and chronic anemia continue to be associated with increased mortality in a number of clinical settings, including cardiac and non-cardiac surgery.
- Trial name
- NCT01883713
- Testing
- Brain Oximetry
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Unity Health Toronto
Elective Cardiac Surgery
Acceptable Range of Inspiratory Effort During Mechanical Ventilation
Partially assisted mechanical ventilation is ideally titrated to maintain adequate inspiratory muscle activity (i.e. preventing disuse atrophy) while avoiding excessive (i.e. fatiguing) inspiratory loads.
- Trial name
- EFFORT (NCT02838524)
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Unity Health Toronto
Early Inflammatory Arthritis
Peer to Peer Mentoring For Individuals With Early Inflammatory Arthritis: An Effectiveness Study (Pilot RCT)- Peer Mentor Training
Peer support (including informational, emotional, appraisal support) has been shown to help persons with chronic conditions. The goal of this research is to examine the impact of early peer support on the health and quality of…
- Trial name
- P2P EIA RCT (NCT01347372)
- Testing
- Peer Mentor Training
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Acute Respiratory Distress Syndrome
Validation of a Simple Approach to Estimate Alveolar Recruitability in ARDS Patients
This study will test the validity of a new approach to assess alveolar recruitability at the bedside in comparison to direct measurements of lung volume and derecruitment.
- Trial name
- NCT02457741
- Where
- 3 sites in Canada, China and 1 more
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
Assessing Diaphragm Muscle Inactivity in Mechanically Ventilated ICU Patients
Background: Mechanical ventilation is a life saving intervention in patients with acute respiratory failure, for instance, due to infection or trauma.
- Trial name
- DIVIP (NCT02434016)
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Unity Health Toronto