Clinical trials: not yet recruiting
Temporomandibular Joint Internal Derangement, TMJ-ID
Comparing Dextrose Prolotherapy vs. Sodium Hyaluronic Acid Injections for Jaw Joint Internal Derangement
This is a randomized comparative study to evaluate the effectiveness of two intra-articular injections for the management of Temporomandibular Joint (TMJ) internal derangement.
- Conditions
- Temporomandibular Joint Internal Derangement, TMJ-ID, TMPDS, Disc Displacement
- Trial name
- TMJ-ID (NCT07911358)
- Testing
- Dextrose Prolotherapy, Sodium Hyaluronic Acid
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Allama Iqbal Medical College
Myeloid Leukemia
Phase 1/2 FLAG-IDA, VEN and Asciminib in CML and Ph+ AML
The goal of Phase 1b is to establish the safety of asciminib in combination with FLAG-Ida and venetoclax in patients with CML-MBP, CML-LBP, and Ph+ AML.
- Trial name
- NCT07604233
- Testing
- Fludarabine, Cytarabine, Idarubicin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Post-mastectomy Pain Syndrome
Regenerative Peripheral Nerve Interface for Prophylaxis Against Post-Breast Surgery Pain Syndrome
Regenerative peripheral nerve interface (RPNI) was first developed in 2012 by Dr. Paul Cederna at the University of Michigan as a means for amputees to control their prothesis with their minds.
- Trial name
- NCT06580951
- Testing
- Regenerative Peripheral Nerve Interface
- Volunteers
- 200 people
- Sponsor
- George Kokosis
Multiple Myeloma or Plasmacytoma
Engineered Dendritic Cell Vaccines for Multiple Myeloma
The purpose of this study is to determine the feasibility, safety, and efficacy of dendritic cell (DC) vaccines in the treatment of multiple myeloma (MM) or plasmacytoma based on immune-modified DC vaccines (DCvac).
- Trial name
- NCT06435910
- Testing
- DC vaccines
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Exercise Adherence, Healthy Aging
Effectiveness of a Smartphone Chatbot to Improve Exercise Adherence in Older Adults
This randomized controlled trial aims to evaluate the effectiveness of a smartphone-based chatbot in improving adherence to a 12-week home-based multicomponent exercise program in community-dwelling older adults.
- Trial name
- EXEBOT (NCT07832097)
- Testing
- Chatbot-Supported Home-Based Exercise Program, Paper-Based Home Exercise Program Mostrar más líneas
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Dementia
Inpatient Hospice Transitions Checklist
This is an NIH Stage IB single-arm feasibility study will adapt and test the Inpatient Hospice Transitions Checklist (I-HTC), an Epic-embedded intervention supporting hospice eligibility assessment and clinician-surrogate…
- Trial name
- I-HTC (NCT07889830)
- Testing
- I-HTC
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York University
Ureteropelvic Junction Obstruction, Hypospadias
Effect of Oxybutynin on Opioid Use After Urologic Surgery in Children
The goal of this clinical trial is to determine whether giving oxybutynin before urologic reconstruction surgery reduces the amount of opioid pain medication needed in children.
- Trial name
- NCT07911137
- Testing
- Oxybutynin
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block
LBBAP Versus ILR in Patients With New-Onset LBBB and Moderately Reduced LVEF After TAVI
Patients with new-onset complete LBBB (QRS > 120 ms, persisting > 24 h after TAVI) and moderately reduced LVEF (35-50%) will be screened in participating centers.
- Conditions
- TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block, Reduced Left Ventricular Ejection Fraction
- Trial name
- LBB(AP)TAVI (NCT07909239)
- Testing
- Left bundle branch area pacing with pacemaker, Implantation loop recorder
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Clermont-Ferrand
Clinical Competence, Health Communication
Validation of the Healthcare Relationship Assessment Scale (ERA) in Health Sciences Students.
This study aims to design and psychometrically validate a practical and agile observational instrument-the Healthcare Relationship Assessment scale (ERA scale)-to evaluate communication skills and person-centered care among…
- Conditions
- Clinical Competence, Health Communication, Professional-Patient Relations, Patient-Centered Care
- Trial name
- COPS-ERA (NCT07911241)
- Testing
- ERA Scale (Healthcare Relationship Assessment Scale)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidad Loyola Andalucia
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
ECP-DL Cell Infusion for Induction in Living Donor Kidney (LDK) Transplants
This is a phase 1 trial, 36 month duration for subjects with end-stage renal disease (ESRD). The objectives of the trail are1) Determine the safety of ECP-DL cell infusion in living donor renal transplant recipients.
- Trial name
- ECP (NCT07083830)
- Testing
- ECP-DL treated mononuclear cell infusion
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Generalized Anxiety Disorder (GAD)
Temporal Interference Transcranial Alternating Current Stimulation Targeting the BNST or Amygdala for Generalized Anxiety Disorder
This randomized controlled trial will use a three-arm, parallel-group design to evaluate the efficacy and safety of 5-Hz Temporal Interference transcranial Alternating Current Stimulation (TI-tACS) in adults with generalized…
- Trial name
- TIs-GAD (NCT07909200)
- Testing
- Temporal Interference transcranial Alternating Current Stimulation (TI-tACS)
- Where
- 4 sites in China
- Volunteers
- 75 people
- Sponsor
- Central South University
Anxiety, Pain
Mindfulness Intervention on Minimally Invasive Vascular Surgery
The goal of this clinical trial is to learn whether a virtual reality (VR)-based mindfulness intervention can reduce anxiety and pain in adults undergoing minimally invasive surgery for lower-extremity varicose veins under local…
- Conditions
- Anxiety, Pain, Varicose Veins of Lower Limb
- Trial name
- NCT07463638
- Testing
- VR-Based Mindfulness Intervention
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tongji Hospital
Anxiety, Cesarean Section
Virtual Reality for Anxiety and Birth Satisfaction During Elective Cesarean Section
This study will examine whether virtual reality during planned cesarean birth reduces women's anxiety and improves their satisfaction with the birth experience.
- Conditions
- Anxiety, Cesarean Section, Birth Satisfaction
- Trial name
- NCT07908771
- Testing
- Virtual Reality Distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people
- Sponsor
- Tarsus University
Airway Ultrasound, Difficult Airway Management
Title of Study: Anesthesiologists' Learning Curves for Ultrasound Assessment of Difficult Airway
This study aims to determine how many supervised practice attempts anesthesia trainees need to become competent in using ultrasound to assess the airway.
- Conditions
- Airway Ultrasound, Difficult Airway Management, Airway Ultrasonography, Medical Education
- Trial name
- ALUDA (NCT07910071)
- Testing
- Airway Ultrasound Education and Supervised Training
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pancreatic Ductal Adenocarcinoma (PDAC)
A Study of Perioperative Navlimetostat Combined With Modified FOLFIRINOX in Patients With MTAP-Deleted Pancreatic Cancer
The purpose of this study is to assess the safety, feasibility, and recommended dose of navlimetostat (BMS-986504) combined with mFOLFIRINOX before and after surgery in patients with localized pancreatic cancer with MTAP deletion.
- Trial name
- M-POP (NCT07905131)
- Testing
- Navlimetostat, mFOLFIRINOX Treatment Regimen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Daniel Nussbaum, M.D.
Facial Palsy
Deep-plane Facelift As A Staged Adjunct To Facial Reanimation : Functional And Aesthetic Outcomes in Comparison to Facial Reanimation Alone
Long-standing unilateral facial paralysis is a complex functional and aesthetic disorder characterized by impaired facial movement, static asymmetry, and progressive soft-tissue changes.
- Trial name
- NCT07910253
- Testing
- Facial reanimation in patients with facial palsy without deep plane facelift., Deep plane facelift adjunct to facial reanimation in Group 2
- Volunteers
- 4 people
- Sponsor
- Assiut University
Extensive-stage Small Cell Lung Cancer
A Study of TRB191 in Patients With Extensive-stage Small Cell Lung Cancer
The purpose of this study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity (IG) and preliminary anti-tumor activity and to determine a recommended dose (RD) of TRB191 in patients with…
- Trial name
- NCT07908667
- Testing
- TRB191
- Volunteers
- 120 people
- Sponsor
- Novartis Pharmaceuticals
Cervicogenic Headache
Trigger Point Injection and Myofascial Release for Cervicogenic Headache
Cervicogenic headache is a type of headache associated with problems in the neck. This study aims to compare the effects of trigger point injection, myofascial release, and their combination in patients with cervicogenic…
- Trial name
- TPI-MFR-CGH (NCT07910877)
- Testing
- Trigger Point Injection + Home Exercise, Experimental: Myofascial Release + Home Exercise, Combined Trigger Point Injection and Myofascial Release
- Volunteers
- 120 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Anxiety
Pre-Examination Reflexology for Anxiety and Pain During Pelvic Examination
The purpose of this study is to evaluate whether a brief standardized reflexology session administered before the first pelvic examination reduces maternal state anxiety among term pregnant women admitted for induction of labor.
- Trial name
- NCT07910136
- Testing
- Pre-Examination Reflexology
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Goni Sintov
Sarcoma, Osteoid Sarcoma
Combination Immunotherapy Targeting Sarcomas
The aim of this clinical trial is to assess the feasibility, safety and efficacy of a combination low dose chemotherapy and immunotherapy in patients who have sarcoma that is relapsed or late staged.
- Conditions
- Sarcoma, Osteoid Sarcoma, Ewing Sarcoma
- Trial name
- NCT04433221
- Testing
- Multiple sarcoma-specific CAR-T cells and sarcoma vaccines
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
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