Clinical trials: sponsored by The Netherlands Cancer Institute
Carcinoma, Non-Small-Cell Lung
Anti-PD-1 Re-challenge After Immune Priming by Ipilimumab and Immune Boosting by Radiotherapy in Advanced NSCLC
Still many advanced non-small cell lung cancer (NSCLC) patients do not benefit from PD-(L)1 inhibition or will eventually develop progression through secondary resistance.
- Trial name
- RAD-IO (NCT05401786)
- Testing
- Ipilimumab, Cemiplimab, SBRT
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- The Netherlands Cancer Institute
Ovarian Cancer, Epithelial Cancer
The PROOV Study: Exploiting the Synergistic Effect of PARP Inhibition With Cisplatin and Hyperthermia During Interval Cytoreductive Surgery and HIPEC in Ovarian Cancer
The PROOV study is an open-label, monocenter, single-arm, prospective phase I/II trial with a safety lead-in, evaluating the feasibility of combining PARPi with HIPEC in stage III EOC patients.
- Conditions
- Ovarian Cancer, Epithelial Cancer, Fallopian Tube Cancer
- Trial name
- PROOV (NCT07460180)
- Testing
- Olaparib
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- The Netherlands Cancer Institute
Oncology, Breast Cancer
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further…
- Conditions
- Oncology, Breast Cancer, Prostate Cancer, Gynecologic Cancer
- Trial name
- MOMENTUM (NCT04075305)
- Testing
- Radiation therapy
- Where
- 18 sites in United States, Australia and 7 more
- Volunteers
- 8,000 people
- Sponsor
- UMC Utrecht
Resectable MMR-deficient Solid Tumors, Resectable MMR-proficient Solid Tumors
Pan-tumor Neoadjuvant Basket Study of Immune Check-point Inhibition and Novel Immuno-oncology Combinations
In this study, the efficacy of botensilimab and balstilimab in mismatch repair deficient (dMMR) and mismatch repair proficient (pMMR) tumors will be assessed.
- Trial name
- NEOASIS (NCT06279130)
- Testing
- botensilimab, balstilimab, FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel)
- Where
- Netherlands
- Volunteers
- 133 people
- Sponsor
- The Netherlands Cancer Institute
NSCLC Stage IV
18F-PD-L1 PET/CT in Nivolumab Treated Patients With NSCLC
A multicenter single arm biomarker exploration and validation study. Eighty patients with NSCLC that are eligible for first line chemo-immunotherapy, first line nivolumab/ipilimumab or 2nd line and beyond PD-(L)1 immunotherapy…
- Trial name
- NCT03564197
- Testing
- 18F-PD-L1
- Where
- 8 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- The Netherlands Cancer Institute
Familial Adenomatous Polyposis
A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis
The purpose of this study is to determine the efficacy and safety of a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients with familial adenomatous polyposis (FAP)
- Trial name
- NCT04677998
- Testing
- Personalized surveillance and intervention protocol
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Familial Adenomatous Polyposis
A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy
The purpose of this study is to determine the efficacy and safety of a personalised surveillance and intervention protocol for patients with familial adenomatous polyposis (FAP) that have undergone (procto)colectomy.
- Trial name
- NCT04678011
- Testing
- Personalized surveillance and intervention protocol
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sarcoma of Soft Tissue, Sarcoma
Short Course of Radiotherapy Prior to Surgery of Soft Tissue Sarcomas
Based upon the preliminary data derived from first SCOPES clinical trial and the results of patients treated during the recent COVID-19 pandemic, patients with soft tissue sarcomas (STS) can be preoperatively irradiated in a…
- Conditions
- Sarcoma of Soft Tissue, Sarcoma, Sarcoma, Soft Tissue
- Trial name
- SCOPES II (NCT07071727)
- Testing
- Preoperative radiotherapy
- Where
- 6 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- The Netherlands Cancer Institute
Prostate Cancer (Adenocarcinoma)
Dose De-escalation in Prostate Radiotherapy Using an MR-Linac in Two Fractions
The goal of this clinical trial is to find out whether lowering the radiation dose to parts of the prostate without visible tumor on MRI can reduce side effects while still effectively treating prostate cancer in men with low or…
- Trial name
- DESTINATION 2 (NCT07391982)
- Testing
- uniform dose radiotherapy, De-escalated dose radiotherapy
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- The Netherlands Cancer Institute
Head and Neck Cancer
Lymph Drainage Mapping for Tailoring Elective Nodal Irradiation in Head and Neck Cancer
This study aims to explore the safety and outcome of lymph drainage mapping(LDM) to individually tailor the elective nodal irradiation (ENI) to the ipsilateral neck only.
- Trial name
- SUSPECT-2 (NCT03968679)
- Testing
- Unilateral elective nodal irradiation
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- The Netherlands Cancer Institute
DCIS
Management of Low-risk (Grade I and II) DCIS
A substantial number of DCIS lesions will never form a health hazard, particularly if it concerns slow-growing low-risk DCIS (grade I and II).
- Trial name
- LORD (NCT02492607)
- Testing
- Standard treatment, digital mammography, radiotherapy
- Where
- 60 sites in Netherlands
- Volunteers
- 2,500 people
- Sponsor
- The Netherlands Cancer Institute
Soft Tissue Sarcoma Adult
Sarcomas and DDR-Inhibition; a Combined Modality Study
To assess the safety and tolerability profile, in the pre- and perioperative period (up to 30 days post-surgery), of combined modality treatment (CMT) by administering AZD1390 with or without durvalumab and RT concurrently…
- Trial name
- SADDRIN-1 (NCT05116254)
- Testing
- AZD1390 + radiotherapy, AZD1390 + durvlaumab + radiotherapy
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Renal Cancer, Partial Nephrectomy
Navigated Partial Nephrectomy
This study aims to evaluate electromagnetic (EM) tracked navigation in robot-assisted partial nephrectomy (RAPN), addressing kidney movement issues by attaching a tracked EM sensor close to the lesion.
- Trial name
- NCT07315100
- Testing
- Image guided surgery
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- The Netherlands Cancer Institute
Melanoma, Breast Cancer
Contrast-enhanced Ultrasound for Sentinel Node Detection
This is a prospective single-center interventional non-inferiority study where subjects are participating for one day for patients 18 years or older with melanoma, breast cancer or head \& neck cancer (including melanoma of head…
- Conditions
- Melanoma, Breast Cancer, Head & Neck Cancer
- Trial name
- NCT07310758
- Testing
- Sonazoid
- Where
- Netherlands
- Volunteers
- 91 people
- Sponsor
- The Netherlands Cancer Institute
Abdominal Cancer
Vessel- and Bone-based Ultrasound Registration
In this study we aim to develop an automatic artery and bone segmentation algorithm, which is required for future clinical implementation of US registration for surgical navigation.
- Trial name
- NCT05637346
- Testing
- Intra-operative ultrasound measurement
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- The Netherlands Cancer Institute
Cisplatin-related Hearing Loss
Transtympanic STS Against Cisplatin-induced SNHL: the SOUND Trial
The goal of this clinical trial is to learn if transtympanic sodium thiosulfate (STS) injections can prevent hearing loss caused by cisplatin chemotherapy in adults with head and neck cancer.
- Trial name
- SOUND (NCT07281508)
- Testing
- Transtympanic sodium thiosulphate (STS) 0.1M/0,5% hyaluronate
- Where
- 5 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- The Netherlands Cancer Institute
Prostatic Neoplasm
EBRT + Lu-PSMA for N1M0 Prostate Cancer
The PROQURE project aims to provide prostate cancer patients with more cure and better quality of life. The first part of this project (PROQURE-1) aims to explore an innovative combined modality treatment strategy for patients…
- Trial name
- PROQURE-1 (NCT05162573)
- Testing
- 177Lu-PSMA-617, EBRT
- Where
- 2 sites in Netherlands
- Volunteers
- 14 people
- Sponsor
- The Netherlands Cancer Institute
Colorectal Cancer
Pembrolizumab for Locally Advanced, Irresectable, Non-metastatic dMMR Colorectal Cancers
In this study, the efficacy of pembrolizumab in patients with locally advanced, irresectable dMMR colorectal cancer will be assessed.
- Trial name
- PUMA (NCT05131919)
- Testing
- Pembrolizumab
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- The Netherlands Cancer Institute
Urologic Neoplasms, Urogenital Neoplasms
Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer
This is a single-armed, single-centre, non-blinded phase II trial to assess efficacy of induction chemo-immunotherapy for resectable node-positive squamous cell carcinoma of the penis
- Conditions
- Urologic Neoplasms, Urogenital Neoplasms, Male Urogenital Diseases, Penile Cancer
- Trial name
- PRIAM (NCT06353906)
- Testing
- Carboplatin/Paclitaxel, Pembrolizumab, Partial or total penectomy with inguinal and/or pelvic lymph node dissection
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 27 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Chemosensitivity During Phases of the Menstrual Cycle in Breast Cancer Patients
This study is a prospective, multicenter study in which a serum sample will be collected at the day of starting neo adjuvant treatment in breast cancer patients
- Trial name
- Chemosense (NCT06273800)
- Testing
- Blood sample
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- The Netherlands Cancer Institute