Clinical trials: sponsored by Tata Memorial Centre
CNS Tumor
Artificial Intelligence in CNS Radiation Oncology
Radiotherapy involves the use of high-energy X-rays, which can be used to stop the growth of tumor cells. Radiotherapy constitutes an essential avenue in the treatment of brain tumors.
- Trial name
- AI-RAD (NCT06036394)
- Testing
- The images (CT, MRI, PET) used for RT planning, mid-treatment imaging as part of IGRT or disease evaluation, and response assessment/ surveillance post-RT
- Where
- India
- Volunteers
- 6,000 people
- Sponsor
- Tata Memorial Centre
Medulloblastoma, WNT-activated
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma.
This clinical study is going to be done on a type of brain tumor in children called Medulloblastoma. The WNT pathway type of medulloblastoma is considered to be low risk and have the best outcomes in terms of survival.
- Trial name
- FOR-WNT2 (NCT04474964)
- Testing
- Low dose Craniospinal Irradiation plus Focal Radiotherapy
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Tata Memorial Centre
Glioma
Spatial and Temporal Characterization of Gliomas Using Radiomic Analysis
Glioma are type of primary brain tumors arising within the substance of brain. Different type of gliomas are seen which are classified depending upon pathological examination and advanced molecular techniques, which help to…
- Trial name
- GLIO-RAD (NCT06036381)
- Testing
- Radiomic analysis of imaging - MRI, PET, CT
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- Tata Memorial Centre
Malignant Neoplasm of Anal Canal
IMRT Versus IMPT With Concurrent Chemotherapy for Locally Advanced Anal Canal Cancer
The standard practice in management of carcinoma of anal canal is to treat patients with radiotherapy using the IMRT technique along with chemotherapy.
- Trial name
- IMPAC (NCT06630793)
- Testing
- IMPT (Intensity Modulated Proton Therapy), IMRT (Intensity Modulated Radiation Therapy)
- Where
- India
- Volunteers
- 108 people
- Sponsor
- Tata Memorial Centre
Professional Role, Research Peer Review
Delphi Process to Achieve Global Consensus on Gender Equity in Critical Care
Gender inequalities in healthcare, including among critical care professionals, have been widely recognized over the last decade.
- Trial name
- NCT06847802
- Testing
- Survey
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tata Memorial Centre
Prostate Carcinoma
Reduced Length of ADT and ARTA With XRT in High-Risk Prostate Cancer (RELAX): A Randomised Trial
Aim of the study to improve the treatment of high-risk non-metastatic prostate cancer by comparing reduced duration of hormone therapy to the standard duration of two years, when combined with curative intent standard of care…
- Trial name
- RELAX (NCT06818682)
- Testing
- ADT for 9 months and ARTA for 6 months, ADT for 2 years
- Where
- India
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Tata Memorial Centre
Prostate Adenocarcinoma
Prostate Radiotherapy Comparing Moderate and Extreme Hypo-fractionation (PRIME Trial)
Aim: The aim of the study is to compare the efficacy with SBRT and moderate hypo-fractionation in high risk and node positive prostate cancer PRIMARY STUDY OBJECTIVES: To assess whether extreme hypo-fractionation with SBRT in…
- Trial name
- PRIME (NCT03561961)
- Testing
- Moderate Hypo-fractionation, Extreme Hypo-fractionation
- Where
- India
- Volunteers
- 526 people
- Sponsor
- Tata Memorial Centre
Bladder Cancer, Urothelial Carcinoma Bladder
Bladder Cancer Adjuvant Radiotherapy Trial
Aim and objectives: This trial aims to evaluate the role of adjuvant radiotherapy following chemotherapy in patients with high-risk features on histo-pathology after radical surgery for transitional cell carcinoma of urinary…
- Trial name
- BART (NCT02951325)
- Testing
- Adjuvant RT
- Where
- India
- Volunteers
- 153 people
- Sponsor
- Tata Memorial Centre
Prostate Cancer
Randomized Trial of Prostate Only or Pelvic RT in High Risk Prostate Cancer
Evidence to justify the use of the pelvic field is lacking for men with high risk localized prostate cancer. An additional randomized study is needed in men with a potential risk of nodal involvement to test the hypothesis that…
- Trial name
- POP-RT (NCT02302105)
- Testing
- IGRT
- Where
- India
- Volunteers
- 224 people
- Sponsor
- Tata Memorial Centre
Seminoma
Radiotherapy vs Observation for Post Chemotherapy Residual Mass in Advanced Seminoma
Testicular tumors account for 1% of all cancers in males and germ cell tumors comprise 95% of all testicular cancers. Seminomas consist of around 50% of cases.
- Trial name
- NCT05142982
- Testing
- Radiotherapy
- Where
- 2 sites in India
- Volunteers
- 74 people
- Sponsor
- Tata Memorial Centre
Glioma
Craniospinal Irradiation in Histone AlteRed Midline Glioma
Paediatric H3K27/H3G34 mutant diffuse midline gliomas are high grade gliomas that arise in midline structures/cerebral hemispheres and are known to have dismal outcomes.
- Trial name
- CHARM (NCT06720727)
- Testing
- craniospinal irradiation
- Where
- India
- Volunteers
- 32 people
- Sponsor
- Tata Memorial Centre
Critically Ill Adults in the ICU, Requiring Endotracheal Intubation
Effect of a FLUid Bolus or a Low Dose VAsopressor Infusion on Cardiovascular Collapse Among Critically Ill Adults Undergoing Tracheal Intubation.
Tracheal intubation, which is one of the most commonly performed procedures in the care of critically ill patients in intensive care unit, is associated with a high incidence of complications.
- Trial name
- FLUVA (NCT05318066)
- Testing
- Ringer Lactate and Norepinephrine infusion
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Centre
Colorectal Cancer, Ovarian Cancer
An Audit of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Peritoneal carcinomatosis is a common event in the natural history of colorectal and other digestive tract cancers. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provides a promising…
- Conditions
- Colorectal Cancer, Ovarian Cancer, Peritoneal Disease
- Trial name
- NCT02754115
- Testing
- Hyperthermic intraperitoneal chemotherapy
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Tata Memorial Centre
Rectal Adenocarcinoma, Rectal Cancer
Asian Watch-and-Wait Database (AWWD)
The standard treatment approach of localized rectal adenocarcinoma involves neoadjuvant radiotherapy and chemotherapy followed by assessment for surgery and optional adjuvant chemotherapy.
- Trial name
- AWWD (NCT06631443)
- Where
- India
- Volunteers
- 337 people
- Sponsor
- Tata Memorial Centre
High Risk Prostate Carcinoma
Towards Optimal Treatment for High Risk Prostate Cancer
The goal of this clinical trial is to combine several optimized treatments of high risk prostate cancer. The main question to answer is: is it safe to combine these optimized treatments.
- Trial name
- HYPOPRIME (NCT06204341)
- Testing
- HYPOPRIME treatment
- Where
- Netherlands
- Volunteers
- 207 people
- Sponsor
- Haaglanden Medical Centre
Oral Mucositis (Ulcerative)
Ability of Curcumin to Decrease Cytokines Involved in Mucositis in the Autologous Transplant
Mucositis is a very common complication in bone marrow transplant setting. It is a result of injury to the gut caused by high dose chemotherapy.
- Trial name
- NCT04870060
- Testing
- Curcumin Lozenges
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Tata Memorial Centre
Postoperative Acute Pancreatitis, Pancreaticoduodenectomy
Clinical and Economic Validation of the ISGPS Definition of PPAP
This prospective validation study aims to investigate the incidence of PPAP after pancreaticoduodenectomy (PD) by applying the ISGPS definition and grading system, to demonstrate its clinical impact by examining associated…
- Conditions
- Postoperative Acute Pancreatitis, Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Postoperative Complications
- Trial name
- ISGPS-PPAP (NCT05680623)
- Testing
- PPAP diagnosis
- Where
- Italy
- Volunteers
- 2,900 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Female Breast Cancer
Effect of TIVA Propofol vs Sevoflurane Anaesthetic on Serum Biomarkers and on PBMCs in Breast Cancer Surgery
Surgery, perioperative stress, anaesthetics and analgesics may modulate the immunosurveillance mechanisms and overwhelm host defences that normally maintain a balance between immunity \& carcinogenesis.
- Trial name
- NCT03005860
- Testing
- 2,6-Diisopropylphenol, Fluoromethyl hexafluoroisopropyl ether, Fentanyl Citrate
- Where
- India
- Sponsor
- Tata Memorial Centre
Cancer, Cervical, Recurrence
Retrospective Cervical Cancer Oligo States (Recurrence, Metastasis) Multicentre Outcomes Study
This multi centric international retrospective study aims to register patients with oligo metastatic and oligo recurrent cervical cancer.
- Conditions
- Cancer, Cervical, Recurrence, Metastasis
- Trial name
- Retro-COSMOS (NCT06150222)
- Testing
- Concurrent Chemoradiation, Systemic Chemotherapy other locally directed therapies (like surgery, ablation, etc.)
- Volunteers
- 350 people
- Sponsor
- Erasmus Medical Center
Oral Mucositis (Ulcerative)
Randomized Trial of Curcumin to Reduce Mucositis in Autologous Transplant Setting
Mucositis is a very common complication in bone marrow transplant setting. It is a result of injury to the gut caused by high dose chemotherapy.
- Trial name
- NCT04896164
- Testing
- Curcumin Lozenges
- Where
- India
- Volunteers
- 190 people
- Sponsor
- Tata Memorial Centre