Clinical trials: Early Phase 1, completed
Multiple Sclerosis
Oral FMT (Fecal Microbial Transplant) in Subjects With Multiple Sclerosis
The goal of this pilot study is to determine whether fecal microbial transplant (FMT) has the potential to be an effective, safe and tolerable therapy for the treatment of multiple sclerosis (MS).
- Trial name
- NCT04096443
- Testing
- Fecal microbial transplant (FMT)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Griffin Hospital
Bacterial Vaginosis
Impact of Clinician-administered Vaginal Live Biotherapeutic Product
This is an open-label, single-arm, Phase Ib trial assessing the consistency of response and colonization kinetics of a vaginally inserted live biotherapeutic intervention with optimized adherence.
- Trial name
- NCT07305844
- Testing
- LC106
- Where
- 2 sites in United States, South Africa
- Volunteers
- 26 people
- Sponsor
- Caroline Mitchell
Healthy Volunteer
Impact of Exogenous Ketones on Breathing in Healthy Volunteers
Exogenous ketones (EK) are compounds that can increase the level of ketones in the body without needing to change what an individual eats.
- Trial name
- K-BREATHE (NCT07220122)
- Testing
- 1,3 butanediol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Skin Basal Cell Carcinoma, Skin Nodular Basal Cell Carcinoma
Intratumoral Injection of Standard Universal Donor Expanded Natural Killer Cells and TGF-beta Imprinted Natural Killer Cells for the Treatment of Skin Squamous Cell Carcinoma and Basal Cell Carcinoma
This early phase I trial compares the safety, side effects and the biological or cellular activity of two types of universal donor (UD) natural killer (NK) cells (standard NK cells and transforming growth factor [TGF] beta…
- Conditions
- Skin Basal Cell Carcinoma, Skin Nodular Basal Cell Carcinoma, Skin Squamous Cell Carcinoma
- Trial name
- NCT07144384
- Testing
- Biopsy Procedure, Natural Killer Cell Therapy, Surgical Procedure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Renal Cell Carcinoma
Rapid Sequencing of Approved Therapies in Patients With Metastatic or Unresectable Clear Cell Renal Cell Carcinoma
This is a pilot, single-center, single-arm study where 20 patients with metastatic or unresectable clear cell renal cell carcinoma will receive same sequential treatment strategy (Cabozantinib for 12 weeks, then proceed with…
- Trial name
- NCT05188118
- Testing
- Cabozantinib, Ipilimumab, Nivolumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Social Cognition
Losartan and Social Processing
This study explores the effects of single-dose losartan (50mg) versus placebo on social processing in healthy volunteers.
- Trial name
- NCT06624904
- Testing
- Losartan potassium 50mg
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Familial Alcoholism Vulnerability
Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant
The purpose of this study is to evaluate the role of Mavoglurant in clarifying the neurobiology of alcoholism risk. This is a one-site, randomized, within subjects, counterbalanced double-blind study of a single dose (200mg) of…
- Trial name
- NCT05203965
- Testing
- Mavoglurant (AFQ056)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes, Hypercholesterolaemia
The Effect of Providing Genetic Risk Information on Lifestyle Behaviors in African Americans
Cardiovascular disease (CVD) is a major and persistent health disparity for African Americans. Linking GAINS is a randomized pilot and feasibility study designed to evaluate whether receiving genetic risk information early in a…
- Conditions
- Diabetes, Hypercholesterolaemia, Hypertension, Obesity Type 2 Diabetes Mellitus
- Trial name
- LINKING GAINS (NCT07833384)
- Testing
- Color Genomics Genetic Testing Panels
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity
Angiotensin-(1-7) and Energy Expenditure in Human Obesity
The objective of this study is to better define the role of the hormone angiotensin-(1-7) in energy balance. We will test the overall hypothesis that angiotensin-(1-7) increases resting energy expenditure and promotes markers of…
- Trial name
- NCT03777215
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Amy Arnold
Pancreatic Cancer
Cancer Coaching and Remote Education for Self-Empowerment (CARES) Study
This Pilot Study will evaluate a 12-week pilot program that offers digital health coaching for individuals with pancreatic cancer and their caregivers.
- Trial name
- NCT06323291
- Testing
- Coaching Sessions
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Breast Cancer, Breast Cancer Female
HER2 Directed Dendritic Cell Vaccine During Neoadjuvant Therapy of HER2+Breast Cancer
The purpose of this study is to learn more about how to treat patients with HER-2/neu positive invasive breast cancer (IBC). HER-2/neu is a type of protein that is known to be over-expressed in aggressive breast cancer.
- Conditions
- Breast Cancer, Breast Cancer Female, Breast Cancer, Male, Invasive Breast Cancer
- Trial name
- NCT03387553
- Testing
- Dendritic Cell Vaccine (DC1), Neoadjuvant Chemotherapy, Curative Surgery
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Decompensated Heart Failure
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure
This study is designed to investigate the quantitative effects of sodium-free chloride supplementation on electrolyte balance, volume status, and sodium avidity in stable heart failure patients in a highly controlled environment.
- Trial name
- NCT03440970
- Testing
- Lysine Chloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Psychological Stress, Anesthesia
RELIEF OF PSYCHOEMOTIONAL STRESS USING XENON SEDATION
The goal of this clinical trial is to propose for implementation and evaluate the effectiveness of xenon sedation for the relief of psychoemotional stress disorder before the operation of refractive laser vision correction…
- Conditions
- Psychological Stress, Anesthesia, Anxiety, Xenon
- Trial name
- NCT06080100
- Testing
- Xenon, premedication hydroxyzine 25 mg
- Where
- Russia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Malignant Neoplasm
Ketoconazole in Treating Participants With Ongoing EGFR Inhibitor-Induced Rash
This early phase I trial studies the side effects of ketoconazole and how well it works in treating participants with ongoing EGFR inhibitor-induced rash.
- Trial name
- NCT03471364
- Testing
- Ketoconazole, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- 6 sites in United States
- Volunteers
- 58 people
- Sponsor
- Mayo Clinic
Healthy
A Phase 0, Open-Label, Crossover Microdose Pharmacokinetic Study of PRX-P4-003 in Healthy Volunteers
This is a Phase 0, open-label, crossover microdose pharmacokinetic study of PRX-P4-003 in healthy volunteers.
- Trial name
- NCT04638803
- Testing
- PRX-P4-003, (-)-FCF
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Praxis Bioresearch, LLC
Prostate Cancer
Adaptive Abiraterone Therapy for Metastatic Castration Resistant Prostate Cancer
Abiraterone is approved in the United States by the U.S. Food and Drug Administration (FDA) to treat metastatic prostate cancer at 1000 mg daily.
- Trial name
- NCT02415621
- Testing
- Abiraterone Acetate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Diabetic Macular Edema (DME), Retinal Vein Occlusion (RVO)
Effectiveness of Intravitreal Injection of Aflibercept 8 mg in Resistant Diabetic Macular Edema, Retinal Vein Occlusion and Myopic Choroidal Neovascularisation Patients
Generally, DM is caused by insufficient insulin secretion in the body; however, the other biological mechanisms remain unclear. Long-term illness in patients with DM damages various organs in the body, such as the eyes, kidneys…
- Conditions
- Diabetic Macular Edema (DME), Retinal Vein Occlusion (RVO), Myopic Choroidal Neovascularisation
- Trial name
- NCT06879301
- Testing
- Intravitreal injection of aflibercept 8 mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Normal Physiology
Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People
Background: Brain activity creates waste products. The body s glymphatic system removes this waste, especially during sleep. One brain waste product is amyloid-beta (Ab). It plays a role in Alzheimer s disease.
- Trial name
- NCT02669225
- Testing
- [18F]florbetaben
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Naltrexone, Placebo
Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences
The study is a randomized, placebo-controlled design with the opioid antagonist, oral naltrexone. Following random assignment, participants will take 50mg of naltrexone or placebo once a day for 7 days.
- Trial name
- NCT05007561
- Testing
- Naltrexone Hydrochloride
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Normal Physiology, Opioid Use Disorders
Brain Dopaminergic Signaling in Opioid Use Disorders
Background: The chemical messenger dopamine carries signals between brain cells. It may affect addiction. Heavy use of pain medicines called opioids may decrease the amount of dopamine available to the brain.
- Trial name
- NCT03190954
- Testing
- [11C]raclopride plus drug, [11C]NNC-112
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)