Clinical trials: sponsored by Massachusetts General Hospital
Myotonic Dystrophy Type 1
Cerebrospinal Fluid Biomarkers of Myotonic Dystrophy
Myotonic dystrophy is associated with central sleep apnea, excessive daytime sleepiness, diminished working memory, impaired visuospatial skills, and deficits in problem-solving skills.
- Trial name
- NCT06075693
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Massachusetts General Hospital
Germ Cell Tumor, Central Nervous System Germ Cell Tumor
Proton Beam Radiation Therapy for Central Nervous System (CNS) Germ Cell Tumors
The purpose of this research study is to determine if radiation using proton beam therapy will kill the germ cell tumor in the participant's central nervous system.
- Trial name
- NCT01049230
- Testing
- Proton Beam radiation
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Neurofibromatosis Type 2, Vestibular Schwannoma
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)
This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with NF2-related schwannomatosis (NF2-SWN, formerly known as neurofibromatosis type 2) with…
- Conditions
- Neurofibromatosis Type 2, Vestibular Schwannoma, Non-vestibular Schwannoma, Meningioma
- Trial name
- INTUITT-NF2 (NCT04374305)
- Testing
- Brigatinib, Neratinib, Retifanlimab
- Where
- 6 sites in United States
- Volunteers
- 109 people
- Sponsor
- Scott R. Plotkin, MD, PhD
Epilepsy
PET/MRI/EEG Imaging Study in Epilepsy
This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy.
- Trial name
- NCT06974305
- Testing
- FDG-PET/fMRI/EEG imaging
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
ALS (Amyotrophic Lateral Sclerosis)
T-regulatory Cells in ALS
This study is a randomized, placebo-controlled, phase 2a trial to study the biological activity, safety, and tolerability of regulatory T Lymphocytes (Tregs) taken and expanded outside of the body and returned back to the same…
- Trial name
- Tregs in ALS (NCT04055623)
- Testing
- Monthly autologous Treg cells infusions + 3 times per week Interleukin-2 injections
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- The Methodist Hospital Research Institute
Healthy Subjects (HS), Cardiovascular Diseases (CVD)
Multi-organ Imaging of Microvascular and Metabolic Function
What if heart disease starts outside the heart? This research will study how to simultaneously assess brain and body physiology, how they are jointly related to heart function, and how their response to physical and mental stress…
- Trial name
- NCT07604207
- Testing
- 18F-FDG, Positron Emission Tomography (PET)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Adult
Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism
The goal of this clinical trial is to learn how nicotinamide riboside (NR), a form of vitamin B3, affects brain energy metabolism in healthy adults.
- Trial name
- NCT07649161
- Testing
- Niagen®
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cancer Survivorship, Insomnia
Innovating CBT-I for Cancer Survivors: An Optimization Trial
The overall goal of this project is to conduct a factorial, randomized controlled trial to optimize synchronous, virtual delivery of CBT-I for cancer survivors.
- Trial name
- NCT06181643
- Testing
- Survivorship Sleep Program with Individual Delivery + No Booster Sessions, Survivorship Sleep Program with Group Delivery + No Booster Sessions, Survivorship Sleep Program with Individual Delivery + 3 Booster Sessions
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes, Diabetes in Children
The T1D Parent Check-In: A Preventative Intervention
The goal of this clinical trial is to learn how to best support families during the first year of a child or teen's Type 1 diabetes (T1D) diagnosis.
- Trial name
- NCT06160934
- Testing
- T1D Parent Check-in
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Crohn Disease
Biomarkers to Predict and Monitor Response to Infliximab
The aim of the study is to generate novel minimally-invasive serum protein signatures and biomarkers in children and adolescents with Crohn's Disease (CD) that correlate with and can predict and monitor patients who will have a…
- Trial name
- NCT04655729
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Massachusetts General Hospital
Optic Neuritis
Efgartigimod for the Treatment of Acute Optic Neuritis
The goal of this pilot clinical trial is to test efgartigimod alfa against placebo in adults with first-time optic neuritis (optic nerve inflammation).
- Trial name
- PET-AON (NCT06453694)
- Testing
- Efgartigimod Alfa
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Anastasia Vishnevetsky, MD, MPH
Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
- Trial name
- INC-6602 (NCT01193088)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Cervical Cancer, Hiv
Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2
The investigators will conduct the formative work that is necessary to develop a novel, multi-level intervention (inclusive of patient- and provider-level components), which will increase awareness of and modify the complex…
- Trial name
- NCT06182241
- Testing
- Retention in cervical cancer care intervention
- Where
- 3 sites in United States, South Africa
- Volunteers
- 62 people
- Sponsor
- Boston University Charles River Campus
Suicide, Attempted, Suicide and Self-harm
Real-time Intervention for Suicide Risk Reduction: Primary Open Pilot
The goal of this study is to provide an initial pilot test of an Ecological Momentary Intervention (EMI) designed the reduce the distress associated with negative emotion among individuals at risk for suicide that pairs content…
- Trial name
- NCT03950765
- Testing
- Ecological momentary intervention
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Depressive Disorder, Major, Inflammation
Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
This study is a mechanistic randomized controlled trial that investigates whether inhibition of tumor necrosis factor signaling via intravenous infusion of infliximab improves psychomotor speed and executive functioning in…
- Trial name
- NCT06136546
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Health Care Utilization, End Stage Disease
ACP Video Intervention for Patients With Life-Limiting Illness
The goal of this research is to increase patients' knowledge about advance care planning (ACP) discussions and hospice care for patients with serious illness receiving home-based care.
- Trial name
- NCT04778761
- Testing
- Home ACP Video
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Neurocognitive Disorders, Postoperative Delirium
Creatine and Perioperative Brain Health
The overall goal of this study is to explore the effects of perioperative oral creatine supplementation on cognitive function and physiological responses to surgery in older adults.
- Conditions
- Neurocognitive Disorders, Postoperative Delirium, Postoperative Outcomes
- Trial name
- CREATE (NCT07310043)
- Testing
- Creatine monohydrate
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Avoidant/Restrictive Food Intake Disorder (ARFID)
Cognitive-behavioral Therapy vs. Nutrition Counseling for Avoidant/Restrictive Food Intake Disorder Part II
This study is a randomized controlled trial assessing the efficacy of cognitive- behavioral therapy (CBT-AR) and nutrition counseling for avoidant/restrictive food intake disorder (ARFID) for children and adolescents (ages 10-18…
- Trial name
- COUNTERACT-2 (NCT07641205)
- Testing
- Cognitive-Behavioral Therapy for Avoidance Restrictive Food Intake Disorder (CBT-AR), Nutrition Counseling for Avoidant/Restrictive Food Intake Disorder
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Borderline Personality Disorder (BPD)
Combining Transcranial Magnetic Stimulation With Emotion Regulation Skills Training in Borderline Personality Disorder
Impaired emotion regulation is a core feature of borderline personality disorder (BPD) and a known driver of functional impairment, interpersonal difficulties, self-harm, and suicidality.
- Trial name
- NCT07714005
- Testing
- Transcranial Magnetic Stimulation (TMS), Emotion Regulation Skills Training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Charcot Marie Tooth Disease
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C…
- Trial name
- INC-6601 (NCT01193075)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Michael Shy
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