Clinical trials: sponsored by Unity Health Toronto
Alcohol Addiction, Opiate Addiction
Effectiveness of a Hospital Addiction Service in Treating Opioid and Alcohol Addiction
Hypothesis: Patients who are addicted to opioids or alcohol will have reduced substance use, health care utilization if they have immediate and convenient access to pharmacotherapy and addiction counselling.
- Trial name
- H-SOAP (NCT01934751)
- Testing
- Delayed Intervention (DI), Rapid Intervention (RI)
- Where
- Canada
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Diabetes Mellitus, Cardiovascular Disease
Evaluation of a Toolkit to Improve Cardiovascular Disease Screening and Treatment for People With Type 2 Diabetes
Diabetes is a common and serious chronic disease. However, there is a large gap between the level of care that people should receive (based on research and guidelines) and the level of care they actually receive.
- Trial name
- NCT01026688
- Testing
- Toolkit, Control
- Where
- Canada
- Volunteers
- 1,592 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cystic Fibrosis, Vitamin D Deficiency
Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients
The main aim of the research question to test the primary hypothesis of this study, namely, Does 12 weeks of an additional 5000 IU daily of cholecalciferol increase serum 25OHD levels in adults with Cystic Fibrosis (CF) who have…
- Trial name
- NCT00685971
- Testing
- 5000 IU of cholecalciferol
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Chronic Kidney Disease
The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis
Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality.
- Trial name
- NCT01844882
- Volunteers
- 1 people
- Sponsor
- Unity Health Toronto
Real Function Post Conversion From Prograf to Advagraf, Examin Ethnicity and Pharmacogenetics of the Cohort Requiring Dose Adjustment Post-conversion
Renal Function and Pharmacogenetics in Renal Transplant Recipients Converted From Tac BID to Tac OD
In Kidney transplant recipients Once daily Tacrolimus has the poteb]ntial advantage of better adnerence, and perhpas improvement in reanl function compred with the twice daily tacrolimus formulation.
- Trial name
- NCT01884480
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Malabsorption; Carbohydrate, Ileostomy - Stoma
Digestibility of Selected Resistant Starches in Humans
Dietary fiber is a type of carbohydrate which is not digested in the human small intestine. Whole grains are a source of dietary fiber that are used to promote health; however, using whole grains in commercial products results in…
- Trial name
- NCT01939600
- Testing
- Starch-free breakfast, Hi-Maize 260, Hylon VII
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Unity Health Toronto
Mental Health
Coordinated Access to Care From Hospital Emergency Departments
The study will assess the effectiveness and cost-effectiveness of providing brief, intensive case management for frequent users of hospital Emergency Departments who have mental health and/or addictions problems.
- Trial name
- CATCH-ED (NCT01622244)
- Testing
- Co-ordinated Access to Care from Hospital Emergency Departments, Coordinated Access to Care from Hospital Emergency Departments, Counseling and Resource Education
- Where
- 2 sites in Canada
- Volunteers
- 166 people
- Sponsor
- Unity Health Toronto
Pregnancy, Maternal Nutrition
Effects of Maternal Folate and Folic Acid Supplementation on DNA Methylation in the Newborn Infant
An overwhelming body of evidence of the protective effect of folic acid supplementation on neural tube defect affected pregnancies led to mandatory folic acid fortification in Canada in 1998.
- Conditions
- Pregnancy, Maternal Nutrition, Fetal Health, Epigenetics
- Trial name
- NCT02244684
- Where
- Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Kidney Injury
Standard Versus Accelerated Initiation of Dialysis in Acute Kidney Injury
The objectives of this trial are to determine whether, in critically ill patients with severe acute kidney injury (AKI), randomization to accelerated initiation of renal replacement therapy (RRT), compared with standard…
- Trial name
- STARRT-AKI (NCT01557361)
- Testing
- Accelerated RRT initiation, Standard RRT initiation
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
ARDS
The Educational ARDS Diagnosis Study
Without rigorous, high-quality training materials, the results of the LUNG-SAFE study examining the global incidence and outcomes of severe lung failure (acute respiratory distress syndrome [ARDS]) could be confused by either…
- Trial name
- READS (NCT02054611)
- Testing
- Online Educational Module
- Where
- 2 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes, Endothelial Dysfunction
Magnetic Resonance Imaging of Vascular Function
A major function of blood vessels is to control blood flow by dilating or constricting depending on the demand. Vascular dysfunction is a state in which blood vessels fail to carry out its normal roles such as regulating blood…
- Trial name
- NCT02206919
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Dyspnea, Acute Heart Failure
Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department
The purpose of this study is to evaluate a validated diagnostic prediction model in the appropriate diagnosis of Acute Heart Failure (AHF) in patients presenting at the emergency department with undifferentiated dyspnea.
- Conditions
- Dyspnea, Acute Heart Failure, Shortness of Breath
- Trial name
- NCT01193998
- Testing
- Treatment as per model probability, Treatment as per usual care
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 186 people
- Sponsor
- Unity Health Toronto
Healthy
Standardized Comparison of Triage in EMS
The objective of this study is to evaluate the reliability and validity of acuity estimates by paramedics employing the Canadian Triage Acuity Scale (CTAS) in the out of hospital setting.
- Trial name
- NCT00468780
- Where
- 2 sites in Canada
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Obesity
Effects of Viscous Fibre Containing Foods on Satiety (Gel Form)
The purpose of this study is to assess whether low caloric, low energy density, konjac food products are effective in appetite regulation when administered as caloric replacements.
- Trial name
- NCT02134938
- Testing
- Konjac Glucomannan
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Arterial Stiffness, Blood Pressure
Korean Red Ginseng Rg3 Extract on Arterial Stiffness and Blood Pressure
The purpose of the study is to evaluate the acute effect of a standardized extract of KRG (Rg3-KRG) consisting of 30% total ginsenosides, including 10% Rg3 ginsenoside on arterial stiffness and blood pressure, as measured by the…
- Trial name
- KRAB (NCT01951443)
- Testing
- Ginseng, Wheat Bran
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type 2 Diabetes, Metabolic Syndrome
Acute Dose Response of Korean White Ginseng in Metabolic Syndrome or Type 2 Diabetes
The study is a Phase-I like double blind randomized placebo controlled crossover design trial. The objective is to assess the dose response relationship on glycemic and vascular effects of an acutely administered Korean White…
- Trial name
- KWG (NCT01699074)
- Testing
- 1 gram of White Korean Ginseng, 3 grams of White Korean Ginseng, 6 grams of White Korean Ginseng
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Pregnant Women Who Test Positive for Bacterial Vaginosis
Probiotic Therapy for the Reversal of Bacterial Vaginosis in Pregnancy
This study will add to the current knowledge and literature on the ability of an oral lactobacilli preparation to return the vaginal flora to a normal state in pregnant women.
- Trial name
- ProVIP (NCT01697683)
- Testing
- Probiotic Lactobacilli
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Healthy
Acute Effect of Nitrate From Natural Dietary Sources on Arterial Stiffness and Blood Pressures in Healthy Individuals
The purpose of this study is to evaluate the acute effect of a meal high in dietary nitrates on aortic augmentation index, brachial and aortic blood pressures, and subendocardial viability ration (SEVR).
- Trial name
- DNAB (NCT01604993)
- Testing
- Spinach soup, Asparagus soup
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases
Effect of Flax, Poppy, Sesame & Salba on Postprandial Blood Glucose Response, Vascular, Appetite & Sensory Parameters
Consumption of whole grains has been heavily endorsed by both government and major health agencies, as evidenced in Health Canada's Food Guide, the US Department of Agriculture's Food Pyramid, and the Heart and Stroke…
- Trial name
- NCT01579656
- Testing
- Salba, Poppy, Flaxseed
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Healthy
Effects of Mode of Administration of Soluble Fibre Blend on Glycemia, Appetite & Sensory Parameters
Soluble, viscous fibre has been established as an effective dietary component for lowering postprandial glycemia and promoting satiety.
- Trial name
- FI-FORM (NCT01657058)
- Testing
- Soluble viscous fibre blend powder in hydrophobic matrix, Soluble viscous fibre blend in pre hydrated form, No soluble viscous fibre blend
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto