Clinical trials: sponsored by Unity Health Toronto
Sex Steroids
Effect of Pregnancy on Androgenic Steroids in Different Genetic Panels
Androgens are important sex steroids in women. Androgens influence protein synthesis and muscle growth, are involved in maturation of the reproductive organs, have a fat reducing effect , have a negative effect on the serum lipid…
- Trial name
- NCT03064412
- Testing
- Urine sample collection, Saliva collection
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Voiding Dysfunction After Pelvic Organ Prolapse Surgery
Post-operative Voiding Dysfunction: the Preferred Method for Catheterization
This study is divided into two parts. The first part is a prospective observational study of patients undergoing pelvic organ prolapse (POP) surgery.
- Trial name
- NCT01597544
- Testing
- CISC instruction pre-operatively
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Unity Health Toronto
Stage I-IV Breast Cancer (Neo-adjuvant, Adjuvant, Locally Advanced and Metastatic)
Assessment of Cardiotoxicity by Cardiac Magnetic Resonance (CMR) in Breast Cancer Patients Receiving Trastuzumab
Herceptin has shown significant improvement in breast cancer therapy and improved survival of patients over-expressing the HER-2 protein by 50%.
- Trial name
- NCT01022086
- Testing
- Cardiac MRI, Biomarker Testing
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Obesity
Obesity Heterogeneity Study
The investigators will assess the heterogeneity of obese individuals in the United States to help researchers, clinicians and policymakers to establish goals for obesity treatment and identify whether differing interventions may…
- Trial name
- NCT03155880
- Volunteers
- 1,685 people
- Sponsor
- Unity Health Toronto
Heart Rate, Heart Rate Variability
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
In this study, the pills formulated are being used to try to ameliorate the effect of air pollution on epigenetic changes, specifically DNA methylation, potentially linked with particulate matter air pollution inhalation and…
- Conditions
- Heart Rate, Heart Rate Variability, Inflammation
- Trial name
- EPI-Air (NCT01864824)
- Testing
- methyl donor
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Endoscopy Simulation
Impact of a Simulation-based Training Curriculum of Non-technical Skills on Colonoscopy Performance
The investigators aim to test a curriculum of non-technical skills (NTS) training for simulation-based training of colonoscopy. There is no known literature to date on the optimal approach on how to teach NTS in endoscopy.
- Trial name
- NCT02877420
- Testing
- Non-Technical Skills Training Curriculum, Conventional Simulation Training Group
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Hypercholesterolemia
Magnetic Resonance Imaging-Portfolio Diet Study #7
Presently in Canada, 29% of deaths are due to cardiovascular disease (CVD), costing $20.9 billion annually. The investigators have, therefore, brought together an unique network of investigators at different stages in their…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Diabetes, Metabolic Syndrome
- Trial name
- MRIPD#7 (NCT02078635)
- Testing
- Portfolio Plus Diet, DASH-like (high fibre) dietary advice
- Where
- 4 sites in Canada
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Type 2 Diabetes
Enhanced Multicenter Dietary Portfolio Study
"Is it possible to recruit and retain up to 200 participants in a Randomize Control Trial (RCT) of high impact lifestyle approach of diet and exercise designed to significantly reduce cardiovascular events in middle-aged and…
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes, Hypercholesterolemia
- Trial name
- EDP8 (NCT01954472)
- Testing
- Enhanced portfolio plus structured exercise, High fiber diet plus routine exercise
- Where
- 4 sites in Canada
- Sponsor
- Unity Health Toronto
End-stage Renal Disease, Left Ventricular Hypertrophy
In-Centre Nocturnal Hemodialysis (INHD): A Long-Term Follow-Up Study
Background: In 2010, approximately 39000 Canadians had end-stage renal disease (ESRD), and the prevalence rate of dialysis has increased by 189% over the past 2 decades.
- Trial name
- INHD (NCT02684773)
- Testing
- Conventional Hemodialysis, In-centre Nocturnal Hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency, Ventilator-Induced Lung Injury
APRV/BIPAP With Spontaneous Breathing on Lung Protection
Mechanical ventilation (MV) is a cornerstone of management of acute respiratory failure, but MV per se can provoke ventilator-induced lung injury (VILI), especially in acute respiratory distress syndrome (ARDS).
- Trial name
- APRV/BIPAP (NCT02071277)
- Testing
- Pressure targeted modes
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Immunoglobulins, Intravenous, Hemolysis
Isoagglutinins in the Development of IVIG-associated Hemolysis
Patients at high risk of IVIG-associated hemolysis (defined as receipt of a 28-day cumulative dose of ≥ 2 g/kg, adjusted for ideal body weight, and non-O blood group) will be prospectively monitored using a standardized protocol…
- Trial name
- NCT02259478
- Where
- 6 sites in Canada
- Volunteers
- 144 people
- Sponsor
- Toronto Transfusion Medicine Collaborative
HIV Positive Pregnant Women
Positive Pregnancy Program
The Positive Pregnancy Program is an innovative, unique, interprofessional model of care for HIV-positive pregnant women. This program has been in place at St. Michael's Hospital for five years.
- Trial name
- P3 (NCT03073421)
- Testing
- Qualitative interview
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Coronary Artery Disease
Optimizing Timing of CABG in Patients Presenting With ACS and Treated With Ticagrelor
The administration of Ticagrelor have demonstrated superiority to Clopidogrel in patients presenting with acute coronary syndrome (ACS) and remains a first line therapy as an adjunct to aspirin for patients admitted with ACS.
- Trial name
- CABG-TIME (NCT02627521)
- Testing
- PRU guided CABG, CABG per standard of care, VerifyNow assay
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Unity Health Toronto
Hypertension, Blood Pressure
Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation
Ginseng has been used for many years in a wide array of anecdotal medicinal properties. Animal and limited clinical research points to the vascular effects of Korean Red Ginseng (KRG).
- Conditions
- Hypertension, Blood Pressure, Endothelial Function
- Trial name
- ESGC (NCT00728221)
- Testing
- Korean Red Ginseng, Korean Red Ginseng (Panax ginseng), Cornstarch
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hepatopulmonary Syndrome
A Pilot Study of Norfloxacin for Hepatopulmonary Syndrome
The hepatopulmonary syndrome (HPS)and pre-HPS is a disease seen in patients with chronic liver disease, whereby patients develop dilations in the blood vessels of the lungs, resulting in low oxygen levels and shortness of breath.
- Trial name
- NCT00362752
- Testing
- Norfloxacin
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Unity Health Toronto
Education, Medical, Critical Care Ultrasonography
Focused Cardiac and Lung Ultrasound in Anesthesia/Critical Care - The Role of Self-directed Simulation-assisted Training Compared to a Traditional Supervised Approach
The purpose of this study is to determine whether a self-directed and simulation-based lung ultrasound (LUS) and focused cardiac ultrasound (FCU) curriculum is efficacious on anesthesia trainees' image acquisition skills and…
- Trial name
- NCT01972698
- Testing
- Self-directed and simulation-assisted training, Traditional apprenticeship training
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Myocardial Infarction
Ticagrelor for PCI Post Thrombolysis
Ticagrelor is a first line therapy along with aspirin for patients undergoing primary PCI for STEMI. However, many patients are still treated with fibrinolytic therapy and the safety and efficacy of Ticagrelor has not been…
- Trial name
- SETFAST (NCT01930591)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 5 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
LDL Cholesterol
Effect of Viscous Soluble Fibers on Serum Cholesterol Levels
Research over the past several decades have linked the intake of dietary fiber with lower blood cholesterol levels. The distinction between soluble and insoluble fiber fractions emerged shortly after and there is now a general…
- Trial name
- CHOL-META (NCT02068248)
- Testing
- Soluble Fibre
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV, Human Immunodeficiency Virus
PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5
Canada continues to see an unrelenting stream of new HIV diagnoses, with a disproportionate burden among gay, bisexual, and other MSM in major centers such as Toronto.
- Trial name
- PREP-5 (NCT02149888)
- Testing
- Tenofovir/emtricitabine
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hypertension, Pulmonary
Pulmonary Hypertension: Assessment of Cell Therapy
The primary objective is to establish the safety of autologous progenitor cell-based gene therapy of heNOS in patients with severe Pulmonary Arterial Hypertension(PAH) refractory to conventional treatment.
- Trial name
- PHACeT (NCT00469027)
- Testing
- eNOS transfected EPCs will be delivered via a PA line
- Where
- 2 sites in Canada
- Volunteers
- 7 people
- Sponsor
- Northern Therapeutics