Clinical trials: sponsored by Unity Health Toronto
Crisis Resource Management
Peer Debriefing Versus Instructor Debriefing for Interprofessional Simulation Based Education
Crisis management is important for operating room practice and non-technical skills are acknowledged as key to ensure patient safety in these situations.
- Trial name
- PICS (NCT01067378)
- Testing
- Peer-led debriefing, Expert instructor debriefing
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Ischemic Stroke
Efficacy of Virtual Reality Exercises in STroke Rehabilitation: A Multicentre Study (EVREST Multicentre)
A multicentre, randomized, two parallel group study comparing virtual reality using Wii gaming technology versus Recreational activities in patients receiving conventional rehabilitation after an ischemic stroke.
- Trial name
- NCT01406912
- Testing
- Recreational Activity, Wii Gaming System Arm
- Where
- 13 sites in Argentina, Brazil and 3 more
- Volunteers
- 141 people
- Sponsor
- Unity Health Toronto
Diabetic Foot
Can Topical Oxygen Therapy (Natrox™) Improve Wound Healing in Diabetic Foot Ulcers?
Diabetic foot complications care represent a significant burden to the Canadian healthcare system. The estimated annual expenditure in Canada for diabetic foot ulcers is more than $150 million.
- Trial name
- NCT02599805
- Testing
- Natrox™ Oxygen Delivery System (ODS)
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Diabetes Mellitus, Type 1
Pharmacokinetics Study of Gamma-aminobutyric Acid
The purpose of this study is to determine upon administering GABA orally to a person how it is absorbed, distributed, as well as the drug's pharmacological effects on the body such as glucose levels, serum C-peptide and/or…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Diseases
- Trial name
- GABA-PK (NCT01917760)
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
End-stage Renal Disease, Left Ventricular Hypertrophy
Impact of In-centre Nocturnal Hemodialysis on Ventricular Remodeling and Function in End-stage Renal Disease
Background: Recent data indicate that home nocturnal hemodialysis (8 hours of hemodialysis at home for 5-6 nights per week) may have substantial cardiovascular benefits, including regression of left ventricular (LV) hypertrophy…
- Trial name
- NCT00718848
- Testing
- Incentre nocturnal hemodialysis, Remaining on conventional hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Congestive Heart Failure
Improvement of Patients With Chronic Heart Failure Using NT-proBNP
This will be a multicentre Phase IV study in which patients with chronic HF who are managed and followed by HF/heart functions clinics will be followed over a period of two years.
- Trial name
- EXIMPROVECHF (NCT00601679)
- Testing
- NT-proBNP guided care
- Where
- 2 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Coronary Heart Disease, Congestive Heart Failure
Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with coronary heart disease and LVEF < 40%.
- Conditions
- Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction, Low Cardiac Output
- Trial name
- SMART-ICD (NCT00524862)
- Testing
- Optimized medical therapy, Implantable Cardioverter Defibrillator
- Where
- 10 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Unity Health Toronto
Hypertension
The Evaluation and Standardization of Ginseng and Its Components for Blood Pressure Regulation
While the use of herbals is increasing considerably, their efficacy and safety in the humans remains largely unknown. This surge in demand prompts a call for its evaluation.
- Trial name
- NCT00730951
- Testing
- Korean Red Ginseng, Corn Starch
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus Type 2
Metabolic and Therapeutic Effects of American and Korean Red Ginseng in the Treatment of Type 2 Diabetes
The study is a 2 phase double blind randomized placebo control trial. The objective is to asses the metabolic and therapeutic effects of American Ginseng (Panax quinquefolius L.) extract and Korean Red Ginseng (steamed Panax C.A.
- Trial name
- NCT00728403
- Testing
- American Ginseng (Panax quinquefolius L.) and Korean Red Ginseng (steamed Panax C.A. Meyer), American Ginseng (Panax quinquefolius L.), Wheat Bran
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Kidney Stones
A Randomized Study of Whether Alfuzosin(Xatral) Helps in the Passage of Kidney Stones
Patients who present for the first time to Emergency Room with renal colic due to a distal ureteral calculus (as diagnosed with spiral CT scan and KUB) will be randomized to receive Xatral 10mg po once a day or placebo once…
- Trial name
- NCT00583258
- Testing
- Alfuzosin (Xatral)
- Where
- Canada
- Sponsor
- Unity Health Toronto
Cardiac Surgery
Transfusion Triggers in Cardiac Surgery
A high proportion of patients having cardiac surgery receive red cell transfusions. Yet, the investigators do not know whether transfusions are beneficial and they may be associated with harm.
- Trial name
- TTRICS (NCT00470444)
- Testing
- Transfusion with Red Blood Cells, 1 unit of donated red blood cells
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Pulmonary Hypertension
Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery?
Post-operative pulmonary hypertension is a risk factor for right ventricular failure and an increasing cause of morbidity and mortality in patients undergoing high-risk cardiac surgery.
- Trial name
- NCT00334490
- Testing
- Sildenafil
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Pituitary Neoplasms, Prolactinoma
Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools
The purpose of this research study is to determine the utility of educational materials designed to inform patients of their pituitary condition, in an effort to assist the patients, families, and staff deal with pituitary…
- Conditions
- Pituitary Neoplasms, Prolactinoma, ACTH-Secreting Pituitary Adenoma, Gigantism
- Trial name
- NCT01775332
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
End-stage Renal Disease
Two phosphAte taRGets in End-stage Renal Disease Trial (TARGET)
Patients with end-stage renal disease (ESRD) who have elevated serum phosphate (P) levels have significantly higher mortality rates compared to those with normal P.
- Trial name
- TARGET (NCT01994733)
- Testing
- Calcium carbonate ( Intensive phosphate control), Calcium carbonate (Liberalized phosphate control)
- Where
- 5 sites in Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Infectious Disease, Cardiovascular Disease
Promoting Evidence-Based Decision-Making in India: District Evaluation Study on Health
The purpose of this study is to assess the impact of disseminating information on comparative performance, along with actionable messages on how to improve health outcomes, to district-level decision-makers in India using a…
- Trial name
- DESH (NCT01003587)
- Testing
- District health information package
- Where
- 2 sites in Canada, India
- Volunteers
- 594 people
- Sponsor
- Unity Health Toronto
Cardiac Arrest
The Strategies for Post Arrest Resuscitation and Care Network
Background: One of the 2010 Impact Goals of the Emergency Cardiac Care (ECC) Committee of the American Heart Association is to double survival from cardiac arrest.
- Trial name
- SPARC (NCT00683683)
- Testing
- Knowledge Translation
- Volunteers
- 32 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
A Diaphragmatic Electrical Activity Based Optimization Strategy During Pressure Support Ventilation
Pressure support (PS) is a commonly used mode of ventilation which is triggered based upon the patient's own inspiratory efforts. For the most part, pressure support is well tolerated by patients.
- Trial name
- NCT02067403
- Testing
- Pressure-support Eadi optimization
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis Pulmonary Exacerbation
Pharmacokinetic Study of Extended Infusion Meropenem in Adult Cystic Fibrosis Patients
Meropenem is an intravenous antibiotic commonly used to treat acute exacerbation of respiratory infections in cystic fibrosis. The research study aims to determine if a different method of infusing the drug over 3 hours or…
- Trial name
- NCT01158937
- Testing
- Meropenem Infusion
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Unity Health Toronto
Surgical Technical Skill, Technical Errors in Surgery
Comprehensive Surgical Coaching
Simulation in surgical skills training is widely accepted as a necessary step to improve surgical training outside the operating room. Simulation predominately focuses on teaching a specific task or procedure.
- Trial name
- NCT01875679
- Testing
- Comprehensive Surgical Coaching, Conventional Surgical Training
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Kidney Stone
The Effect of Ureteric Stent Tethers on Patient Symptoms and Urinary Infection
RESEARCH QUESTION Do ureteric stents with tethers, left in-situ for 1-2 weeks, increase the rate of stent bacterial colonization, urinary bacterial colonization and stent related lower urinary tract symptoms compared to stents…
- Trial name
- NCT01812772
- Testing
- Double J-stent with a long tether, Double J-stent without a long tether
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto