Clinical trials: sponsored by Laval University
COPD Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Assessing Functional Capacity in Directly and Remotely Monitored Home-based Settings: A Protocol for a Multinational Validation Study in Individuals With Chronic Respiratory Diseases
The goal of this validation study is to provide further evidence of the metrological properties of the 6-minute stepper test in individuals with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD).
- Trial name
- 6MST (NCT06447831)
- Where
- 3 sites in Canada, France
- Volunteers
- 89 people
- Sponsor
- Laval University
Atrial Functional Mitral Regurgitation
Effects of VALsartan On atRIAl Mitral Regurgitation (VALORIA) - Pilot
The goal of this clinical trial is to learn whether valsartan can slow the progression of atrial functional mitral regurgitation (AFMR) in adults with preserved left ventricular ejection fraction.
- Trial name
- VALORIA-Pilot (NCT07539298)
- Testing
- Valsartan
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Jonathan Beaudoin
Intra-abdominal Surgery, Anesthesia
Open Lung Protective Extubation Following General Anesthesia
Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development.
- Conditions
- Intra-abdominal Surgery, Anesthesia, Lung Injury, Ventilator-Induced Lung Injury
- Trial name
- OLEXT-3 (NCT06296173)
- Testing
- Protective "open-lung" extubation, Conventional extubation
- Where
- 5 sites in Canada
- Volunteers
- 270 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Bicuspid Aortic Valve Disease
TAVR vs SAVR in Severe Bicuspid Aortic Stenosis
The study is a multicenter, randomized superiority trial of standard of care therapies for severe aortic stenosis (AS) in patients with a bicuspid aortic valve (BAV).
- Trial name
- BELIEVERS (NCT07413965)
- Testing
- Transcatheter Aortic Valve Replacement, the open chest surgery to replace the aortic valve
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Cedars-Sinai Medical Center
Stroke, Acute, Carotid Stenosis
Endovascular Acute Stroke Intervention - Tandem OCclusion Trial
Patients with tandem occlusion or tandem lesion (TL), that is, stroke with an acute intracranial anterior circulation occlusion and an ipsilateral cervical ICA (c-ICA) high-grade stenosis or occlusion, constitute about 15-20% of…
- Conditions
- Stroke, Acute, Carotid Stenosis, Carotid Artery Diseases
- Trial name
- EASI-TOC (NCT04261478)
- Testing
- Carotid artery stenting, Antiplatelet Agents
- Where
- Canada
- Volunteers
- 458 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Bronchopulmonary Dysplasia, Child Development
Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia
The aim of this randomized controlled trial is to determine whether docosahexaenoic acid (or DHA, an omega-3 lipid) supplementation in lactating mothers providing breast-milk to their infant born below 29 0/7 weeks of gestational…
- Conditions
- Bronchopulmonary Dysplasia, Child Development, Neonatal and Perinatal Conditions
- Trial name
- MOBYDIck (NCT02371460)
- Testing
- DHA-rich algal oil
- Where
- 16 sites in Canada
- Volunteers
- 461 people
- Sponsor
- CHU de Quebec-Universite Laval
Breast Cancer, Breast Cancer Recurrent
Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)
Breast-conserving surgery followed by re-irradiation with partial breast irradiation (rPBI) has recently been found to be a safe alternative to mastectomy for women who have undergone prior whole breast radiation.
- Trial name
- PRESERVE (NCT05592938)
- Testing
- rPBI
- Where
- 19 sites in United States, Australia and 8 more
- Volunteers
- 171 people
- Sponsor
- University Health Network, Toronto
Obesity, Morbid
Investigating Metabolic, Brain, and Cognitive Alterations Through Bariatric Surgery
Despite global efforts, the prevalence of obesity continues to rise, with rates in Canada tripling over the past three decades. In addition to the well-established risk of cardiometabolic conditions such as heart disease and…
- Trial name
- BRAINS (NCT07704229)
- Testing
- Sleeve Gastrectomy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Laval University
Obesity & Overweight, Cardiometabolic Conditions
Incretin-based Therapies, Nutrition, and Physical Activity
The goal of this clinical trial is to evaluate whether combining a six-month structured lifestyle intervention (physical activity and nutrition) with incretin-based weight-loss medication improves preservation of muscle mass and…
- Trial name
- HARMONY (NCT07409831)
- Testing
- Intervention, Incretin-Based Treatment
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Laval University
Cardiovascular Disease, Cardiovascular Care
Evaluation of Anxiety Reduction in the Cathlab by Means of Pharmacological and Non-pharmacological Strategies
The goal of this prospective pilot study is to learn if the use of virtual reality and/or relaxing soundscapes can help lower anxiety in adult patients undergoing a scheduled coronary angiography or angioplasty as compared to the…
- Conditions
- Cardiovascular Disease, Cardiovascular Care, Pain and Anxiety During Cardiac Catheterization
- Trial name
- EASY-HD (NCT07681180)
- Testing
- Auditive experience, Audiovisual immersive experience
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Olivier F. Bertrand
Peripheral Artery Disease
Home-based Exercise Therapy in Patients With Moderate to Severe Peripheral Artery Disease
Peripheral arterial disease (PAD) is a chronic atherosclerotic condition associated with impaired mobility, reduced quality of life, cardiovascular events, and risk of lower limb amputation.
- Trial name
- PILOT-PADCYCLE (NCT07655206)
- Testing
- Home-Based Exercise Therapy Using Portable Pedal Exerciser
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Laval University
Short-coupled Ventricular Fibrillation, Idiopathic Ventricular Fibrillation
Role of Anti-TREK-1 Autoantibodies in SCVF
Short-coupled ventricular fibrillation (SCVF) is a lethal, primary electrical disorder and an important cause of unexplained cardiac arrest.1 Recent work from our group suggests that a substantial proportion of SCVF cases is…
- Trial name
- TRACK-VF (NCT06943365)
- Testing
- Repeat plasma screening for the presence or absence of anti-TREK-1 autoantibodies, DPP6 risk haplotype
- Where
- 5 sites in Canada, Netherlands
- Volunteers
- 300 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Bariatric Surgery, Exercise
Effects of a 12-week Supervised Exercise Program Post Bariatric Surgery on Body Composition, Muscle Strength, and Insulin Resistance
The goal of this clinical trial is to evaluate the impact of supervised training program on body composition, muscular strenght, insulino-resistance profile, heart rate variability and on heart structure and function between 3 to…
- Conditions
- Bariatric Surgery, Exercise, Body Composition Changes
- Trial name
- ACTIVE (NCT07651254)
- Testing
- 12-week supervised exercise program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- Laval University
Peripheral Artery Disease (PAD), Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Hemodynamic Parameters in People With Atherosclerotic Vascular Disease Referred to a Secondary Prevention and Cardiovascular Rehabilitation Program
The main purpose of this study is to evaluate the hemodynamic changes in the forefoot of patients with coronary, cerebrovascular or peripheral atherosclerotic disease referred a 12-week cardiovascular rehabilitation program (PREV…
- Conditions
- Peripheral Artery Disease (PAD), Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Cerebrovascular Atherosclerosis
- Trial name
- NCT06701032
- Testing
- Cardiovascular rehabilitation program
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Laval University
Cancer of the Prostate, Anxiety
A SMART Design to Optimize the Delivery of TEMPO for Men With Prostate Cancer and Their Caregivers
Men with prostate cancer and their family caregivers face many physical and emotional challenges from the cancer itself and its treatment(s), which often lead to high anxiety.
- Trial name
- NCT06363266
- Testing
- TEMPO, Active Monitoring dyads' anxiety
- Where
- 2 sites in Canada
- Volunteers
- 376 people
- Sponsor
- St. Mary's Research Center, Canada
Insomnia Disorder
Virtual Reality Relaxation for Insomnia
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effects of a virtual reality (VR) relaxation intervention among adults aged 25 to 50 with insomnia disorder.
- Trial name
- NCT07630532
- Testing
- Virtual reality relaxation intervention
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Conduction Disturbances, Transcatheter Aortic Valve Replacement
Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following TAVR
The high incidence and variety of conduction disturbances post-TAVR represents a major challenge in the periprocedural management of TAVR recipients.
- Conditions
- Conduction Disturbances, Transcatheter Aortic Valve Replacement, Permanent Pacemaker Implantation
- Trial name
- PROMOTE (NCT04139616)
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Obesity and Obesity-related Medical Conditions
Egg Intake, Metabolic Outcomes and Choline Levels
The purpose of this research is to determine the effect of additional daily egg intake on metabolic phenotypes and metabolism in the context of obesity.
- Trial name
- NCT06687122
- Testing
- 3 whole eggs
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Prediabetic State
Restoring 24-hour Substrate Rhythmicity to Improve Glycemic Control by Timing of Lifestyle Factors
Exercise is well-known to improve skeletal muscle energy metabolism and is an established intervention to improve muscle insulin sensitivity and to counter the development of type 2 diabetes (T2D).
- Trial name
- TIMED (NCT05123963)
- Testing
- High-intensity interval training
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Université de Sherbrooke
Body Composition Changes, Body Weight Change
Effect of Dairy Protein Yogourt vs Plant-based Yogourt on Body Weight, Body Composition, Bone Health and Gut Microbiota
The consumption of an adequate quantity of protein in the diet is essential to maintain a healthy body composition and functioning.
- Conditions
- Body Composition Changes, Body Weight Change, Metabolic Health, Bone Metabolism
- Trial name
- PROYO (NCT07578103)
- Testing
- Dairy yogurt, Plant based yogurt, No yogurt
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Laval University