Clinical trials: sponsored by Unity Health Toronto
Chronic Postoperative Pain, Headache
Effects of Perioperative Pregabalin for Post-Craniotomy Pain
Objective: To compare the incidence of chronic pain at 3 months among adults undergoing craniotomy between those received two different doses of pregabalin and those receiving placebo.
- Trial name
- NCT01591980
- Testing
- Pregabalin
- Where
- Canada
- Sponsor
- Unity Health Toronto
Diabetes, Healthy
Soluble Fibre Enriched CHO Food Study
The proposed study will examine the effects of incorporating a soluble fibre blend into commonly consumed refined carbohydrate foods on sensory parameters and postprandial blood glucose.
- Trial name
- NCT01898026
- Testing
- Bread, Mashed Potatoes, Muffins
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Disease
A Virtual Ward to Reduce Readmissions After Hospital Discharge
The purpose of this study is to see whether a Virtual Ward reduces readmissions after hospital discharge.
- Trial name
- NCT01108172
- Testing
- Virtual Ward, Usual care
- Where
- 5 sites in Canada
- Volunteers
- 1,928 people
- Sponsor
- Unity Health Toronto
Diabetic Macular Edema
Efficacy and Safety Study to Evaluate Two Doses of Oral DMI-5207 in Adult Subjects With Diabetic Macular Edema
The drug being tested in this study is low doses of Optina (formerly known as Danazol) (DMI-5207) that may be an effective treatment for diabetic retinopathy and diabetic macular edema (DME).
- Trial name
- NCT02002403
- Testing
- Danazol
- Volunteers
- 34 people
- Sponsor
- Unity Health Toronto
Breast Cancer, Psychosocial Effects of Cancer and Its Treatment
Stress Reduction in Older Women With Stage II, Stage III, or Stage IV Breast Cancer
RATIONALE: Transcendental meditation may be an effective way to decrease the amount of stress in older women with breast cancer.
- Trial name
- NCT00006346
- Testing
- psychosocial assessment and care, quality-of-life assessment
- Where
- 3 sites in United States
- Sponsor
- Unity Health Toronto
Healthy
Acute Vascular Response To Meals Varying In Glycemic Index And Glycemic Load
This study examines the effects of carbohydrate type (high- or low-Glycemic Index (GI)) and amount (high- or low-Glycemic Load (GL)) have on blood glucose levels, blood pressure and arterial stiffness in healthy individuals.
- Trial name
- HILO (NCT01883700)
- Testing
- Boiled Pasta, Boiled Chickpeas with Oil, Instant Mashed Potatoes
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Homeless Persons, Emergency Medical Services
Attitudes of Medical Trainees Towards Homeless Persons Presenting for Care in the Emergency Department
Homelessness is a significant problem in Canada, and many homeless people will seek routine care in the Emergency Department (ED) as a result of barriers to access.
- Trial name
- NCT00281398
- Testing
- Questionnaire
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Obesity
Satiety Study of a Carbohydrate Meal to a Highly Viscous Gel Meal
To evaluate the effects of Konjac on satiety and subsequent food intake in healthy individuals.
- Trial name
- InGel (NCT01875627)
- Testing
- Konjac noodles, Carbohydrate and Konjac Noodles, Carbohydrate noodles
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Impaired Glucose Tolerance, Diabetes
Effect of Ginseng on Glycemic Control
Ginseng (American ginseng, Asian ginseng, Korean ginseng etc) is expected to show positive hypoglycemic effects, including improvements in glycated blood proteins[HbA1c], fasting glucose, fasting insulin, and the homeostasis…
- Trial name
- NCT01841229
- Where
- Canada
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Complex Anal Fistula
Success Rate, Continence, and Quality of Life With a Bioprosthetic Plug for Treating Complex Anal Fistula
Anal abscess-fistula disease is of common occurrence and has a significant impact on the quality of life of affected individuals.
- Trial name
- NCT01612195
- Testing
- Anal fistula plug
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Angioplasty, Coronary Artery Disease
Arterial Closure vs Direct Compression for Hemostasis After PCI - The ACDC Trial
Hemostasis at the arterial puncture site after percutaneous coronary interventions is achieved by either placement of a puncture closure device or by delaying sheath removal for hours to allow normalization of heparin induced…
- Trial name
- NCT00264264
- Testing
- Closure Device, Direct Compression
- Where
- Canada
- Volunteers
- 572 people
- Sponsor
- Unity Health Toronto
Chronic Kidney Disease
Intensive Dietary Education to Lower Serum Phosphorus in Patients With Chronic Kidney Disease
A low phosphorus diet is recommended for patients with chronic kidney disease who exhibit high levels of phosphorus. The purpose of this study is to determine the effects of a more intensive, innovative dietary phosphorus…
- Trial name
- NCT00656279
- Testing
- Intensive dietary phosphorus education
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Anemia, Liver Disease
Phase 2 Study of PEG-Intron in Hereditary Hemorrhagic Telangiectasia
The purpose of the study is to evaluate the safety and tolerability of pegylated interferon alpha-2b (PEG-Intron) in patients with severe complications related to Hereditary hemorrhagic telangiectasia (HHT).
- Conditions
- Anemia, Liver Disease, Hypoxemia
- Trial name
- NCT00588146
- Testing
- Pegylated Interferon Alpha2b, Standard care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Cardiac Surgery
Transfusion Requirements in Cardiac Surgery
This is a multi-centre randomized controlled pilot trial of two transfusion strategies in high risk patients having cardiac surgery. This study will be conducted in 7 Canadian centers and 1 American centre.
- Trial name
- TRICSII (NCT01484639)
- Testing
- Liberal transfusion triggers, Restrictive transfusion triggers
- Where
- 8 sites in United States, Canada
- Volunteers
- 208 people
- Sponsor
- Nadine Shehata
Critical Care Trial Participation Consent by SDM
The Approach Study
In the Approach Study, the investigators will study the 'process' by which Substitute Decision Makers (SDMs) are approached for consent for their loved one's participation in critical care research.
- Trial name
- NCT01232621
- Testing
- Physician Introduction of research personnel
- Where
- Canada
- Volunteers
- 138 people
- Sponsor
- Unity Health Toronto
Heart Failure
The Prevalence of Thiamin Deficiency in Ambulatory Patients With Heart Failure
Patients with heart failure are at an increased risk for thiamin deficiency (TD), for many reasons such as malnutrition and the use of diuretic drugs.
- Trial name
- NCT00953823
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Immunization
Testing Educational Materials in a Paediatric Setting
Immunization procedures are a common source of iatrogenic pain for infants. A recently developed clinical practice guideline, led by Taddio et al., created evidence-based strategies for management of immunization pain.
- Trial name
- NCT01713322
- Testing
- Pain management education, No pain management education
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Education, General Surgery
Individualized Deliberate Practice on a Virtual Reality Simulator
Training on simulated models in a surgical skills laboratory has been shown to improve technical performance in the operating room.
- Trial name
- NCT01753947
- Testing
- Deliberate Practice
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Ankle Arthritis
Gait Analysis of Ankle Arthroplasty and Arthrodesis
Surgical options for managing hindfoot arthritis include: joint fusion, total ankle joint replacement or osteotomies (realignment) of bones.
- Trial name
- NCT00921076
- Testing
- Gait Analysis
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Borderline Personality Disorder
Hope for the Chronically Suicidal Patient
The aim of this study is to evaluate the clinical and cost effectiveness of Dialectical Behavior Therapy (DBT) for chronically suicidal behavior in individuals diagnosed with borderline personality disorder (BPD).
- Trial name
- NCT00154154
- Testing
- General Psychiatric Management, Dialectical Behaviour Therapy
- Where
- 2 sites in Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health