Clinical trials: sponsored by Unity Health Toronto
Early Inflammatory Arthritis
Peer to Peer Mentoring For Individuals With Early Inflammatory Arthritis: An Effectiveness Study (Pilot RCT)- Peer Mentoring Program
Peer support (including informational, emotional, appraisal support) has been shown to help persons with chronic conditions. The goal of this research is to examine the impact of early peer support on the health and quality of…
- Trial name
- P2P EIA RCT (NCT01347359)
- Testing
- One-on-one peer support, Standard of care
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Respiratory Insufficiency
Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation
Mechanically ventilated patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SLEEWE (NCT02464735)
- Testing
- Polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis
HFN Versus NIV in Cystic Fibrosis. The HIFEN Study
Many patients with cystic fibrosis (CF) require hospitalization and/or Intensive Care Unit (ICU) admission because of acute exacerbation of chronic respiratory failure or for any acute deterioration of clinical status.
- Trial name
- NCT02262871
- Testing
- High flow nasal oxygen cannula, Noninvasive ventilation
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
Monitoring Intercostal Muscles After Extubation
Mechanical ventilation is a life-saving treatment for critically ill patients who are unable to breathe on their own. At the time of recovery, separation from the ventilator is performed without difficulty for the majority of…
- Trial name
- MIME (NCT02853201)
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Unity Health Toronto
Hypertension, Blood Pressure, High
Dietary Nitrate on Blood Pressure and Cardiovascular Disease Risk Factors
The project aims to determine the effect of a high-nitrate dietary intervention on blood pressure and markers of vascular function compared to a low-nitrate intervention in people with elevated blood pressure.
- Trial name
- NCT03478631
- Testing
- High-nitrate dehydrated vegetable powder, Low-nitrate dehydrated vegetable powder
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Unity Health Toronto
Heart Failure
A Trial of Thiamin Supplementation in Patients With Heart Failure
Background: Patients with heart failure (HF) are at increased risk of developing thiamin deficiency (TD). Thiamin (vitamin B1) is required for the production of energy and therefore TD may contribute to the energy depletion…
- Trial name
- NCT00959075
- Testing
- Vitamin B1
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Colorectal Cancer
Colonoscopic Skill Acquisition and Transfer Via Simulated Curriculum of Progressive Training
It is hypothesized that a progressive simulated learning strategy will result in better global clinical performance (e.g., technical, communication) and transfer of endoscopic skill, as compared with a high-fidelity simulation…
- Trial name
- NCT02000180
- Testing
- Progressive Group
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Mild Haemophilia A Without Inhibitor
DDAVP vs. Exercise in Patients With Mild Hemophilia A
Individuals with mild hemophilia A (MHA) bleed infrequently but can in the setting of trauma which often is when participating in sports/exercise.
- Trial name
- NCT03136003
- Testing
- DDAVP, Exercise
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Hypercholesterolemia, Cardiovascular Risk Factor
The Effect of Psyllium Fibre on LDL-C, Non-HDL-C, and Apolioprotein-B: A Systematic Review and Meta-analysis
Serum cholesterol is a major modifiable risk factor for cardiovascular disease, which despite considerable reduction in prevalence, remains the leading cause of premature mortality worldwide.
- Trial name
- NCT03346733
- Testing
- Psyllium Fibre
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Patient Educational Materials
Patient Educational Materials for Prostate Cancer Screening
Although the harms of screening for prostate cancer with the prostate-specific antigen (PSA) test outweigh the benefits, 560,000 Ontario men undergo PSA screening each year.
- Trial name
- NCT03222466
- Testing
- Co-created PEM
- Where
- Canada
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Critically Ill
Screening Elderly Patients for Weaning
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- NCT02243449
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Unity Health Toronto
Critically Ill
Screening Frequency Trial to Identify Weaning Candidates
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- RELEASE (NCT02001220)
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 53 people
- Sponsor
- Unity Health Toronto
Kidney Stones
Narrow Versus Wide Focal Zones for Shock Wave Lithotripsy of Renal Calculi
Shockwave lithotripsy (SWL) is a safe, non-invasive treatment for renal calculi. During SWL energy is focused on in order to break kidney stones and this energy can be varied in size from a narrow (or small) focal zone to a wide…
- Trial name
- NCT01226875
- Testing
- SWL: Shock Wave Lithotripsy Intervention
- Where
- 3 sites in Canada
- Volunteers
- 275 people
- Sponsor
- Unity Health Toronto
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease after minor head trauma, especially in elderly patients. This medical condition is characterized by blood collection in the subdural space, which can result in severe…
- Trial name
- TRACE (NCT03280212)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type 2 Diabetes
Evaluate the Value of Telehomecare for Diabetes
This is a mixed methods study that evaluates the effectiveness of the BlueStar app and its implementation in 3 hospital/health system sites across Ontario.
- Trial name
- NCT02813343
- Testing
- BlueStar app
- Where
- Canada
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
ST Elevation Myocardial Infarction, Coronary Stenting
Revascularization StrategIes for ST Elevation Myocardial Infarction Trial
This study is being conducted in patients with a major heart attack caused by a blocked artery undergoing Percutaneous Coronary Intervention (PCI) to open up the blockage.
- Conditions
- ST Elevation Myocardial Infarction, Coronary Stenting, Primary Angioplasty
- Trial name
- ASSIST-MI (NCT03263468)
- Testing
- Same sitting PCI with complete revascularization, Staged PCI with complete revsacularization >48 hours pf primary PCI
- Volunteers
- 3,520 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus
The Effect of NVFS on GC in Individuals With DM: SR & MA of RCTs
Purpose of Study (The Effect of Non-Viscous Fibre Supplementation on Glycemic Control (NVFS \& GC) in Individuals with Diabetes Mellitus.
- Trial name
- NVFS&GC (NCT03259724)
- Where
- Canada
- Volunteers
- 514 people
- Sponsor
- Unity Health Toronto
Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus)
Effect of Viscous Soluble Fibres on Body Weight
Abstract: Background: Obesity is a global pandemic affects all age groups and is independent risk factors for most chronic diseases. Dietary intervention is an essential component of obesity management.
- Conditions
- Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus), General Population
- Trial name
- NCT03257449
- Testing
- Viscous Fibre
- Where
- Canada
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cough, Larynx
The Efficacy of Capsaicin Sensitivity Testing in Patients With Irritable Larynx Syndrome
Irritable larynx syndrome (ILS) is a hyperkinetic laryngeal dysfunction that is characterized by a persistent cough, voice changes, or breathing difficulties, which are often triggered by an irritant.
- Trial name
- NCT02065128
- Testing
- Capsaicin cough challenge test
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome
Respiratory Mechanics Registry for ARDS Patients
This registry was proposed to investigate the epidemiology of respiratory mechanics in patients with ARDS through collecting data from a QI project which was constituted with systematic assessments of respiratory mechanics and…
- Trial name
- NCT02623192
- Testing
- Patients who have performed the ARDS pulmonary function test
- Where
- 2 sites in Canada, Italy
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto