Clinical trials: sponsored by Sir Run Run Shaw Hospital
Speckle Tracking, Diaphragm
End-Expiratory Diaphragmatic Residual Contraction Index for Identifying Intrinsic PEEP and Assisting PEEP Titration: A Prospective Physiological Study
This study proposes the End-expiratory Diaphragmatic Residual Contraction (EDRC) index to quantify residual diaphragmatic activity at end-expiration during Pressure Support Ventilation (PSV) mode.
- Trial name
- NCT07697703
- Testing
- Short-term PEEP Step Trial and EDRC Ultrasound Assessment
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, PFA Ablation and LAAC Procedures
Left Atrial Appendage Closure With Versus Without Pulsed Field Ablation in Atrial Fibrillation Patients With Mild Symptoms and High Stroke Risk
This study is a prospective, multicenter, single-blinded, randomized controlled trial to investigate whether concomitant left atrial appendage closure (LAAC) and pulsed field ablation (PFA) is more effective than LAAC alone in…
- Trial name
- REVERSE-OPTION (NCT07453940)
- Testing
- LAAC plus PFA for persistent AF with high risk of stroke, LAAC for persistent AF with high risk of stroke
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital
Rectal Cancer
Node-sparing Short-Course Radiation Combined With CAPOX and Tislelizumab for MSS Rectal Cancer
This is a randomized, prospective, multicenter, open-label, Phase III clinical trial to evaluate node-sparing modified short-course radiation (Radiation targeting the tumor bed without irradiating surrounding tumor-draining lymph…
- Trial name
- mRCAT-III (NCT06507371)
- Testing
- node-sparing modified short-course radiotherapy, PD-1 antibody, Capecitabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sir Run Run Shaw Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Study on the Impact of Decolonization Treatment of Pneumocystis Jirovecii on the Frequency of Acute Exacerbation in COPD
Previous researches have found the common colonization of Pneumocystis jirovecii (Pj) in the airways of people with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07665359
- Testing
- Trimethoprim-Sulfamethoxazole (TMP-SMX)
- Where
- 20 sites in China
- Volunteers
- 630 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
AF Ablation Patients With Moderate+ FMR and Persistent AF
Catheter Ablation for Functional Mitral Regurgitation in Persistent Atrial Fibrillation: Development and Validation of a Predictive Model-A Multicenter Prospective Cohort Study
Mitral Regurgitation (MR) is the most prevalent type of valvular heart disease in clinical practice, with an average prevalence of approximately 1% in populations with moderate-to-severe or worse MR, which increases significantly…
- Trial name
- NCT07096219
- Testing
- Catheter Ablation, ultrasonic cardiography (UCG)
- Where
- 2 sites in China
- Volunteers
- 556 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Peripheral Pulmonary Nodules, Ablation Techniques
Diagnosis and Treatment of Lung Lesions
To evaluate the safety and feasibility of a single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB).
- Trial name
- NCT07642986
- Testing
- A single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Jisong Zhang
LVAD (Left Ventricular Assist Device) Thrombosis, LVAD
STudy of Aspirin Removal in Patients Supported by the Fully Magnetically Levitated CH-VAD Pump
This multi-center, prospective, randomized, double-blinded, placebo-controlled study aims to investigate whether withdrawal of aspirin from the antithrombotic regimen in patients supported with the CH-VAD pump is non-inferior to…
- Conditions
- LVAD (Left Ventricular Assist Device) Thrombosis, LVAD, LVAD (Left Ventricular Assist Device), LVAD-related GI Bleed
- Trial name
- STAR (NCT07644247)
- Testing
- Warfarin (INR 2-3) with aspirin
- Volunteers
- 370 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Anxiety States
Intranasal Dexmedetomidine for Acute Anxiety State in Adults
This study employs a randomized, double-blind, placebo-controlled clinical trial design to evaluate the efficacy and safety of dexmedetomidine hydrochloride nasal spray in the treatment of acute anxiety in adults.
- Trial name
- NCT07550881
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tongji University
Malignant Pulmonary Nodules, Lung Cancer
Evaluation of the Safety and Efficacy of a Wideband Electric Pulse Tumor Ablation System for Malignant Pulmonary Nodules
To evaluate the safety and efficacy of the wideband electric pulse tumor ablation system, for the treatment of malignant pulmonary nodules.
- Trial name
- NCT07638228
- Testing
- wideband electric pulse tumor ablation system treatment
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Sir Run Run Shaw Hospital
Nausea and Vomiting, Postoperative
Application of Multimodal Intervention in the Prevention of Postoperative Nausea and Vomiting After Gynecological Laparoscopic Surgery
1. Background Postoperative nausea and vomiting (PONV) is a common complication after general anesthesia, with an incidence as high as 80% in gynecological laparoscopic surgery.
- Trial name
- NCT07631910
- Testing
- Amisulpride Injection, Dexamethasone (intravenous), Transcutaneous electrical acupoint stimulation (TEAS)
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Sir Run Run Shaw Hospital
Type 2 Diabetes Mellitus (T2DM), MASH - Metabolic Dysfunction-Associated Steatohepatitis
Diagnostic Value of the Liver Inflammation Index for MASH in Patients With T2DM and MAFLD
This observational study aims to evaluate a new diagnostic tool, the Liver Inflammation Index, in detecting Metabolic Dysfunction-Associated Steatohepatitis (MASH) among adults who have both Type 2 Diabetes Mellitus (T2DM) and…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), MASH - Metabolic Dysfunction-Associated Steatohepatitis, Metabolic Dysfunction-associated Fatty Liver Disease
- Trial name
- NCT07632677
- Testing
- iLivTouch (Vibration-controlled transient elastography)
- Where
- 22 sites in China
- Volunteers
- 10,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Acute Type A Aortic Dissection, Stanford Type A Aortic Dissection
AI-Guided Intensified Follow-up After Surgery for Acute Type A Aortic Dissection
This multicenter, prospective, randomized controlled trial will evaluate whether an artificial intelligence (AI) multimodal prediction model-guided intensified follow-up strategy improves 1-year outcomes after surgery for acute…
- Conditions
- Acute Type A Aortic Dissection, Stanford Type A Aortic Dissection, Postoperative Aortic Dissection Follow-up
- Trial name
- AIMS-ATAAD-FU (NCT07623213)
- Testing
- Usual Postoperative Follow-up Strategy, AI Prediction Model-Guided Intensified Follow-up Strategy
- Volunteers
- 1,314 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Advanced Gastric or Gastroesophageal Junction Cancer
A Study of Gentuximab + Paclitaxel in Patients With Advanced Gastric or Gastroesophageal Junction Cancer
The objective of the study is to evaluate Tolerability, Safety, and primary Efficacy of Gentuximab Injection at different dosage in combination with Paclitaxel in Advanced Gastric or Gastroesophageal Junction Cancer patients, to…
- Trial name
- NCT04053205
- Testing
- Gentuximab, Paclitaxel
- Where
- 12 sites in China
- Volunteers
- 76 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Cholangiocarcinoma
Study of Becotatug Vedotin Added to Standard Treatment for Advanced Bile Duct Cancer With EGFR Mutations
This study tests whether adding becotatug vedotin (EGFR-ADC) to standard chemotherapy plus immunotherapy improves outcomes compared to chemotherapy plus immunotherapy alone as first-line treatment for patients with advanced or…
- Trial name
- NCT07598318
- Testing
- Becotatug Vedotin, Pucotenlimab, Gemcitabine
- Volunteers
- 164 people
- Sponsor
- Sir Run Run Shaw Hospital
Biliary Tract Cancer
Gemcitabine-Cisplatin Plus Envafolimab in Resectable Biliary Tract Malignancies
This trial is to evaluate the efficacy of Gemcitabine-Cisplatin (GC) plus Envafolimab neoadjuvant therapy in the patients at high risk of recurrence. Primary endpoint: Major Pathologic Response (MPR).
- Trial name
- GENE (NCT07599995)
- Testing
- Neoadjuvant therapy followed by surgery
- Volunteers
- 34 people
- Sponsor
- Sir Run Run Shaw Hospital
Ovarian Clear Cell Carcinoma
INVIGORATE: A Study of QL1706 and Bevacizumab in Advanced First-Line Ovarian Clear Cell Carcinoma
The goal of this phase 3 clinical trial is to evaluate whether QL1706 plus bevacizumab can effectively treat adult female patients (18 to <75 years old) with newly diagnosed FIGO stage IC-IV ovarian clear cell carcinoma.
- Trial name
- INVIGORATE (NCT07002346)
- Testing
- QL1706 (bispecific antibody targeting PD-1 and CTLA-4), Bevacizumab, carboplatin
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Tongji Hospital
Chronic Non-specific Low Back Pain
Effect of VR-MBCT in Chronic Nonspecific Low Back Pain
This is a multi-center, prospective, open-label randomized controlled trial evaluating the efficacy and safety of virtual reality-based mindfulness-based cognitive therapy (VR-MBCT) as an adjunct to usual care in adults with…
- Trial name
- VR-MBCT-CNLBP (NCT07589790)
- Testing
- Virtual Reality-Based Mindfulness Cognitive Therapy (VR-MBCT), Waitlist Usual Care Control Group
- Where
- China
- Volunteers
- 214 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Heart Failure, Intraventricular Block
A Randomized Controlled Trial of LOT-CRT Versus conventionaL BiVP in Heart Failure Patients With NICD
BATTLE study has been designed as a prospective, multi-center, randomized, controlled trial. This study will enroll 83 patients with chronic heart failure accompanied by intraventricular block (NICD) over an estimated recruitment…
- Trial name
- BATTLE (NCT06061627)
- Testing
- LOT-CRT group, BiVP group
- Where
- China
- Volunteers
- 86 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Rectal Neoplasms
The Safety and Efficiency of Stent-based Diverting Technique Versus Ileostomy in Rectal Cancer Patients
The goal of this clinical trial is to evaluate the safety and efficiency of stent-based tiverting technique (SDT) versus ileostomy in rectal cancer patients.
- Trial name
- NCT06204497
- Testing
- Stent-based Diverting Technique
- Where
- 20 sites in China
- Volunteers
- 570 people
- Sponsor
- Sir Run Run Shaw Hospital
Antimicrobial
Long Peripheral Intravenous Catheter Insertion Site and Catheter-related Complications in Antimicrobial Therapy
This study applies long PIVCs to patients undergoing antimicrobial therapy, and compares the effects of different placement sites, aiming to provide a reference basis for patients undergoing antimicrobial treatment to select the…
- Trial name
- NCT06455228
- Testing
- insert catheter
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sir Run Run Shaw Hospital