Clinical trials: sponsored by Ohio State University
Anxiety
Uncertainty and Firearms: Obtaining Secure Storage
The goal of this clinical trial is to test whether inclusion of cognitive behavioral therapy (CBT) for Uncertainty-Enhanced (CUE) with Lethal Means Counseling (LMC) is acceptable, feasible, and efficacious in addressing secure…
- Trial name
- UFOS (NCT05818696)
- Testing
- Lethal Means Counseling (LMC), CBT for Uncertainty - Enhanced (CUE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Recurrent Respiratory Papillomatosis (RRP)
Efficacy of Booster Injection With Gardasil-9 Vaccine on Intersurgical Interval* for Adults With Recurrent Respiratory Papillomatosis*
The investigators propose the study titled "Efficacy of booster injection with Gardasil-9 vaccine on intersurgical interval (ISI) for adults with recurrent respiratory papillomatosis (RRP)".
- Trial name
- *ISI *RRP (NCT07339163)
- Testing
- GARDASIL®9 (Human Papillomavirus 9-valent Vaccine, Recombinant)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Cancer, Cancer Risk
Total Cancer Care Protocol: A Lifetime Partnership With Patients Who Have or May be at Risk of Having Cancer
The overall objective of this study is to ultimately develop an improved standard of cancer care by facilitating new cancer research, clinical trials, new technology, new informatics solutions, and "personalized medicine" for the…
- Trial name
- TCCP (NCT03977402)
- Testing
- Biological specimen collection
- Where
- United States
- Volunteers
- 47,500 people
- Sponsor
- New Mexico Cancer Research Alliance
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
A Video Intervention to Improve Patient Understanding of Tumor Genomic Testing in Patients With Metastatic Cancer
This clinical trial tests whether a video intervention improves patient understanding of tumor genomic testing in patients with cancer that has spread to other parts of the body (metastatic).
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Carcinoma, Metastatic Malignant Solid Neoplasm
- Trial name
- NCT05215769
- Testing
- Health Education, Questionnaire Administration
- Where
- 4 sites in United States
- Volunteers
- 243 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma
Lenvatinib, Pembrolizumab, and Paclitaxel for Treatment of Recurrent Endometrial, Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This phase II clinical trial studies the effect of lenvatinib, pembrolizumab, and paclitaxel in treating patients with endometrial, epithelial ovarian, fallopian tube, or primary peritoneal cancer that has come back (recurrent).
- Conditions
- Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Recurrent Endometrial Carcinoma
- Trial name
- NCT04781088
- Testing
- Lenvatinib, Paclitaxel, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Floor Backes, MD
Heart Failure, Liver Fibrosis
Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc.
- Conditions
- Heart Failure, Liver Fibrosis, Cardiac Transplant Rejection, Aortic Aneurysms
- Trial name
- MRE (NCT01757730)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Arunark Kolipaka
Abdominal Aortic Aneurysm
Magnetic Resonance Elastography in Patients With Abdominal Aortic Aneurysms
The main objective of this study is to utilize Magnetic Resonance Elastography (MRE) to determine tissue stiffness of abdominal aortic aneurysms (AAA).
- Trial name
- AAA-MRE (NCT02387255)
- Testing
- Resoundant Driver System
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Ohio State University
T-Cell Large Granular Lymphocyte Leukemia
Oral Azacitidine for the Treatment of Relapsed or Refractory T-cell Large Granular Lymphocytic Leukemia
This phase I/II trial studies the best dose, possible benefits and/or side effects of oral azacitidine in treating patients with T-cell large granular lymphocytic leukemia that has come back (relapsed) or has not responded to…
- Trial name
- NCT05141682
- Testing
- Oral Azacitidine
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Jonathan Brammer
Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm
Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases
This phase II trial studies the effect of neuropsychological evaluation and intervention in maintaining quality of life after radiation therapy in patients with cancer that has spread to the brain (metastases).
- Trial name
- NCT05503251
- Testing
- Best Practice, Neuropsychological Assessment, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Hearing Loss
Nucleus Hybrid L24 Extended Duration Post Approval Study
This post approval study evaluates the long term safety and efficacy of the Nucleus Hybrid L24 Implant System in a group of already implanted recipients.
- Trial name
- HED (NCT02379273)
- Testing
- Nucleus Hybrid L24 Implant
- Volunteers
- 35 people
- Sponsor
- Cochlear
Depression, Anxiety
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
The goal of this study is to learn how psychedelics may help symptoms of depression and anxiety. Participants with major depressive disorder experiencing symptoms of depression and anxiety will receive one dose of either a drug…
- Conditions
- Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT06820723
- Testing
- CYB003
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Recurrent Acute Pancreatitis, Chronic Pancreatitis
Soy Tomato Juice to Improve Outcomes in Pancreatitis
This goal of this clinical trial is to see if people with recurrent acute pancreatitis or chronic pancreatitis can tolerate and regularly drink a tomato juice beverage.
- Trial name
- STOP (NCT07447687)
- Testing
- Soy-tomato juice product, Will include a soy-tomato juice product to be consumed during the 4 week intervention phase. A total of about 12 ounces (administered in two small cans) of the juice will be consumed
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Ohio State University
Hearing Loss, Sensorineural, Hearing Loss
Clinical Utility of Residual Hearing in the Cochlear Implant Ear
The current study is a randomized multi-center clinical trial that investigates the role an intraoperative hearing monitoring system (electrocochleography) has on helping to save residual hearing in patients undergoing cochlear…
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Hearing Loss, Bilateral
- Trial name
- NCT04707885
- Testing
- Electrocochleography
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Pancreatic Cancer
Disposable Perfusion Phantom for Accurate DCE (Dynamic Contrast Enhanced)-MRI Measurement of Pancreatic Cancer Therapy Response
The goal of this study is to investigate whether the therapeutic response of pancreatic tumors can be accurately assessed using quantitative DCE-MRI, when the inter/intra-scanner variability is reduced using the Point-of-care…
- Trial name
- NCT04588025
- Testing
- Point-of-care Portable Perfusion Phantom, P4
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Ohio State University
Healthy Aging
Effect of Vestibular Perceptual Learning on Vestibular Thresholds and Balance
The intervention being studied is a minimal risk perceptual learning protocol delivered in an academic laboratory setting; the goal of the intervention is to improve the perception of passive whole-body tilts and/or translations…
- Trial name
- NCT05818787
- Testing
- Roll Tilt Training, Translation Training, Both Tilt and Translation Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Post Traumatic Stress Disorder, Depression - Major Depressive Disorder
Mindfulness-based Psilocybin Therapy for PTSD
The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD).
- Trial name
- NCT07104916
- Testing
- Psilocybin + MBCT therapy, Active Comparator: Psilocybin with Support Only
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anthony P King
Borderline-resectable Pancreatic Cancer
DCE-MRI Guided Neoadjuvant Chemotherapy for Borderline Resectable Pancreatic Cancer
The goal of this study is to test whether chemotherapy guided by a new imaging method named DCE-MRI can more effectively reduce a pancreatic tumor, enabling curable surgery, over the conventional method when a tumor is…
- Trial name
- NCT06173310
- Testing
- Point-of-care Portable Perfusion Phantom (P4)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Heart Failure With Preserved Ejection Fraction
Ketogenic Diet vs Mixed Diet in Patients With Heart Failure
This study is being done to evaluate the effects of a low carbohydrate ketogenic diet (KD) versus a low-fat diet (MD) on exercise tolerance in participants with heart failure with normal pumping function and diabetes or…
- Trial name
- NCT06081543
- Testing
- Ketogenic diet, Low-fat Mixed diet
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Lung Transplantation, Chronic Lung Disease
Inspiratory Muscle Training Immediately After Lung Transplantation
Following lung transplantation (LTX), patients may exhibit respiratory and skeletal muscle weakness that will affect exercise capacity, increase dyspnea and fatigue, limit activities of daily living (ADL) and decrease quality of…
- Conditions
- Lung Transplantation, Chronic Lung Disease, Muscle Weakness, Rehabilitation
- Trial name
- NCT05309551
- Testing
- IMT- Intervention group
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Cervical Fusion
Clinical and Radiological Outcomes of Posterior Cervical Fusion Supplemented With Interfacet Spacers
This is a prospective study to assess fusion rates and cervical sagittal parameters following posterior cervical arthrodesis procedures supplemented with CIS.
- Trial name
- NCT04041583
- Testing
- Cervical Interfacet Spacers
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Ohio State University
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