Clinical trials: sponsored by Alcon Research
Myopia
A Prospective Study of Two Daily Disposable Contact Lenses
The purpose of this study was to evaluate the performance of a novel silicone hydrogel contact lens, DAILIES TOTAL1® (DT1) compared to the standard hydrogel material in 1-DAY ACUVUE® MOIST® (1DAVM) contact lens in contact lens…
- Trial name
- NCT01636986
- Testing
- Delefilcon A contact lenses, Etafilcon A contact lenses
- Volunteers
- 62 people
- Sponsor
- Alcon Research
Glaucoma
A Comparison of Azopt Versus Placebo Added to Xalatan in Patients With Elevated Intraocular Pressure (IOP) on a Prostaglandin
The purpose of this study was to assess the efficacy of adding Azopt dosed three times a day to Xalatan as compared to that of adding placebo to Xalatan in patients with elevated intraocular pressure.
- Trial name
- NCT00759941
- Testing
- Brinzolamide 1% ophthalmic solution (Azopt), Latanoprost 0.005% ophthalmic solution (Xalatan)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Alcon Research
Myopia
Clinical Evaluation of Two Daily Disposable Silicone Hydrogel Contact Lenses
The purpose of this crossover study was to evaluate the end-of-day comfort of two commercially available, daily disposable, silicone hydrogel contact lenses.
- Trial name
- NCT01561560
- Testing
- Delefilcon A contact lenses, Narafilcon A contact lenses
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Alcon Research
Dry Eye
The Effect of SYSTANE® BALANCE on Tear Film Break Up Time in Dry Eye Subjects
The purpose of this study was to evaluate the ability of SYSTANE® BALANCE dosed 4 times a day for 30 days to increase non-invasive tear film break up time over baseline, compared to a saline control, in dry eye subjects with…
- Trial name
- NCT01718028
- Testing
- Propylene glycol 0.6% ocular emulsion, Sodium chloride 0.9% saline solution
- Where
- Argentina
- Volunteers
- 51 people
- Sponsor
- Alcon Research
Myopia
Clinical Evaluation of Two Daily Disposable Silicone Hydrogel Contact Lenses
The purpose of this study was to compare the subjective performance of DAILIES TOTAL1® daily disposable contact lenses to that of 1-DAY ACUVUE® TruEye® daily disposable contact lenses.
- Trial name
- NCT01634659
- Testing
- Delefilcon A contact lenses (DAILIES TOTAL1®), Narafilcon B contact lenses (1-DAY ACUVUE® TruEye®)
- Volunteers
- 330 people
- Sponsor
- Alcon Research
Myopia, Astigmatism
Daily Disposable Toric Comparative Trial in Europe
The purpose of this study is to investigate the subjective and objective performance of two daily disposable lenses for wearers with astigmatism.
- Trial name
- NCT01070381
- Testing
- nelfilcon A contact lens, ocufilcon D contact lens
- Volunteers
- 220 people
- Sponsor
- CIBA VISION
Acute Otitis Externa
Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa
The purpose of this study was to demonstrate superiority of AL-60371 relative to Vehicle based on clinical cures at test-of-cure (TOC) for the treatment of acute otitis externa (AOE).
- Trial name
- NCT01535560
- Testing
- AL-60371, 0.3% otic suspension, AL-60371 Vehicle
- Volunteers
- 589 people
- Sponsor
- Alcon Research
Dry Eye Syndrome, Myopia
Clinical Evaluation of a Daily Disposable Contact Lens in Symptomatic Weekly/Monthly Lens Wearers
The purpose of this study was to evaluate the reduction of contact lens-related dryness symptoms when symptomatic weekly/monthly contact lens wearers were switched to DAILIES® AquaComfort Plus® lenses for a two-week period using…
- Trial name
- NCT01614600
- Testing
- Nelfilcon A contact lenses
- Volunteers
- 88 people
- Sponsor
- Alcon Research
Refractive Error
Multi-Center Clinical Evaluation of Two Daily Disposable Contact Lenses (Study 2)
The purpose of this study is to compare the subjective performance of two daily disposable contact lenses with respect to comfort and handling.
- Trial name
- NCT01917162
- Testing
- Nelfilcon A contact lens, UltraFilcon B contact lens
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- Alcon Research
Cataract
A Comparison of Aspheric Toric Intraocular Lens (IOL) Implantation Versus Aspheric Non-Toric Lens Implantation
The purpose of this study was to evaluate and compare uncorrected distance visual acuity measurement in pseudophakic subjects with bilateral implantation of an AcrySof IQ Toric Intraocular Lens (IOL) versus bilateral implantation…
- Trial name
- NCT01225926
- Testing
- Toric T3 - T9, IQ SN60WF
- Volunteers
- 24 people
- Sponsor
- Alcon Research
Open-angle Glaucoma, Ocular Hypertension
Safety and Intraocular Pressure (IOP) Lowering Effect of AL-59412C
The purpose of this study was to assess the safety and efficacy of AL-59412C injected intravitreally relative to Vehicle.
- Trial name
- NCT01312454
- Testing
- AL-59412C injectable solution, Travoprost injectable solution, AL-59412C Vehicle
- Volunteers
- 4 people
- Sponsor
- Alcon Research
Glaucoma
Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on COMBIGAN® (Brimonidine 0.2%/Timolol 0.5% Fixed Combination) Therapy in Brazil
The purpose of this study was to assess the efficacy and tolerability of changing to AZARGA® from prior COMBIGAN® pharmacotherapy in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT01514734
- Testing
- Brinzolamide/timolol maleate fixed combination
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- Alcon Research
Open-Angle Glaucoma, Ocular Hypertension
Travoprost 3-Month Safety and Efficacy Study
The purpose of this study was to demonstrate that the intraocular pressure-lowering efficacy of Travoprost 0.003% is equivalent to TRAVATAN® in adult patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT01453855
- Testing
- Travoprost ophthalmic solution, 0.003%, Travoprost ophthalmic solution, 0.004%
- Volunteers
- 1,099 people
- Sponsor
- Alcon Research
Myopia, Astigmatism
Prospective Study of an Investigational Toric Soft Contact Lens
The purpose of this study was to demonstrate substantial equivalence of an investigational toric soft contact lens to the commercially available Focus® DAILIES® Toric soft contact lens when worn in a daily wear, daily disposable…
- Conditions
- Myopia, Astigmatism, Refractive Error
- Trial name
- NCT01461811
- Testing
- Nelfilcon A toric contact lenses (with comfort additives), Nelfilcon A toric contact lenses
- Volunteers
- 154 people
- Sponsor
- CIBA VISION
Contact Lens Care
Evaluation of Marketed Contact Lens Disinfectant Systems on Eyelid Tissues
The purpose of this study was to assess and compare the effect of the repeated usage of two different contact lens care systems (one hydrogen peroxide-based cleaning and disinfecting system, and one polyaminopropyl biguanide…
- Trial name
- NCT01494818
- Testing
- Hydrogen peroxide-based contact lens care system, PHMB-containing contact lens solution, Soft contact lenses
- Volunteers
- 79 people
- Sponsor
- Alcon Research
Myopia
A Lifestyle Investigation With Spectacles and Daily Disposable Contact Lenses in Young Patients
The purpose of this study was to evaluate the relative benefits of daily disposable contact lenses versus spectacles in young adults.
- Trial name
- NCT01445652
- Testing
- nelfilcon A contact lens, Spectacles
- Where
- United Kingdom
- Volunteers
- 113 people
- Sponsor
- CIBA VISION
Macular Degeneration
Open-Label Posterior Juxtascleral Injections of Anecortave Acetate 15mg Dose for Long Term Use in Patients With AMD
The purpose of this study is to investigate the long-term efficacy and safety of posterior juxtascleral injections of open label Anecortave Acetate 15mg administered every 6 months.
- Trial name
- NCT00065728
- Testing
- Anecortave Acetate (AL-3789) Sterile Suspension, 30 mg/mL
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Alcon Research
Glaucoma, Ocular Hypertension
Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-Angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN® Z) or Bimatoprost 0.01% (LUMIGAN®)
The purpose of this study was to assess efficacy and tolerability of travoprost 0.004% vs. bimatoprost 0.01% during the after office hour period (4 pm to 8 pm) in subjects with open-angle glaucoma or ocular hypertension after 6…
- Conditions
- Glaucoma, Ocular Hypertension, Open-Angle Glaucoma
- Trial name
- NCT01464424
- Testing
- Travoprost 0.004% ophthalmic solution, Bimatoprost 0.01% ophthalmic solution
- Volunteers
- 84 people
- Sponsor
- Alcon Research
Cataract
Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients
The purpose of this study was to determine the moxifloxacin aqueous penetration when dosing with a combination drug Vigadexa preoperatively in cataract patients.
- Trial name
- NCT01859702
- Testing
- Moxifloxacin 0.5%/Dexamethasone 0.1% ophthalmic solution
- Volunteers
- 36 people
- Sponsor
- Alcon Research
Myopia
Performance Evaluation of DAILIES® TOTAL1™ in First Time Contact Lens Wearers
The purpose of this study was to evaluate the performance of DAILIES® TOTAL1™ in first time contact lens wearers.
- Trial name
- NCT01494545
- Testing
- Delefilcon A contact lens
- Volunteers
- 102 people
- Sponsor
- Alcon Research