Clinical trials: sponsored by Unity Health Toronto
Blood Pressure
Effect of Ginseng on Blood Pressure
To determine the effect of ginseng on blood pressure control.
- Trial name
- NCT01913210
- Testing
- Ginseng
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Blood Pressure
Effects of Soluble Fiber on Blood Pressure: A Meta-analysis of Randomly-controlled Trials
The present study conducted a meta-analysis of 22 randomly controlled trials to assess the effects of soluble fiber intake on blood pressure in human subjects.
- Trial name
- NCT02670967
- Testing
- Soluble Fibre
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Epiretinal Membrane
Topical Use of Corticosteroid to Prevent Epiretinal Membrane Following Retinal Tear
In this prospective randomized controlled double blind pilot clinical study, we aim to assess whether administration of a topical corticosteroid would attenuate epiretinal membrane formation following development of retinal tears…
- Trial name
- NCT02412059
- Testing
- Prednisolone acetate
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Heart Failure
Evaluating Teach Back as a Method for Improving Self-Care Behaviours in Heart Failure Patients
Patient education using Teach Back has the potential to increase self-care behaviour in heart failure (HF) patients and reduce adverse clinical outcomes.
- Trial name
- NCT01311583
- Testing
- Teach Back method of patient discharge teaching
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
Diabetic Macular Edema
Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study
Diabetic macular edema refers to swelling (fluid accumulation) in the center of the retina. The retina is like the film of a camera and is located in the back of the eye.
- Trial name
- NCT02651168
- Testing
- aflibercept
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Epiretinal Membrane, Macular Edema
A Pilot Study of the Effectiveness of Intra-operative Ozurdex® in Vitrectomy Surgery for Epiretinal Membranes
To determine if an intravitreal sustained release dexamethasone implant (Ozurdex®) injected at the conclusion of surgery in patients undergoing vitrectomy and membrane peeling for idiopathic epiretinal membranes is safe and…
- Trial name
- NCT01701518
- Testing
- Ozurdex
- Where
- 2 sites in Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Anterior Cruciate Ligament Reconstruction
Transtibial Versus Anteromedial Femoral Tunnel Technique in ACL Reconstruction
The anteromedial (AM) portal technique was introduced to position the femoral tunnel in anterior cruciate ligament (ACL) reconstruction to more closely replicate the original footprint compared to the transtibial (TT)…
- Trial name
- NCT02633410
- Testing
- Femoral tunnel creation
- Volunteers
- 96 people
- Sponsor
- Panam Clinic
Acute Stroke
The CLOQS Trial - Countdown Lights to Optimize Quality in Stroke
To reduce door-to-needle times in acute stroke treatment. Using an organizational behaviour intervention (a large stopwatch), we will post a visual cue to remind all parties that "time is brain".
- Trial name
- CLOQS (NCT01148602)
- Testing
- LED stopwatch-clock timers
- Where
- 3 sites in Canada
- Volunteers
- 3,452 people
- Sponsor
- Sunnybrook Health Sciences Centre
Heart Disease, Diabetes
Fruits, Vegetables, and Whole Grains: A Community-based Intervention
The aim of this study is to see if the investigators can encourage people to eat more fruits, vegetables and whole grains and drink less pop by giving them advice about their diet, or by providing them with samples of different…
- Conditions
- Heart Disease, Diabetes, Hypertension
- Trial name
- NCT00516620
- Testing
- No further instruction, Food Delivery, Fruits (F), vegetables (V), and whole grain (WG) counseling
- Where
- Canada
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Peripheral Vascular Disease Patient
Multi-spectral Imaging to Assess Wounds in Peripheral Vascular Disease Patients
Peripheral vascular disease (PVD) is a common disease of impaired blood flow resulting in the compromised tissue perfusion of lower limbs.
- Trial name
- NCT02624674
- Testing
- Multi-spectral Imaging Device (MSID)
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
TBI (Traumatic Brain Injury), Acute Brain Injuries
Study of Cerebral Tissue Oxygenation During Transfusion in Traumatic Brain Injury
This proposal aims to provide some objective, non-invasively achieved, physiologically relevant data in order to provide some rational basis for decision-making for transfusion in sTBI.
- Trial name
- NIRSTBI (NCT01728831)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Hyperglycemia, Postprandial
Effect of Salba & Flax on Postprandial Glycemia and Subjective Satiety
The purpose of this study is to determine whether drinks containing Salvia hispanica L (Salba) or Flax lower postprandial blood glucose levels and improve appetite in healthy individuals.
- Trial name
- NCT02621307
- Testing
- Salba, Flax, Control
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Urinary Tract Infections
Factorial Trial of Antimicrobial Therapy and/or Catheter Change for Catheter Urinary Tract Infections.
Urinary tract infection (UTI) is a common infection in patients in the intensive care unit (ICU) that increases length of stay but not mortality. It is not known whether antibiotic treatment will alter outcomes.
- Trial name
- CAUTION (NCT00795470)
- Testing
- Antimicrobial, Catheter change
- Where
- Canada
- Sponsor
- Unity Health Toronto
Postoperative Nausea and Vomiting
Study of Prevention of Postoperative Nausea and Vomiting Using Cesamet
Untreated, one third of patients undergoing general anesthesia will have postoperative nausea, vomiting, or both. Patients often rate postoperative nausea and vomiting (PONV) as worse than postoperative pain.
- Trial name
- Cesamet (NCT02115529)
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 331 people
- Sponsor
- Unity Health Toronto
Human Immunodeficiency Virus, HIV
Nevirapine Dosing in Neonates for Prophylaxis of Mother-to-Child-Transmission (MTCT) of HIV Infection
The purpose of this study is to determine whether the current dose of nevirapine recommended in the Ontario Ministry of Health vertical transmission prevention protocol achieves therapeutic drug levels in newborn infants at high…
- Conditions
- Human Immunodeficiency Virus, HIV, Vertical Infection Transmission
- Trial name
- NCT02166502
- Where
- 2 sites in Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Multiple Sclerosis
Regional Cortical Cerebral Quantitative MRI Perfusion Correlation Neurocognition in Multiple Sclerosis
Multiple Sclerosis (MS) is a common disease affecting 1/1000 Canadians. Cognition impairment is reported in 40-65% of patients and is socially and functionally disabling.
- Trial name
- NCT00812474
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Screening for Partner Violence
Computer-assisted Screening for Intimate Partner Violence in Family Practice
This study tested the effectiveness of computer-assisted screening for identifying patients at risk of intimate partner violence (IPV) in a Canadian family practice.
- Trial name
- NCT00385034
- Testing
- Interactive computer based health-risk survey before doctor's visit
- Where
- Canada
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Education, Simulation
Developing a Curriculum to Teach Laparoscopic Colorectal Surgery
Although a significant amount of work has been done to validate simulators as viable systems to teach technical skills outside the operating room, the next necessary step is to integrate simulator training into a comprehensive…
- Conditions
- Education, Simulation, Technical Skills Training, Laparoscopy
- Trial name
- NCT01371136
- Testing
- curricular training
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Obesity
Design and Validation of a Simulation-based Training Curriculum for Laparoscopic Bariatric Surgery
Laparoscopic bariatric surgery is an advanced laparoscopic procedure with a potential for significant morbidity and mortality along the early part of a surgeon's learning curve.
- Trial name
- NCT01610466
- Testing
- Laparoscopic bariatric surgery ex-vivo training curriculum
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Education, Laparoscopic Surgery
Comprehensive Laparoscopic Curriculum for Medical Students
Laparoscopic surgery has become the standard approach to a vast variety of surgical procedures. Due factors such as 2D- to 3D conversion, reduced tactile sensation, amplification of tremor and fulcrum effect of the abdominal…
- Trial name
- NCT01857180
- Testing
- Curriculum
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto