Clinical trials: sponsored by University Hospital, Geneva
Stroke (Subacute)
Virtual Reality-based Mindfulness Training for Mental Health After Stroke
Background: anxiety has a high prevalence in stroke patients and can dampen recovery of motor and cognitive impairment. Psychotropic medication can induce cognitive side effects, while psychotherapy and mindfulness-based stress…
- Trial name
- VITAL (NCT07614373)
- Testing
- Virtual-reality hypnotherapy device
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Nicolas Nicastro
Cardiac Dysfunction, Cardiovascular Diseases
Cardiac Dysfunction in Childhood Cancer Survivors
This multicenter, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. The hypothesis of this study is that cardiac dysfunction can be detected earlier when using speckle tracking…
- Conditions
- Cardiac Dysfunction, Cardiovascular Diseases, Childhood Cancer
- Trial name
- Cardio-Onco (NCT03790943)
- Testing
- cardiac assessment
- Where
- 6 sites in Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Bern
Childhood Cancer, Fertility Disorders
Female Fertility Preservation Using Ovarian Tissue Cryopreservation Before Highly Gonadotoxic Cancer Treatment
Background: Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients.
- Trial name
- NCT03180827
- Testing
- ovarian tissue biopsy
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- Gumy-Pause Fabienne
Childhood Cancer, Fertility Disorders
Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment
Background: Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients.
- Trial name
- NCT03180918
- Testing
- testicular tissue biopsy
- Where
- 3 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- Gumy-Pause Fabienne
Monkeypox, Mpox
Assessment of the Efficacy and Safety of Tecovirimat in Patients With Monkeypox Virus Disease
The overall purpose of this study is to evaluate whether tecovirimat is an efficient and safe antiviral in the treatment of monkeypox in adults and adolescents (14 years old and older).
- Trial name
- UNITY (NCT05597735)
- Testing
- Tecovirimat
- Where
- 12 sites in Argentina, Brazil and 1 more
- Volunteers
- 480 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Critical Illness, ICU
Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study
This multicentric randomized controlled trial aims to evaluate whether indirect calorimetry (IC)-guided nutritional support improves patient-centered outcomes in critically ill adult patients compared to standard formula-based…
- Trial name
- OPTICal (NCT07343440)
- Testing
- Indirect Calorimetry Group, Control Group - Formula-Based Group
- Where
- 3 sites in Switzerland
- Volunteers
- 356 people
- Sponsor
- HEIDEGGER CP
Obesity, Childhood, Type 2 Diabetes Mellitus in Obese
Beta-Cell - Liver Interactions in Situations of Modified Beta-Cell Function
The investigators will measure blood levels of 1,5-anhydroglucitol in obese children with or without type 2 diabetes and correlate them with parameters related to functional beta-cell mass and glucose metabolism.
- Trial name
- NCT06682481
- Testing
- Measurement of biomarker
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Philippe Klee, MD-PhD
Diabetes Mellitus, Type 1
Anhydroglucitol in Children With Type 1 Diabetes
The investigators will measure blood levels of 1,5-anhydroglucitol in children with type 1 diabetes and correlate them with parameters related to functional beta-cell mass in diabetic patients.
- Trial name
- NCT05594706
- Testing
- Measurement of blood levels of 1,5-anhydroglucitol
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Breast Reconstruction, Lipofilling
Hyperbaric Oxygen Therapy to Improve Autologous Fat Graft Intake in Irradiated Breast
The goal of this clinical trial is to learn if hyperbaric oxygen therapy (HBOT) enhances fat graft survival in lipofilling procedures in irradiated breast cancer patients.
- Conditions
- Breast Reconstruction, Lipofilling, Hyperbaric Oxygen Therapy
- Trial name
- NCT07140198
- Testing
- Hyperbaric Oxygen Therapy, Control
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University Hospital, Geneva
Hereditary Cancer, Breast Cancer
The DIALOGUE Study: Swiss-Korean Billateral Collaboration
In Hereditary Breast and Ovarian Cancer (HBOC) communication of genetic test results with relatives is essential to cascade testing.
- Conditions
- Hereditary Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- DIALOGUE (NCT04214210)
- Testing
- Adapted Family Gene Toolkit, Targeted intervention
- Where
- 8 sites in Switzerland
- Volunteers
- 128 people
- Sponsor
- University of Basel
Low Back Pain, Neck Pain
Prediction of Outcome of Interventional Pain Management
Interventional pain management for back and neck pain is widely used, but the indications and relative merits of these techniques rest subject to discussion.
- Conditions
- Low Back Pain, Neck Pain, Chronic Pain
- Trial name
- POINTPM (NCT02774694)
- Testing
- nociceptive flexion reflex (NFR) threshold ("Paintracker", Dolosys GmbH, Berlin, Germany)
- Where
- Switzerland
- Volunteers
- 350 people
- Sponsor
- Benno Rehberg-Klug
Airway Management
Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2)
This study aims to investigate the optimal oxygen flow rate needed during tracheal intubation with the C-MAC video laryngoscope (Karl Storz, Tuttlingen, Germany) using Miller-blade or Macintosh-blade size No. 0 or No.
- Trial name
- OPTIMISE-2 (NCT05967507)
- Testing
- Low-flow nasal supplemental oxygen with a conventional nasal cannula during tracheal intubation with the C-MAC video laryngoscope, High-flow nasal supplemental oxygen (Fisher & Paykel, Auckland, New Zealand) during tracheal intubation with the C-MAC video laryngoscope
- Where
- 11 sites in United States, Australia and 5 more
- Volunteers
- 1,192 people
- Sponsor
- Thomas Riva
Heavy Menstrual Bleeding, Bleeding Disorder
Hormonal Management of Heavy Menstrual Bleeding in Adolescents
The goal of this study is to evaluate whether hormonal medications (such as contraceptive pill, patch, injectable progestins and hormonal intra-uterine device) have similar efficacy at managing heavy menstrual bleeding in…
- Trial name
- JAdoRE (NCT06740929)
- Where
- Switzerland
- Volunteers
- 163 people
- Sponsor
- University Hospital, Geneva
Renal Insufficiency, Chronic
Time-restricted Eating in Patients With Moderate Chronic Kidney Disease and Albuminuria
Chronic kidney disease (CKD) affects approximately 12 to 15% of adults worldwide, with an increasing incidence expected. Major causes include diabetic nephropathy, hypertension, and various glomerulonephritis.
- Trial name
- TRECK (NCT06618859)
- Testing
- Time-restricted eating, Active control
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- de Seigneux Sophie
Breast Cancer
Ablative SBRT in Elderly BC Patients
Stereotactic body radiotherapy (SBRT) is a modern radiotherapy technique, through which extremely high doses of irradiation are delivered in a very precise manner, within a few fractions.
- Trial name
- EASE (NCT06523894)
- Testing
- SBRT
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University Hospital, Geneva
Morbid Obesity Requiring Bariatric Surgery
Can Pre-operative Lean Mass Predict Weight Loss After Roux-en-Y Gastric Bypass?
The goal of this observational study is to evaluate whether preoperative fat-free mass predicts post-operative weight loss in patients undergoing Roux-En-Y gastric bypass.
- Trial name
- FLAG (NCT07565051)
- Where
- Switzerland
- Volunteers
- 91 people
- Sponsor
- University Hospital, Geneva
Chronic Wound Care, Local Infection
Short-Term Safety and Performance of Two Wound Dressings Evaluation
Chronic wounds, including venous leg ulcers, diabetic foot ulcers, and pressure ulcers, are defined as wounds that fail to heal within 4-8 weeks despite appropriate care.
- Conditions
- Chronic Wound Care, Local Infection, Safety
- Trial name
- POLTX_Fiber (NCT07576322)
- Testing
- Politix Fiber arm
- Where
- 3 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Sebastian Probst
Venous Leg Ulcer, Wound Heal
COMS for Chronic Ulcers Treatment
Chronic leg and foot ulcers are defined as wounds that fail to heal in a timely manner, typically persisting for over 4 to 8 weeks without substantial healing despite standard care.
- Conditions
- Venous Leg Ulcer, Wound Heal, Magnetic Field Exposure
- Trial name
- NAZARÉ (NCT06528873)
- Testing
- Concurrent optical and magnetic stimulation (COMS) treatment
- Where
- 10 sites in Austria, France and 2 more
- Volunteers
- 122 people
- Sponsor
- Sebastian Probst
Advance Care Planning, Outpatients
A Nurse-led Patient-centred Intervention to Increase Written Advance Directives
Background and rationale: Since 2013, with the new Swiss Adult Protection Law, Anticipated Directives (ADs) have been used to identify patients' wills in case they cannot express them later.
- Conditions
- Advance Care Planning, Outpatients, Palliative Care
- Trial name
- anticip@imad (NCT04065685)
- Testing
- serious game named Go Wish, usual care
- Where
- Switzerland
- Sponsor
- Katia Iglesias
Post-operative Pain
PAIN OUT: Improvement in Postoperative PAIN OUTcome
PAIN OUT is a multi-national, non-interventional registry and benchmark project, assessing and analysing clinical and patient-reported outcome data of postoperative pain.
- Trial name
- PAIN-OUT (NCT02083835)
- Where
- Germany
- Volunteers
- 200,000 people
- Sponsor
- University of Jena