Clinical trials: terminated
Advanced EGFR Mutant Non Small Cell LungCancer (NSCLC), KRAS G12-mutant NSCLC
Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors
The purpose of this first in human (FIH) trial was to characterize the safety and tolerability of the SHP2 inhibitor TNO155 alone and in combination with EGF816 (nazartinib) and identify a recommended dose for future studies in…
- Conditions
- Advanced EGFR Mutant Non Small Cell LungCancer (NSCLC), KRAS G12-mutant NSCLC, Esophageal Squamous Cell Cancer (SCC), Head/Neck SCC
- Trial name
- NCT03114319
- Testing
- TNO155, TNO155 in combination with EGF816 (nazartinib)
- Where
- 18 sites in United States, Canada and 7 more
- Volunteers
- 227 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Myeloma
Safety and Efficacy of bb2121 (Ide-cel) Combinations in Multiple Myeloma
This is a global, open-label, multi-arm, multi-cohort, multi-center, phase 1/2 study to determine the safety, tolerability, efficacy, PK of bb2121 in combination with other therapies in adult subjects with R/RMM.
- Trial name
- KarMMa-7 (NCT04855136)
- Testing
- BB2121, CC-220, BMS-986405
- Where
- 17 sites in United States, Spain
- Volunteers
- 21 people
- Sponsor
- Celgene
Celiac Disease
Effect of Intravenous Iron Supplementation on Celiac Disease Remission (IRONCEL)
The study aims is to evaluate the efficacy of intravenous iron supplementation on celiac disease remission (total intestinal mucosal recovery).
- Trial name
- IRONCEL (NCT05114278)
- Testing
- Ferinject, oral iron
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Diseases, Coronary Artery Disease
Senescence in Myocardial Infarction
The investigators of this study have found that after a heart attack, some heart cells rapidly age (become senescent) and release proteins that make the heart disease worse.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Aging, Atherosclerosis
- Trial name
- SMI (NCT07693712)
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Ovarian Cancer, Lung Cancer
A Phase I Study of [177Lu]Lu-EVS459 in Patients With Ovarian and Lung Cancers
The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of [177Lu]Lu-EVS459 and the safety and imaging properties of [68Ga]Ga-EVS459 in patients aged ≥ 18 years with advanced…
- Trial name
- NCT06376253
- Testing
- [68Ga]Ga-EVS459, [177Lu]Lu-EVS459
- Where
- Israel
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy, Diabetic Macular Edema
Evaluation of NeoRetina Artificial Intelligence Algorithm for the Screening of Diabetic Retinopathy at the CHUM
This prospective study aims to validate if NeoRetina, an artificial intelligence algorithm developped by DIAGNOS Inc. and trained to automatically detect the presence of diabetic retinopathy (DR) by the analysis of macula…
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, Diabetic Maculopathy
- Trial name
- DR-NeoRetina (NCT04699864)
- Testing
- Screening of DR and DME with artificial intelligence using NeoRetina, Routine ophthalmological evaluation of DR and DME, Manual grading of DR and DME by CHUM ophthalmologists based on retinal photographies acquired by Diagnos
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Metastatic Solid Tumors, Advanced Non-squamous Non-small-cell Lung Cancer
A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplification
This is a first-in-human (FIH), open-label, multicenter, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BGB-53038 as…
- Conditions
- Metastatic Solid Tumors, Advanced Non-squamous Non-small-cell Lung Cancer, Advanced Colorectal Cancer, Advanced Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06585488
- Testing
- BGB-53038, Tislelizumab, Cetuximab
- Where
- 17 sites in United States, Australia and 3 more
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- BeOne Medicines
Endometrial Cancer
The UPPROACH (Upfront Intensity Modulated Proton Beam Therapy) Approach
A phase 2 study with the primary objective of testing treatment compliance of Upfront Intensity Modulated Proton Beam Therapy (IMPT) and Concurrent Chemotherapy (UPPROACH) for Post-operative Treatment in Loco-regionally Advanced…
- Trial name
- NCT04527900
- Testing
- carboplatin and paclitaxel, pelvic IMPT (Intensity Modulated Proton Therapy)
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- University of Maryland, Baltimore
Lysosomal Acid Lipase Deficiency
Lysosomal Acid Lipase Deficiency in Risk Groups
A multicenter real-world observational study of the prevalence, diagnostic pathways, and clinical characteristics of lysosomal acid lipase deficiency in pediatric and adolescent risk groups in the Russian Federation (HELIOS)
- Trial name
- HELIOS (NCT07455864)
- Where
- 2 sites in Russia
- Volunteers
- 25 people
- Sponsor
- AstraZeneca
Hepatocellular Carcinoma
Clinical Investigation Evaluating Safety and Efficacy of Selective Intra-arterial 166Holmium Radiation Therapy in Combination With Atezolizumab and Bevacizumab for Non Resectable Hepatocellular Carcinoma
The goal of this clinical trial is to evaluate the added value of 166Holmium SIRT to Atezolizumab-Bevacizumab in patients with non resectable HCC.
- Trial name
- HOLMBRAVE (NCT05705791)
- Testing
- QuiremSpheres
- Where
- 6 sites in France
- Volunteers
- 10 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
HIV, Tuberculosis
Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST Study
The purpose of this study was to compare a 3-month rifapentine (RPT)/clofazimine (CFZ)-containing regimen with a CFZ loading dose with the 6-month standard of care (SOC) regimen for drug-susceptible (DS) tuberculosis (TB).
- Trial name
- NCT04311502
- Testing
- Rifapentine, Rifampicin, Isoniazid
- Where
- 6 sites in Haiti, India and 3 more
- Volunteers
- 104 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rib Fractures
Lidocaine Patches in Elderly Patients With Traumatic Rib Fractures
Many patients are prescribed lidocaine patches for rib fractures despite mixed evidence to their efficacy. The outcome of this trial offers significant benefit to patient care if it finds benefit of their use or if it does not.
- Trial name
- NCT05714631
- Testing
- 4% Lidocaine Patch
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Atrial Fibrillation, Stroke
"Cryptogenic Stroke and Atrial Fibrillation Detection Through Implantable Loop Recorder (ILR)"
STUDY TYPE: Prospective, national , multicenter, and observational study. OBJECTIVE: To assess the incidence of AF in patients with cryptogenic stroke who have implanted an AF detection device during a period of 2 years.
- Trial name
- CRYPTONITE (NCT01025947)
- Where
- 2 sites in Spain
- Volunteers
- 100 people
- Sponsor
- University of Valencia
Neurofibroma
Non-interventional Study of Patients With PN NF1 Starting Selumetinib in Russia
The purpose of this study is to evaluate the effectiveness, safety of selumetinib and patient's parameters of symptomatic inoperable PN NF1 in real clinical practice in Russia
- Trial name
- NCT05891847
- Where
- 5 sites in Russia
- Volunteers
- 150 people
- Sponsor
- AstraZeneca
Cancer
A Geriatric Assessment Electronic Platform for Older Patients With Cancer (eGAP - Electronic Geriatric Assessment Platform)
This project assesses the feasibility and usability of the geriatric assessment platform (electronic Geriatric Assessment Platform or eGAP in 50 older patients with cancer, their caregivers, and their oncology team.
- Trial name
- eGAP (NCT04824859)
- Testing
- Behavioral
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Rochester
Nephrolithiasis
Massage Percussion for Passage of Urolithiasis Fragments After Ureteroscopy.
Flexible ureteroscopy is characterized as first-line therapy for renal stones < 2 cm in size. Stones are commonly treated with dusting or fragmentation techniques which requires passage of stone fragments after surgery.
- Trial name
- NCT05872230
- Testing
- Massage Percussion Therapy device
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Unresectable Locally Advanced or Metastatic Cancer
First-in-Human Study of TAK-280 in Participants With Solid Tumors
The main aim of this study is to find out the safety, tolerability, and effect of TAK- 280 in participants with unresectable, locally advanced or metastatic cancer who have experienced treatment failure or are intolerant to…
- Trial name
- NCT05220098
- Testing
- TAK-280
- Where
- 23 sites in United States, Australia and 2 more
- Volunteers
- 69 people
- Sponsor
- Takeda
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Nab-paclitaxel and Alpelisib for the Treatment of Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations
This phase II trial studies how well nab-paclitaxel and alpelisib works in treating patients with triple negative breast cancer with PIK3CA or PTEN alterations that does not respond to anthracycline chemotherapy (anthrocycline…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT04216472
- Testing
- Alpelisib, Nab-paclitaxel
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Gastro-oesophageal Reflux Disease
Osteopathic Manipulative Treatment for Gastro-oesophageal Reflux Disease
To evaluate the effects of osteopathic manipulative treatment in patients affected by symptoms related to gastro-oesophageal reflux disease (GERD)
- Trial name
- NCT06317675
- Testing
- Osteopathic manipulative treatment (OMT)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Studio Osteopatico Busto Arsizio
Solid Tumors
A Study of TAK-103 in Adult With Solid Tumors
In this study, people with mesothelin-expressing advanced or metastatic solid tumors will receive TAK-103 with their white blood cells.
- Trial name
- NCT05164666
- Testing
- TAK-103
- Where
- 3 sites in Japan
- Volunteers
- 2 people
- Sponsor
- Takeda