Clinical trials: sponsored by Anhui Medical University
Medical Education, Endocrine System Diseases
Integrated PBL-CBL-CTTM Teaching to Enhance Clinical Self-Efficacy in Endocrine Critical Illness Among Internal Medicine Residents: An RCT
This randomized controlled trial evaluates whether an integrated online-offline multimodal teaching approach combining Problem-Based Learning (PBL), Case-Based Learning (CBL), and Case Three-Dimensional Teaching Method (CTTM)…
- Conditions
- Medical Education, Endocrine System Diseases, Critical Illness
- Trial name
- PBL-CBL-CTTM (NCT07801170)
- Testing
- Lecture-based learning (LBL), PBL plus LBL, Integrated PBL-CBL-CTTM
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chaohu Hospital of Anhui Medical University
Invasive Breast Cancer (Stage I-III)
Neoadjuvant Endocrine Therapy Combined With Chemotherapy in ER-positive, HER2-negative Stage I-III Breast Cancer
The goal of this investigator-initiated, open-label, phase II clinical trial is to evaluate the efficacy and safety of neoadjuvant chemotherapy combined with endocrine therapy in patients with hormone receptor-positive, human…
- Trial name
- NCT07801898
- Testing
- NaCET: For chemotherapy, the TEC or EC-T regimen is selected; for endocrine therapy, letrozole is administered; for premenopausal patients, an LHRH agonist-goserelin or leuprolide
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The Second Hospital of Anhui Medical University
Fibromyalgia, Pregabalin
The Efficacy and Safety of Pregabalin Combined With Venlafaxine in Patients With Fibromyalgia
Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread pain, fatigue, and emotional disorders. Its onset is related to factors such as central sensitization and imbalance of neurotransmitters.
- Conditions
- Fibromyalgia, Pregabalin, Venlafaxine, Pain
- Trial name
- NCT07186751
- Testing
- Pregabalin, Pregabalin with venlafaxine
- Where
- 2 sites in China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Metastatic Hormone-Sensitive Prostate Cancer
A Prospective Study Based on Spatial Multi-omics to Predict the Efficacy of ADT Combined With Second-generation Novel Hormonal Agents in Metastatic Hormone-sensitive Prostate Cancer.
This study plans to enroll patients with newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC) and conduct a prospective, single-center, observational study.
- Trial name
- NCT07795177
- Testing
- ADT plus abiraterone or other ARPIs（apalutamide, enzalutamide, rezvilutamide, darolutamide)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Diabetic Foot Disease
Development and Pilot Application of a Solution-Focused Intervention for Social Isolation in Elderly Diabetic Foot Patients
The goal of this interventional study is to develop and preliminarily evaluate a solution-focused model-based intervention program for reducing social isolation in elderly patients with diabetic foot ulcers.
- Trial name
- NCT07787884
- Testing
- Intervention Group
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Anhui Medical University
Acute Ischemic Stroke
Real-World Evaluation of Recombinant Human Prourokinase for Acute Ischemic Stroke Within 4.5 Hours
Acute ischemic stroke is a major cause of disability and death. Intravenous thrombolytic therapy is an important treatment option when given within the appropriate time window.
- Trial name
- PRISM (NCT07787325)
- Testing
- Recombinant Human Prourokinase
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Type 2 Diabetes
Development and Pilot Implementation of a Shared Decision-Making Intervention for Type 2 Diabetes Using the Ottawa Framework
The goal of this clinical trial is to evaluate the effectiveness of a shared decision-making (SDM) intervention program based on the Ottawa Decision Support Framework in adult patients with type 2 diabetes (aged ≥18 years…
- Trial name
- NCT07785440
- Testing
- Intervention Group
- Volunteers
- 70 people
- Sponsor
- Anhui Medical University
Wet Age Related Macular Degeneration, Neovascular (Wet) Age-Related Macular Degeneration
Evaluation of PAN-90806 Eye Drops in Healthy Subjects
The goal of this clinical trial is to learn about the safety, tolerability, and systemic pharmacokinetics of PAN-90806 eye drops in healthy adults.
- Trial name
- NCT07764965
- Testing
- PAN-90806 Ophthalmic Solution, Vehicle Ophthalmic Solution
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Parkinson s Disease
The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease
This study aimed to evaluate the clinical efficacy and safety of temporal interference stimulation (TIS) targeting different targets in patients with Parkinson's disease (PD), and to investigate the associated neurophysiological…
- Trial name
- NCT07572903
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Lung Cancer (NSCLC)
Construction and Empirical Study of Indirect Intervention Model for Protective Medical Lung Cancer Patients Based on Family System Theory
To clarify the irrational cognition of family caregivers of lung cancer patients at various perioperative stages under the background of protective medical treatment, construct an indirect intervention model for lung cancer…
- Trial name
- FST (NCT07749443)
- Testing
- Caregiver cognitive intervention based on printed handbook, Graded information disclosure strategies, Routine perioperative health education
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Myopia, Randomized Controlled Trial (RCT)
The Rebound Effect on Repeated Low-Level Red Light Therapy for Myopia
Myopia is a global public health issue, projected to affect 49.8% of the world population by 2050, increasing risks of cataracts, glaucoma, macular degeneration, and retinal detachment.
- Trial name
- NCT07748546
- Testing
- Repeated low-level red light (RLRL) therapy
- Volunteers
- 159 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Ulcerative Colitis (UC)
Alpha-0261 Tablets for Moderate-to-Severe Ulcerative Colitis
The purpose of this protocol is to evaluate the safety and efficacy of Alpha-0261 in participants with moderately to severely active ulcerative colitis.
- Trial name
- NCT07744646
- Testing
- Alpha-0261
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Posttraumatic Stress Disorder
Multicenter iTBS Neuromodulation for PTSD Treatment
The proposed study aims to evaluate the efficacy of intermittent theta-burst transcranial magnetic stimulation (iTBS) targeting primary motor cortex (M1) as adjunct treatment for PTSD patients.
- Trial name
- TMCP (NCT06434766)
- Testing
- intermittent theta-burst stimulation (iTBS)
- Where
- 5 sites in China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Mesenteric Ischemia
ThromBus Aspiration for Acute Mesenteric Artery Occlusion With Emergent Laparoscopic Surgery
This study is designed as a prospective, multicenter, single-arm clinical trial. Patients with acute mesenteric ischemia (AMI) caused by superior mesenteric artery (SMA) thrombosis or thromboembolism will be enrolled.
- Trial name
- BOWEL-2 (NCT07741318)
- Testing
- thrombus aspiration-based endovascular therapy
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Acute Ischemic Stroke
Normobaric Hyperoxia Combined With Intravenous Thrombolysis for Acute Ischemic Stroke (OPENS-3)
The purpose of this study is to determine the efficacy and safety of Normobaric Hyperoxia combined with intravenous thrombolysis for acute ischemic stroke.
- Trial name
- NCT05965687
- Testing
- Normobaric Hyperoxia, Nasal oxygen, Intravenous thrombolysis(rt-PA)
- Where
- China
- Volunteers
- 1,230 people
- Sponsor
- Ji Xunming,MD,PhD
Comprehensive Complication Index
Assessing the Effectiveness of Continuous Glucose Monitoring in Enhancing Surgical Outcomes for Patients With Diabetes
The goal of this multi-center, pragmatic, randomized controlled trial is to assess the effectiveness of continuous glucose monitoring (CGM) compared with conventional monitoring in enhancing surgical outcomes for diabetic…
- Trial name
- NCT06331923
- Testing
- Continuous glucose monitoring (CGM) device
- Where
- 8 sites in China
- Volunteers
- 9,877 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Endometrioid Endometrial Cancer
Clinical Efficacy Study of PD-1 Inhibitor Combined With Neoadjuvant Chemotherapy in Advanced Endometrial Cancer
Exploring the therapeutic effect of neoadjuvant chemotherapy combined with PD-1 inhibitor camrelizumab on advanced stage III-IV endometrial cancer
- Trial name
- NCT06561308
- Testing
- Camrelizumab, Carboplatin, Paclitaxel
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Mantle Cell Lymphoma (MCL)
Orelabrutinib Plus Lisaftoclax and Rituximab in Untreated Mantle Cell Lymphoma With High-Risk Disease
This multicenter, open-label, trial aims to evaluate the efficacy and safety of orelabrutinib plus lisaftoclax and rituximab in patients with high-risk mantle cell lymphoma (MCL).
- Trial name
- NCT07272499
- Testing
- Orelabrutinib, Rituximab (R), Lisaftoclax (APG-2575)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Ruijin Hospital
Chronic Subdural Hematoma
Frontal vs Parietal Eminence Drainage for Chronic Subdural Hematoma
This clinical trial aims to find out whether the puncture site used during minimally invasive surgery with twist-drill puncture and closed-system drainage affects the treatment of chronic subdural hematoma (cSDH).
- Trial name
- NCT07731620
- Testing
- Frontal-region puncture drainage, Parietal Eminence region puncture drainage
- Where
- 3 sites in China
- Volunteers
- 440 people
- Sponsor
- The Second Hospital of Anhui Medical University
Problematic Screen Use in Preschool Children, Anxiety Symptoms in Preschool Children
Effects of an SMS-Based Parenting Intervention on Anxiety Symptoms in Preschool Children
Excessive screen use and anxiety symptoms in preschool children have become increasingly prominent public health problems. This randomized controlled trial aims to determine whether, compared with a control group, an ecological…
- Conditions
- Problematic Screen Use in Preschool Children, Anxiety Symptoms in Preschool Children, Social-emotional Behavior Problems in Preschool Children
- Trial name
- NCT07728344
- Testing
- Ecological Momentary Parenting Intervention, General Pediatric Health Education
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University